LT4035B - Novel bicyclic amino-substituted compounds, process for their preparation and pharmaceutical preparation - Google Patents
Novel bicyclic amino-substituted compounds, process for their preparation and pharmaceutical preparation Download PDFInfo
- Publication number
- LT4035B LT4035B LTIP1733A LTIP1733A LT4035B LT 4035 B LT4035 B LT 4035B LT IP1733 A LTIP1733 A LT IP1733A LT IP1733 A LTIP1733 A LT IP1733A LT 4035 B LT4035 B LT 4035B
- Authority
- LT
- Lithuania
- Prior art keywords
- enantiomer
- alkyl
- treatment
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8904127A SE8904127D0 (sv) | 1989-12-07 | 1989-12-07 | New biocyclic amino-substituted compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
LTIP1733A LTIP1733A (en) | 1995-08-25 |
LT4035B true LT4035B (en) | 1996-09-25 |
Family
ID=20377709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTIP1733A LT4035B (en) | 1989-12-07 | 1993-12-30 | Novel bicyclic amino-substituted compounds, process for their preparation and pharmaceutical preparation |
Country Status (18)
Country | Link |
---|---|
US (1) | US5376687A (no) |
EP (1) | EP0457883B1 (no) |
JP (1) | JPH04503819A (no) |
KR (1) | KR920701122A (no) |
AT (1) | ATE137490T1 (no) |
AU (1) | AU639742B2 (no) |
CA (1) | CA2046292A1 (no) |
DE (1) | DE69026816T2 (no) |
DK (1) | DK0457883T3 (no) |
ES (1) | ES2086528T3 (no) |
FI (1) | FI913713A0 (no) |
GR (1) | GR3020122T3 (no) |
LT (1) | LT4035B (no) |
LV (1) | LV10607B (no) |
NO (1) | NO176018C (no) |
RU (1) | RU2086537C1 (no) |
SE (1) | SE8904127D0 (no) |
WO (1) | WO1991009006A1 (no) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2691149B1 (fr) * | 1992-05-18 | 1994-07-08 | Adir | Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
IT1278045B1 (it) * | 1995-03-09 | 1997-11-17 | Sigma Tau Ind Farmaceuti | Uso di 2-amminotetraline-6,7-sostituite per la preparazione di composizioni farmaceutiche atte al trattamento dello shock, e di |
US5646188A (en) * | 1995-07-05 | 1997-07-08 | Teva Pharmaceutical Industries, Ltd. | Polyamine derivatives of 1-aminoindan |
US5807897A (en) * | 1996-03-01 | 1998-09-15 | Zeneca Limited | Aminotetralin derivative and compositions and method of use thereof |
US6498196B1 (en) | 1998-12-22 | 2002-12-24 | Edward Roberts | Compounds useful in pain management |
AU3092800A (en) * | 1998-12-22 | 2000-07-12 | Astra Pharma Inc. | Novel thio-aminotetralin compounds useful in pain management |
US6844368B1 (en) | 1998-12-22 | 2005-01-18 | Edward Roberts | Compounds useful in pain management |
US20050032873A1 (en) * | 2003-07-30 | 2005-02-10 | Wyeth | 3-Amino chroman and 2-amino tetralin derivatives |
WO2007088450A2 (en) * | 2006-02-01 | 2007-08-09 | Pfizer Products Inc. | Chromane antagonist of the h-3 receptor |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0222996A2 (de) | 1985-09-03 | 1987-05-27 | Ciba-Geigy Ag | 3-Amino-dihydro-[1]-benzopyrane und Benzothiopyrane |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2803582A1 (de) * | 1978-01-27 | 1979-08-02 | Sandoz Ag | Neue tetralinderivate, ihre herstellung und verwendung |
