IT1288123B1 - Uso di nitroderivati per l'incontinenza urinaria - Google Patents

Uso di nitroderivati per l'incontinenza urinaria

Info

Publication number
IT1288123B1
IT1288123B1 IT96MI001821A ITMI961821A IT1288123B1 IT 1288123 B1 IT1288123 B1 IT 1288123B1 IT 96MI001821 A IT96MI001821 A IT 96MI001821A IT MI961821 A ITMI961821 A IT MI961821A IT 1288123 B1 IT1288123 B1 IT 1288123B1
Authority
IT
Italy
Prior art keywords
phenyl
chloro
alkyl
amino
methyl
Prior art date
Application number
IT96MI001821A
Other languages
English (en)
Inventor
Soldato Piero Del
Francesco Sannicolo'
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT96MI001821A priority Critical patent/IT1288123B1/it
Application filed by Nicox Sa filed Critical Nicox Sa
Priority to DE69738846T priority patent/DE69738846D1/de
Priority to DE69730036T priority patent/DE69730036T2/de
Priority to BR9712008A priority patent/BR9712008A/pt
Priority to PCT/EP1997/004774 priority patent/WO1998009948A2/en
Priority to CA002264081A priority patent/CA2264081A1/en
Priority to CNA200710102648XA priority patent/CN101050193A/zh
Priority to AT04102724T priority patent/ATE401302T1/de
Priority to ES04101544T priority patent/ES2318239T3/es
Priority to ES04102724T priority patent/ES2309451T3/es
Priority to KR10-2004-7013501A priority patent/KR100513324B1/ko
Priority to AU43010/97A priority patent/AU729533B2/en
Priority to CA002592537A priority patent/CA2592537A1/en
Priority to KR1019997001853A priority patent/KR100546037B1/ko
Priority to CNA2007101026475A priority patent/CN101049296A/zh
Priority to AT04101544T priority patent/ATE415956T1/de
Priority to EP04101544A priority patent/EP1437132B1/en
Priority to CN97199130A priority patent/CN1234792A/zh
Priority to CA002591612A priority patent/CA2591612A1/en
Priority to AT97919021T priority patent/ATE271858T1/de
Priority to RU2003117406/04A priority patent/RU2269510C2/ru
Priority to RU99106676/04A priority patent/RU2210563C9/ru
Priority to ES97919021T priority patent/ES2224237T3/es
Priority to EP04102724A priority patent/EP1473288B1/en
Priority to JP10512226A priority patent/JP2000517332A/ja
Priority to DE69739149T priority patent/DE69739149D1/de
Priority to EP97919021A priority patent/EP0931065B1/en
Publication of ITMI961821A1 publication Critical patent/ITMI961821A1/it
Publication of IT1288123B1 publication Critical patent/IT1288123B1/it
Application granted granted Critical
Priority to US10/686,907 priority patent/US20040082652A1/en
Priority to US11/018,501 priority patent/US7544711B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
    • C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT96MI001821A 1996-09-04 1996-09-04 Uso di nitroderivati per l'incontinenza urinaria IT1288123B1 (it)

Priority Applications (29)

