LTC1284974I2 - Triazoliltropano dariniai kaip CCR5 moduliatoriai - Google Patents
Triazoliltropano dariniai kaip CCR5 moduliatoriaiInfo
- Publication number
- LTC1284974I2 LTC1284974I2 LTPA2008004C LTPA2008004C LTC1284974I2 LT C1284974 I2 LTC1284974 I2 LT C1284974I2 LT PA2008004 C LTPA2008004 C LT PA2008004C LT PA2008004 C LTPA2008004 C LT PA2008004C LT C1284974 I2 LTC1284974 I2 LT C1284974I2
- Authority
- LT
- Lithuania
- Prior art keywords
- triazolyltropane
- derivatives
- ccr5 modulators
- ccr5
- modulators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0014046A GB0014046D0 (en) | 2000-05-26 | 2000-05-26 | Compounds useful in therapy |
GB0015835A GB0015835D0 (en) | 2000-06-27 | 2000-06-27 | Compounds useful in therapy |
PCT/IB2001/000806 WO2001090106A2 (en) | 2000-05-26 | 2001-05-09 | Tryasolyl tropane derivatives as ccr5 modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
LTPA2008004I1 LTPA2008004I1 (lt) | 2020-07-27 |
LTC1284974I2 true LTC1284974I2 (lt) | 2020-11-10 |
Family
ID=26244452
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTPA2008004C LTC1284974I2 (lt) | 2000-05-26 | 2008-02-25 | Triazoliltropano dariniai kaip CCR5 moduliatoriai |
Country Status (51)
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1526134T3 (da) * | 2000-05-26 | 2008-11-17 | Pfizer | Triazolyltropanderivater som CCR5-modulatorer |
EP1401821A4 (en) * | 2001-06-12 | 2006-05-31 | Sk Corp | NEW PHENYL ALKYL DIAMINE ANDAMIDANALOGA |
SE0200919D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Chemical compounds |
GB0208071D0 (en) * | 2002-04-08 | 2002-05-22 | Pfizer Ltd | Tropane derivatives useful in therapy |
GEP20074210B (en) * | 2002-04-08 | 2007-10-10 | Pfizer | Tropane derivatives as ccr5 modulators |
US6855724B2 (en) | 2002-04-08 | 2005-02-15 | Agouron Pharmaceuticals, Inc. | Tropane derivatives useful in therapy |
BR0309982A (pt) * | 2002-05-23 | 2005-03-22 | Pfizer | Método para identificação de um ligando, pelo qual o tempo de residência no receptor é medido |
JP2006514646A (ja) * | 2002-12-13 | 2006-05-11 | スミスクライン ビーチャム コーポレーション | Ccr5アンタゴニストとしてのシクロヘキシル化合物類 |
DE10336274A1 (de) * | 2003-08-07 | 2005-03-10 | Honeywell Specialty Chemicals | Verfahren zur Herstellung von geminalen Difluoralkanen |
AR045536A1 (es) | 2003-08-29 | 2005-11-02 | Ranbaxy Lab Ltd | Inhibidores de la fosfodiesterasa tipo -iv |
CA2579609A1 (en) | 2003-09-10 | 2005-03-17 | Virochem Pharma Inc. | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity |
JP4874107B2 (ja) * | 2003-10-03 | 2012-02-15 | ファイザー・インク | Hiv及び炎症の治療のためのccr5受容体拮抗活性を有するイミダゾピリジン置換トロパン誘導体 |
TW200610761A (en) * | 2004-04-23 | 2006-04-01 | Astrazeneca Ab | Chemical compounds |
RU2006146608A (ru) | 2004-06-09 | 2008-07-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | ОКТАГИДРОПИРРОЛО[3,4-с]-ПРОИЗВОДНЫЕ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПРОТИВОВИРУСНЫХ АГЕНТОВ |
US20060122220A1 (en) * | 2004-11-19 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and UK-427,857 |
