MA31451B1 - Antagonistes des recepteurs de l'orexine de pyridyl piperidine. - Google Patents

Antagonistes des recepteurs de l'orexine de pyridyl piperidine.

Info

Publication number
MA31451B1
MA31451B1 MA32427A MA32427A MA31451B1 MA 31451 B1 MA31451 B1 MA 31451B1 MA 32427 A MA32427 A MA 32427A MA 32427 A MA32427 A MA 32427A MA 31451 B1 MA31451 B1 MA 31451B1
Authority
MA
Morocco
Prior art keywords
orexin receptors
antagonists
pyridyl piperidine
compounds
pyridyl
Prior art date
Application number
MA32427A
Other languages
English (en)
Inventor
Michael J Breslin
Paul J Coleman
Christopher D Cox
John D Schreier
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA31451B1 publication Critical patent/MA31451B1/fr

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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  • Child & Adolescent Psychology (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DES COMPOSÉS PYRIDYL PIPÉRIDINE DE FORMULE (I) QUI SONT DES ANTAGONISTES DE RÉCEPTEUR D'OREXINE, ET QUI SONT UTILES DANS LE TRAITEMENT OU LA PRÉVENTION DE TROUBLES ET MALADIES NEUROLOGIQUES ET PSYCHIATRIQUES DANS LESQUELS LES RÉCEPTEURS D'OREXINE SONT IMPLIQUÉS. L'INVENTION CONCERNE DES COMPOSITIONS PHARMACEUTIQUES COMPRENANT CES COMPOSÉS ET L'UTILISATION DE CES COMPOSÉS ET COMPOSITIONS DANS LA PRÉVENTION ET LE TRAITEMENT DE TELLES MALADIES DANS LESQUELLES DES RÉCEPTEURS D'OREXINE SONT IMPLIQUÉS.
MA32427A 2007-05-23 2009-12-17 Antagonistes des recepteurs de l'orexine de pyridyl piperidine. MA31451B1 (fr)

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CN101679366A (zh) 2010-03-24
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SI2152690T1 (sl) 2012-05-31
ZA200907495B (en) 2010-08-25
CA2687321A1 (fr) 2008-12-04
JP2010528011A (ja) 2010-08-19
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CR11146A (es) 2010-03-01
US8569311B2 (en) 2013-10-29
RS52200B (en) 2012-10-31
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