MA27608A1 - Derives d'hydroxyethylamine utilises pour le traitement de la maladie d'alzheimer - Google Patents
Derives d'hydroxyethylamine utilises pour le traitement de la maladie d'alzheimerInfo
- Publication number
- MA27608A1 MA27608A1 MA28368A MA28368A MA27608A1 MA 27608 A1 MA27608 A1 MA 27608A1 MA 28368 A MA28368 A MA 28368A MA 28368 A MA28368 A MA 28368A MA 27608 A1 MA27608 A1 MA 27608A1
- Authority
- MA
- Morocco
- Prior art keywords
- disease
- treatment
- alzheimer
- beta
- hydroxyethylamine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
NOUVEAUX COMPOSES La présente invention concerne de nouveaux composés hydroxyéthylamine possédant une activité inhibitrice de l'Asp2 ((bêta)-sécrétase, BACE1 ou Mémapsine), des procédés pour leur préparation, des compositions les contenant et leur utilisation dans le traitement de maladies caractérisées par des concentrations en ((bêta)-amyloïdes ou dépôts de (bêta)-amyloïdes élevé(e)s, en particulier, la maladie d'Alzheimer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0228410.7A GB0228410D0 (en) | 2002-12-05 | 2002-12-05 | Novel Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27608A1 true MA27608A1 (fr) | 2005-11-01 |
Family
ID=9949141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28368A MA27608A1 (fr) | 2002-12-05 | 2005-07-01 | Derives d'hydroxyethylamine utilises pour le traitement de la maladie d'alzheimer |
Country Status (25)
Country | Link |
---|---|
US (1) | US7253198B2 (fr) |
EP (1) | EP1567488B1 (fr) |
JP (1) | JP2006514634A (fr) |
KR (1) | KR20050084143A (fr) |
CN (1) | CN1735592A (fr) |
AT (1) | ATE354565T1 (fr) |
AU (1) | AU2003292198B2 (fr) |
BR (1) | BR0317020A (fr) |
CA (1) | CA2508325A1 (fr) |
DE (1) | DE60312031T2 (fr) |
DK (1) | DK1567488T3 (fr) |
ES (1) | ES2282685T3 (fr) |
GB (1) | GB0228410D0 (fr) |
HK (1) | HK1083624A1 (fr) |
IS (1) | IS7925A (fr) |
MA (1) | MA27608A1 (fr) |
MX (1) | MXPA05006088A (fr) |
NO (1) | NO20053263L (fr) |
NZ (1) | NZ539841A (fr) |
PL (1) | PL377587A1 (fr) |
PT (1) | PT1567488E (fr) |
RU (1) | RU2005121146A (fr) |
SI (1) | SI1567488T1 (fr) |
WO (1) | WO2004050619A1 (fr) |
ZA (1) | ZA200503693B (fr) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0314302D0 (en) * | 2003-06-19 | 2003-07-23 | Glaxo Group Ltd | Novel compounds |
GB0328900D0 (en) * | 2003-12-12 | 2004-01-14 | Glaxo Group Ltd | Novel compounds |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
AU2004311749A1 (en) * | 2003-12-19 | 2005-07-21 | Merck & Co., Inc. | Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of Alzheimer's disease |
JP2007528402A (ja) * | 2004-03-09 | 2007-10-11 | エラン ファーマシューティカルズ,インコーポレイテッド | 置換ヒドロキシエチルアミン系のアスパラギン酸プロテアーゼ阻害薬 |
JP2007528403A (ja) * | 2004-03-09 | 2007-10-11 | エラン ファーマシューティカルズ,インコーポレイテッド | 二環式アスパラギン酸プロテアーゼ阻害薬を用いるアミロイドーシスの処置方法 |
WO2005087751A2 (fr) | 2004-03-09 | 2005-09-22 | Elan Pharmaceuticals, Inc. | Aspartyle a base d'hydroxyethylamine substitue inhibiteurs de la protease |
JP2007528404A (ja) * | 2004-03-09 | 2007-10-11 | エラン ファーマシューティカルズ,インコーポレイテッド | 置換された尿素およびカルバメート、フェナシル−2−ヒドロキシ−3−ジアミノアルカン、ならびにベンズアミド−2−ヒドロキシ−3−ジアミノアルカン系のアスパラギン酸プロテアーゼ阻害薬 |
JP4764418B2 (ja) | 2004-04-20 | 2011-09-07 | メルク・シャープ・エンド・ドーム・コーポレイション | アルツハイマー病の治療のためのβ−セクレターゼ阻害剤として有用な2,4,6−置換ピリジル誘導体化合物 |
