MA31608B1 - Pyrimidines bicycliques condensees - Google Patents

Pyrimidines bicycliques condensees

Info

Publication number
MA31608B1
MA31608B1 MA32617A MA32617A MA31608B1 MA 31608 B1 MA31608 B1 MA 31608B1 MA 32617 A MA32617 A MA 32617A MA 32617 A MA32617 A MA 32617A MA 31608 B1 MA31608 B1 MA 31608B1
Authority
MA
Morocco
Prior art keywords
condensed bicyclic
bicyclic pyrimidines
pyrimidines
condensed
compounds
Prior art date
Application number
MA32617A
Other languages
English (en)
Inventor
Swen Hoelder
Matthias Vennemann
Gerrit Beneke
Armin Zuelch
Volker Gekeler
Thomas Beckers
Astrid Zimmermann
Hemant Joshi
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07118736A external-priority patent/EP2050748A1/fr
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MA31608B1 publication Critical patent/MA31608B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

L'INVENTION PORTE SUR DES COMPOSÉS DE LA FORMULE (I), SUR UN TAUTOMÈRE OU UN STÉRÉOISOMÈRE DE CES DERNIERS, OU SUR UN SEL DE CES DERNIERS, DANS LAQUELLE LE CYCLE B ET LA PYRIMIDINE AVEC LAQUELLE IL EST CONDENSÉ, R4, R5, R6 ET R7 SONT TELS QUE DÉFINIS DANS LA DESCRIPTION ET LES REVENDICATIONS, LESQUELS COMPOSÉS SONT DES INHIBITEURS EFFICACES DE LA VOIE PI3K/AKT.
MA32617A 2007-08-14 2010-02-12 Pyrimidines bicycliques condensees MA31608B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1572MU2007 2007-08-14
EP07118736A EP2050748A1 (fr) 2007-10-18 2007-10-18 Nouveau pyrimidines fusionnés

Publications (1)

Publication Number Publication Date
MA31608B1 true MA31608B1 (fr) 2010-08-02

Family

ID=40153211

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32617A MA31608B1 (fr) 2007-08-14 2010-02-12 Pyrimidines bicycliques condensees

Country Status (38)

Country Link
US (2) US7776864B2 (fr)
EP (1) EP2188291B1 (fr)
JP (1) JP5344637B2 (fr)
KR (1) KR20100053556A (fr)
CN (1) CN101778851B (fr)
AR (1) AR067945A1 (fr)
AU (1) AU2008288392B2 (fr)
BR (1) BRPI0815207A2 (fr)
CA (1) CA2694058C (fr)
CL (1) CL2008002398A1 (fr)
CO (1) CO6260077A2 (fr)
CR (1) CR11270A (fr)
CY (1) CY1113486T1 (fr)
DK (1) DK2188291T3 (fr)
DO (1) DOP2010000058A (fr)
EA (1) EA020996B1 (fr)
EC (1) ECSP109964A (fr)
ES (1) ES2396177T3 (fr)
HK (1) HK1146273A1 (fr)
HN (1) HN2010000313A (fr)
HR (1) HRP20121022T1 (fr)
IL (1) IL203163A (fr)
MA (1) MA31608B1 (fr)
MX (1) MX2010001746A (fr)
MY (1) MY169738A (fr)
NZ (1) NZ583267A (fr)
PA (1) PA8793201A1 (fr)
PE (1) PE20090944A1 (fr)
PL (1) PL2188291T3 (fr)
PT (1) PT2188291E (fr)
RS (1) RS52559B (fr)
SI (1) SI2188291T1 (fr)
SV (1) SV2010003483A (fr)
TN (1) TN2010000070A1 (fr)
TW (1) TWI439272B (fr)
UA (1) UA99735C2 (fr)
UY (1) UY31293A1 (fr)
WO (1) WO2009021992A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8410087B2 (en) * 2006-10-19 2013-04-02 Takeda Pharmaceutical Company Limited Indole compound
MX2010001746A (es) 2007-08-14 2010-03-10 Bayer Schering Pharma Ag Pirimidinas biciclicas fusionadas.
WO2009155121A2 (fr) 2008-05-30 2009-12-23 Amgen Inc. Inhibiteurs de la pi3 kinase
US8957064B2 (en) * 2009-02-13 2015-02-17 Bayer Intellectual Property Gmbh Fused pyrimidines
CN102361872B (zh) * 2009-02-13 2014-12-03 拜耳知识产权有限责任公司 作为akt抑制剂的稠合嘧啶
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
US20120071475A1 (en) 2009-04-27 2012-03-22 Shionogi & Co., Ltd. Urea derivatives having pi3k-inhibiting activity
CN103189379A (zh) * 2010-07-13 2013-07-03 拜耳知识产权有限责任公司 双环嘧啶
CA2806655A1 (fr) 2010-07-28 2012-02-02 Bayer Intellectual Property Gmbh Imidazo[1,2-b]pyridazines substituees
EA024890B1 (ru) 2011-04-07 2016-10-31 Байер Интеллектчуал Проперти Гмбх Имидазопиридазины в качестве ингибиторов akt киназы
MX361136B (es) 2013-01-23 2018-11-28 Astrazeneca Ab Compuestos quimicos.
BR112015022206A2 (pt) * 2013-03-15 2017-07-18 Bayer Cropscience Lp composições, aditivos, e métodos para atenuar ou controlar a poeira da semente
US20140274685A1 (en) 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
TW201920185A (zh) 2017-09-15 2019-06-01 美商艾杜諾生物科技公司 吡唑并嘧啶酮化合物及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1307200A2 (fr) 2000-06-30 2003-05-07 Wyeth Triazolopyrimidines substitues comme agents anticancereux
US7449488B2 (en) * 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
EP1622616B1 (fr) 2003-04-24 2011-06-15 Merck Sharp & Dohme Corp. Inhibiteurs de l'activite akt
ATE499364T1 (de) * 2004-04-09 2011-03-15 Merck Sharp & Dohme Hemmer der akt aktivität
AR050188A1 (es) * 2004-08-03 2006-10-04 Uriach Y Compania S A J Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
US7544677B2 (en) 2004-08-23 2009-06-09 Merck & Co., Inc. Inhibitors of Akt activity
EP1827436A4 (fr) 2004-12-15 2011-08-10 Merck Sharp & Dohme Inhibiteurs d'activite akt
ATE543821T1 (de) * 2004-12-28 2012-02-15 Exelixis Inc Ä1h-pyrazoloä3,4-düpyrimidin-4-ylü-piperidin- oder piperazinverbindungen als serin-threonin- kinasemodulatoren (p70s6k, atk1 und atk2) zur behandlung von immunologischen, entzündlichen und proliferativen erkrankungen
CA2597456A1 (fr) 2005-02-14 2006-08-31 Merck & Co., Inc. Inhibiteurs d'activite d'akt
NZ563423A (en) 2005-06-10 2010-05-28 Merck Sharp & Dohme Inhibitors of AKT activity
MX2010001746A (es) 2007-08-14 2010-03-10 Bayer Schering Pharma Ag Pirimidinas biciclicas fusionadas.
US8957064B2 (en) * 2009-02-13 2015-02-17 Bayer Intellectual Property Gmbh Fused pyrimidines

