EA201491447A1 - Ендиины, их конъюгаты и способы их получения и применения - Google Patents

Ендиины, их конъюгаты и способы их получения и применения

Info

Publication number
EA201491447A1
EA201491447A1 EA201491447A EA201491447A EA201491447A1 EA 201491447 A1 EA201491447 A1 EA 201491447A1 EA 201491447 A EA201491447 A EA 201491447A EA 201491447 A EA201491447 A EA 201491447A EA 201491447 A1 EA201491447 A1 EA 201491447A1
Authority
EA
Eurasian Patent Office
Prior art keywords
conjugates
application
endines
reception
methods
Prior art date
Application number
EA201491447A
Other languages
English (en)
Other versions
EA027925B1 (ru
Inventor
Найду С. Човарди
Санжив Гангвар
Билал Суфи
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47722570&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201491447(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201491447A1 publication Critical patent/EA201491447A1/ru
Publication of EA027925B1 publication Critical patent/EA027925B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Abstract

Описанные ендиины, имеющие структуру формулы (I)где R, R, R, R, R, Rи Rимеют значение по определению в данной заявке, можно применять в химиотерапевтических лекарственных средствах, в особенности в виде конъюгатов, для лечения заболеваний, таких как рак.
EA201491447A 2012-02-13 2013-02-08 Ендиины, их конъюгаты и способы их получения и применения EA027925B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261598143P 2012-02-13 2012-02-13
US201261653785P 2012-05-31 2012-05-31
PCT/US2013/025247 WO2013122823A1 (en) 2012-02-13 2013-02-08 Enediyne compounds, conjugates thereof, and uses and methods therefor

Publications (2)

Publication Number Publication Date
EA201491447A1 true EA201491447A1 (ru) 2014-11-28
EA027925B1 EA027925B1 (ru) 2017-09-29

Family

ID=47722570

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491447A EA027925B1 (ru) 2012-02-13 2013-02-08 Ендиины, их конъюгаты и способы их получения и применения

Country Status (30)

Country Link
US (2) US8709431B2 (ru)
EP (1) EP2814829B1 (ru)
JP (1) JP6113194B2 (ru)
KR (1) KR101660146B1 (ru)
CN (1) CN104220441B (ru)
AR (1) AR089972A1 (ru)
AU (1) AU2013221873B2 (ru)
BR (1) BR112014019990A8 (ru)
CA (1) CA2864420C (ru)
CL (1) CL2014002096A1 (ru)
CO (1) CO7061078A2 (ru)
CY (1) CY1118899T1 (ru)
DK (1) DK2814829T3 (ru)
EA (1) EA027925B1 (ru)
ES (1) ES2615268T3 (ru)
HK (1) HK1204326A1 (ru)
HR (1) HRP20170334T1 (ru)
HU (1) HUE033704T2 (ru)
IL (1) IL233965B (ru)
LT (1) LT2814829T (ru)
MX (1) MX350539B (ru)
PE (1) PE20141791A1 (ru)
PL (1) PL2814829T3 (ru)
PT (1) PT2814829T (ru)
RS (1) RS55763B1 (ru)
SG (1) SG11201404667XA (ru)
SI (1) SI2814829T1 (ru)
TW (1) TW201336851A (ru)
WO (1) WO2013122823A1 (ru)
ZA (1) ZA201406723B (ru)

