MA37942A3 - Hétéroaryldihydropyrimidines d'acide 6-aminé pour le traitement et la prophylaxie d'une infection par le virus de l'hépatite b - Google Patents

Hétéroaryldihydropyrimidines d'acide 6-aminé pour le traitement et la prophylaxie d'une infection par le virus de l'hépatite b

Info

Publication number
MA37942A3
MA37942A3 MA37942A MA37942A MA37942A3 MA 37942 A3 MA37942 A3 MA 37942A3 MA 37942 A MA37942 A MA 37942A MA 37942 A MA37942 A MA 37942A MA 37942 A3 MA37942 A3 MA 37942A3
Authority
MA
Morocco
Prior art keywords
heteroaryldihydropyrimidines
prophylaxis
hepatitis
treatment
amino acid
Prior art date
Application number
MA37942A
Other languages
English (en)
Other versions
MA37942A2 (fr
MA37942B1 (fr
Inventor
Mingwei Zhou
Guozhi Tang
Lisha Wang
Lei Guo
taishan Hu
Yimin Hu
Buelent Kocer
Xianfeng Lin
Haixia Liu
Alexander V Mayweg
Zongxing Qiu
Hong Shen
Guolong Wu
Shixiang Yan
Weixing Zhang
Wei Zhu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49212746&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA37942(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA37942A2 publication Critical patent/MA37942A2/fr
Publication of MA37942A3 publication Critical patent/MA37942A3/fr
Publication of MA37942B1 publication Critical patent/MA37942B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne de nouveaux composés ayant la formule générale : où r1, r2, r3, r4 et a sont tels que décrits ici, des compositions comprenant les composés et des procédés d'utilisation des composés.
MA37942A 2012-09-10 2013-09-06 Hétéroaryldihydropyrimidines d'acide 6-aminé pour le traitement et la prophylaxie d'une infection par le virus de l'hépatite b MA37942B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2012/081190 2012-09-10
CNPCT/CN2013/080301 2013-07-29
CNPCT/CN2013/081196 2013-08-09
CNPCT/CN2013/081287 2013-08-12
PCT/EP2013/068429 WO2014037480A1 (fr) 2012-09-10 2013-09-06 Hétéroaryldihydropyrimidines d'acide 6-aminé pour le traitement et la prophylaxie d'une infection par le virus de l'hépatite b

Publications (3)

Publication Number Publication Date
MA37942A2 MA37942A2 (fr) 2016-12-30
MA37942A3 true MA37942A3 (fr) 2018-05-31
MA37942B1 MA37942B1 (fr) 2020-01-31

Family

ID=49212746

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37942A MA37942B1 (fr) 2012-09-10 2013-09-06 Hétéroaryldihydropyrimidines d'acide 6-aminé pour le traitement et la prophylaxie d'une infection par le virus de l'hépatite b

Country Status (24)

Country Link
US (1) US9447086B2 (fr)
EP (1) EP2892893B2 (fr)
JP (1) JP6113285B2 (fr)
KR (1) KR20150054795A (fr)
CN (1) CN104603125A (fr)
AR (1) AR092503A1 (fr)
AU (1) AU2013311705A1 (fr)
BR (1) BR112015004113A2 (fr)
CA (1) CA2881322A1 (fr)
CL (1) CL2015000482A1 (fr)
CO (1) CO7170160A2 (fr)
CR (1) CR20150085A (fr)
EA (1) EA201590384A1 (fr)
ES (1) ES2617906T3 (fr)
HK (1) HK1210152A1 (fr)
IL (1) IL236691A0 (fr)
MA (1) MA37942B1 (fr)
MX (1) MX2015002954A (fr)
PE (1) PE20150776A1 (fr)
PH (1) PH12015500347A1 (fr)
SG (1) SG11201500377UA (fr)
TW (1) TW201416360A (fr)
WO (1) WO2014037480A1 (fr)
ZA (1) ZA201500580B (fr)

Families Citing this family (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ606156A (en) 2010-07-22 2015-01-30 Gilead Sciences Inc Methods and compounds for treating paramyxoviridae virus infections
EA037918B1 (ru) 2011-12-21 2021-06-07 Новира Терапьютикс, Инк. Противовирусные агенты против гепатита в
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
CN103626752B (zh) * 2012-08-24 2015-08-12 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
WO2014033176A1 (fr) 2012-08-28 2014-03-06 Janssen R&D Ireland Sulfamoyl-arylamides et leur utilisation en tant que médicaments dans le traitement de l'hépatite b
MX366913B (es) 2012-09-10 2019-07-30 Reata Pharmaceuticals Inc Derivados de c17-alcanodiilo y alquenodiilo de ácido oleanólico y métodos de uso de los mismos.
