MA32970B1 - Analogues du glucagon - Google Patents
Analogues du glucagonInfo
- Publication number
- MA32970B1 MA32970B1 MA34020A MA34020A MA32970B1 MA 32970 B1 MA32970 B1 MA 32970B1 MA 34020 A MA34020 A MA 34020A MA 34020 A MA34020 A MA 34020A MA 32970 B1 MA32970 B1 MA 32970B1
- Authority
- MA
- Morocco
- Prior art keywords
- glucagon
- methods
- present
- isotope
- peptides
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
Abstract
L'invention concerne des matériaux et des méthodes pour faciliter la perte de poids ou empêcher la prise de poids, et traiter le diabète, le syndrome métabolique et les troubles associés. L'invention concerne, en particulier de nouveaux peptides analogues du glucagon efficaces dans ces méthodes. Les peptides peuvent médier leur effet par leur sélectivité accrue pour le récepteur du GLP-1 par rapport au glucagon humain.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/GB2008/004121 WO2010070251A1 (fr) | 2008-12-15 | 2008-12-15 | Analogues du glucagon |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32970B1 true MA32970B1 (fr) | 2012-01-02 |
Family
ID=40428061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34020A MA32970B1 (fr) | 2008-12-15 | 2008-12-15 | Analogues du glucagon |
Country Status (19)
Country | Link |
---|---|
US (2) | US8685919B2 (fr) |
EP (2) | EP2370459A1 (fr) |
JP (1) | JP5635529B2 (fr) |
KR (2) | KR20150116912A (fr) |
CN (1) | CN102282167B (fr) |
AP (1) | AP2011005774A0 (fr) |
AU (1) | AU2008365555B2 (fr) |
BR (1) | BRPI0823378A2 (fr) |
CA (1) | CA2747109A1 (fr) |
EA (1) | EA020537B1 (fr) |
HK (1) | HK1203531A1 (fr) |
IL (1) | IL213477A0 (fr) |
MA (1) | MA32970B1 (fr) |
MX (1) | MX2011006313A (fr) |
MY (1) | MY160219A (fr) |
SG (1) | SG172170A1 (fr) |
TN (1) | TN2011000295A1 (fr) |
UA (1) | UA104605C2 (fr) |
WO (1) | WO2010070251A1 (fr) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101200227B1 (ko) | 2005-05-04 | 2012-11-13 | 질랜드 파마 에이/에스 | 글루카곤 유사 펩티드-2(glp-2) 유사체 |
NZ576260A (en) | 2006-11-08 | 2012-04-27 | Zealand Pharma As | GLUCAGON-LIKE-PEPTIDE-2 (GLP-2) ANALOGUES comprising one of more substitutions as compared to h[Gly2]GLP-2 |
WO2010070255A1 (fr) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Analogues du glucagon |
JP5635531B2 (ja) | 2008-12-15 | 2014-12-03 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
CN102292347A (zh) | 2008-12-15 | 2011-12-21 | 西兰制药公司 | 胰高血糖素类似物 |
ME02220B (me) | 2009-07-13 | 2016-02-20 | Zealand Pharma As | Analozi acilovanog glukagona |
CN107129538B (zh) | 2010-04-27 | 2021-07-16 | 西兰制药公司 | Glp-1受体激动剂和胃泌素的肽缀合物及其用途 |
UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
BR112012033225A2 (pt) * | 2010-06-24 | 2017-06-20 | Zealand Pharma As | análogos do glucagon |
MA34913B1 (fr) * | 2011-01-20 | 2014-02-01 | Zealand Pharma As | Combinaison d'analogues du glucagon acylé à des analogues d'insuline |
CA2849673A1 (fr) | 2011-09-23 | 2013-03-28 | Novo Nordisk A/S | Nouveaux analogues du glucagon |
WO2013064669A1 (fr) | 2011-11-03 | 2013-05-10 | Zealand Pharma A/S | Conjugués de peptide agoniste du récepteur du glp-1 et de gastrine |
CA2872315A1 (fr) | 2012-05-03 | 2013-11-07 | Zealand Pharma A/S | Analogues du glucagon-like peptide 2 (glp-2) |
US10100097B2 (en) | 2012-05-03 | 2018-10-16 | Zealand Pharma A/S | GIP-GLP-1 dual agonist compounds and methods |
EP2664374A1 (fr) * | 2012-05-15 | 2013-11-20 | F. Hoffmann-La Roche AG | Dérivés de dipeptide d'acide lysine-glutamique |
CN104583234A (zh) | 2012-06-14 | 2015-04-29 | 赛诺菲 | 毒蜥外泌肽-4肽类似物 |
CN104662038B (zh) | 2012-07-23 | 2018-11-06 | 西兰制药公司 | 胰高血糖素类似物 |
TWI608013B (zh) * | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