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KR102494646B1 (ko) 2014-03-20 2023-01-31 브리스톨-마이어스 스큅 컴퍼니 안정화된 피브로넥틴 기반 스캐폴드 분자
CA2968382A1 (en) 2014-11-21 2016-05-26 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
UY36404A (es) 2014-11-21 2016-06-01 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware ANTICUERPOS MONOCLONALES (Ab) COMO DETECTORES DE CD73 E INHIBIDORES DE SU ACTIVIDAD ENZIMÁTICA, Y COMPOSICIONES QUE LOS CONTIENEN
KR102632418B1 (ko) 2014-11-25 2024-01-31 브리스톨-마이어스 스큅 컴퍼니 영상화를 위한 신규 pd-l1 결합 폴리펩티드
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BR112018012524A2 (pt) 2015-12-21 2018-12-11 Bristol Myers Squibb Co anticorpos variantes para conjugação sítio-específica
KR20230038311A (ko) 2016-03-04 2023-03-17 브리스톨-마이어스 스큅 컴퍼니 항-cd73 항체와의 조합 요법
CN106267188A (zh) * 2016-08-15 2017-01-04 深圳大学 小分子免疫激动剂偶联pd‑1抗体的新型抗体及其在抗肿瘤中的应用
US20190218294A1 (en) 2016-09-09 2019-07-18 Bristol-Myers Squibb Company Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment
KR20200013241A (ko) 2017-05-25 2020-02-06 브리스톨-마이어스 스큅 컴퍼니 변형된 중쇄 불변 영역을 포함하는 항체
CN111683686A (zh) * 2017-12-06 2020-09-18 西纳福克斯股份有限公司 烯二炔缀合物
CN110183659B (zh) * 2018-02-21 2022-04-26 香港科技大学 含有杂环的聚合物、其制备方法及其应用
US20220106400A1 (en) 2018-11-28 2022-04-07 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
HRP20230500T1 (hr) 2018-11-30 2023-07-21 Bristol-Myers Squibb Company Antitijelo koje sadrži c-terminalnu ekstenziju lakog lanca koja sadrži glutamin, njegovi konjugati, i postupci i primjene
EP3894443A2 (en) 2018-12-12 2021-10-20 Bristol-Myers Squibb Company Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses
AU2020279478A1 (en) * 2019-05-22 2021-12-09 Board Of Regents, The University Of Texas System Functionalized gold carbene naphthoquinone complexes for use in the treatment of cancer
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Also Published As

Publication number Publication date
JP2015508074A (ja) 2015-03-16
SG11201404667XA (en) 2014-09-26
US20140193438A1 (en) 2014-07-10
BR112014019990A2 (ru) 2017-06-20
PE20141791A1 (es) 2014-11-19
AU2013221873A1 (en) 2014-10-02
JP6113194B2 (ja) 2017-04-12
MX2014009234A (es) 2014-11-10
US9156850B2 (en) 2015-10-13
DK2814829T3 (en) 2017-03-20
MX350539B (es) 2017-09-08
TW201336851A (zh) 2013-09-16
EP2814829A1 (en) 2014-12-24
HUE033704T2 (en) 2017-12-28
CO7061078A2 (es) 2014-09-19
SI2814829T1 (sl) 2017-02-28
CY1118899T1 (el) 2018-01-10
CN104220441B (zh) 2017-03-29
CL2014002096A1 (es) 2014-11-28
KR20140120374A (ko) 2014-10-13
AR089972A1 (es) 2014-10-01
PL2814829T3 (pl) 2017-06-30
US20130209494A1 (en) 2013-08-15
CA2864420C (en) 2016-11-15
PT2814829T (pt) 2017-02-15
EP2814829B1 (en) 2016-12-07
US8709431B2 (en) 2014-04-29
AU2013221873B2 (en) 2016-11-17
BR112014019990A8 (pt) 2017-07-11
LT2814829T (lt) 2017-02-27
CN104220441A (zh) 2014-12-17
IL233965B (en) 2018-01-31
KR101660146B1 (ko) 2016-09-26
ZA201406723B (en) 2016-05-25
HRP20170334T1 (hr) 2017-04-21
EA027925B1 (ru) 2017-09-29
RS55763B1 (sr) 2017-07-31
HK1204326A1 (en) 2015-11-13
CA2864420A1 (en) 2013-08-22
ES2615268T3 (es) 2017-06-06
WO2013122823A1 (en) 2013-08-22

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