PT2961732T (pt) 2013-02-28 2017-06-26 Janssen Sciences Ireland Uc Sulfamoil-arilamidas e utilização das mesmas como medicamentos para o tratamento de hepatite b
US8993771B2 (en) 2013-03-12 2015-03-31 Novira Therapeutics, Inc. Hepatitis B antiviral agents
BR112015025052A2 (pt) 2013-04-03 2021-07-06 Janssen Sciences Ireland Uc derivados de n-fenil-carboxamida e o seu uso como medicamentos para o tratamento da hepatite b
US9266904B2 (en) * 2013-05-17 2016-02-23 Hoffmann-La Roche Inc. 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
JO3603B1 (ar) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
SI3024819T1 (en) 2013-07-25 2018-06-29 Janssen Sciences Ireland Uc Glyoxamide-substituted pyrrolamide derivatives and their use as medicines for the treatment of hepatitis B
UA117261C2 (uk) 2013-10-23 2018-07-10 ЯНССЕН САЙЄНСЕЗ АЙРЛЕНД ЮСі Похідні карбоксаміду та їх застосування як медикаментів для лікування гепатиту b
CN104650068B (zh) * 2013-11-19 2018-08-10 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
AU2014356984B2 (en) * 2013-11-27 2018-01-04 Sunshine Lake Pharma Co., Ltd. Processes for preparing dihydropyrimidine derivatives and intermediates thereof
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US9181288B2 (en) 2014-01-16 2015-11-10 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
JP6553059B2 (ja) 2014-02-05 2019-07-31 ノヴィラ・セラピューティクス・インコーポレイテッド Ｈｂｖ感染の治療のための併用療法
MX367689B (es) 2014-02-06 2019-09-02 Janssen Sciences Ireland Uc Derivados de sulfamoilpirrolamida y su uso como medicamentos para el tratamiento de la hepatitis b.
EP4129407A1 (fr) 2014-02-25 2023-02-08 Achillion Pharmaceuticals, Inc. Composés aryle, hétéroaryle et hétérocycliques pour le traitement de troubles induits par un complément
PL3116316T3 (pl) 2014-03-13 2020-03-31 Indiana University Research And Technology Corporation Allosteryczne modulatory białka rdzeniowego wirusa zapalenia wątroby typu B
US9400280B2 (en) 2014-03-27 2016-07-26 Novira Therapeutics, Inc. Piperidine derivatives and methods of treating hepatitis B infections
MX2016012573A (es) * 2014-03-28 2018-02-19 Sunshine Lake Pharma Co Ltd Compuestos de dihidropirimidina y su aplicacion en productos farmaceuticos.
EP3139954A4 (fr) * 2014-05-09 2018-02-28 Indiana University Research and Technology Corporation Méthodes et compositions pour traiter les infections par le virus de l'hépatite b
WO2016012470A1 (fr) * 2014-07-25 2016-01-28 F. Hoffmann-La Roche Ag Nouvelles formes amorphes et cristallines de l'acide (3s)-4-[[(4r)-4-(2-chloro-4-fluorophényl)-5-méthoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]méthyl]morpholine-3-carboxilique
WO2016016196A1 (fr) * 2014-07-31 2016-02-04 F. Hoffmann-La Roche Ag Nouvelle résolution chirale d'esters d'acide 4-aryl-2-thiazol-2-yl-1,4-dihydropyrimidin-5-carboxylique
CN104327006A (zh) * 2014-10-19 2015-02-04 湖南华腾制药有限公司 一种5-乙基-4-甲酰胺基恶唑的制备方法
TWI740546B (zh) 2014-10-29 2021-09-21 美商基利科學股份有限公司 製備核糖苷的方法
AR103222A1 (es) * 2014-12-23 2017-04-26 Hoffmann La Roche Procedimiento para la preparación de análogos de 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidina
CN107208102B (zh) 2015-01-27 2021-07-06 豪夫迈·罗氏有限公司 重组hbv cccdna、其产生方法及其用途
CN105859708B (zh) * 2015-02-07 2020-01-21 广东东阳光药业有限公司 二氢嘧啶衍生物的盐及其在药物中的应用
HUE050029T2 (hu) 2015-03-04 2020-11-30 Gilead Sciences Inc 4,6-Diamino-pirido[3,2-d]pirimidin-származékok és alkalmazásuk toll-szerû receptorok modulátoraként
AU2016232353B2 (en) * 2015-03-16 2019-05-16 F. Hoffmann-La Roche Ag Combined treatment with a TLR7 agonist and an HBV capsid assembly inhibitor
US9884831B2 (en) 2015-03-19 2018-02-06 Novira Therapeutics, Inc. Azocane and azonane derivatives and methods of treating hepatitis B infections
US10442788B2 (en) 2015-04-01 2019-10-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
JP2018511621A (ja) * 2015-04-14 2018-04-26 ギリアード サイエンシーズ， インコーポレイテッド Ｂ型肝炎ウイルスを処置する方法
US10738035B2 (en) 2015-05-13 2020-08-11 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2016202721A1 (fr) 2015-06-16 2016-12-22 F. Hoffmann-La Roche Ag Sels d'acide (s)-4-[(r)-6-(2-chloro-4-fluoro-phényl)-5-méthoxycarbonyl-2-thiazol-2-yl-3,6- dihydro-pyrimidin-4-ylméthyl]-morpholine-3-carboxylique, agent salifiant et leurs procédés de préparation et d'utilisation
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