AR092873A1 (es) | 2012-09-26 | 2015-05-06 | Cadila Healthcare Ltd | Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
BR112015014510A2 (pt) | 2012-12-21 | 2017-11-21 | Sanofi Sa | agonistas de glp1/gip duais ou de glp1/gip/glucagon trigonais |
MX365465B (es) | 2013-03-21 | 2019-06-04 | Sanofi Aventis Deutschland | Sintesis de productos peptidicos que contienen imida ciclica. |
SG11201506804VA (en) | 2013-03-21 | 2015-09-29 | Sanofi Aventis Deutschland | Synthesis of hydantoin containing peptide products |
AR095986A1 (es) | 2013-04-03 | 2015-11-25 | Sanofi Sa | Proteínas modificadas que regulan glucosa en sangre con perfil alterado de actividad farmacológica y preparación de las mismas |
KR20160021758A (ko) | 2013-04-18 | 2016-02-26 | 노보 노르디스크 에이/에스 | 의학용으로 사용하기 위한 안정하고 연장된 glp-1/글루카곤 수용체 코-아고니스트 |
GB201315335D0 (en) * | 2013-08-29 | 2013-10-09 | Of Singapore | Amino diacids containing peptide modifiers |
CN105745222A (zh) | 2013-10-17 | 2016-07-06 | 西兰制药公司 | 酰化胰高血糖素类似物 |
US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
CA2929107C (fr) * | 2013-11-06 | 2023-09-26 | Zealand Pharma A/S | Composes agonistes triples glucagon-glp-1-gip |
TWI670281B (zh) * | 2013-11-06 | 2019-09-01 | 西蘭製藥公司 | Gip-glp-1雙重促效劑化合物及方法 |
WO2015086731A1 (fr) | 2013-12-13 | 2015-06-18 | Sanofi | Analogues peptidiques de l'exendine-4 en tant qu'agonistes mixtes des récepteurs glp-1/glucagon |
EP3080149A1 (fr) | 2013-12-13 | 2016-10-19 | Sanofi | Agonistes mixtes des récepteurs du glp-1/glucagon |
WO2015086730A1 (fr) | 2013-12-13 | 2015-06-18 | Sanofi | Analogues peptidiques de l'exendine 4 non acylés |
WO2015086729A1 (fr) | 2013-12-13 | 2015-06-18 | Sanofi | Agonistes mixtes des récepteurs glp-1/gip |
TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物 |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
US10570184B2 (en) | 2014-06-04 | 2020-02-25 | Novo Nordisk A/S | GLP-1/glucagon receptor co-agonists for medical use |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
ES2883345T3 (es) | 2014-10-29 | 2021-12-07 | Zealand Pharma As | Compuestos agonistas del GIP y métodos |
MY175669A (en) | 2015-02-17 | 2020-07-03 | Lilly Co Eli | Nasal powder formulation for treatment of hypoglycemia |
TWI748945B (zh) * | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
MX2017011182A (es) | 2015-03-18 | 2018-06-06 | Zealand Pharma As | Analogos de amilina. |
WO2016168388A2 (fr) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Thérapies pour l'obésité, le diabète et indications associées |
JP6989385B2 (ja) | 2015-04-16 | 2022-01-05 | ジーランド ファーマ アクティーゼルスカブ | アシル化グルカゴン類似体 |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
WO2016198628A1 (fr) | 2015-06-12 | 2016-12-15 | Sanofi | Dérivés d'exendine-4 non-acylée comme agonistes doubles du récepteur glp -1/glucagon |
WO2016198624A1 (fr) | 2015-06-12 | 2016-12-15 | Sanofi | Dérivés d'exendine 4 utilisés en tant qu'agonistes trigonaux des récepteurs du glp-1/glucagon/gip |
AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
LT3494120T (lt) | 2016-08-05 | 2021-05-25 | Boehringer Ingelheim International Gmbh | Oksadiazolopiridino dariniai, skirti naudoti kaip grelino o-aciltransferazės (goat) inhibitoriai |
US10071140B2 (en) | 2016-09-09 | 2018-09-11 | Zealand Pharma A/S | Amylin analogues |
TW201832783A (zh) | 2016-12-02 | 2018-09-16 | 法商賽諾菲公司 | 包含glp-1/胰高血糖素雙重激動劑、連接子和透明質酸的接合物 |
BR112019010624A2 (pt) | 2016-12-09 | 2019-10-22 | Zealand Pharma As | agonistas duplos de glp-1/glp-2 acilados e composição |
WO2018103868A1 (fr) * | 2016-12-09 | 2018-06-14 | Zealand Pharma A/S | Agonistes doubles de glp-1/glp-2 acylés |
EP3746449B1 (fr) | 2018-02-02 | 2022-03-30 | Boehringer Ingelheim International GmbH | Dérivés d'oxadiazolopyridine à substitution pyrazole et indazole destinés à être utilisés en tant qu'inhibiteurs de la ghréline o-acyl transférase (goat) |
