LT4540B - Nauja r- -propilpiperonilamino ir jo analogų asimetrinė sintezė - Google Patents

Nauja r- -propilpiperonilamino ir jo analogų asimetrinė sintezė Download PDF

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Publication number
LT4540B
LT4540B LT98-132A LT98132A LT4540B LT 4540 B LT4540 B LT 4540B LT 98132 A LT98132 A LT 98132A LT 4540 B LT4540 B LT 4540B
Authority
LT
Lithuania
Prior art keywords
compound
acid
formula
alcohol
hours
Prior art date
Application number
LT98-132A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT98132A (en
Inventor
Hui-Yin Li
Luigi Anzalone
Robert Eugene Waltermire
Original Assignee
Du Pont Pharmaceuticals Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharmaceuticals Company filed Critical Du Pont Pharmaceuticals Company
Publication of LT98132A publication Critical patent/LT98132A/xx
Publication of LT4540B publication Critical patent/LT4540B/lt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LT98-132A 1996-03-22 1998-09-18 Nauja r- -propilpiperonilamino ir jo analogų asimetrinė sintezė LT4540B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1395596P 1996-03-22 1996-03-22

Publications (2)

Publication Number Publication Date
LT98132A LT98132A (en) 1999-03-25
LT4540B true LT4540B (lt) 1999-08-25

Family

ID=21762727

Family Applications (1)

Application Number Title Priority Date Filing Date
LT98-132A LT4540B (lt) 1996-03-22 1998-09-18 Nauja r- -propilpiperonilamino ir jo analogų asimetrinė sintezė

Country Status (23)

Country Link
US (1) US5932749A (no)
EP (1) EP0888329A1 (no)
JP (1) JP2000506891A (no)
KR (1) KR20000064735A (no)
CN (1) CN1218463A (no)
AR (1) AR006521A1 (no)
AU (1) AU719633B2 (no)
BR (1) BR9708233A (no)
CA (1) CA2249401A1 (no)
CZ (1) CZ295098A3 (no)
EA (1) EA001207B1 (no)
EE (1) EE9800299A (no)
HR (1) HRP970165A2 (no)
IL (1) IL126223A0 (no)
LT (1) LT4540B (no)
LV (1) LV12259B (no)
NO (1) NO984344D0 (no)
NZ (1) NZ331875A (no)
PL (1) PL329070A1 (no)
SI (1) SI9720023A (no)
SK (1) SK127398A3 (no)
WO (1) WO1997034887A1 (no)
ZA (1) ZA972342B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012474A1 (en) 1998-08-31 2000-03-09 Du Pont Pharmaceuticals Company An efficient process for the preparation of a human leukocyte elastase inhibitor
PL372705A1 (en) * 2001-09-12 2005-07-25 Anormed Inc. Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
EA022785B8 (ru) * 2008-12-15 2016-06-30 Тайджен Байотекнолоджи Ко., Лтд. Стереоселективный синтез производных пиперидина
AR090100A1 (es) 2012-02-21 2014-10-22 Celgene Corp Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina
US9126906B2 (en) 2012-02-21 2015-09-08 Celgene Corporation Asymmetric synthetic processes for the preparation of aminosulfone compounds
US10953003B2 (en) 2015-12-14 2021-03-23 X4 Pharmaceuticals, Inc. Methods for treating cancer
CA3008279A1 (en) 2015-12-14 2017-06-22 X4 Pharmaceuticals, Inc. Methods for treating cancer
SI3393468T1 (sl) 2015-12-22 2023-01-31 X4 Pharmaceuticals, Inc. Postopki za zdravljenje bolezni imunske pomanjkljivosti
US11337969B2 (en) 2016-04-08 2022-05-24 X4 Pharmaceuticals, Inc. Methods for treating cancer
EP3808748A1 (en) 2016-06-21 2021-04-21 X4 Pharmaceuticals, Inc. Substituted piperidines as cxcr4-inhibitors
US11332470B2 (en) 2016-06-21 2022-05-17 X4 Pharmaceuticals, Inc. CXCR4 inhibitors and uses thereof
JP7084624B2 (ja) 2016-06-21 2022-06-15 エックス４ ファーマシューティカルズ， インコーポレイテッド Ｃｘｃｒ４阻害剤およびその使用
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
WO2023034510A1 (en) 2021-09-01 2023-03-09 ATAI Life Sciences AG Synthesis of mdma or its optically active ( r)- or ( s)-mdma isomers
EP4401725A1 (en) * 2021-09-17 2024-07-24 atai Life Sciences AG Preparation of optically active enantiomers of piperonyl amines by resolution of the diastereomeric salts
US11845736B2 (en) 2021-10-01 2023-12-19 Empathbio, Inc. Prodrugs of MDMA, MDA, and derivatives thereof
US11912680B2 (en) 2021-12-28 2024-02-27 Empathbio, Inc. Nitric oxide releasing prodrugs of MDA and MDMA