US10179131B2 (en) * 2015-07-13 2019-01-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2017035361A1 (fr) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Composés disubstitués destinés au traitement de troubles médicaux
WO2017035401A1 (fr) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Composés amide pour le traitement de troubles immunitaires et inflammatoires
WO2017035405A1 (fr) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Composés amino pour le traitement de troubles immunitaires et inflammatoires
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
WO2017035351A1 (fr) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Composés amino pour le traitement de troubles médicaux
AR105808A1 (es) 2015-08-26 2017-11-08 Achillion Pharmaceuticals Inc Compuestos de amida para el tratamiento de trastornos médicos
ES2908479T3 (es) 2015-08-26 2022-04-29 Achillion Pharmaceuticals Inc Compuestos para el tratamiento de trastornos inmunitarios e inflamatorios
WO2017035357A1 (fr) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Composés phosphonate destinés au traitement de troubles médicaux
JP2018525412A (ja) 2015-08-26 2018-09-06 ギリアード サイエンシーズ， インコーポレイテッド 重水素化トール様受容体調節因子
WO2017035409A1 (fr) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Composés aryle, hétéroaryle, et hétérocycliques pour le traitement de troubles immunitaires et inflammatoires
AR105809A1 (es) 2015-08-26 2017-11-08 Achillion Pharmaceuticals Inc Compuestos para el tratamiento de trastornos médicos
WO2017035355A1 (fr) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Composés éther pour le traitement de troubles médicaux
TWI721016B (zh) 2015-09-15 2021-03-11 美商艾森伯利生物科學公司 B型肝炎核心蛋白質調節劑
EP3349758B1 (fr) 2015-09-16 2022-04-06 Gilead Sciences, Inc. Procédés pour le traitement d'infections virales à arenaviridae
CN108430971A (zh) 2015-09-29 2018-08-21 诺维拉治疗公司 乙型肝炎抗病毒剂的晶体形式
WO2017064156A1 (fr) 2015-10-16 2017-04-20 F. Hoffmann-La Roche Ag Nouvelles 2-hétéroaryldihydropyrimidines fusionnées en position 6 pour le traitement et la prophylaxie de l'infection par le virus de l'hépatite b
KR102181168B1 (ko) 2015-11-03 2020-11-23 에프. 호프만-라 로슈 아게 Hbv 캡시드 조립 억제제와 인터페론의 조합 치료
WO2017108630A1 (fr) * 2015-12-21 2017-06-29 F. Hoffmann-La Roche Ag Polythérapie à inhibiteur hbsag et inhibiteur d'assemblage de capside du vhb
WO2017136403A1 (fr) 2016-02-02 2017-08-10 Enanta Pharmaceuticals, Inc. Agents antiviraux contre l'hépatite b
AR107633A1 (es) 2016-02-19 2018-05-16 Hoffmann La Roche Procedimiento para la preparación del ácido 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidin-6-il-[metil]-3-oxo-5,6,8,8a-tetrahidro-1h-imidazo[1,5a]pirazin-2-il-carboxílico
KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
CN107200733A (zh) * 2016-03-18 2017-09-26 广东东阳光药业有限公司 二氢嘧啶衍生物的晶型及其在药物中的应用
MX2018012557A (es) 2016-04-15 2019-07-04 Janssen Sciences Ireland Uc Combinaciones y métodos que comprenden un inhibidor del ensamblaje de la cápside.
MX2018014377A (es) 2016-05-27 2019-03-14 Gilead Sciences Inc Metodos para tratar infecciones por virus de hepatitis b usando inhibidores de proteina no estructural 5a (ns5a), proteina no estructural 5b (ns5b) o proteina no estructural 3 (ns3).
BR102017010009A2 (pt) 2016-05-27 2017-12-12 Gilead Sciences, Inc. Compounds for the treatment of hepatitis b virus infection
AU2017277664A1 (en) 2016-06-10 2019-01-24 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2018036941A1 (fr) 2016-08-24 2018-03-01 F. Hoffmann-La Roche Ag Thérapie de combinaison d'un inhibiteur d'ensemble capside du vhb et d'un analogue de nucléotide/nucléoside
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
WO2018045150A1 (fr) 2016-09-02 2018-03-08 Gilead Sciences, Inc. Dérivés de 4,6-diamino-pyrido [3,2-d] pyrimidine en tant que modulateurs du récepteur de type toll
CN109923106B (zh) 2016-09-02 2022-09-13 吉利德科学公司 toll样受体调节剂化合物
AU2017326400B2 (en) 2016-09-13 2023-03-30 F. Hoffmann-La Roche Ag Combined treatment with a TLR7 agonist and an HBV capsid assembly inhibitor
EP3512845A1 (fr) 2016-09-15 2019-07-24 Assembly Biosciences, Inc. Modulateurs des protéines du noyau de l'hépatite b
KR20210118240A (ko) 2016-10-14 2021-09-29 프리시젼 바이오사이언시스 인코포레이티드 B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제
MX2019005119A (es) 2016-11-18 2019-06-20 Sichuan Kelun Biotech Biopharmaceutical Co Ltd Compuesto de dihidropirimidina y metodo de preparacion y uso del mismo.
