MA31617B1 - Agents cytotoxiques comprenant de nouveaux dérivés de la tomaymycine et leur utilisation thérapeutique. - Google Patents

Agents cytotoxiques comprenant de nouveaux dérivés de la tomaymycine et leur utilisation thérapeutique.

Info

Publication number
MA31617B1
MA31617B1 MA32630A MA32630A MA31617B1 MA 31617 B1 MA31617 B1 MA 31617B1 MA 32630 A MA32630 A MA 32630A MA 32630 A MA32630 A MA 32630A MA 31617 B1 MA31617 B1 MA 31617B1
Authority
MA
Morocco
Prior art keywords
therapeutic use
cytotoxic agents
derivatives
tomaymycin derivatives
novel
Prior art date
Application number
MA32630A
Other languages
English (en)
Inventor
Herve Bouchard
Ravi V J Chari
Alain Commercon
Yonghong Deng
Laurence Gauzy
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39048765&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA31617(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA31617B1 publication Critical patent/MA31617B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

L'INVENTION CONCERNE DE NOUVEAUX DÉRIVÉS DE LA TOMAYMYCINE COMPRENANT UN LIEUR. L'INVENTION CONCERNE ÉGALEMENT DES MOLÉCULES CONJUGUÉES QUI COMPRENNENT UN OU PLUSIEURS DESDITS DÉRIVÉS DE LA TOMAYMYCINE LIÉS DE MANIÈRE COVALENTE À UN AGENT DE LIAISON CELLULAIRE PAR UN GROUPE LIANT QUI EST PRÉSENT SUR LE LIEUR DU DÉRIVÉ DE LA TOMAYMYCINE. L'INVENTION CONCERNE ÉGALEMENT LA PRÉPARATION DES DÉRIVÉS DE LA TOMAYMYCINE ET DES MOLÉCULES CONJUGUÉES.
MA32630A 2007-07-19 2010-02-17 Agents cytotoxiques comprenant de nouveaux dérivés de la tomaymycine et leur utilisation thérapeutique. MA31617B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07290904.7A EP2019104B1 (fr) 2007-07-19 2007-07-19 Agents cytotoxiques comprenant de nouveaux dérivés de tomaymycine et leur utilisation thérapeutique

Publications (1)

Publication Number Publication Date
MA31617B1 true MA31617B1 (fr) 2010-08-02

Family

ID=39048765

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32630A MA31617B1 (fr) 2007-07-19 2010-02-17 Agents cytotoxiques comprenant de nouveaux dérivés de la tomaymycine et leur utilisation thérapeutique.

Country Status (40)