Also Published As

Publication number Publication date
DOP2010000058A (es) 2010-02-28
JP5344637B2 (ja) 2013-11-20
BRPI0815207A2 (pt) 2017-03-28
KR20100053556A (ko) 2010-05-20
HK1146273A1 (en) 2011-05-20
HN2010000313A (es) 2013-03-18
SI2188291T1 (sl) 2013-01-31
UA99735C2 (uk) 2012-09-25
AR067945A1 (es) 2009-10-28
CN101778851A (zh) 2010-07-14
RS52559B (en) 2013-04-30
EP2188291B1 (fr) 2012-09-19
HRP20121022T1 (hr) 2013-01-31
AU2008288392A1 (en) 2009-02-19
US8614218B2 (en) 2013-12-24
TWI439272B (zh) 2014-06-01
US7776864B2 (en) 2010-08-17
EA201000298A1 (ru) 2010-10-29
MX2010001746A (es) 2010-03-10
CN101778851B (zh) 2013-05-08
EP2188291A2 (fr) 2010-05-26
TW200922592A (en) 2009-06-01
UY31293A1 (es) 2009-03-31
CO6260077A2 (es) 2011-03-22
SV2010003483A (es) 2010-07-06
EA020996B1 (ru) 2015-03-31
DK2188291T3 (da) 2013-01-07
US20100184782A1 (en) 2010-07-22
CA2694058A1 (fr) 2009-02-19
MY169738A (en) 2019-05-14
PA8793201A1 (es) 2009-04-23
ECSP109964A (es) 2010-03-31
US20090137607A1 (en) 2009-05-28
NZ583267A (en) 2012-03-30
ES2396177T3 (es) 2013-02-19
WO2009021992A2 (fr) 2009-02-19
CA2694058C (fr) 2016-06-07
CL2008002398A1 (es) 2009-07-31
CR11270A (es) 2010-05-19
PT2188291E (pt) 2012-12-20
JP2010535848A (ja) 2010-11-25
IL203163A (en) 2015-01-29
AU2008288392B2 (en) 2013-10-24
TN2010000070A1 (en) 2011-09-26
WO2009021992A3 (fr) 2009-04-16
CY1113486T1 (el) 2016-06-22
PL2188291T3 (pl) 2013-06-28
PE20090944A1 (es) 2009-08-09

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