US11166954B2 (en) 2016-11-18 2021-11-09 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Dihydropyrimidine compound and preparation method and use thereof
TWI784370B (zh) 2017-01-31 2022-11-21 美商基利科學股份有限公司 替諾福韋埃拉酚胺(tenofovir alafenamide)之晶型
JOP20180008A1 (ar) 2017-02-02 2019-01-30 Gilead Sciences Inc مركبات لعلاج إصابة بعدوى فيروس الالتهاب الكبدي b
WO2018160891A1 (fr) 2017-03-01 2018-09-07 Achillion Pharmaceutical, Inc. Composés pharmaceutiques destinés au traitement de troubles médicaux
WO2018160892A1 (fr) 2017-03-01 2018-09-07 Achillion Pharmaceuticals, Inc. Composés macrocycliques destinés au traitement de troubles médicaux
CN110603252A (zh) 2017-03-01 2019-12-20 艾其林医药公司 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物
CN110621672A (zh) 2017-03-02 2019-12-27 组装生物科学股份有限公司 环状磺酰胺化合物及其使用方法
WO2018169946A1 (fr) 2017-03-14 2018-09-20 Gilead Sciences, Inc. Méthodes de traitement d'infections par le coronavirus félin
JOP20180040A1 (ar) 2017-04-20 2019-01-30 Gilead Sciences Inc مثبطات pd-1/pd-l1
AU2018262501B2 (en) 2017-05-01 2020-12-10 Gilead Sciences, Inc. Crystalline forms of (S) 2 ethylbutyl 2 (((S) (((2R,3S,4R,5R) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
CN110809574A (zh) 2017-06-27 2020-02-18 詹森药业有限公司 杂芳基二氢嘧啶衍生物和治疗乙型肝炎感染的方法
CN111093627B (zh) 2017-07-11 2024-03-08 吉利德科学公司 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物
EP3672970A1 (fr) 2017-08-22 2020-07-01 Gilead Sciences, Inc. Composés hétérocycliques thérapeutiques
SG11202001685TA (en) 2017-08-28 2020-03-30 Enanta Pharm Inc Hepatitis b antiviral agents
US10428070B2 (en) 2017-12-06 2019-10-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10723733B2 (en) 2017-12-06 2020-07-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
JP7098748B2 (ja) 2017-12-20 2022-07-11 インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． Ｓｔｉｎｇアダプタータンパク質を活性化するホスホン酸結合を有する２’３’環状ジヌクレオチド
EP3728283B1 (fr) 2017-12-20 2023-11-22 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. Dinucléotides 3'3' cycliques ayant une liaison phosphonate activant la protéine adaptatrice de sting
JP7256810B2 (ja) 2017-12-28 2023-04-12 エフ． ホフマン－ラ ロシュ アーゲー Ｂ型肝炎ウイルス感染の治療及び予防のためのジヒドロピリミジニルチアゾール
US11058678B2 (en) 2018-01-22 2021-07-13 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
CN111818915B (zh) 2018-01-31 2024-05-24 德西费拉制药有限责任公司 治疗胃肠道间质瘤的组合疗法
KR102445054B1 (ko) 2018-02-13 2022-09-22 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
CN111788204B (zh) 2018-02-26 2023-05-05 吉利德科学公司 作为hbv复制抑制剂的取代吡咯嗪化合物
US10973801B2 (en) 2018-03-14 2021-04-13 Janssen Sciences Ireland Unlimited Company Capsid assembly modulator dosing regimen
WO2019191166A1 (fr) 2018-03-29 2019-10-03 Enanta Pharmaceuticals, Inc. Agents antiviraux de l'hépatite b
US10870691B2 (en) 2018-04-05 2020-12-22 Gilead Sciences, Inc. Antibodies and fragments thereof that bind hepatitis B virus protein X
TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
TW202005654A (zh) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 ２，２，─環二核苷酸
US11142750B2 (en) 2018-04-12 2021-10-12 Precision Biosciences, Inc. Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome
CN108218809B (zh) * 2018-04-14 2021-03-26 宁夏法安德药业有限公司 一种医药中间体2-氨基噻唑-4-甲酸乙酯的合成方法
CA3093130C (fr) 2018-04-19 2023-10-17 Gilead Sciences, Inc. Inhibiteurs pd-1/pd-l1
WO2019211799A1 (fr) 2018-05-03 2019-11-07 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. Analogue de dinucléotide 2'3'-cyclique comprenant un nucléotide modifié par cyclopentanyle
EP3817818A1 (fr) 2018-07-06 2021-05-12 Gilead Sciences, Inc. Composés hétérocycliques thérapeutiques
US11098027B2 (en) 2018-07-06 2021-08-24 Gilead Sciences, Inc. Therapeutic heterocyclic compounds
US10774071B2 (en) 2018-07-13 2020-09-15 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
WO2020028097A1 (fr) 2018-08-01 2020-02-06 Gilead Sciences, Inc. Formes solides d'acide (r)-11-(méthoxyméthyl)-12-(3-méthoxypropoxy)-3,3-diméthyl-8-0 x0-2,3,8,13b-tétrahydro-1h-pyrido[2,1-a] pyrrolo[1,2-c]phtalazine-7-carboxylique
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
EP3846803A4 (fr) 2018-09-06 2022-08-10 Achillion Pharmaceuticals, Inc. Composés macrocycliques pour le traitement de troubles médicaux
KR20210057086A (ko) 2018-09-06 2021-05-20 아칠리온 파르마세우티칼스 인코포레이티드 다니코판의 형태체 형태
MX2021003253A (es) 2018-09-21 2021-08-11 Enanta Pharm Inc Heterociclos funcionalizados como agentes antivirales.