Country Link
US (1) US8404678B2 (fr)
EP (2) EP2019104B1 (fr)
JP (1) JP5551070B2 (fr)
KR (1) KR101627871B1 (fr)
CN (1) CN101784550B (fr)
AR (1) AR067575A1 (fr)
AT (1) ATE530553T1 (fr)
AU (1) AU2008281439B2 (fr)
BR (1) BRPI0814267A2 (fr)
CA (1) CA2693551C (fr)
CL (1) CL2008002139A1 (fr)
CO (1) CO6290692A2 (fr)
CR (1) CR11225A (fr)
CY (2) CY1112278T1 (fr)
DK (2) DK2019104T3 (fr)
DO (1) DOP2010000014A (fr)
EA (1) EA019938B1 (fr)
EC (1) ECSP109875A (fr)
ES (2) ES2435779T3 (fr)
GT (1) GT201000008A (fr)
HK (1) HK1144289A1 (fr)
HR (1) HRP20120067T1 (fr)
IL (1) IL203318A (fr)
JO (1) JO2744B1 (fr)
MA (1) MA31617B1 (fr)
ME (1) ME00969B (fr)
MY (1) MY151245A (fr)
NI (1) NI201000005A (fr)
NZ (1) NZ582679A (fr)
PA (1) PA8790201A1 (fr)
PE (2) PE20130590A1 (fr)
PL (2) PL2019104T3 (fr)
PT (2) PT2019104E (fr)
RS (1) RS52245B (fr)
SI (2) SI2019104T1 (fr)
TN (1) TN2010000002A1 (fr)
TW (1) TWI500618B (fr)
UA (1) UA98153C2 (fr)
WO (1) WO2009016516A2 (fr)
ZA (1) ZA201000389B (fr)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7811572B2 (en) 2005-08-24 2010-10-12 Immunogen, Inc. Process for preparing purified drug conjugates
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
EP2185544B1 (fr) 2007-07-19 2014-11-26 Cymabay Therapeutics, Inc. Derives subtitues heterocycliques a liaison n de pyrrole, pyrazole, imidazole, triazole et tetrazole comme agonistes de recepteurs rup3 ou gpr119 utilises dans le traitement du diabete et des troubles metaboliques
DE102008056086A1 (de) * 2008-11-06 2010-05-12 Gp Solar Gmbh Additiv für alkalische Ätzlösungen, insbesondere für Texturätzlösungen sowie Verfahren zu dessen Herstellung
IL295601B1 (en) 2009-02-05 2024-07-01 Immunogen Inc History of benzodiazepines and processes for their preparation
AU2015224492B2 (en) * 2009-02-05 2017-04-20 Immunogen, Inc. Novel benzodiazepine derivatives
MX349210B (es) 2009-06-03 2017-07-18 Immunogen Inc Métodos de conjugación.
FR2947269B1 (fr) 2009-06-29 2013-01-18 Sanofi Aventis Nouveaux composes anticancereux
FR2949469A1 (fr) * 2009-08-25 2011-03-04 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
CN102666553B (zh) 2009-10-01 2015-05-06 赛马拜制药公司 取代的四唑-1-基-苯氧基甲基-噻唑-2-基-哌啶基-嘧啶盐
CN105001334A (zh) 2010-02-10 2015-10-28 伊缪诺金公司 Cd20抗体及其用途
US20110256157A1 (en) * 2010-04-15 2011-10-20 Spirogen Limited Pyrrolobenzodiazepines and conjugates thereof
CN107019804A (zh) 2010-04-15 2017-08-08 西雅图基因公司 靶向吡咯并苯并二氮杂卓结合物
CN102971329B (zh) 2010-04-15 2016-06-29 麦迪穆有限责任公司 用于治疗增殖性疾病的吡咯并苯并二氮杂卓
CN103037843A (zh) 2010-06-23 2013-04-10 麦它波莱克斯股份有限公司 5-乙基-2-{4-[4-(4-四唑-1-基-苯氧甲基)-噻唑-2-基]-哌啶-1-基}-嘧啶的组合物
FR2963007B1 (fr) 2010-07-26 2013-04-05 Sanofi Aventis Derives anticancereux, leur preparation et leur application therapeutique
BR112013020540B1 (pt) 2011-02-15 2020-12-29 Immunogen, Inc métodos para preparação de conjugados compreendendo agente de ligação à célula conjugado a composto citotóxico com grupo ligante
AU2012236398B2 (en) 2011-03-29 2016-02-11 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
US9156854B2 (en) 2011-04-18 2015-10-13 Immunogen, Inc. Maytansinoid derivatives with sulfoxide linker
CA2849039C (fr) 2011-09-20 2018-09-18 Spirogen Sarl Pyrrolobenzodiazepines comme composes dimeres de pbd asymetriques pour inclusion dans des conjugues cibles
WO2013053871A1 (fr) 2011-10-14 2013-04-18 Spirogen Sàrl Pyrrolobenzodiazépines
US9387259B2 (en) 2011-10-14 2016-07-12 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
EP2755642B1 (fr) 2011-10-14 2018-07-18 Seattle Genetics, Inc. Pyrrolobenzodiazépines et conjugués ciblés
