MA38009A1 - Composes d'azaindoline substitues qui ont une activite inhibitrice de la proteine d'apoptose pour leurs utilisations dans le traitement et/ou la prophylaxie du cancer - Google Patents
Composes d'azaindoline substitues qui ont une activite inhibitrice de la proteine d'apoptose pour leurs utilisations dans le traitement et/ou la prophylaxie du cancerInfo
- Publication number
- MA38009A1 MA38009A1 MA38009A MA38009A MA38009A1 MA 38009 A1 MA38009 A1 MA 38009A1 MA 38009 A MA38009 A MA 38009A MA 38009 A MA38009 A MA 38009A MA 38009 A1 MA38009 A1 MA 38009A1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- cancer
- treatment
- prophylaxis
- inhibitory activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
L'invention concerne des composés de formule (i), ou leurs sels pharmaceutiquement acceptables, dans laquelle w, y, z, r1, r2, r3 et r4 sont tels que décrits dans la présente demande, et des procédés d'utilisation des composés dans le traitement du cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261712305P | 2012-10-11 | 2012-10-11 | |
PCT/EP2013/070881 WO2014056871A1 (fr) | 2012-10-11 | 2013-10-08 | Azaindolines |
Publications (2)
Publication Number | Publication Date |
---|---|
MA38009A1 true MA38009A1 (fr) | 2018-02-28 |
MA38009B1 MA38009B1 (fr) | 2018-09-28 |
Family
ID=49304982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA38009A MA38009B1 (fr) | 2012-10-11 | 2013-10-08 | Composes d'azaindoline substitues qui ont une activite inhibitrice de la proteine d'apoptose pour leurs utilisations dans le traitement et/ou la prophylaxie du cancer |
Country Status (19)
Country | Link |
---|---|
US (1) | US9309248B2 (fr) |
EP (1) | EP2906559B1 (fr) |
JP (1) | JP6333826B2 (fr) |
KR (1) | KR20150067182A (fr) |
CN (1) | CN104540825B (fr) |
AU (1) | AU2013328870A1 (fr) |
CA (1) | CA2880324A1 (fr) |
CL (1) | CL2015000886A1 (fr) |
CR (1) | CR20150148A (fr) |
EA (1) | EA201590656A1 (fr) |
ES (1) | ES2623304T3 (fr) |
HK (1) | HK1206738A1 (fr) |
IL (1) | IL237115A (fr) |
MA (1) | MA38009B1 (fr) |
MX (1) | MX2015004525A (fr) |
PE (1) | PE20150965A1 (fr) |
PH (1) | PH12015500399A1 (fr) |
SG (1) | SG11201501314TA (fr) |
WO (1) | WO2014056871A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016079527A1 (fr) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Polythérapie |
WO2016097773A1 (fr) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Antagonistes des iap thérapeutiques pour traiter des troubles prolifératifs |
PL3458101T3 (pl) | 2016-05-20 | 2021-05-31 | F. Hoffmann-La Roche Ag | Koniugaty PROTAC-przeciwciało i sposoby ich stosowania |
EP3649127B1 (fr) | 2017-07-06 | 2021-09-08 | Janssen Pharmaceutica NV | Dérivés d'azaindoline substitués en tant qu'inhibiteurs de nik |
WO2023056069A1 (fr) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Conjugués agent de dégradation-anticorps et leurs procédés d'utilisation |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2118985A1 (fr) | 1993-04-02 | 1994-10-03 | Dinesh V. Patel | Inhibiteurs heterocycliques de la farnesyl proteine transferase |
US7351702B2 (en) * | 2001-05-23 | 2008-04-01 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