AU2019346464A1 (en) 2018-09-25 2021-04-08 Achillion Pharmaceuticals, Inc. Morphic forms of complement factor D inhibitors
MX2021004580A (es) 2018-10-22 2021-09-08 Assembly Biosciences Inc Compuestos de heteroarilcarboxamida de 5 miembros para el tratamiento del vhb.
AU2019366355B2 (en) 2018-10-24 2022-10-13 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
HRP20240541T1 (hr) 2018-10-31 2024-07-05 Gilead Sciences, Inc. Supstituirani spojevi 6-azabenzimidazola kao inhibitori hpk1
CN117105933A (zh) 2018-10-31 2023-11-24 吉利德科学公司 具有hpk1抑制活性的取代的6-氮杂苯并咪唑化合物
WO2020087107A1 (fr) 2018-10-31 2020-05-07 The University Of Sydney Compositions et méthodes de traitement d'infections virales
AU2019385477A1 (en) 2018-11-21 2021-06-10 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
TW202035412A (zh) * 2018-12-20 2020-10-01 比利時商健生藥品公司 雜芳基二氫嘧啶衍生物和治療ｂ型肝炎感染之方法
CA3127152A1 (fr) 2019-02-22 2020-08-27 Janssen Sciences Ireland Unlimited Company Derives d'amide utiles dans le traitement d'une infection par le virus de l'hepatite b ou de maladies induites par le virus de l'hepatite b
CN113574063A (zh) 2019-03-07 2021-10-29 捷克共和国有机化学与生物化学研究所 3’3’-环二核苷酸及其前药
WO2020178768A1 (fr) 2019-03-07 2020-09-10 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. Analogue du dinucléotide 3'3'-cyclique comprenant un nucléotide modifié par cyclopentanyle utilisé en tant que modulateur de sting
DK3934757T3 (da) 2019-03-07 2023-04-17 Inst Of Organic Chemistry And Biochemistry Ascr V V I 2'3'-cykliske dinukleotider og prodrugs deraf
BR112021019054A2 (pt) 2019-03-25 2021-11-30 Hoffmann La Roche Formas sólidas de um composto do modificador alostérico da proteína do núcleo do vhb
CA3134173A1 (fr) 2019-04-10 2020-10-15 Nanjing Zhengxiang Pharmaceuticals Co., Ltd. Inhibiteur de la phosphatidylinositol 3-kinase
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202104210A (zh) 2019-04-17 2021-02-01 美商基利科學股份有限公司 Hiv蛋白酶抑制劑
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
BR112021021454A2 (pt) 2019-05-06 2021-12-21 Janssen Sciences Ireland Unlimited Co Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv
TWI826690B (zh) 2019-05-23 2023-12-21 美商基利科學股份有限公司 經取代之烯吲哚酮化物及其用途
BR112021023622A2 (pt) 2019-05-24 2022-04-19 Assembly Biosciences Inc Composições farmaceuticas para o tratamento de hbv
US11236111B2 (en) 2019-06-03 2022-02-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US11760755B2 (en) 2019-06-04 2023-09-19 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US11472808B2 (en) 2019-06-04 2022-10-18 Enanta Pharmaceuticals, Inc. Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents
CA3139365A1 (fr) 2019-06-06 2020-12-10 Aligos Therapeutics, Inc. Composes heterocycliques
CA3140708A1 (fr) 2019-06-18 2020-12-24 Helen Horton Association de vaccins contre le virus de l'hepatite b (vhb) et de derives de pyridopyrimidine
WO2020263830A1 (fr) 2019-06-25 2020-12-30 Gilead Sciences, Inc. Protéines de fusion flt3l-fc et procédés d'utilisation
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US20220257619A1 (en) 2019-07-18 2022-08-18 Gilead Sciences, Inc. Long-acting formulations of tenofovir alafenamide
CN114206862A (zh) * 2019-07-31 2022-03-18 杨森科学爱尔兰无限公司 二氢嘧啶衍生物及其在治疗hbv感染或hbv诱发疾病中的用途
JP2022543010A (ja) * 2019-07-31 2022-10-07 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ジヒドロピリミジン誘導体及びｈｂｖ感染又はｈｂｖ誘導性疾患の処置におけるその使用
TW202122082A (zh) 2019-08-12 2021-06-16 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
CN114615982A (zh) 2019-08-12 2022-06-10 德西费拉制药有限责任公司 用于治疗胃肠道间质瘤的瑞普替尼
US20220296619A1 (en) 2019-08-19 2022-09-22 Gilead Sciences, Inc. Pharmaceutical formulations of tenofovir alafenamide