JP6170497B2 (ja) 2011-10-14 2017-07-26 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピン
SG11201403179QA (en) * 2011-12-13 2014-07-30 Immunogen Inc Use of n-hydroxysuccinimide to improve conjugate stability
AR090549A1 (es) 2012-03-30 2014-11-19 Genentech Inc Anticuerpos anti-lgr5 e inmunoconjugados
BR112014027166A2 (pt) 2012-05-01 2017-06-27 Genentech Inc anticorpo, ácido nucleico, célula hospedeira, método para produzir um anticorpo, imunoconjugado, formulação farmacêutica, método de tratamento, método de inibir proliferação e métodos de detecção.
WO2013177481A1 (fr) 2012-05-25 2013-11-28 Immunogen, Inc. Benzodiazépines et leurs conjugués
BR112015000441A2 (pt) 2012-07-09 2017-12-19 Genentech Inc imunoconjugados, formulação farmacêutica e método de tratamento e método para inbir a proliferação de uma célula positiva para cd22
BR112015000437A2 (pt) 2012-07-09 2017-06-27 Genentech Inc imunoconjugados, formulação farmacêutica, métodos de tratamento e de inbir a proliferação de uma célula
MX2015001399A (es) 2012-08-02 2015-09-07 Genentech Inc Anticuerpos anti-etbr e inmunoconjugados.
EP2887965A1 (fr) 2012-08-22 2015-07-01 ImmunoGen, Inc. Dérivés de benzodiazépine cytotoxique
WO2014055877A1 (fr) * 2012-10-04 2014-04-10 Immunogen, Inc. Utilisation d'une membrane de pvdf pour purifier des conjugués d'agent de liaison cellulaire-agent cytotoxique
JP6270859B2 (ja) 2012-10-12 2018-01-31 エイディーシー・セラピューティクス・エス・アー・エール・エルＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａｒｌ ピロロベンゾジアゼピン−抗体結合体
US9745303B2 (en) 2012-10-12 2017-08-29 Medimmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
CN105102068B (zh) 2012-10-12 2018-06-01 Adc疗法责任有限公司 吡咯并苯并二氮杂卓-抗体结合物
ES2649990T3 (es) 2012-10-12 2018-01-16 Medimmune Limited Conjugados de anticuerpos anti-CD22-pirrolobenzodiazepinas
KR101645905B1 (ko) 2012-10-12 2016-08-04 스피로즌 살 피롤로벤조디아제핀 및 그의 컨주게이트
AU2013328674B2 (en) 2012-10-12 2017-06-22 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
EP2906250B1 (fr) 2012-10-12 2018-05-30 ADC Therapeutics SA Conjugués pyrrolobenzodiazepine-anticorps anti-psma
WO2014057120A1 (fr) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Conjugués anticorps - pyrrolobenzodiazépine
ES2703151T3 (es) 2012-10-12 2019-03-07 Adc Therapeutics Sa Conjugados de anticuerpos de pirrolobenzodiazepinas
JP6133431B2 (ja) 2012-11-24 2017-05-24 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用
WO2014140862A2 (fr) 2013-03-13 2014-09-18 Spirogen Sarl Pyrrolobenzodiazépines et leurs conjugués
EP2968494B1 (fr) 2013-03-13 2018-11-14 Seattle Genetics, Inc. Filtration par charbon actif pour la purification d'adc de benzodiazépine
BR112015023070B1 (pt) * 2013-03-13 2022-06-07 Genentech, Inc. Conjugados e compostos de pirrolobenzodiazepinas, composição farmacêutica que compreende os mesmo, bem como seus usos para o tratamento de uma doença proliferativa
US9562099B2 (en) 2013-03-14 2017-02-07 Genentech, Inc. Anti-B7-H4 antibodies and immunoconjugates
EP2970474B1 (fr) 2013-03-14 2017-12-20 Genentech, Inc. Anticorps et immunoconjugués anti-b7-h4
TWI636792B (zh) 2013-08-12 2018-10-01 建南德克公司 １－（氯甲基）－２，３－二氫－１ｈ－苯并［ｅ］吲哚二聚體抗體－藥物結合物化合物及使用與治療方法
AR097685A1 (es) 2013-09-17 2016-04-06 Genentech Inc Métodos de uso de anticuerpos anti-lgr5
WO2015052534A1 (fr) 2013-10-11 2015-04-16 Spirogen Sàrl Conjugués anticorps-pyrrolobenzodiazépine
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
US9956299B2 (en) 2013-10-11 2018-05-01 Medimmune Limited Pyrrolobenzodiazepine—antibody conjugates