KR20200116978A (ko) | 2018-02-02 | 2020-10-13 | 베링거 인겔하임 인터내셔날 게엠베하 | 그렐린 o-아실 트랜스퍼라제(goat) 억제제로서의 벤질-치환된, (피리딘-3-일)메틸-치환된 또는 (피리딘-4-일)메틸-치환된 옥사디아졸로피리딘 유도체 |
SG11202006300XA (en) | 2018-02-02 | 2020-07-29 | Boehringer Ingelheim Int | Heterocyclyl-substituted oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors |
JP7083397B2 (ja) | 2018-02-02 | 2022-06-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンo-アシルトランスフェラーゼ(goat)阻害剤として使用するためのトリアゾロピリミジン誘導体 |
JP7434169B2 (ja) * | 2018-04-10 | 2024-02-20 | サノフィ-アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 固相からの固相結合ペプチドの切断方法 |
CN112996811B (zh) | 2018-12-21 | 2022-11-22 | 江苏恒瑞医药股份有限公司 | 双特异性蛋白 |
TWI771669B (zh) | 2019-04-26 | 2022-07-21 | 美商美國禮來大藥廠 | 製備穩定胜肽調配物之方法 |
CN114641303A (zh) | 2019-11-11 | 2022-06-17 | 勃林格殷格翰国际有限公司 | Npy2受体激动剂 |
EP4192853A1 (fr) | 2020-08-07 | 2023-06-14 | Boehringer Ingelheim International GmbH | Agonistes du récepteur npy2 solubles |
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PL192359B1 (pl) | 1996-08-30 | 2006-10-31 | Novo Nordisk As | Pochodna GLP-1(7-37) lub analogu GLP-1(7-37), środek farmaceutyczny oraz zastosowanie pochodnej GLP-1(7-37) lub analogu GLP-1(7-37) |
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GB0121709D0 (en) | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
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GB0300571D0 (en) | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
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WO2006134340A2 (fr) | 2005-06-13 | 2006-12-21 | Imperial Innovations Limited | Nouveaux composes et leurs effets sur le comportement alimentaire |
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CA2628241C (fr) * | 2005-11-07 | 2016-02-02 | Indiana University Research And Technology Corporation | Analogues de glucagon a solubilite et a stabilite physiologiques ameliorees |
WO2007081824A2 (fr) | 2006-01-06 | 2007-07-19 | Case Western Reserve University | Protéines résistantes à la fibrillation |
CA2638800A1 (fr) | 2006-02-22 | 2007-09-07 | Merck & Co., Inc. | Derives d'oxyntomoduline |
ES2673822T3 (es) | 2006-07-18 | 2018-06-25 | Sanofi | Anticuerpo antagonista contra EphA2 para el tratamiento de cáncer |
WO2008043033A2 (fr) | 2006-10-04 | 2008-04-10 | Case Western Reserve University | Insuline et analogues de l'insuline résistants à la fibrillation |
TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
KR20150116465A (ko) | 2007-02-15 | 2015-10-15 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 글루카곤/glp-1 수용체 공동-항진물질 |
DK2158214T3 (da) | 2007-06-15 | 2011-12-05 | Zealand Pharma As | Glukagonanaloger |
EP2025684A1 (fr) | 2007-08-15 | 2009-02-18 | Zealand Pharma A/S | Analogues du glucagon |
NZ603812A (en) | 2007-11-20 | 2014-06-27 | Ambrx Inc | Modified insulin polypeptides and their uses |
DE102008003566A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
KR20100111683A (ko) | 2008-01-09 | 2010-10-15 | 사노피-아벤티스 도이칠란트 게엠베하 | 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체 |
CA2711749A1 (fr) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Nouveaux derives d'insuline a profil temporel/d'action extremement retarde |
DE102008003568A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
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JP5753779B2 (ja) | 2008-06-17 | 2015-07-22 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | 生理学的pHの緩衝液中で向上した溶解性及び安定性を示すグルカゴン類縁体 |
PL219335B1 (pl) | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
AU2009276346B2 (en) | 2008-07-31 | 2014-07-03 | Case Western Reserve University | Halogen-stabilized insulin |