WO2006017295A2 (fr) | 2004-07-12 | 2006-02-16 | Idun Pharmaceuticals, Inc. | Analogues de tetrapeptide |
BRPI0613045A2 (pt) | 2005-07-15 | 2010-12-14 | Hoffmann La Roche | aminas cÍclicas fundidas a heteroarila |
US20110117081A1 (en) * | 2008-05-05 | 2011-05-19 | Aegera Therapeutics, Inc. | Functionalized pyrrolidines and use thereof as iap inhibitors |
JP2011529962A (ja) * | 2008-08-02 | 2011-12-15 | ジェネンテック, インコーポレイテッド | Iapのインヒビター |
EP2373163B1 (fr) | 2008-12-19 | 2015-06-10 | Genentech, Inc. | Composés hétérocycliques et leurs procédés d'utilisation |
EP2784076A1 (fr) * | 2009-10-28 | 2014-10-01 | Joyant Pharmaceuticals, Inc. | Mimétiques de SMAC dimère |
WO2011092293A2 (fr) | 2010-02-01 | 2011-08-04 | Novartis Ag | Dérivés de cyclohexylamide utilisés en tant qu'antagonistes du récepteur du crf |
CN104640860B (zh) * | 2012-10-11 | 2017-05-31 | 霍夫曼-拉罗奇有限公司 | 氮杂二氢吲哚 |
-
2013
- 2013-10-08 JP JP2015536090A patent/JP6333826B2/ja not_active Expired - Fee Related
- 2013-10-08 US US14/433,216 patent/US9309248B2/en not_active Expired - Fee Related
- 2013-10-08 MA MA38009A patent/MA38009B1/fr unknown
- 2013-10-08 WO PCT/EP2013/070881 patent/WO2014056871A1/fr active Application Filing
- 2013-10-08 PE PE2015000475A patent/PE20150965A1/es not_active Application Discontinuation
- 2013-10-08 EP EP13773766.4A patent/EP2906559B1/fr active Active
- 2013-10-08 AU AU2013328870A patent/AU2013328870A1/en not_active Abandoned
- 2013-10-08 CN CN201380042809.4A patent/CN104540825B/zh not_active Expired - Fee Related
- 2013-10-08 EA EA201590656A patent/EA201590656A1/ru unknown
- 2013-10-08 KR KR1020157008986A patent/KR20150067182A/ko not_active Application Discontinuation
- 2013-10-08 SG SG11201501314TA patent/SG11201501314TA/en unknown
- 2013-10-08 ES ES13773766.4T patent/ES2623304T3/es active Active
- 2013-10-08 CA CA2880324A patent/CA2880324A1/fr not_active Abandoned
- 2013-10-08 MX MX2015004525A patent/MX2015004525A/es unknown
-
2015
- 2015-02-05 IL IL237115A patent/IL237115A/en not_active IP Right Cessation
- 2015-02-24 PH PH12015500399A patent/PH12015500399A1/en unknown
- 2015-03-19 CR CR20150148A patent/CR20150148A/es unknown
- 2015-04-08 CL CL2015000886A patent/CL2015000886A1/es unknown
- 2015-07-31 HK HK15107344.1A patent/HK1206738A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2880324A1 (fr) | 2014-04-17 |
AU2013328870A1 (en) | 2015-02-26 |
PE20150965A1 (es) | 2015-06-20 |
EP2906559A1 (fr) | 2015-08-19 |
CR20150148A (es) | 2015-04-30 |
ES2623304T3 (es) | 2017-07-10 |
HK1206738A1 (en) | 2016-01-15 |
CN104540825A (zh) | 2015-04-22 |
IL237115A (en) | 2016-12-29 |
WO2014056871A1 (fr) | 2014-04-17 |
US9309248B2 (en) | 2016-04-12 |
EP2906559B1 (fr) | 2017-02-08 |
KR20150067182A (ko) | 2015-06-17 |
CN104540825B (zh) | 2017-10-24 |
JP6333826B2 (ja) | 2018-05-30 |
CL2015000886A1 (es) | 2015-07-17 |
SG11201501314TA (en) | 2015-03-30 |
EA201590656A1 (ru) | 2015-07-30 |
PH12015500399A1 (en) | 2015-04-27 |
US20150266879A1 (en) | 2015-09-24 |
MX2015004525A (es) | 2015-07-06 |
JP2015534570A (ja) | 2015-12-03 |
MA38009B1 (fr) | 2018-09-28 |
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