CA2931340A1 (fr) 2013-12-13 2015-06-18 Genentech, Inc. Anticorps et immunoconjugues anti-cd33
MX2016007578A (es) 2013-12-16 2016-10-03 Genentech Inc Compuestos de conjugado anticuerpo-farmaco dimerico de 1-(clorometil)-2,3-dihidro-1h-benzo [e] indol, y metodos de uso y tratamiento.
JP6417421B2 (ja) 2014-02-28 2018-11-07 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 荷電連結体及び共役体のためのその使用
JP2017522861A (ja) 2014-05-22 2017-08-17 ジェネンテック， インコーポレイテッド 抗ｇｐｃ３抗体及びイムノコンジュゲート
MX2017002605A (es) 2014-08-28 2017-05-19 Bioatla Llc Receptores de antigeno quimerico condicionalmente activos para celulas t modificadas.
TW201613930A (en) 2014-09-03 2016-04-16 Immunogen Inc Cytotoxic benzodiazepine derivatives
DK3189056T3 (da) 2014-09-03 2020-09-14 Immunogen Inc Cytotoksiske benzodiazepinderivater
PE20170670A1 (es) 2014-09-12 2017-06-06 Genentech Inc Anticuerpos anti-cll-1 e inmunoconjugados
KR102508173B1 (ko) 2014-09-12 2023-03-10 제넨테크, 인크. 항-her2 항체 및 면역콘주게이트
CN113698485A (zh) 2014-09-12 2021-11-26 基因泰克公司 抗-b7-h4抗体及免疫缀合物
TW201625688A (zh) 2014-09-12 2016-07-16 建南德克公司 經半胱胺酸改造之抗體及接合物
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CA2957148A1 (fr) 2014-09-17 2016-03-24 Genentech, Inc. Immunoconjugues comprenant des anticorps anti-her2 et des pyrrolobenzodiazepines
EP3223854A1 (fr) 2014-11-25 2017-10-04 ADC Therapeutics SA Conjugués anticorps-pyrrolobenzodiazépine
BR112017014937A2 (pt) 2015-01-14 2018-03-13 Bristol-Myers Squibb Company dímeros de benzodiazepina ligados em ponte a heteroarileno, conjugados dos mesmos, e métodos de preparação e uso
BR112017014599A2 (pt) 2015-01-14 2018-01-16 Bristol-Myers Squibb Company dímeros de benzodiazepina, conjugados dos mesmos, e métodos de preparação e uso
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
MX2017015814A (es) 2015-06-23 2018-04-10 Squibb Bristol Myers Co Dimeros de benzodiazepina macrociclica, conjugados de los mismos, preparacion y usos.
CN113350518A (zh) 2015-07-12 2021-09-07 杭州多禧生物科技有限公司 与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
HUE051541T2 (hu) 2015-07-21 2021-03-01 Immunogen Inc Eljárások citotoxikus benzodiazepin származékok elõállítására
MA43354A (fr) 2015-10-16 2018-08-22 Genentech Inc Conjugués médicamenteux à pont disulfure encombré
CN107405408B (zh) * 2015-12-21 2021-07-02 江苏恒瑞医药股份有限公司 一种抗体药物偶联物的制备方法
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
KR102606938B1 (ko) 2016-04-15 2023-11-29 바이오아트라, 인코퍼레이티드 항 Axl항체 및 이의 면역접합체와 이것들의 용도
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
WO2017196847A1 (fr) 2016-05-10 2017-11-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps anti-nouveau récepteur variable d'antigène (vnar) et conjugués d'anticorps ciblant des antigènes tumoraux et viraux
AU2017263568B2 (en) 2016-05-13 2024-01-18 Bioatla, Llc Anti-Ror2 antibodies, antibody fragments, their immunoconjugates and uses thereof
JP7022080B2 (ja) 2016-05-27 2022-02-17 ジェネンテック， インコーポレイテッド 部位特異的抗体－薬物複合体の特徴付けのための生化学分析的方法
CN107469089B (zh) * 2016-06-07 2022-01-07 北京键凯科技股份有限公司 一种peg连接子及配基药物偶联物
WO2017214182A1 (fr) 2016-06-07 2017-12-14 The United States Of America. As Represented By The Secretary, Department Of Health & Human Services Anticorps entièrement humain ciblant pdi pour l'immunothérapie anticancéreuse
AU2017305170A1 (en) 2016-08-02 2019-02-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monoclonal antibodies targeting glypican-2 (GPC2) and use thereof
AU2017305392A1 (en) 2016-08-03 2019-02-21 Cymabay Therapeutics, Inc. Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