Application Number Priority Date Filing Date Title
IT96MI001821A IT1288123B1 (it) 1996-09-04 1996-09-04 Uso di nitroderivati per l'incontinenza urinaria
CN97199130A CN1234792A (zh) 1996-09-04 1997-09-02 硝酸酯衍生物和它们在治疗尿失禁和其它疾病中的用途
AT04101544T ATE415956T1 (de) 1996-09-04 1997-09-02 Verwendung von salpetersäureester-derivaten zur herstellung eines arzneimittels für die behandlung von gastrointestinalen tumoren
PCT/EP1997/004774 WO1998009948A2 (en) 1996-09-04 1997-09-02 Nitric ester derivatives and their use in urinary incontinence and other diseases
CA002264081A CA2264081A1 (en) 1996-09-04 1997-09-02 Nitric ester derivatives and their use in urinary incontinence and other diseases
CNA200710102648XA CN101050193A (zh) 1996-09-04 1997-09-02 硝酸酯衍生物、其药物组合物和它们的药用用途
AT04102724T ATE401302T1 (de) 1996-09-04 1997-09-02 Salpetersäureester-derivaten von cox-2 hemmern und deren verwendung zur behandlung von inflammation und kardiovaskulären krankheiten
ES04101544T ES2318239T3 (es) 1996-09-04 1997-09-02 Uso de derivados de ester nitrico en la fabricacion de un medicamento para el tratamiento de tumores gastrointestinales.
ES04102724T ES2309451T3 (es) 1996-09-04 1997-09-02 Derivados de esteres nitricos de inhibidores de cox2 su utilizacion para el tratamiento de la inflamacion y enfermedades cardiovasculares.
KR10-2004-7013501A KR100513324B1 (ko) 1996-09-04 1997-09-02 요실금 및 다른 질환에 사용되는 질산에스테르 유도체들및 그들의 용도
AU43010/97A AU729533B2 (en) 1996-09-04 1997-09-02 Nitric ester derivatives and their use in urinary incontinence and other diseases
CA002592537A CA2592537A1 (en) 1996-09-04 1997-09-02 Nitric ester derivatives in the treatment of inflammatory diseases
KR1019997001853A KR100546037B1 (ko) 1996-09-04 1997-09-02 요실금 및 다른 질환에 사용되는 질산에스테르 유도체들 및 그들의 용도
CNA2007101026475A CN101049296A (zh) 1996-09-04 1997-09-02 硝酸酯衍生物和它们在治疗尿失禁和其它疾病中的用途
DE69738846T DE69738846D1 (de) 1996-09-04 1997-09-02 Salpetersäureester-Derivaten von COX-2 Hemmern und deren Verwendung zur Behandlung von Inflammation und kardiovaskulären Krankheiten
BR9712008A BR9712008A (pt) 1996-09-04 1997-09-02 Uso de derivados do -ster n¡trico ou suas composi-{es e derivados do -ster n¡trico ou suas composi-{es
EP04102724A EP1473288B1 (en) 1996-09-04 1997-09-02 Nitric ester derivatives of COX-2 inhibitors and their use for treating inflammation and cardiovascular diseases
CA002591612A CA2591612A1 (en) 1996-09-04 1997-09-02 Nitric ester derivatives and their use in urinary incontinence and other diseases
AT97919021T ATE271858T1 (de) 1996-09-04 1997-09-02 Verwendung von salpetersäureester-derivaten zur behandlung von harninkontinenz
RU2003117406/04A RU2269510C2 (ru) 1996-09-04 1997-09-02 Средство для лечения желудочно-кишечных опухолей
RU99106676/04A RU2210563C9 (ru) 1996-09-04 1997-09-02 Производные нитроэфиров и композиции на их основе для использования при контролировании недержания мочи
ES97919021T ES2224237T3 (es) 1996-09-04 1997-09-02 Utilizacion de derivados de esteres nitricos para el tratamientodela incontinencia urinaria.
DE69730036T DE69730036T2 (de) 1996-09-04 1997-09-02 Verwendung von SALPETERSÄUREESTER-DERIVATEn zur BEHANDLUNG VON HARNINKONTINENZ
JP10512226A JP2000517332A (ja) 1996-09-04 1997-09-02 硝酸エステル誘導体ならびに尿失禁およびその他の疾患におけるそれらの使用
DE69739149T DE69739149D1 (de) 1996-09-04 1997-09-02 Verwendung von Salpetersäureester-Derivaten zur Herstellung eines Arzneimittels für die Behandlung von gastrointestinalen Tumoren
EP97919021A EP0931065B1 (en) 1996-09-04 1997-09-02 use of NITRIC ESTER DERIVATIVES IN the treatment of URINARY INCONTINENCE
EP04101544A EP1437132B1 (en) 1996-09-04 1997-09-02 Use of nitric ester derivatives in the manufacture of a medicament for the treatment of gastrointestinal tumors
US10/686,907 US20040082652A1 (en) 1996-09-04 2003-10-17 Nitric ester derivatives and their use in treating gastrointestinal tumors
US11/018,501 US7544711B2 (en) 1996-09-04 2004-12-22 Use of nitroderivatives in urinary incontinence