CN102292347A (zh) | 2008-12-15 | 2011-12-21 | 西兰制药公司 | 胰高血糖素类似物 |
WO2010070255A1 (fr) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Analogues du glucagon |
JP5635531B2 (ja) | 2008-12-15 | 2014-12-03 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
WO2010080606A1 (fr) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Analogues d'insuline |
AU2009335715B2 (en) | 2008-12-19 | 2016-09-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
CN101519446A (zh) | 2009-03-31 | 2009-09-02 | 上海一就生物医药有限公司 | 一种重组人胰岛素及其类似物的制备方法 |
ME02220B (me) | 2009-07-13 | 2016-02-20 | Zealand Pharma As | Analozi acilovanog glukagona |
EP2525809B1 (fr) | 2010-01-20 | 2016-08-03 | Zealand Pharma A/S | Glucagon-glp1 agonistes doubles pour le traitement des maladies cardiaques |
UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
BR112012033225A2 (pt) | 2010-06-24 | 2017-06-20 | Zealand Pharma As | análogos do glucagon |
MA34913B1 (fr) | 2011-01-20 | 2014-02-01 | Zealand Pharma As | Combinaison d'analogues du glucagon acylé à des analogues d'insuline |
-
2008
- 2008-12-15 MA MA34020A patent/MA32970B1/fr unknown
- 2008-12-15 AP AP2011005774A patent/AP2011005774A0/xx unknown
- 2008-12-15 UA UAA201108817A patent/UA104605C2/uk unknown
- 2008-12-15 BR BRPI0823378A patent/BRPI0823378A2/pt not_active IP Right Cessation
- 2008-12-15 KR KR1020157027018A patent/KR20150116912A/ko not_active Application Discontinuation
- 2008-12-15 AU AU2008365555A patent/AU2008365555B2/en not_active Ceased
- 2008-12-15 MX MX2011006313A patent/MX2011006313A/es active IP Right Grant
- 2008-12-15 JP JP2011540187A patent/JP5635529B2/ja not_active Expired - Fee Related
- 2008-12-15 EP EP08875670A patent/EP2370459A1/fr not_active Withdrawn
- 2008-12-15 WO PCT/GB2008/004121 patent/WO2010070251A1/fr active Application Filing
- 2008-12-15 MY MYPI2011002751A patent/MY160219A/en unknown
- 2008-12-15 US US13/139,493 patent/US8685919B2/en not_active Expired - Fee Related
- 2008-12-15 KR KR1020117016184A patent/KR20110126589A/ko not_active Application Discontinuation
- 2008-12-15 CA CA2747109A patent/CA2747109A1/fr not_active Abandoned
- 2008-12-15 EP EP14175826.8A patent/EP2799447B1/fr active Active
- 2008-12-15 CN CN200880132682.4A patent/CN102282167B/zh not_active Expired - Fee Related
- 2008-12-15 SG SG2011043700A patent/SG172170A1/en unknown
- 2008-12-15 EA EA201190047A patent/EA020537B1/ru not_active IP Right Cessation
-
2011
- 2011-06-10 TN TN2011000295A patent/TN2011000295A1/fr unknown
- 2011-06-12 IL IL213477A patent/IL213477A0/en unknown
-
2014
- 2014-03-03 US US14/195,533 patent/US20150080295A1/en not_active Abandoned
-
2015
- 2015-05-05 HK HK15104289.5A patent/HK1203531A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
MY160219A (en) | 2017-02-28 |
TN2011000295A1 (en) | 2012-12-17 |
CN102282167A (zh) | 2011-12-14 |
EP2370459A1 (fr) | 2011-10-05 |
EP2799447A3 (fr) | 2014-12-31 |
AP2011005774A0 (en) | 2011-06-30 |
EA020537B1 (ru) | 2014-11-28 |
EA201190047A1 (ru) | 2012-02-28 |
CA2747109A1 (fr) | 2010-06-24 |
US20110286982A1 (en) | 2011-11-24 |
WO2010070251A1 (fr) | 2010-06-24 |
JP5635529B2 (ja) | 2014-12-03 |
BRPI0823378A2 (pt) | 2019-09-24 |
KR20110126589A (ko) | 2011-11-23 |
US8685919B2 (en) | 2014-04-01 |
EP2799447A2 (fr) | 2014-11-05 |
US20150080295A1 (en) | 2015-03-19 |
IL213477A0 (en) | 2011-07-31 |
KR20150116912A (ko) | 2015-10-16 |
UA104605C2 (uk) | 2014-02-25 |
HK1203531A1 (en) | 2015-10-30 |
AU2008365555B2 (en) | 2016-01-14 |
EP2799447B1 (fr) | 2016-11-23 |
MX2011006313A (es) | 2011-09-27 |
CN102282167B (zh) | 2014-08-13 |
AU2008365555A1 (en) | 2011-07-21 |
SG172170A1 (en) | 2011-07-28 |
JP2012511899A (ja) | 2012-05-31 |
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