WO2018031662A1 (fr) 2016-08-11 2018-02-15 Genentech, Inc. Promédicaments de pyrrolobenzodiazépine et conjugués d'anticorps de ceux-ci
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
EP3538080A4 (fr) 2016-11-14 2020-07-08 Hangzhou Dac Biotech Co., Ltd. Lieurs de conjugaison, conjugués médicament-molécule de liaison à une cellule contenant lesdits lieurs, procédés de préparation et d'utilisation de tels conjugués avec les lieurs
AU2017361887B2 (en) 2016-11-21 2019-08-15 Cureab Gmbh Anti-GP73 antibodies and immunoconjugates
CA3044391A1 (fr) 2016-11-23 2018-05-31 Immunogen, Inc. Sulfonation selective de derives de benzodiazepine
US11236171B2 (en) 2016-12-21 2022-02-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies specific for FLT3 and uses thereof
US20210388102A1 (en) 2016-12-23 2021-12-16 Immunogen, Inc. Immunoconjugates targeting adam9 and methods of use thereof
TW201825515A (zh) 2017-01-04 2018-07-16 美商伊繆諾金公司 Ｍｅｔ抗體以及其免疫結合物及用途
ES2871001T3 (es) 2017-02-08 2021-10-28 Adc Therapeutics Sa Conjugados de pirrolobenzodiazepinas y anticuerpos
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
RS63502B1 (sr) 2017-04-18 2022-09-30 Medimmune Ltd Konjugati pirolobenzodiazepina
US20200129637A1 (en) 2017-04-20 2020-04-30 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
US20180346488A1 (en) 2017-04-20 2018-12-06 Immunogen, Inc. Cytotoxic benzodiazepine derivatives and conjugates thereof
AU2018268970A1 (en) 2017-05-19 2019-10-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibody targeting tnfr2 for cancer immunotherapy
US11318211B2 (en) 2017-06-14 2022-05-03 Adc Therapeutics Sa Dosage regimes for the administration of an anti-CD19 ADC
WO2019005208A1 (fr) 2017-06-30 2019-01-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps de la mésothéline humaine et utilisations dans une thérapie anticancéreuse
CA3066953A1 (fr) 2017-06-30 2019-01-03 Lentigen Technology, Inc. Anticorps monoclonaux humains specifiques de cd33 et leurs procedes d'utilisation
DK3668874T3 (da) 2017-08-18 2022-02-14 Medimmune Ltd Pyrrolobenzodiazepin-konjugater
IL301637B1 (en) 2017-09-29 2024-06-01 Daiichi Sankyo Co Ltd Conjugation of an antibody with a pyrrolobenzodiazepine derivative
US11793885B2 (en) 2017-12-28 2023-10-24 Immunogen, Inc. Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
AU2019301675A1 (en) 2018-07-12 2021-01-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Affinity matured CD22-specific monoclonal antibody and uses thereof
WO2020033430A1 (fr) 2018-08-08 2020-02-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux à haute affinité ciblant le glypicane-2 et leurs utilisations
TW202029980A (zh) 2018-10-26 2020-08-16 美商免疫遺傳股份有限公司 Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途
EP3898693A4 (fr) 2018-12-21 2022-09-21 Avidity Biosciences, Inc. Anticorps anti-récepteurs de transferrine et utilisations associées
US20220096641A1 (en) * 2019-01-03 2022-03-31 Legochem Biosciences, Inc. Pyrrolobenzodiazepine dimer compound with improved safety and use thereof
CN113490510A (zh) 2019-01-08 2021-10-08 美国政府(由卫生和人类服务部的部长所代表) 用于治疗实体瘤的靶向间皮素的跨物种单结构域抗体
US20220098323A1 (en) 2019-01-22 2022-03-31 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services High affinity monoclonal antibodies targeting glypican-1 and methods of use
WO2020160156A2 (fr) 2019-01-30 2020-08-06 Immutics, Inc. Anticorps anti-gal3 et leurs utilisations
JP2022529583A (ja) 2019-03-29 2022-06-23 イミュノジェン・インコーポレーテッド 異常細胞増殖を阻害するまたは増殖性疾患を治療するための細胞毒性ビス－ベンゾジアゼピン誘導体及び細胞結合剤とのその複合体
