LU88346I2 - Torasemide (Exhydran) - Google Patents

Torasemide (Exhydran)

Info

Publication number
LU88346I2
LU88346I2 LU88346C LU88346C LU88346I2 LU 88346 I2 LU88346 I2 LU 88346I2 LU 88346 C LU88346 C LU 88346C LU 88346 C LU88346 C LU 88346C LU 88346 I2 LU88346 I2 LU 88346I2
Authority
LU
Luxembourg
Prior art keywords
exhydran
torasemide
Prior art date
Application number
LU88346C
Other languages
English (en)
Original Assignee
Christiaens Sa A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Christiaens Sa A filed Critical Christiaens Sa A
Publication of LU88346I2 publication Critical patent/LU88346I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
LU88346C 1974-04-17 1993-06-30 Torasemide (Exhydran) LU88346I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1683674A GB1477664A (en) 1974-04-17 1974-04-17 Pyridine derivatives
YU1507/81A YU42409B (en) 1974-04-17 1981-06-15 Process for obtaining new pyridine derivatives

Publications (1)

Publication Number Publication Date
LU88346I2 true LU88346I2 (fr) 1994-05-04

Family

ID=26252269

Family Applications (2)

Application Number Title Priority Date Filing Date
LU72284A LU72284A1 (fr) 1974-04-17 1975-04-15
LU88346C LU88346I2 (fr) 1974-04-17 1993-06-30 Torasemide (Exhydran)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LU72284A LU72284A1 (fr) 1974-04-17 1975-04-15

Country Status (19)

Country Link
US (2) US4018929A (fr)
JP (1) JPS5951536B2 (fr)
AR (4) AR211097A1 (fr)
AT (1) AT344170B (fr)
BE (1) BE827844A (fr)
CA (1) CA1070313A (fr)
CH (3) CH612424A5 (fr)
DD (2) DD126887A5 (fr)
DE (1) DE2516025A1 (fr)
ES (4) ES436581A1 (fr)
FR (1) FR2267775B1 (fr)
GB (1) GB1477664A (fr)
HU (1) HU171420B (fr)
IL (1) IL47084A (fr)
LU (2) LU72284A1 (fr)
NL (2) NL183580C (fr)
SE (2) SE424320B (fr)
YU (1) YU42409B (fr)
ZA (1) ZA752243B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593609A (en) * 1978-01-31 1981-07-22 Christiaens Sa A Pyridine sulfonamides
US4776878A (en) * 1978-12-04 1988-10-11 E. I. Du Pont De Nemours And Company Agricultural pyridinesulfonamides
LU85193A1 (fr) * 1984-01-31 1985-09-12 Christiaens Sa A Nouveaux derives de la 4-phenylaminopyridine,leur utilisation et leur preparation
DE3529529A1 (de) * 1985-08-17 1987-02-19 Boehringer Mannheim Gmbh Verfahren zur herstellung einer stabilen modifikation von torasemid
US4853389A (en) * 1987-07-24 1989-08-01 American Home Products Corporation Diuretic and antihypertensive substituted-5-pyrimidinesulfonylureas
US4914203A (en) * 1987-07-24 1990-04-03 American Home Products Corporation 5 step process for preparing certain 2,4-diamino-5-pyrimidine-sulfonyl ureas
FR2659080B1 (fr) * 1990-03-02 1994-07-08 Adir Nouveaux derives de la pyridylsulfonyluree et de la pyridylsulfonylthiouree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5166162A (en) * 1990-03-02 1992-11-24 Adir Et Compagnie Pyridylsulfonylurea and pyridylsulfonylthiourea compounds
US5486530A (en) * 1991-04-27 1996-01-23 Boehringer Mannheim Gmbh Use of torasemide for the treatment of brain oedemas
IT1288123B1 (it) * 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
HRP980532B1 (en) * 1998-10-02 2005-06-30 Pliva Novel crystalline torasemide modification
US6166045A (en) * 1998-06-02 2000-12-26 Roche Diagnostics Gmbh Torasemide of modification III
US8722668B2 (en) * 1998-12-23 2014-05-13 Daryl W. Hochman Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders
US8008283B2 (en) * 1998-12-23 2011-08-30 Neurotherapeutics Pharma, Inc. Methods and compositions for the treatment of neuropsychiatric disorders
US7214711B2 (en) * 1998-12-23 2007-05-08 Neurotherapeutics Pharma Llc Method of treating migraine headache without aura
KR20020025217A (ko) * 1999-08-11 2002-04-03 추후보정 토르세미드 동질이상
HUP0600143A2 (en) * 2000-02-17 2006-10-28 Teva Pharma A stable pharmaceutical formulation comprising torsemide modification ii
HRP20000162B1 (en) 2000-03-20 2004-06-30 Pliva D D Amorphous torasemide modification
PL370039A1 (en) 2000-03-20 2005-05-16 Teva Pharmaceutical Industries Ltd. Novel processes for preparing torsemide intermediate
EP1741429A3 (fr) * 2000-03-20 2007-01-17 Teva Pharmaceutical Industries Ltd. Procédé pour la préparation de torsemide
HRP20000328A2 (en) 2000-05-19 2002-02-28 Pliva Farmaceutska Ind Dionik Novel polymorph v of torasemide
US20030022921A1 (en) * 2001-02-21 2003-01-30 Minutza Leibovici Stable pharmaceutical formulation comprising torsemide modification II
IN192178B (fr) 2001-08-03 2004-03-06 Ranbaxy Lab
IL149771A0 (en) * 2002-05-21 2002-11-10 Fintech Lab Ltd Process for preparation of torsemide
HRP20020603B1 (en) * 2002-07-19 2008-11-30 Pliva D.D. New process for the preparation of modification i n-(1-methylethylaminocarbonyl)-4-(3-methylphenylamino)-3-pyridinesulfonamide
CN1681495B (zh) 2002-08-19 2010-05-12 辉瑞产品公司 用于治疗过度增生性疾病的组合物
CA2401546C (fr) * 2002-09-06 2006-09-19 Brantford Chemicals Inc. Synthese de derives de la 3-sulfonamido-4-phenylaminopyridine
ITMI20022749A1 (it) * 2002-12-23 2004-06-24 Cosma S P A Nuovo procedimento per la sintesi della tosemide, in particolare della forma ii pura e stabile.
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
US20050215600A1 (en) * 2003-10-27 2005-09-29 Arie Gutman Polymorphs of torsemide hydrochloride and process for production thereof
US7378527B2 (en) * 2004-03-16 2008-05-27 Daqing Che Process for the preparation of torsemide and related intermediates
WO2007047447A2 (fr) * 2005-10-17 2007-04-26 Neurotherapeutics Pharma, Inc. Analogues de compose diuretique ou de type diuretique
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7625896B2 (en) * 2005-11-25 2009-12-01 Hoffman-La Roche Inc. Pyridylsulfonamide derivatives
US7939532B2 (en) * 2006-10-26 2011-05-10 Hoffmann-La Roche Inc. Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
JP2010526844A (ja) * 2007-05-16 2010-08-05 エフ．ホフマン−ラ ロシュ アーゲー アリールピリジルスルホンアミド誘導体、それらの製造法及び医薬剤としての使用
NL2006622C2 (en) 2011-04-18 2012-10-22 Eurovet Animal Health B V Use of a composition comprising torasemide.
US9616075B2 (en) 2012-07-20 2017-04-11 University Of Rochester Method of treating and preventing brain impairment using Na+-K+-2Cl-cotransporter isoform 1 inhibitors
WO2014170786A1 (fr) 2013-04-17 2014-10-23 Pfizer Inc. Dérivés de n-pipéridin-3-ylbenzamide dans le traitement des maladies cardiovasculaires
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
CN113582889A (zh) * 2015-02-16 2021-11-02 昆士兰大学 磺酰脲和相关化合物及其用途
PE20212077A1 (es) 2017-07-07 2021-10-28 Inflazome Ltd Nuevos compuestos sulfonamida de carboxamida
CN113574055A (zh) 2019-01-18 2021-10-29 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674794A (en) * 1970-03-18 1972-07-04 Ciba Geigy Corp Certain-3-pyridine-sulfonamide derivatives
GB1368948A (en) * 1970-11-11 1974-10-02 Manuf Prod Pharma Pyridine derivatives
GB1414793A (en) * 1972-07-28 1975-11-19 Manuf Prod Pharma Derivatives of phenylaminopyridine
US3904636A (en) * 1971-11-09 1975-09-09 Christiaens Sa A 3-sulfonamido-4-phenyl aminopyridines and derivatives

