MA37961A1 - Nouveaux traitements thérapeutiques par anticorps anti-her2 à basse fucosylation - Google Patents
Nouveaux traitements thérapeutiques par anticorps anti-her2 à basse fucosylationInfo
- Publication number
- MA37961A1 MA37961A1 MA37961A MA37961A MA37961A1 MA 37961 A1 MA37961 A1 MA 37961A1 MA 37961 A MA37961 A MA 37961A MA 37961 A MA37961 A MA 37961A MA 37961 A1 MA37961 A1 MA 37961A1
- Authority
- MA
- Morocco
- Prior art keywords
- her2 antibodies
- new therapeutic
- therapeutic treatments
- low fucosylation
- fucosylation anti
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Radiology & Medical Imaging (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention se rapporte au domaine de la cancérothérapie par anticorps anticancéreux. Cette invention, qui fait preuve d'une efficacité accrue, concerne plus particulièrement l'utilisation d'anticorps anti-her2 présentant des caractéristiques de glycosylation améliorées, en particulier une fucosylation réduite..
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12197768 | 2012-12-18 | ||
PCT/EP2013/065189 WO2014013019A1 (fr) | 2012-07-18 | 2013-07-18 | Nouveaux traitements thérapeutiques par anticorps anti-her2 à basse fucosylation |
Publications (1)
Publication Number | Publication Date |
---|---|
MA37961A1 true MA37961A1 (fr) | 2016-06-30 |
Family
ID=49948317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA37961A MA37961A1 (fr) | 2012-12-18 | 2013-07-18 | Nouveaux traitements thérapeutiques par anticorps anti-her2 à basse fucosylation |
Country Status (16)
Country | Link |
---|---|
US (1) | US20150166664A1 (fr) |
EP (1) | EP2874658A1 (fr) |
JP (1) | JP2015528802A (fr) |
KR (1) | KR20150036710A (fr) |
CN (1) | CN104394887A (fr) |
AU (1) | AU2013291964B2 (fr) |
BR (1) | BR112014032169A2 (fr) |
CA (1) | CA2875486A1 (fr) |
EA (1) | EA201590237A1 (fr) |
IL (1) | IL236714A0 (fr) |
MA (1) | MA37961A1 (fr) |
MX (1) | MX2015000730A (fr) |
NZ (1) | NZ701974A (fr) |
SG (1) | SG11201407841YA (fr) |
WO (1) | WO2014013019A1 (fr) |
ZA (1) | ZA201408938B (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU92659B1 (en) * | 2015-02-23 | 2016-08-24 | Glycotope Gmbh | Glycooptimized antibody drug conjugates |
JP2020512382A (ja) * | 2017-03-29 | 2020-04-23 | グリコトープ ゲーエムベーハー | Pd−l1抗体およびta−muc1抗体 |
CN112566667B (zh) * | 2018-06-15 | 2023-06-09 | 上海美雅珂生物技术有限责任公司 | 治疗癌症的方法和材料 |
WO2022022526A1 (fr) * | 2020-07-28 | 2022-02-03 | 百奥泰生物制药股份有限公司 | Anticorps anti-her2 et son utilisation |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA01007170A (es) | 1999-01-15 | 2002-07-30 | Genentech Inc | Variantes de polipeptidos con funcion efectora alterada. |
EP2275540B1 (fr) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Procédé de contrôle de l'activité de molécule fonctionnelle immunologique |
CA2412701A1 (fr) | 2000-06-28 | 2002-01-03 | Glycofi, Inc. | Procede de production de glycoproteines modifiees |
JP2005532253A (ja) | 2001-10-25 | 2005-10-27 | ジェネンテック・インコーポレーテッド | 糖タンパク質組成物 |
US7691568B2 (en) | 2002-04-09 | 2010-04-06 | Kyowa Hakko Kirin Co., Ltd | Antibody composition-containing medicament |