JP2022552875A (ja) 2019-10-22 2022-12-20 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 多様な固形腫瘍を処置するためのｂ７ｈ３（ｃｄ２７６）を標的とする高親和性ナノボディ
EP4041769A1 (fr) 2019-12-12 2022-08-17 The United States of America, as represented by the Secretary, Department of Health and Human Services Conjugués anticorps-médicament spécifiques à cd276 et leurs utilisations
WO2021188390A1 (fr) 2020-03-19 2021-09-23 Avidity Biosciences, Inc. Compositions et méthodes de traitement d'une dystrophie musculaire facio-scapulo-humérale
IL296393A (en) 2020-03-27 2022-11-01 Avidity Biosciences Inc Preparations and methods for the treatment of muscle atrophy
US20230391852A1 (en) 2020-10-26 2023-12-07 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Single domain antibodies targeting sars coronavirus spike protein and uses thereof
WO2022232612A1 (fr) 2021-04-29 2022-11-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nanocorps spécifiques du virus de lassa et leurs méthodes d'utilisation
CN117500831A (zh) 2021-06-09 2024-02-02 美国政府(由卫生和人类服务部的部长所代表) 用于治疗实体瘤的靶向pd-l1的跨物种单结构域抗体
WO2023288252A1 (fr) 2021-07-13 2023-01-19 Truebinding, Inc. Méthodes de prévention de l'agrégation de protéines
CA3231330A1 (fr) 2021-09-16 2023-03-23 Avidity Biosciences, Inc. Compositions et methodes de traitement d'une dystrophie musculaire facio-scapulo-humerale
TW202406934A (zh) 2022-05-03 2024-02-16 美商建南德克公司 抗Ｌｙ６Ｅ抗體、免疫結合物及其用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1516743A (fr) 1966-04-01 1968-02-05 Rhone Poulenc Sa Nouvel antibiotique et son procédé de préparation par culture de streptomyces croceus
US4981979A (en) 1987-09-10 1991-01-01 Neorx Corporation Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
ES2149768T3 (es) 1992-03-25 2000-11-16 Immunogen Inc Conjugados de agentes enlazantes de celulas derivados de cc-1065.
GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
EP1193270B1 (fr) 1998-08-27 2003-05-14 Spirogen Limited Pyrrolobenzodiazépines
EP1242401B1 (fr) 1999-11-24 2006-12-27 Immunogen, Inc. Agents cytotoxiques comprenant des taxanes et leur utilisation therapeutique
US6756397B2 (en) 2002-04-05 2004-06-29 Immunogen, Inc. Prodrugs of CC-1065 analogs
US8034904B2 (en) 2002-06-14 2011-10-11 Immunogen Inc. Anti-IGF-I receptor antibody
AU2003285878B2 (en) 2002-11-07 2011-04-28 Immunogen, Inc. Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same
DE60324607D1 (de) * 2003-03-31 2008-12-18 Council Scient Ind Res Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür
WO2004091542A2 (fr) 2003-04-15 2004-10-28 Covx Pharmaceuticals, Inc. Composes de ciblage d'integrine contenant de l'azote
WO2005009369A2 (fr) 2003-07-21 2005-02-03 Immunogen, Inc. Conjugue cytotoxique specifique de l'antigene ca6 et procedes d'utilisation
GB0321295D0 (en) * 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
AU2004284075A1 (en) * 2003-10-22 2005-05-06 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
GB0404577D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
GB0404578D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
US7528126B2 (en) 2004-03-09 2009-05-05 Spirogen Limited Pyrrolobenzodiazepines
GB0410725D0 (en) * 2004-05-13 2004-06-16 Spirogen Ltd Pyrrolobenzodiazepine therapeutic agents
PL1813614T3 (pl) * 2006-01-25 2012-03-30 Sanofi Sa Środki cytotoksyczne zawierające nowe pochodne tomaymycyny
ZA200900545B (en) * 2006-07-18 2010-03-31 Sanofi Aventis Antagonist antibody against EPHA2 for the treatment of cancer
EP1914242A1 (fr) 2006-10-19 2008-04-23 Sanofi-Aventis Nouveau anticorps Anti-CD38 pour le traitement du cancer

