LV11177B - Novel pharmaceutical product - Google Patents
Novel pharmaceutical product Download PDFInfo
- Publication number
- LV11177B LV11177B LVP-95-284A LV950284A LV11177B LV 11177 B LV11177 B LV 11177B LV 950284 A LV950284 A LV 950284A LV 11177 B LV11177 B LV 11177B
- Authority
- LV
- Latvia
- Prior art keywords
- benzo
- benzoyl
- piperidinoethoxy
- hydroxy
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (7)
- LV 11177 Izgudrojuma formula 1. 6-Hidroksi-2-(4-hidroksifenil)-3-[4-(2-piperidinoetoksi)-benzoil]benzo[b]tiofēna hidrogenhlorīds nesolvatētu kristālu formā, kas dod pamatā šādu rentgenstaru difrakcijas ainu ar vara katoda starojumu: 13,3864 71,31 9,3598 .33,16 8,4625 2,08 7,3888 7,57 6,9907 5,80 6,6346 51,04 6,1717 29,57 5,9975 5,67 5,9135 9,87 5,6467 38,47 5,4773 10,54 5,2994 4,74 4,8680 4,03 4,7910 5,98 4,6614 57,50 4,5052 5,75 4,3701 9,03 4,2516 69,99 4,2059 57,64 4,1740 65,07 4,0819 12,44 3,9673 22,53 3,9318 100,00 3,8775 9,07 3,7096 33,38 3,6561 21,65 1 l/lo(x100) 3,5576 3,36 3,5037 7,97 3,4522 18,02 3,4138 4,65 3,2738 10,23 3,1857 8,90 3,1333 6,24 3,0831 9,43 3,0025 12,13 2,9437 4,96 2,8642 7,70 2,7904 11,95 2,7246 3,05 2,6652 3,32 2,5882 7,30 d-liniju attālumi (angstrēmos)
- 2. benzoil]benzo[b]tiofēna hidrogenhlorīds nesolvatētu kristālu formā pēc 1. punkta, kurā 6-hidroksi-2-(4-hidroksifenil)-3-[4-(2-piperidinoetoksi)-benzoil]-benzo[b]tiofēna hidrogenhlorīda saturs ir vismaz 95 masas %.
- 3. 6-Hidroksi-2-(4-hidroksifenil)-3-[4-(2-piperidinoetQksL)r benzoil]benzo[b]tiofēna hidrogenhlorīds kristālu formā pēc 1. vai 2. punkta, kas praktiski nesatur hlorbenzolu.
- 4. 6-Hidroksi-2-(4-hidroksifenil)-3-[4-(2-piperidinoetoksi)-benzoil]benzo[b]tiofēna hidrogenhlorīds kristālu formā pēc 1., 2. vai 3. punkta, kas praktiski nesatur alumīnija sālis vai alumīnijorganisko savienojumu piemaisījumus.
- 5. 6-Hidroksi-2-(4-hidroksifenil)-3-[4-(2-piperidinoetQksi)-benzoil]benzo[b]tiofēna hidrogenhlorīds kristālu formā pēc jebkura no iepriekšējiem punktiem, kas praktiski ir bez smaržas.
- 6. Farmaceitiskā kompozīcija, kas satur kristālisko vielu pēc jebkura no iepriekšējiem punktiem un vienu vai vairākus farmaceitiski pieņemamus nesējus, atšķaidītājus vai pildvielas.
- 7. Savienojuma kristāliskā veidā pēc jebkura no 1.-5. punktiem pielietojums par medikamentu. 2
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/308,325 US5629425A (en) | 1994-09-19 | 1994-09-19 | Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene |
US42791495A | 1995-04-26 | 1995-04-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
LV11177A LV11177A (lv) | 1996-04-20 |
LV11177B true LV11177B (en) | 1996-08-20 |
Family
ID=26976194
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-95-285A LV11178B (en) | 1994-09-19 | 1995-09-18 | Synthesis of 3-£4-(2-aminoethoxy) benzoyl|-2-aryl-6-hydroxybenzo £b| thiophenes |
LVP-95-284A LV11177B (en) | 1994-09-19 | 1995-09-18 | Novel pharmaceutical product |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-95-285A LV11178B (en) | 1994-09-19 | 1995-09-18 | Synthesis of 3-£4-(2-aminoethoxy) benzoyl|-2-aryl-6-hydroxybenzo £b| thiophenes |
Country Status (51)
Families Citing this family (72)
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US5478847A (en) | 1994-03-02 | 1995-12-26 | Eli Lilly And Company | Methods of use for inhibiting bone loss and lowering serum cholesterol |
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US6458811B1 (en) * | 1996-03-26 | 2002-10-01 | Eli Lilly And Company | Benzothiophenes formulations containing same and methods |
EP0910369B1 (en) * | 1996-03-26 | 2010-04-21 | Eli Lilly And Company | Benzothiophenes, formulations containing same, and methods |
RU2203060C2 (ru) | 1996-10-30 | 2003-04-27 | Эли Лилли Энд Компани | Способ профилактики рака молочной железы |
CA2236254A1 (en) * | 1997-04-30 | 1998-10-30 | David Warren Hoard | Process for preparing benzo¬b|thiophenes |
ATE301129T1 (de) | 1999-05-04 | 2005-08-15 | Strakan Int Ltd | Androgen glykoside und die androgenische aktivität davon |
WO2002042289A2 (en) * | 2000-11-27 | 2002-05-30 | Eli Lilly And Company | Process for preparing 3-aryl-benzo[b]thiophenes |
EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
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DE102004029784A1 (de) | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
DE102004030502A1 (de) | 2004-06-24 | 2006-01-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel |
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-
1995
- 1995-06-02 CO CO95023869A patent/CO4410190A1/es unknown
- 1995-06-02 CO CO95023870A patent/CO4410191A1/es unknown
- 1995-06-05 TW TW084105613A patent/TW412534B/zh not_active IP Right Cessation
- 1995-06-06 US US08/467,485 patent/US5731327A/en not_active Expired - Lifetime
- 1995-06-06 US US08/469,093 patent/US6399778B1/en not_active Expired - Fee Related
- 1995-06-06 US US08/469,961 patent/US6472531B1/en not_active Expired - Lifetime
- 1995-06-07 PE PE1995270674A patent/PE14796A1/es not_active Application Discontinuation
- 1995-06-07 PE PE1995270673A patent/PE32796A1/es not_active IP Right Cessation
- 1995-09-13 ES ES09501774A patent/ES2109882B1/es not_active Revoked
- 1995-09-13 ES ES009501775A patent/ES2129293B1/es not_active Expired - Fee Related
- 1995-09-14 UA UA95094168A patent/UA44240C2/uk unknown
- 1995-09-14 IL IL11531595A patent/IL115315A/xx not_active IP Right Cessation
- 1995-09-14 IL IL12528395A patent/IL125283A/en not_active IP Right Cessation
- 1995-09-14 IL IL11531495A patent/IL115314A/xx not_active IP Right Cessation
- 1995-09-14 UA UA95094169A patent/UA42716C2/uk unknown
- 1995-09-14 NL NL1001196A patent/NL1001196C2/nl active Search and Examination
- 1995-09-14 NL NL1001194A patent/NL1001194C2/nl active Search and Examination
- 1995-09-15 IT IT95MI001935A patent/IT1277601B1/it active IP Right Grant
- 1995-09-15 CA CA002158400A patent/CA2158400C/en not_active Expired - Lifetime
- 1995-09-15 DK DK199501028A patent/DK175897B1/da not_active IP Right Cessation
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1997
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1998
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2002
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