WO2021055425A2 (fr) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Hétérocycles fonctionnalisés utiles en tant qu'agents antiviraux
AR120096A1 (es) 2019-09-30 2022-02-02 Gilead Sciences Inc Vacunas para vhb y métodos de tratamiento de vhb
KR102264881B1 (ko) 2019-11-08 2021-06-14 중앙대학교 산학협력단 듀얼 msm 소자를 구비한 휴대단말기 카메라용 액추에이터 및 이를 구비한 휴대단말기용 카메라모듈
WO2021113765A1 (fr) 2019-12-06 2021-06-10 Precision Biosciences, Inc. Méganucléases modifiées optimisées ayant une spécificité pour une séquence de reconnaissance dans un génome du virus de l'hépatite b
BR112022012625A2 (pt) 2019-12-24 2022-09-06 Carna Biosciences Inc Compostos moduladores de diacilglicerol quinase
HRP20231699T1 (hr) 2019-12-30 2024-05-10 Deciphera Pharmaceuticals, Llc Formulacije inhibitora amorfne kinaze i postupci njihove primjene
KR20220123058A (ko) 2019-12-30 2022-09-05 데시페라 파마슈티칼스, 엘엘씨. 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의 조성물
KR20220132608A (ko) 2020-01-27 2022-09-30 길리애드 사이언시즈, 인코포레이티드 SARS CoV-2 감염증을 치료하기 위한 방법
JP2023516087A (ja) 2020-03-12 2023-04-17 ギリアード サイエンシーズ， インコーポレイテッド １’－シアノヌクレオシドを調製する方法
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
EP4121437A1 (fr) 2020-03-20 2023-01-25 Gilead Sciences, Inc. Promédicaments de nucléosides de 4'-c-substitué-2-halo-2'-désoxyadénosine et leurs procédés de fabrication et d'utilisation
WO2021207049A1 (fr) 2020-04-06 2021-10-14 Gilead Sciences, Inc. Formulations d'inhalation d'analogues de carbanucléosides à substitution 1'-cyano
WO2021216660A1 (fr) 2020-04-22 2021-10-28 Assembly Biosciences, Inc. Composés d'hétéroaryle carboxamide à 5 chaînons pour le traitement du vhb
WO2021216661A1 (fr) 2020-04-22 2021-10-28 Assembly Biosciences, Inc. Composés de pyrazole carboxamide pour le traitement du vhb
WO2021216656A1 (fr) 2020-04-22 2021-10-28 Assembly Biosciences, Inc. Composés d'hétéroaryle carboxamide à 5 chaînons pour le traitement du vhb
EP4139000A1 (fr) 2020-04-22 2023-03-01 Assembly Biosciences, Inc. Composés de pyrazole carboxamide pour le traitement du vhb
AU2021281351A1 (en) 2020-05-29 2023-01-19 Gilead Sciences, Inc. Remdesivir treatment methods
MX2022016405A (es) 2020-06-24 2023-01-30 Gilead Sciences Inc Análogos de nucleósido de 1¿-ciano y usos de estos.
CA3186054A1 (fr) 2020-08-07 2022-02-10 Daniel H. BYUN Promedicaments d'analogues nucleotidiques de phosphonamide et leur utilisation pharmaceutique
US11773122B2 (en) 2020-08-24 2023-10-03 Gilead Sciences. Inc. Phospholipid compounds and uses thereof
TW202233204A (zh) 2020-08-27 2022-09-01 美商基利科學股份有限公司 用於治療病毒感染之化合物及方法
WO2022052923A1 (fr) * 2020-09-08 2022-03-17 和博医药有限公司 Composé dihydropyrimidine et son utilisation
TWI811812B (zh) 2020-10-16 2023-08-11 美商基利科學股份有限公司 磷脂化合物及其用途
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
WO2022166923A1 (fr) * 2021-02-05 2022-08-11 和博医药有限公司 Composé phényldihydropyrimidine et son utilisation
EP4337223A1 (fr) 2021-05-13 2024-03-20 Gilead Sciences, Inc. Combinaison d'un composé de modulation de tlr8 et agent thérapeutique anti-arnsi de vhb
WO2022251318A1 (fr) 2021-05-26 2022-12-01 Gilead Sciences, Inc. Formulations phospholipidiques d'analogues de carba-nucléoside 1'-cyano-substitué
EP4359411A1 (fr) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Composés modulant les diacylglycérol kinases
CN117355531A (zh) 2021-06-23 2024-01-05 吉利德科学公司 二酰基甘油激酶调节化合物
KR20240005901A (ko) 2021-06-23 2024-01-12 길리애드 사이언시즈, 인코포레이티드 디아실글리세롤 키나제 조절 화합물
MX2023014762A (es) 2021-06-23 2024-01-15 Gilead Sciences Inc Compuestos moduladores de diacilglicerol quinasa.