Also Published As

Publication number Publication date
TW200922598A (en) 2009-06-01
ES2376026T3 (es) 2012-03-08
JO2744B1 (en) 2014-03-15
KR20100063021A (ko) 2010-06-10
ECSP109875A (es) 2010-02-26
JP5551070B2 (ja) 2014-07-16
EP2019104A1 (fr) 2009-01-28
WO2009016516A2 (fr) 2009-02-05
EP2170890B1 (fr) 2011-10-26
PL2170890T3 (pl) 2012-04-30
CN101784550B (zh) 2014-06-11
ME00969B (me) 2012-06-20
DK2019104T3 (da) 2013-12-16
RS52245B (en) 2012-10-31
US20100316656A1 (en) 2010-12-16
KR101627871B1 (ko) 2016-06-07
PA8790201A1 (es) 2009-02-09
BRPI0814267A2 (pt) 2015-03-31
GT201000008A (es) 2012-03-26
PE20090889A1 (es) 2009-08-06
DOP2010000014A (es) 2010-02-15
AU2008281439A1 (en) 2009-02-05
PT2019104E (pt) 2013-12-03
MY151245A (en) 2014-04-30
ZA201000389B (en) 2011-04-28
JP2010533703A (ja) 2010-10-28
HRP20120067T1 (hr) 2012-02-29
US8404678B2 (en) 2013-03-26
IL203318A (en) 2016-08-31
EA019938B1 (ru) 2014-07-30
AR067575A1 (es) 2009-10-14
NI201000005A (es) 2010-03-09
CA2693551C (fr) 2016-09-20
CL2008002139A1 (es) 2009-10-23
SI2170890T1 (sl) 2012-02-29
PT2170890E (pt) 2012-02-03
CA2693551A1 (fr) 2009-02-05
ES2435779T3 (es) 2013-12-23
PE20130590A1 (es) 2013-05-22
CN101784550A (zh) 2010-07-21
CY1112278T1 (el) 2015-12-09
PL2019104T3 (pl) 2014-03-31
TN2010000002A1 (en) 2011-09-26
ATE530553T1 (de) 2011-11-15
AU2008281439B2 (en) 2013-02-07
TWI500618B (zh) 2015-09-21
HK1144289A1 (en) 2011-02-11
EP2170890A2 (fr) 2010-04-07
CR11225A (es) 2010-06-23
CY1114922T1 (el) 2016-12-14
EP2019104B1 (fr) 2013-09-04
SI2019104T1 (sl) 2013-12-31
WO2009016516A8 (fr) 2009-04-16
EA201070163A1 (ru) 2010-08-30
UA98153C2 (uk) 2012-04-25
CO6290692A2 (es) 2011-06-20
WO2009016516A3 (fr) 2009-06-11
NZ582679A (en) 2012-04-27
DK2170890T3 (da) 2012-02-27

