MA33367B1 - Nouveau dérivé de phénylimidazole en tant qu'inhibiteur de l'enzyme pde10a - Google Patents
Nouveau dérivé de phénylimidazole en tant qu'inhibiteur de l'enzyme pde10aInfo
- Publication number
- MA33367B1 MA33367B1 MA34464A MA34464A MA33367B1 MA 33367 B1 MA33367 B1 MA 33367B1 MA 34464 A MA34464 A MA 34464A MA 34464 A MA34464 A MA 34464A MA 33367 B1 MA33367 B1 MA 33367B1
- Authority
- MA
- Morocco
- Prior art keywords
- inhibitor
- phenylimidazole derivative
- pde10a
- enzyme
- novel phenylimidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
CETTE INVENTION PORTE SUR LE COMPOSÉ 5,8-DIMÉTHYL-2-[2-(1-MÉTHYL-4-PHÉNYL-1H-IMIDAZOLE-2-YL)-ÉTHYL]-[1,2,4]THAZOLO[1,5-A] PYRAZINE ET SUR SES SELS D'ADDITION AVEC LES ACIDES PHARMACEUTIQUEMENT ACCEPTABLES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/DK2009/050134 WO2009152825A1 (fr) | 2008-06-20 | 2009-06-19 | Nouveau dérivés de phénylimidazole convenant comme inhibiteurs de l'enzyme pde10a |
PCT/DK2010/050147 WO2010145668A1 (fr) | 2009-06-19 | 2010-06-17 | Nouveau dérivé de phénylimidazole en tant qu'inhibiteur de l'enzyme pde10a |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33367B1 true MA33367B1 (fr) | 2012-06-01 |
Family
ID=42321053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34464A MA33367B1 (fr) | 2009-06-19 | 2010-06-17 | Nouveau dérivé de phénylimidazole en tant qu'inhibiteur de l'enzyme pde10a |
Country Status (27)
Country | Link |
---|---|
EP (1) | EP2443105B1 (fr) |
JP (1) | JP5768044B2 (fr) |
AR (1) | AR077144A1 (fr) |
AU (1) | AU2010262190B2 (fr) |
CA (1) | CA2765750A1 (fr) |
CR (1) | CR20110654A (fr) |
CY (1) | CY1115971T1 (fr) |
DK (1) | DK2443105T3 (fr) |
DO (1) | DOP2011000397A (fr) |
ES (1) | ES2527216T3 (fr) |
GE (1) | GEP20146100B (fr) |
GT (1) | GT201100322A (fr) |
HR (1) | HRP20141222T1 (fr) |
IL (1) | IL216684A (fr) |
MA (1) | MA33367B1 (fr) |
MX (1) | MX2011013400A (fr) |
MY (1) | MY156785A (fr) |
NZ (1) | NZ597203A (fr) |
PL (1) | PL2443105T3 (fr) |
PT (1) | PT2443105E (fr) |
SG (1) | SG176680A1 (fr) |
SI (1) | SI2443105T1 (fr) |
SM (1) | SMT201500003B (fr) |
TW (1) | TW201100430A (fr) |
UA (2) | UA102693C2 (fr) |
WO (1) | WO2010145668A1 (fr) |
ZA (1) | ZA201109271B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
TWI501965B (zh) | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物 |
TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物 |
JO3089B1 (ar) * | 2010-11-19 | 2017-03-15 | H Lundbeck As | مشتقات ايميدازول كمثبطات لانزيمات pde10a |
US8552045B2 (en) | 2010-11-19 | 2013-10-08 | H. Lundbeck A/S | Tricyclic imidazole compounds as PDE10 inhibitors |
WO2012112946A1 (fr) | 2011-02-18 | 2012-08-23 | Allergan, Inc. | Dérivés de 6,7-dialkoxy-3-isoquinolinol substitués en tant qu'inhibiteurs de la phosphodiestérase 10 (pde10a) |
WO2013034758A1 (fr) * | 2011-09-09 | 2013-03-14 | H. Lundbeck A/S | Triazolopyrazines substituées et leurs utilisations |
WO2013034755A1 (fr) * | 2011-09-09 | 2013-03-14 | H. Lundbeck A/S | Dérivés de triazolopyrazine et leur utilisation pour le traitement de troubles neurologiques et psychiatriques |