SG2013005590A (en) * | 2003-01-22 | 2015-06-29 | Roche Glycart Ag | Fusion constructs and use of same to produce antibodies with increased fc receptor binding affinity and effector function |
FR2858235B1 (fr) | 2003-07-31 | 2006-02-17 | Lab Francais Du Fractionnement | Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs |
JPWO2005053742A1 (ja) * | 2003-12-04 | 2007-06-28 | 協和醗酵工業株式会社 | 抗体組成物を含有する医薬 |
WO2005086875A2 (fr) * | 2004-03-11 | 2005-09-22 | City Of Hope | Anticorps t84.66 anti-ace humanise et ses applications |
DOP2006000029A (es) * | 2005-02-07 | 2006-08-15 | Genentech Inc | Antibody variants and uses thereof. (variantes de un anticuerpo y usos de las mismas) |
CA2662226C (fr) * | 2006-09-10 | 2020-08-04 | Glycotope Gmbh | Systeme de production a haut rendement, entierement humain, pour anticorps et proteines ameliores |
TR201804897T4 (tr) * | 2009-10-07 | 2018-06-21 | Macrogenics Inc | Fukosi̇lasyon ölçüsünün deği̇şi̇mleri̇nden dolayi geli̇şmi̇ş efektör i̇şlevi̇ sergi̇leyen fc bölgesi̇ni̇ i̇çeren poli̇pepti̇tler ve bunlarin kullanimlarina yöneli̇k yöntemler |
US20120258496A1 (en) * | 2010-09-27 | 2012-10-11 | Boehringer Ingelheim International Gmbh | Production of low fucose antibodies in h4-ii-e rat cells |
-
2013
- 2013-07-18 JP JP2015522098A patent/JP2015528802A/ja active Pending
- 2013-07-18 CN CN201380034959.0A patent/CN104394887A/zh active Pending
- 2013-07-18 MX MX2015000730A patent/MX2015000730A/es unknown
- 2013-07-18 EA EA201590237A patent/EA201590237A1/ru unknown
- 2013-07-18 KR KR20157004250A patent/KR20150036710A/ko not_active Application Discontinuation
- 2013-07-18 SG SG11201407841YA patent/SG11201407841YA/en unknown
- 2013-07-18 CA CA2875486A patent/CA2875486A1/fr not_active Abandoned
- 2013-07-18 WO PCT/EP2013/065189 patent/WO2014013019A1/fr active Application Filing
- 2013-07-18 AU AU2013291964A patent/AU2013291964B2/en not_active Expired - Fee Related
- 2013-07-18 BR BR112014032169A patent/BR112014032169A2/pt not_active IP Right Cessation
- 2013-07-18 US US14/412,797 patent/US20150166664A1/en not_active Abandoned
- 2013-07-18 EP EP13739973.9A patent/EP2874658A1/fr not_active Withdrawn
- 2013-07-18 MA MA37961A patent/MA37961A1/fr unknown
- 2013-07-18 NZ NZ701974A patent/NZ701974A/en not_active IP Right Cessation
-
2014
- 2014-12-05 ZA ZA2014/08938A patent/ZA201408938B/en unknown
-
2015
- 2015-01-14 IL IL236714A patent/IL236714A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA201408938B (en) | 2016-09-28 |
BR112014032169A2 (pt) | 2017-08-01 |
CA2875486A1 (fr) | 2014-01-23 |
IL236714A0 (en) | 2015-02-26 |
WO2014013019A1 (fr) | 2014-01-23 |
SG11201407841YA (en) | 2015-02-27 |
EA201590237A1 (ru) | 2015-05-29 |
KR20150036710A (ko) | 2015-04-07 |
MX2015000730A (es) | 2015-08-06 |
NZ701974A (en) | 2018-03-23 |
EP2874658A1 (fr) | 2015-05-27 |
AU2013291964B2 (en) | 2017-12-14 |
US20150166664A1 (en) | 2015-06-18 |
JP2015528802A (ja) | 2015-10-01 |
AU2013291964A1 (en) | 2015-02-05 |
CN104394887A (zh) | 2015-03-04 |
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