Similar Documents

Publication Publication Date Title
MA31617B1 (fr) Agents cytotoxiques comprenant de nouveaux dérivés de la tomaymycine et leur utilisation thérapeutique.
AP1547A (en) Antibodies to CD23, derivatives thereof, and their therapeutic uses.
LTPA2017009I1 (lt) Brutono tirozinkinazės inhibitoriai
AP2001002088A0 (en) 4,4-Biarylpiperidine derivatives with opiod receptor activity.
DE60130256D1 (de) Naphthalinderivate, die sich an den ep4?rezeptor binden
MA30689B1 (fr) Derives de leptomycine
EA200602062A1 (ru) Амидосоединения и их применение в качестве фармацевтических средств
EA200700725A1 (ru) ПРИМЕНЕНИЕ [D-MeAla]-[EtVal]-ЦИКЛОСПОРИНА ДЛЯ ЛЕЧЕНИЯ ИНФЕКЦИИ ГЕПАТИТА С И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ [D-MeAla]-[EtVal]-ЦИКЛОСПОРИН
WO2004019878A3 (fr) Adzymes et leurs utilisations
DE60039752D1 (de) Herstellung tetravalenter antikörper
DK1869049T3 (da) Imidazopyridazinforbindelser
WO2005110416A3 (fr) 2-arylpyrimidines disubstituees en 4,5
ATE466886T1 (de) Adzyme und deren verwendungen
UA103758C2 (ru) Конъюгаты олигомеров инсулина, их композиции и применение
WO2002006286A3 (fr) Imidazo[1,2-a]pyrazines destinees au traitement d'affections neurologiques
EP2415479A3 (fr) Procédés de régulation de cellules souches
TW200727903A (en) Stable pharmaceutical compositions of 5, 10 methylenetetrahydrofolate
MXPA03004821A (es) Compuestos de union de ciclofilina carbociclica bisubstutuida y su uso.
AU4038000A (en) 4-substituted quinoline derivatives as gaba receptor ligands
BRPI0617673C1 (pt) composições de inibidores de fosfodiesterase do tipo iv
TR200402083T2 (tr) Parkinson hastalığı, adhd ve mikroadenomların tedavisi için ilaçlar
MA31442B1 (fr) 3-(imidazolyl)-pyrazolo [3,4-b]pyridines
BR0308391A (pt) Derivados de pirazolo(1,5-a)piridina como moduladores neurotransmissores
MA29561B1 (fr) DERIVES DE PYRIDO[2,3-d] PYRIMIDINE, LEUR PREPARATION, LEUR APPLICATION EN THERAPEUTIQUE
MA31630B1 (fr) Dérivés de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamides et de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]-diazépine-7-carboxamides, leur préparation et leur application en thérapeutique