CN103874701A (zh) * | 2011-09-09 | 2014-06-18 | H.隆德贝克有限公司 | 吡啶化合物和其用途 |
WO2013034761A1 (fr) * | 2011-09-09 | 2013-03-14 | H. Lundbeck A/S | Composés de pyridine et leurs utilisations |
AR089361A1 (es) | 2011-12-21 | 2014-08-20 | Lundbeck & Co As H | Derivados de quinolina como inhibidores de la enzima pde10a |
WO2013107856A1 (fr) * | 2012-01-20 | 2013-07-25 | H. Lundbeck A/S | Dérivés d'imidazole utilisés comme inhibiteurs d'enzymes pde10a |
WO2013127817A1 (fr) | 2012-02-27 | 2013-09-06 | H. Lundbeck A/S | Dérivés d'imidazole comme inhibiteurs de l'enzyme pde10a |
WO2014071044A1 (fr) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Dérivés de 6,7-dialcoxy-3-isoquinoline substitués à titre d'inhibiteurs de phosphodiestérase 10 (pde10a) |
US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
WO2020094592A1 (fr) * | 2018-11-06 | 2020-05-14 | H. Lundbeck A/S | Composés pour le traitement de symptômes négatifs et de déficiences cognitives |
US20200140446A1 (en) * | 2018-11-06 | 2020-05-07 | H. Lundbeck A/S | 5,8-dimethyl-2-[2-(1-methyl-4-phenyl-1h-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine hemiadipate |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4826833A (en) | 1984-01-30 | 1989-05-02 | Pfizer Inc. | 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof |
IL149106A0 (en) | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
FR2824065A1 (fr) | 2001-04-26 | 2002-10-31 | Neuro3D | Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations |
WO2004024705A1 (fr) | 2002-09-10 | 2004-03-25 | Takeda Pharmaceutical Company Limited | Composes heterocycliques a cinq elements |
CA2503716A1 (fr) | 2002-10-30 | 2004-05-21 | Jean-Jacques Bourguignon | Utilisation d'inhibiteurs des phosphodiesterases des nucleotides cycliques, ayant une structure benzodiazepinique en therapie |
WO2005003129A1 (fr) | 2003-06-30 | 2005-01-13 | Altana Pharma Ag | Pyrrolodihydroisoquinolines comme inhibiteurs de pde10 |
WO2005002579A1 (fr) | 2003-06-30 | 2005-01-13 | Altana Pharma Ag | Derives de pyrrolo-dihydroisoquinoline comme inhibiteurs de pde10 |
EP1651251A4 (fr) | 2003-07-31 | 2008-06-18 | Bayer Pharmaceuticals Corp | Procedes pour traiter le diabete, et les troubles associes, au moyen d'inhibiteurs des pde10a |
WO2005082883A2 (fr) | 2004-02-18 | 2005-09-09 | Pfizer Products Inc. | Derives tetrahydroisoquinolinyliques de quinazoline et d'isoquinoline |
FR2870539B1 (fr) | 2004-05-19 | 2006-08-04 | Greenpharma Sa Sa | Nouvelles methodes et medicaments |
US20090162286A1 (en) | 2004-06-07 | 2009-06-25 | Pfizer Inc. | Phosphodiesterase 10 Inhibition as Treatment for Obesity-Related and Metabolic Syndrome-Related Conditions |
US20060019975A1 (en) | 2004-07-23 | 2006-01-26 | Pfizer Inc | Novel piperidyl derivatives of quinazoline and isoquinoline |
CA2578996A1 (fr) | 2004-09-03 | 2006-03-16 | Memory Pharmaceuticals Corporation | Derives de 4, 6-dialkoxy-cinnoline substitues en position 4 en tant qu'inhibiteurs de phospodiesterase 10 pour le traitement de syndromes psychiatriques ou neurologiques |
US20060183763A1 (en) * | 2004-12-31 | 2006-08-17 | Pfizer Inc | Novel pyrrolidyl derivatives of heteroaromatic compounds |
