MA37955A1 - Beta-secretase inhibitors - Google Patents

Beta-secretase inhibitors

Info

Publication number
MA37955A1
MA37955A1 MA37955A MA37955A MA37955A1 MA 37955 A1 MA37955 A1 MA 37955A1 MA 37955 A MA37955 A MA 37955A MA 37955 A MA37955 A MA 37955A MA 37955 A1 MA37955 A1 MA 37955A1
Authority
MA
Morocco
Prior art keywords
beta
secretase inhibitors
inhibitors
disorders
bace1
Prior art date
Application number
MA37955A
Other languages
French (fr)
Inventor
Yuri Bukhtiyarov
Salvacion Cacatian
Lawrence Wayne Dillard
Cornelia Dorner-Ciossek
Klaus Fuchs
Ulrike Gross
Niklas Heine
Lanqi Jia
Deepak S Lala
Angel Morales-Ramos
Suresh B Singh
Achim Sauer
Shankar Venkatraman
Zhenrong Xu
Jing Yuan
Yi Zhao
Yajun Zheng
Original Assignee
Vitae Pharmaceuticals Inc
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitae Pharmaceuticals Inc, Boehringer Ingelheim Int filed Critical Vitae Pharmaceuticals Inc
Priority claimed from PCT/US2013/056566 external-priority patent/WO2014035860A1/en
Publication of MA37955A1 publication Critical patent/MA37955A1/en

Links

Abstract

La présente invention concerne des acylguanidines spirocycliques et leur utilisation en tant qu'inhibiteurs de l'activité enzymatique bêta-secrétase (bace1), des compositions pharmaceutiques contenant celles-ci, et des procédés d'utilisation de celles-ci comme agents thérapeutiques dans le traitement de troubles neurodégénératifs, de troubles caractérisés par un déclin cognitif, un déficit cognitif, la démence et des maladies caractérisées par la production d'agrégats de ß-amyloïdes.The present invention relates to spirocyclic acylguanidines and their use as inhibitors of enzymatic beta-secretase activity (bace1), pharmaceutical compositions containing them, and methods of using them as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by the production of β-amyloid aggregates.

MA37955A 2012-08-27 2013-08-26 Beta-secretase inhibitors MA37955A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261693512P 2012-08-27 2012-08-27
PCT/US2013/056566 WO2014035860A1 (en) 2012-08-27 2013-08-26 Inhibitors of beta-secretase

Publications (1)

Publication Number Publication Date
MA37955A1 true MA37955A1 (en) 2017-10-31

Family

ID=60765487

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37955A MA37955A1 (en) 2012-08-27 2013-08-26 Beta-secretase inhibitors

Country Status (1)

Country Link
MA (1) MA37955A1 (en)

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