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0481671A1 (en) 1990-10-15 1992-04-22 Merck & Co. Inc. New substituted azetidinones as anti-inflammatory and antidegenerative agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3819438A1 (de) * 1987-06-30 1989-01-19 Basf Ag Verfahren zur herstellung von optisch aktiven 1-arylethylaminen
US5149838A (en) * 1991-09-20 1992-09-22 Merck & Co., Inc. Intermediates for substituted azetidinones useful as anti-inflammatory and antidegenerative agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0481671A1 (en) 1990-10-15 1992-04-22 Merck & Co. Inc. New substituted azetidinones as anti-inflammatory and antidegenerative agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ELEVELD M B, HOGEVEEN H, SCHUDDE E P.: "Diastereoselective synthesis of chiral secondary amines with two chiral centers directly attached to the nitrogen atom", J ORG CHEM., 1986, pages 3635, XP002005655, DOI: doi:10.1021/jo00369a016
GERHARD BRINGMANN ET AL.: "Chiral building blocks for the synthesis of nitrogen-containing natural products, 5. The enantioselective synthesis of optically active, benzene nucleus-substituted 1-phenylethylamines from the corresponding acetophenones", LIEBIGS ANNALEN DER CHEMIE, 1990, pages 795
MING JUNG WU, LENDON N. PRIDGEN: "Synthesis of chiral .alpha.-alkyl phenethylamines via organometallic addition to chiral 2-aryl-1,3-oxazolidines", J. ORG. CHEM., 1991, pages 1340
YUTAKA UKAJI ET AL.: "Diastereofacial Discrimination in the Reaction of Chiral Alkoxymethyl Oxime Ethers with Allyl Metallic Reagents", CHEMISTRY LETTERS, 1991, pages 173

Also Published As

Publication number Publication date
KR20000064735A (ko) 2000-11-06
EE9800299A (et) 1999-06-15
HRP970165A2 (en) 1998-04-30
BR9708233A (pt) 2000-01-04
CN1218463A (zh) 1999-06-02
EA001207B1 (ru) 2000-12-25
NO984344L (no) 1998-09-18
ZA972342B (en) 1998-09-18
AU719633B2 (en) 2000-05-11
CA2249401A1 (en) 1997-09-25
LT98132A (en) 1999-03-25
PL329070A1 (en) 1999-03-15
AR006521A1 (es) 1999-09-08
SI9720023A (sl) 1999-04-30
US5932749A (en) 1999-08-03
JP2000506891A (ja) 2000-06-06
WO1997034887A1 (en) 1997-09-25
CZ295098A3 (cs) 1999-03-17
EA199800844A1 (ru) 1999-02-25
EP0888329A1 (en) 1999-01-07
NZ331875A (en) 2000-01-28
NO984344D0 (no) 1998-09-18
AU2196897A (en) 1997-10-10
SK127398A3 (en) 1999-04-13
IL126223A0 (en) 1999-05-09
LV12259A (lv) 1999-04-20
LV12259B (en) 1999-09-20

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Effective date: 20010317