Also Published As

Publication number Publication date
SE7504409L (sv) 1975-10-20
DE2516025C2 (fr) 1988-11-03
AU8001675A (en) 1976-10-14
AR208769A1 (es) 1977-02-28
US4018929A (en) 1977-04-19
CH612424A5 (fr) 1979-07-31
ATA288275A (de) 1977-11-15
NL183580B (nl) 1988-07-01
USRE30633E (en) 1981-06-02
JPS50142571A (fr) 1975-11-17
IL47084A (en) 1979-01-31
NL940014I1 (nl) 1994-09-16
SE7907618L (sv) 1979-09-13
AR208768A1 (es) 1977-02-28
AR208770A1 (es) 1977-02-28
IL47084A0 (en) 1975-06-25
ES453328A1 (es) 1977-11-01
DD126887A5 (fr) 1977-08-17
GB1477664A (en) 1977-06-22
JPS5951536B2 (ja) 1984-12-14
ZA752243B (en) 1976-03-31
DD121936A5 (fr) 1976-09-05
CH609045A5 (fr) 1979-02-15
ES453327A1 (es) 1977-11-16
SE424320B (sv) 1982-07-12
CA1070313A (fr) 1980-01-22
NL940014I2 (nl) 1997-04-01
AT344170B (de) 1978-07-10
FR2267775B1 (fr) 1978-11-10
YU42409B (en) 1988-08-31
CH610890A5 (fr) 1979-05-15
NL7504521A (nl) 1975-10-21
ES436581A1 (es) 1977-04-01
NL183580C (nl) 1988-12-01
YU150781A (en) 1984-02-29
ES453329A1 (es) 1977-11-16
BE827844A (fr) 1975-10-13
AR211097A1 (es) 1977-10-31
LU72284A1 (fr) 1975-08-20
FR2267775A1 (fr) 1975-11-14
HU171420B (hu) 1978-01-28
DE2516025A1 (de) 1975-11-06

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