WO2006064340A2 (en) * | 2004-12-13 | 2006-06-22 | Pfizer Limited | Process for the preparation of n-acyl beta-aminoaldehydes |
US7665658B2 (en) | 2005-06-07 | 2010-02-23 | First Data Corporation | Dynamic aggregation of payment transactions |
ES2438019T3 (es) | 2005-07-22 | 2014-01-15 | Cytodyn, Inc. | Procedimientos para reducir la carga viral en pacientes infectados por el VIH-1 |
WO2007045573A1 (en) | 2005-10-19 | 2007-04-26 | F. Hoffmann-La Roche Ag | Phenyl-acetamide nnrt inhibitors |
PL2057125T3 (pl) | 2006-08-16 | 2011-09-30 | Hoffmann La Roche | Nienukleozydowe inhibitory odwrotnej transkryptazy |
WO2008063600A2 (en) * | 2006-11-17 | 2008-05-29 | Concert Pharmaceuticals Inc. | Triazolyl tropane derivatives |
JP5415957B2 (ja) | 2006-12-13 | 2014-02-12 | エフ.ホフマン−ラ ロシュ アーゲー | 非ヌクレオシド逆転写酵素阻害剤としての2−(ピペリジン−4−イル)−4−フェノキシ−又はフェニルアミノ−ピリミジン誘導体 |
CA2673566A1 (en) * | 2006-12-19 | 2008-06-26 | Auspex Pharmaceuticals, Inc. | Preparation and utility of ccr5 inhibitors |
EP1958947A1 (en) | 2007-02-15 | 2008-08-20 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type 4 |
WO2008132128A2 (en) * | 2007-04-27 | 2008-11-06 | Solvay (Société Anonyme) | Synthesis of a pharmaceutically active compound |
AU2009220462A1 (en) * | 2008-02-29 | 2009-09-11 | Merck Sharp & Dohme Corp. | CCR5 antagonists as prophylactics for preventing HIV infection and methods of inhibiting transmission of same |
CN101712679B (zh) * | 2008-10-08 | 2013-04-10 | 中国科学院上海药物研究所 | 一种酰胺类化合物、其药物组合物及其制备方法和用途 |
WO2011011652A1 (en) * | 2009-07-24 | 2011-01-27 | Glaxosmithkline Llc | Therapeutic compounds |
CN102140104B (zh) * | 2010-02-03 | 2014-11-12 | 中国科学院上海药物研究所 | 1-(3-(s)-氨基丙基)-哌啶-4-氨基酰胺类化合物、其药物组合物及其制备方法和用途 |
US20130023496A1 (en) | 2010-04-02 | 2013-01-24 | Randy Tressler | Combination Therapy Comprising A CCR5 Antagonist, A HIV-1 Protease Inhibtior and a Pharmacokinetic Enhancer |
CN106977511B (zh) * | 2011-12-19 | 2019-04-12 | 中国科学院上海药物研究所 | 一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途 |
WO2014068265A1 (en) | 2012-10-29 | 2014-05-08 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
CZ306455B6 (cs) | 2013-04-26 | 2017-02-01 | Zentiva, K.S. | Nový způsob syntézy Maravirocu |
CN103497164B (zh) * | 2013-09-23 | 2015-12-23 | 西安近代化学研究所 | 一种蒽衍生物及其制备方法 |
CN104304248B (zh) * | 2014-10-23 | 2016-08-10 | 西北农林科技大学 | 3-芳基丙酸酯类化合物作为制备杀螨药物的应用 |
CN104402883B (zh) * | 2014-10-24 | 2016-04-27 | 艾琪康医药科技(上海)有限公司 | 4,4-二氟金刚烷甲酰胺衍生物、药物组合物及其制备方法和用途 |
CN104387379B (zh) * | 2014-11-26 | 2017-01-11 | 扬州氟药科技有限公司 | 一种二氟亚甲基哌啶甲酰胺衍生物及其制备方法和用途 |
CN104860946A (zh) * | 2015-05-14 | 2015-08-26 | 湖北生物医药产业技术研究院有限公司 | Ccr5拮抗剂的制备方法 |
CN107879963A (zh) * | 2016-09-29 | 2018-04-06 | 中国科学院上海药物研究所 | 新型手性配体、金属螯合物、多种非天然氨基酸、马拉维诺及其关键中间体的合成方法 |
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US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5648511A (en) * | 1990-11-19 | 1997-07-15 | G.D. Searle & Co. | Method for making intermediates useful in the synthesis of retroviral protease inhibitors |
FR2676444B1 (fr) * | 1991-05-16 | 1995-03-10 | Sanofi Elf | Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant. |