JP2007533743A (ja) | 2004-04-20 | 2007-11-22 | メルク エンド カムパニー インコーポレーテッド | アルツハイマー病治療のためのβ−セクレターゼ阻害薬として有用な1,3,5−置換フェニル誘導体化合物 |
GB0411404D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
AU2005265354A1 (en) * | 2004-07-09 | 2006-01-26 | Elan Pharmaceuticals, Inc. | Oxime derivative hydroxyethylamine aspartyl-protease inhibitors |
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WO2007047305A1 (fr) | 2005-10-12 | 2007-04-26 | Elan Pharmaceuticals, Inc. | Procedes de traitement de l'amyloïdose en utilisant des derives de cyclopropyle inhibiteurs de l'aspartyle-protease |
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ES2546063T3 (es) * | 2009-12-10 | 2015-09-18 | The Regents Of The University Of California | Agentes de enlace a amiloides |
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CN104768949A (zh) * | 2012-08-24 | 2015-07-08 | 特温蒂斯公司 | 苯并呋咱抗淀粉样蛋白化合物和方法 |
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CN109485638B (zh) * | 2017-09-12 | 2020-07-17 | 新发药业有限公司 | 一种奥希替尼中间体的制备方法 |
CN109053445A (zh) * | 2018-06-13 | 2018-12-21 | 燕山大学 | 一种酯的交换方法 |
CN110372628B (zh) * | 2019-07-09 | 2021-04-02 | 武汉大学 | 内磺酰胺类化合物及其制备方法 |
CN114591192A (zh) * | 2020-12-04 | 2022-06-07 | 江西仰立新材料有限公司 | 一种n-环丙甲基苯胺类化合物的制备方法 |
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- 2003-12-03 DK DK03767756T patent/DK1567488T3/da active
- 2003-12-03 RU RU2005121146/04A patent/RU2005121146A/ru not_active Application Discontinuation
- 2003-12-03 CN CNA2003801085153A patent/CN1735592A/zh active Pending
- 2003-12-03 WO PCT/EP2003/013806 patent/WO2004050619A1/fr active IP Right Grant
- 2003-12-03 KR KR1020057010104A patent/KR20050084143A/ko not_active Application Discontinuation
- 2003-12-03 DE DE60312031T patent/DE60312031T2/de not_active Expired - Fee Related
- 2003-12-03 AU AU2003292198A patent/AU2003292198B2/en not_active Ceased
- 2003-12-03 CA CA002508325A patent/CA2508325A1/fr not_active Abandoned
- 2003-12-03 PT PT03767756T patent/PT1567488E/pt unknown
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- 2003-12-03 JP JP2004556305A patent/JP2006514634A/ja not_active Withdrawn
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- 2003-12-03 EP EP03767756A patent/EP1567488B1/fr not_active Expired - Lifetime
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AU2003292198A1 (en) | 2004-06-23 |
EP1567488B1 (fr) | 2007-02-21 |
NZ539841A (en) | 2007-11-30 |
RU2005121146A (ru) | 2006-01-20 |
PL377587A1 (pl) | 2006-02-06 |
DE60312031D1 (de) | 2007-04-05 |
KR20050084143A (ko) | 2005-08-26 |
ES2282685T3 (es) | 2007-10-16 |
CN1735592A (zh) | 2006-02-15 |
AU2003292198B2 (en) | 2007-09-06 |
EP1567488A1 (fr) | 2005-08-31 |
JP2006514634A (ja) | 2006-05-11 |
DK1567488T3 (da) | 2007-06-18 |
IS7925A (is) | 2005-06-30 |
HK1083624A1 (en) | 2006-07-07 |
NO20053263D0 (no) | 2005-07-04 |
BR0317020A (pt) | 2005-10-25 |
ZA200503693B (en) | 2008-01-30 |
MXPA05006088A (es) | 2005-08-16 |
ATE354565T1 (de) | 2007-03-15 |
NO20053263L (no) | 2005-08-31 |
GB0228410D0 (en) | 2003-01-08 |
US20060025459A1 (en) | 2006-02-02 |
DE60312031T2 (de) | 2007-11-22 |
PT1567488E (pt) | 2007-05-31 |
US7253198B2 (en) | 2007-08-07 |
CA2508325A1 (fr) | 2004-06-17 |
SI1567488T1 (sl) | 2007-08-31 |
WO2004050619A1 (fr) | 2004-06-17 |
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