KR20240049311A (ko) 2021-08-18 2024-04-16 길리애드 사이언시즈, 인코포레이티드 인지질 화합물 및 이의 제조 및 사용 방법
WO2023069545A1 (fr) 2021-10-20 2023-04-27 Assembly Biosciences, Inc. Composés d'hétéroaryle carboxamide à 5 chaînons pour le traitement du vhb
WO2023069544A1 (fr) 2021-10-20 2023-04-27 Assembly Biosciences, Inc. Composés d'hétéroaryl-carboxamide à 5 chaînons pour le traitement du vhb
WO2023069547A1 (fr) 2021-10-20 2023-04-27 Assembly Biosciences, Inc. Composés d'hétéroaryle carboxamide à 5 chaînons pour le traitement du vhb
WO2023164186A1 (fr) 2022-02-25 2023-08-31 Assembly Biosciences, Inc. Composés benzothia(dia)zépine pour traitement anti-vhb et anti-vhd
WO2023164179A1 (fr) 2022-02-25 2023-08-31 Assembly Biosciences, Inc. Composés de benzothia(dia)zépine pour le traitement du vhb et du vhd
WO2023164183A1 (fr) 2022-02-25 2023-08-31 Assembly Biosciences, Inc. Composés de benzothia(dia)zépine pour le traitement du vhb et du vhd
WO2023164181A1 (fr) 2022-02-25 2023-08-31 Assembly Biosciences, Inc. Composés de benzothia(dia)zépine pour le traitement du vhb et du vhd
US20230295172A1 (en) 2022-03-02 2023-09-21 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
US20230322813A1 (en) 2022-03-02 2023-10-12 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
US20230382940A1 (en) 2022-03-03 2023-11-30 Gilead Sciences, Inc. Antiviral compounds and methods of making and using the same
US20240199676A1 (en) 2022-03-03 2024-06-20 Gilead Sciences, Inc. Antiviral compounds and methods of making and using the same
TW202415386A (zh) 2022-06-06 2024-04-16 美商基利科學股份有限公司 用於治療病毒感染之方法
WO2024006376A1 (fr) 2022-06-29 2024-01-04 Gilead Sciences, Inc. Formes solides d'un analogue nucléosidique et leurs utilisations
WO2024006461A1 (fr) 2022-06-30 2024-01-04 Gilead Sciences, Inc. Formes solides d'un analogue nucléosidique et leurs utilisations
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3234684A1 (de) 1982-09-18 1984-03-22 Bayer Ag, 5090 Leverkusen Neue dihydropyrimidine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
GB8906168D0 (en) 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
SE9702564D0 (sv) * 1997-07-02 1997-07-02 Astra Ab New compounds
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
DE19817264A1 (de) 1998-04-18 1999-10-21 Bayer Ag Neue Dihydropyrimidine
DE19817265A1 (de) 1998-04-18 1999-10-21 Bayer Ag Verwendung von Dihydropyrimidinen als Arzneimittel und neue Stoffe
DE19817262A1 (de) 1998-04-18 1999-10-21 Bayer Ag Neue 2-heterocyclisch substituierte Dihydropyrimidine
JP2000223419A (ja) 1998-06-30 2000-08-11 Sony Corp 単結晶シリコン層の形成方法及び半導体装置の製造方法、並びに半導体装置
AU4289100A (en) * 1999-03-25 2000-10-16 Bayer Aktiengesellschaft Dihydropyrimidines and their use in the treatment of hepatitis
AU3009801A (en) 1999-12-22 2001-07-03 Bayer Aktiengesellschaft Combinations of medicaments for treating viral diseases
DE10012549A1 (de) 2000-03-15 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10012824A1 (de) 2000-03-16 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10012823A1 (de) * 2000-03-16 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013126A1 (de) * 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013125A1 (de) 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
ATE440825T1 (de) 2003-06-06 2009-09-15 Vertex Pharma Pyrimidin-derivate zur verwendung als modulatoren von atp-bindende kassette transportern
US7157461B2 (en) 2003-07-23 2007-01-02 Bristol-Myers Squibb Co. Substituted dihydropyrimidine inhibitors of calcium channel function
EP1756092A4 (fr) 2004-06-17 2009-12-02 Smithkline Beecham Corp Inhibiteurs novateurs de protéines rho-kinases
WO2006033995A2 (fr) 2004-09-16 2006-03-30 Valeant Research And Development Thiazolidine-4-ones possedant une activite antihepatite b
WO2007014023A1 (fr) 2005-07-21 2007-02-01 Valeant Research & Development Thiazolidinones, oxazolidinones et pyrrolidinones pour le vhb