AU2007217750A1 (en) * | 2006-02-21 | 2007-08-30 | Amgen Inc. | Cinnoline derivatives as phosphodiesterase 10 inhibitors |
TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物 |
-
2009
- 2009-06-19 UA UAA201015420A patent/UA102693C2/ru unknown
-
2010
- 2010-06-17 MA MA34464A patent/MA33367B1/fr unknown
- 2010-06-17 JP JP2012515356A patent/JP5768044B2/ja not_active Expired - Fee Related
- 2010-06-17 DK DK10725373.4T patent/DK2443105T3/en active
- 2010-06-17 SG SG2011089919A patent/SG176680A1/en unknown
- 2010-06-17 SI SI201030841T patent/SI2443105T1/sl unknown
- 2010-06-17 ES ES10725373.4T patent/ES2527216T3/es active Active
- 2010-06-17 CA CA2765750A patent/CA2765750A1/fr not_active Abandoned
- 2010-06-17 GE GEAP201012536A patent/GEP20146100B/en unknown
- 2010-06-17 AU AU2010262190A patent/AU2010262190B2/en not_active Ceased
- 2010-06-17 PL PL10725373T patent/PL2443105T3/pl unknown
- 2010-06-17 EP EP10725373.4A patent/EP2443105B1/fr active Active
- 2010-06-17 PT PT107253734T patent/PT2443105E/pt unknown
- 2010-06-17 MY MYPI2011005865A patent/MY156785A/en unknown
- 2010-06-17 WO PCT/DK2010/050147 patent/WO2010145668A1/fr active Application Filing
- 2010-06-17 MX MX2011013400A patent/MX2011013400A/es unknown
- 2010-06-17 NZ NZ597203A patent/NZ597203A/xx not_active IP Right Cessation
- 2010-06-17 UA UAA201200499A patent/UA106378C2/ru unknown
- 2010-06-18 AR ARP100102165A patent/AR077144A1/es active IP Right Grant
- 2010-06-18 TW TW099119840A patent/TW201100430A/zh unknown
-
2011
- 2011-11-29 IL IL216684A patent/IL216684A/en active IP Right Grant
- 2011-12-08 CR CR20110654A patent/CR20110654A/es unknown
- 2011-12-14 GT GT201100322A patent/GT201100322A/es unknown
- 2011-12-15 ZA ZA2011/09271A patent/ZA201109271B/en unknown
- 2011-12-19 DO DO2011000397A patent/DOP2011000397A/es unknown
-
2014
- 2014-12-16 HR HRP20141222AT patent/HRP20141222T1/hr unknown
- 2014-12-19 CY CY20141101071T patent/CY1115971T1/el unknown
-
2015
- 2015-01-05 SM SM201500003T patent/SMT201500003B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
TW201100430A (en) | 2011-01-01 |
MY156785A (en) | 2016-03-31 |
HRP20141222T1 (hr) | 2015-02-27 |
UA106378C2 (ru) | 2014-08-26 |
AR077144A1 (es) | 2011-08-03 |
EP2443105B1 (fr) | 2014-10-29 |
IL216684A (en) | 2016-03-31 |
MX2011013400A (es) | 2012-02-21 |
AU2010262190B2 (en) | 2013-01-31 |
GT201100322A (es) | 2014-02-06 |
NZ597203A (en) | 2013-03-28 |
CR20110654A (es) | 2012-03-09 |
WO2010145668A1 (fr) | 2010-12-23 |
GEP20146100B (en) | 2014-05-27 |
AU2010262190A1 (en) | 2012-01-19 |
CA2765750A1 (fr) | 2010-12-23 |
UA102693C2 (ru) | 2013-08-12 |
ZA201109271B (en) | 2013-02-27 |
JP2012530086A (ja) | 2012-11-29 |
PL2443105T3 (pl) | 2015-03-31 |
SI2443105T1 (sl) | 2015-02-27 |
SG176680A1 (en) | 2012-01-30 |
CY1115971T1 (el) | 2017-01-25 |
IL216684A0 (en) | 2012-02-29 |
JP5768044B2 (ja) | 2015-08-26 |
DK2443105T3 (en) | 2015-01-12 |
ES2527216T3 (es) | 2015-01-21 |
EP2443105A1 (fr) | 2012-04-25 |
SMT201500003B (it) | 2015-03-05 |
DOP2011000397A (es) | 2012-07-15 |
PT2443105E (pt) | 2015-01-14 |
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