SE8004002L (sv) * | 1980-05-29 | 1981-11-30 | Arvidsson Folke Lars Erik | Terapeutiskt anvendbara tetralinderivat |
CA1331191C (en) * | 1988-03-25 | 1994-08-02 | Bengt Ronny Andersson | Therapeutically useful tetralin derivatives |
CA1335591C (en) * | 1988-05-23 | 1995-05-16 | James Arthur Nixon | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes |
CA2026775C (en) * | 1989-01-09 | 1998-04-07 | Per Arvid Emil Carlsson | Halo substituted aminotetralins |
US5225596A (en) * | 1989-01-09 | 1993-07-06 | The Upjohn Company | Halo substituted aminotetralins |
ES2123500T3 (es) * | 1989-05-31 | 1999-01-16 | Upjohn Co | Derivados de 8-heterociclil-2-aminotetralina activos sobre el sistema nervioso central. |
-
1989
- 1989-12-07 SE SE8904127A patent/SE8904127D0/xx unknown
-
1990
- 1990-12-05 EP EP91900976A patent/EP0457883B1/en not_active Expired - Lifetime
- 1990-12-05 ES ES91900976T patent/ES2086528T3/es not_active Expired - Lifetime
- 1990-12-05 AT AT91900976T patent/ATE137490T1/de not_active IP Right Cessation
- 1990-12-05 KR KR1019910700844A patent/KR920701122A/ko not_active Application Discontinuation
- 1990-12-05 JP JP3501388A patent/JPH04503819A/ja active Pending
- 1990-12-05 WO PCT/SE1990/000806 patent/WO1991009006A1/en active IP Right Grant
- 1990-12-05 CA CA002046292A patent/CA2046292A1/en not_active Abandoned
- 1990-12-05 RU SU905001681A patent/RU2086537C1/ru active
- 1990-12-05 US US07/741,438 patent/US5376687A/en not_active Expired - Fee Related
- 1990-12-05 DE DE69026816T patent/DE69026816T2/de not_active Expired - Fee Related
- 1990-12-05 AU AU69587/91A patent/AU639742B2/en not_active Ceased
- 1990-12-05 DK DK91900976.1T patent/DK0457883T3/da active
-
1991
- 1991-08-02 NO NO913023A patent/NO176018C/no unknown
- 1991-08-05 FI FI913713A patent/FI913713A0/fi not_active Application Discontinuation
-
1993
- 1993-07-30 LV LVP-93-1008A patent/LV10607B/en unknown
- 1993-12-30 LT LTIP1733A patent/LT4035B/lt not_active IP Right Cessation
-
1996
- 1996-05-31 GR GR960401501T patent/GR3020122T3/el unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0222996A2 (de) | 1985-09-03 | 1987-05-27 | Ciba-Geigy Ag | 3-Amino-dihydro-[1]-benzopyrane und Benzothiopyrane |
Also Published As
Publication number | Publication date |
---|---|
NO176018B (no) | 1994-10-10 |
LTIP1733A (en) | 1995-08-25 |
CA2046292A1 (en) | 1991-06-08 |
SE8904127D0 (sv) | 1989-12-07 |
KR920701122A (ko) | 1992-08-11 |
EP0457883B1 (en) | 1996-05-01 |
WO1991009006A1 (en) | 1991-06-27 |
LV10607B (en) | 1995-12-20 |
LV10607A (lv) | 1995-04-20 |
EP0457883A1 (en) | 1991-11-27 |
FI913713A0 (fi) | 1991-08-05 |
DE69026816D1 (de) | 1996-06-05 |
GR3020122T3 (en) | 1996-08-31 |
AU6958791A (en) | 1991-07-18 |
JPH04503819A (ja) | 1992-07-09 |
DK0457883T3 (da) | 1996-08-26 |
NO913023L (no) | 1991-08-02 |
DE69026816T2 (de) | 1996-10-02 |
ATE137490T1 (de) | 1996-05-15 |
RU2086537C1 (ru) | 1997-08-10 |
NO176018C (no) | 1995-01-18 |
AU639742B2 (en) | 1993-08-05 |
NO913023D0 (no) | 1991-08-02 |
US5376687A (en) | 1994-12-27 |
ES2086528T3 (es) | 1996-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM9A | Lapsed patents |
Effective date: 19971230 |