US20070112015A1 (en) 2005-10-28 2007-05-17 Chemocentryx, Inc. Substituted dihydropyridines and methods of use
CN101443330B (zh) 2006-06-13 2012-12-19 上海海和药物研究开发有限公司 杂环非核苷类化合物及其制备方法、药物组合物和作为抗病毒抑制剂的用途
CN101104617B (zh) 2006-07-10 2010-06-23 北京摩力克科技有限公司 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
CN101104604B (zh) 2006-07-10 2011-03-02 北京摩力克科技有限公司 光学纯二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
CN101225084A (zh) 2007-01-16 2008-07-23 北京摩力克科技有限公司 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
CN101328168B (zh) * 2007-06-18 2011-09-07 张中能 一种乙氧碳酰基-取代噻唑二氢嘧啶
BRPI0813237B8 (pt) 2007-06-18 2021-05-25 Sunshine Lake Pharma Co Ltd composto, método para preparar o composto, medicamento, e, uso do composto
WO2008154819A1 (fr) 2007-06-18 2008-12-24 Zhang, Zhongneng Thiazolyl-dihydropyrimidines à substitution carbéthoxy
CN101328170B (zh) 2007-06-18 2011-09-14 张中能 一种氟苯基-取代噻唑二氢嘧啶
US8673911B2 (en) 2007-11-02 2014-03-18 Methylgene Inc. Inhibitors of histone deacetylase
WO2010069147A1 (fr) * 2008-12-17 2010-06-24 张中能 Derives de la dihydropyrimidine, leurs compositions et leur utilisation
CN101575318B (zh) 2009-06-25 2012-02-08 中国人民解放军军事医学科学院毒物药物研究所 二氢嘧啶类化合物及其用于制备治疗和/或预防病毒性疾病的药物的用途
CN101575314B (zh) 2009-06-25 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 二氢吡啶类化合物及其用于制备治疗和/或预防病毒性疾病的药物的用途
DK2470546T3 (da) 2009-08-28 2013-10-14 Takeda Pharmaceutical HEXAHYDROOXAZINOPTERIDIN- forbindelser til anvendelse som mTOR INHIBITORER
ES2620177T3 (es) 2009-10-15 2017-06-27 Guerbet Agentes de formación de imágenes y su uso para el diagnóstico in vivo de enfermedades neurodegenerativas, particularmente la enfermedad de Alzheimer y enfermedades derivadas
US9487534B2 (en) * 2011-08-02 2016-11-08 Scripps Research Institute, A Not-For-Profit Public Benefit Corporation Of California Modulators of virus assembly as antiviral agents
AU2013207205B2 (en) * 2012-01-06 2017-02-02 Janssen Sciences Ireland Uc 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of Hepatitis B
WO2013144129A1 (fr) * 2012-03-31 2013-10-03 F. Hoffmann-La Roche Ag Nouveaux 4-méthyl-dihydropyrimidines pour le traitement et la prophylaxie du virus de l'hépatite b
CN103570626A (zh) * 2012-08-06 2014-02-12 上海壹志医药科技有限公司 二氢嘧啶衍生物的盐
CN103626752B (zh) * 2012-08-24 2015-08-12 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
CN103664897B (zh) * 2012-09-01 2018-04-03 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
CN103664925B (zh) * 2012-09-07 2018-01-23 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
CN103664899B (zh) * 2012-09-11 2017-06-16 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
CN103694234A (zh) * 2012-09-27 2014-04-02 广东东阳光药业有限公司 二氢嘧啶衍生物的晶型
KR20150093685A (ko) * 2012-11-09 2015-08-18 인디애나 유니버시티 리서치 앤드 테크놀로지 코포레이션 Hbv 어셈블리 이펙터의 대체 용도
EP2976083A4 (fr) * 2013-03-20 2016-11-23 Univ Indiana Res & Tech Corp Hap fluorescente : colorant de diagnostic pour noyaux vhb dans des cellules
US9266904B2 (en) * 2013-05-17 2016-02-23 Hoffmann-La Roche Inc. 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

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MA37942A2 (fr) 2016-12-30
WO2014037480A1 (fr) 2014-03-13
IL236691A0 (en) 2015-02-26
CR20150085A (es) 2015-04-06
EP2892893B1 (fr) 2016-12-21
SG11201500377UA (en) 2015-02-27
TW201416360A (zh) 2014-05-01
KR20150054795A (ko) 2015-05-20
HK1210152A1 (en) 2016-04-15
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JP2015527382A (ja) 2015-09-17
CA2881322A1 (fr) 2014-03-13
US20150031687A1 (en) 2015-01-29
US9447086B2 (en) 2016-09-20
US20160237078A9 (en) 2016-08-18
MA37942B1 (fr) 2020-01-31
MX2015002954A (es) 2015-06-05
CO7170160A2 (es) 2015-01-28
CN104603125A (zh) 2015-05-06
AR092503A1 (es) 2015-04-22
AU2013311705A1 (en) 2015-02-05
ZA201500580B (en) 2017-09-27
PE20150776A1 (es) 2015-05-21
PH12015500347A1 (en) 2015-04-20
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JP6113285B2 (ja) 2017-04-12
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