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI001821A IT1288123B1 (it) 1996-09-04 1996-09-04 Uso di nitroderivati per l'incontinenza urinaria

Publications (2)

Publication Number Publication Date
ITMI961821A1 ITMI961821A1 (it) 1998-03-04
IT1288123B1 true IT1288123B1 (it) 1998-09-10

Family

ID=11374842

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96MI001821A IT1288123B1 (it) 1996-09-04 1996-09-04 Uso di nitroderivati per l'incontinenza urinaria

Country Status (14)

Country Link
US (1) US7544711B2 (it)
EP (3) EP1473288B1 (it)
JP (1) JP2000517332A (it)
KR (2) KR100546037B1 (it)
CN (3) CN101049296A (it)
AT (3) ATE415956T1 (it)
AU (1) AU729533B2 (it)
BR (1) BR9712008A (it)
CA (1) CA2264081A1 (it)
DE (3) DE69738846D1 (it)
ES (3) ES2224237T3 (it)
IT (1) IT1288123B1 (it)
RU (2) RU2269510C2 (it)
WO (1) WO1998009948A2 (it)

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IT1288123B1 (it) 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
EP1126838A4 (en) 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
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IT1311923B1 (it) 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
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WO2001045703A1 (en) 1999-12-23 2001-06-28 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
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CA2432642A1 (en) 2000-12-21 2002-08-08 Subhash P. Khanapure Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20010733A1 (it) 2001-04-05 2002-10-05 Recordati Chem Pharm Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
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JP2003088335A (ja) * 2001-09-14 2003-03-25 Pharmafoods Kenkyusho:Kk 排尿機能改善用食品組成物及びそれを含有する飲食品
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WO2004002409A2 (en) * 2002-06-27 2004-01-08 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
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FR2842108B1 (fr) * 2002-07-09 2008-05-02 Effik Composes a base d'hormone et de monoxyde d'azote et leur utilisation en obstetrique et en gynecologie
CA2493156A1 (en) 2002-07-29 2004-02-05 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
AU2004270162B2 (en) 2003-08-28 2010-05-13 Nicox S.A. Nitrosated ad nitrosylated diuretic compouds, compositions and methods of use
EP1711457A4 (en) 2004-01-27 2008-01-09 Merck Frosst Company NITROGEN MONOXIDE RELEASING PRODRUGS OF DIARYL-2- (5H) FURANOES AS INHIBITORS OF CYCLOOXYGENASE-2
WO2005070883A1 (en) 2004-01-27 2005-08-04 Merck Frosst Company Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
US7521435B2 (en) * 2005-02-18 2009-04-21 Pharma Diagnostics, N.V. Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
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WO2008050732A1 (fr) * 2006-10-23 2008-05-02 Takeda Pharmaceutical Company Limited Dérivé de l'iminopyridine et son utilisation
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JO3350B1 (ar) 2011-03-07 2019-03-13 Merck Sharp & Dohme مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
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CN1234792A (zh) 1999-11-10
EP1473288A1 (en) 2004-11-03
KR20040084948A (ko) 2004-10-06
ITMI961821A1 (it) 1998-03-04
EP1437132A1 (en) 2004-07-14
US20050101661A1 (en) 2005-05-12
ATE271858T1 (de) 2004-08-15
WO1998009948A2 (en) 1998-03-12
AU729533B2 (en) 2001-02-01
EP0931065A2 (en) 1999-07-28
RU2269510C2 (ru) 2006-02-10
CA2264081A1 (en) 1998-03-12
ATE401302T1 (de) 2008-08-15
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EP1437132B1 (en) 2008-12-03
BR9712008A (pt) 1999-08-24
EP0931065B1 (en) 2004-07-28
KR100513324B1 (ko) 2005-09-07
RU2003117406A (ru) 2004-12-27
AU4301097A (en) 1998-03-26
DE69730036T2 (de) 2004-12-30
DE69730036D1 (de) 2004-09-02
DE69738846D1 (de) 2008-08-28
ATE415956T1 (de) 2008-12-15
EP1473288B1 (en) 2008-07-16
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US7544711B2 (en) 2009-06-09
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