GB9310713D0 (en) * | 1993-05-24 | 1993-07-07 | Zeneca Ltd | Aryl substituted heterocycles |
ATE222587T1 (de) * | 1994-04-19 | 2002-09-15 | Neurosearch As | TROPAN-2-ALDOXIMDERIVATE ALS NEUROTRANSMITTER ßREUPTAKEß INHIBITOREN |
GB9523526D0 (en) * | 1995-11-17 | 1996-01-17 | Zeneca Ltd | Therapeutic compounds |
DE19546462A1 (de) * | 1995-12-13 | 1997-06-19 | Bayer Ag | Diarylacetylenketone |
WO1997024325A1 (en) * | 1995-12-28 | 1997-07-10 | Takeda Chemical Industries, Ltd. | DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS |
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GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
WO1999004794A1 (en) * | 1997-07-25 | 1999-02-04 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
IL125658A0 (en) * | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
AR013669A1 (es) * | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
WO1999037619A1 (en) * | 1998-01-21 | 1999-07-29 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
EP1013276A1 (en) | 1998-12-23 | 2000-06-28 | Pfizer Inc. | Aminoazacycloalkanes as CCR5 modulators |
PE20001420A1 (es) * | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
US7217714B1 (en) * | 1998-12-23 | 2007-05-15 | Agouron Pharmaceuticals, Inc. | CCR5 modulators |
DK1526134T3 (da) * | 2000-05-26 | 2008-11-17 | Pfizer | Triazolyltropanderivater som CCR5-modulatorer |
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2001
- 2001-05-09 DK DK04004193T patent/DK1526134T3/da active
- 2001-05-09 PL PL359267A patent/PL200551B1/pl unknown
- 2001-05-09 RS YUP82202 patent/RS50904B/sr unknown
- 2001-05-09 ES ES01925808T patent/ES2215129T3/es not_active Expired - Lifetime
- 2001-05-09 OA OA1200200343A patent/OA12264A/en unknown
- 2001-05-09 EP EP20010925808 patent/EP1284974B1/en not_active Expired - Lifetime
- 2001-05-09 CA CA 2408909 patent/CA2408909C/en not_active Expired - Lifetime
- 2001-05-09 JP JP2001586293A patent/JP3693957B2/ja not_active Expired - Lifetime
- 2001-05-09 PT PT01925808T patent/PT1284974E/pt unknown
- 2001-05-09 EP EP20040004193 patent/EP1526134B1/en not_active Expired - Lifetime
- 2001-05-09 EA EA200201141A patent/EA005382B1/ru not_active IP Right Cessation
- 2001-05-09 SK SK1643-2002A patent/SK286129B6/sk active Protection Beyond IP Right Term
- 2001-05-09 SI SI200130862T patent/SI1526134T1/sl unknown
- 2001-05-09 RS RSP-2009/0438A patent/RS51436B/en unknown
- 2001-05-09 KR KR1020057003492A patent/KR100548854B1/ko active IP Right Grant
- 2001-05-09 IL IL15253101A patent/IL152531A0/xx unknown
- 2001-05-09 ES ES04004193T patent/ES2311126T3/es not_active Expired - Lifetime
- 2001-05-09 HU HU0302474A patent/HU225810B1/hu active Protection Beyond IP Right Term
- 2001-05-09 EP EP20080163025 patent/EP1990341B1/en not_active Expired - Lifetime
- 2001-05-09 DZ DZ013464A patent/DZ3464A1/fr active
- 2001-05-09 ES ES08163025T patent/ES2401812T3/es not_active Expired - Lifetime
- 2001-05-09 NZ NZ521477A patent/NZ521477A/en not_active IP Right Cessation
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