LT3892628T - Itin ilgai veikiantys insulino-fc sulieti baltymai ir naudojimo būdai - Google Patents

Itin ilgai veikiantys insulino-fc sulieti baltymai ir naudojimo būdai

Info

Publication number
LT3892628T
LT3892628T LTEP21164434.9T LT21164434T LT3892628T LT 3892628 T LT3892628 T LT 3892628T LT 21164434 T LT21164434 T LT 21164434T LT 3892628 T LT3892628 T LT 3892628T
Authority
LT
Lithuania
Prior art keywords
ultra
methods
fusion proteins
long acting
acting insulin
Prior art date
Application number
LTEP21164434.9T
Other languages
English (en)
Inventor
Thomas LANCASTER
Todd Zion
Original Assignee
Akston Biosciences Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akston Biosciences Corporation filed Critical Akston Biosciences Corporation
Publication of LT3892628T publication Critical patent/LT3892628T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
LTEP21164434.9T 2018-06-29 2019-06-28 Itin ilgai veikiantys insulino-fc sulieti baltymai ir naudojimo būdai LT3892628T (lt)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201862692498P 2018-06-29 2018-06-29
US201862692507P 2018-06-29 2018-06-29
US201862693814P 2018-07-03 2018-07-03
US201862696645P 2018-07-11 2018-07-11
US201862698648P 2018-07-16 2018-07-16
US201862702167P 2018-07-23 2018-07-23
US201862719347P 2018-08-17 2018-08-17
US201862740735P 2018-10-03 2018-10-03
US201862743358P 2018-10-09 2018-10-09
US201862774682P 2018-12-03 2018-12-03
US201862781378P 2018-12-18 2018-12-18
US201862781368P 2018-12-18 2018-12-18
US201962824176P 2019-03-26 2019-03-26
US201962827809P 2019-04-01 2019-04-01
US201962837188P 2019-04-22 2019-04-22

Publications (1)

Publication Number Publication Date
LT3892628T true LT3892628T (lt) 2022-12-12

Family

ID=68985236

Family Applications (4)

Application Number Title Priority Date Filing Date
LTEP22203969.5T LT4186920T (lt) 2018-06-29 2019-06-28 Itin ilgai veikiantys insulino-fc sulieti baltymai ir naudojimo būdai
LTEP21164434.9T LT3892628T (lt) 2018-06-29 2019-06-28 Itin ilgai veikiantys insulino-fc sulieti baltymai ir naudojimo būdai
LTEPPCT/US2019/040010T LT3655006T (lt) 2018-06-29 2019-06-28 Itin ilgai veikiantys insulino-fc sulieti baltymai ir naudojimo būdai
LTEP21207279.7T LT4011908T (lt) 2018-06-29 2019-06-28 Itin ilgai veikiantys insulino-fc sulieti baltymai ir naudojimo būdai

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTEP22203969.5T LT4186920T (lt) 2018-06-29 2019-06-28 Itin ilgai veikiantys insulino-fc sulieti baltymai ir naudojimo būdai

Family Applications After (2)

Application Number Title Priority Date Filing Date
LTEPPCT/US2019/040010T LT3655006T (lt) 2018-06-29 2019-06-28 Itin ilgai veikiantys insulino-fc sulieti baltymai ir naudojimo būdai
LTEP21207279.7T LT4011908T (lt) 2018-06-29 2019-06-28 Itin ilgai veikiantys insulino-fc sulieti baltymai ir naudojimo būdai

Country Status (15)

Country Link
US (8) US10851147B2 (lt)
EP (5) EP4344738A3 (lt)
JP (1) JP7417277B2 (lt)
KR (1) KR20210029210A (lt)
CN (1) CN113038964A (lt)
AU (1) AU2019291945A1 (lt)
BR (1) BR112020026777A2 (lt)
CA (1) CA3104144A1 (lt)
DK (4) DK3892628T3 (lt)
FI (2) FI4011908T3 (lt)
HR (4) HRP20221418T1 (lt)
HU (3) HUE062719T2 (lt)
LT (4) LT4186920T (lt)
SI (4) SI4011908T1 (lt)
WO (1) WO2020006529A1 (lt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3551209T1 (sl) 2016-12-09 2021-10-29 Akston Biosciences Corp Inzulin-FC fuzije in postopki uporabe
HRP20221418T1 (hr) 2018-06-29 2023-01-06 Akston Biosciences Corporation Inzulin-fc fuzijski proteini ultra-dugog djelovanja i postupci uporabe
US11267862B2 (en) 2018-06-29 2022-03-08 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
WO2021011827A1 (en) * 2019-07-16 2021-01-21 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
HRP20231433T1 (hr) 2019-12-19 2024-03-29 Akston Biosciences Corporation Inzulin-fc fuzijski proteini ultradugog djelovanja i načini uporabe
US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
CA3146464C (en) 2020-04-10 2024-03-12 Todd C. Zion Antigen specific immunotherapy employing covid-19 fusion proteins and methods of use
US11192930B2 (en) 2020-04-10 2021-12-07 Askton Bioscences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
US11198719B2 (en) 2020-04-29 2021-12-14 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
US20230272030A1 (en) * 2020-07-24 2023-08-31 Jiangsu Gensciences Inc. Insulin-fc fusion protein and application thereof
JP2023554358A (ja) * 2020-12-14 2023-12-27 イーライ リリー アンド カンパニー 糖尿病を治療する方法
WO2023004406A2 (en) 2021-07-23 2023-01-26 Akston Biosciences Corporation Insulin-fc fusion proteins and methods of use to treat cancer
WO2023064711A2 (en) * 2021-10-14 2023-04-20 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
AR127619A1 (es) 2021-11-15 2024-02-14 Lilly Co Eli FORMULACIONES CONSERVADAS DE FUSIONES DE INSULINA-Fc
WO2023174370A1 (zh) * 2022-03-16 2023-09-21 北京拓界生物医药科技有限公司 人胰岛素类似物、其融合蛋白及医药用途
WO2023247640A1 (en) * 2022-06-23 2023-12-28 Sanofi Single chain insulins and fc conjugates thereof

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040601A1 (en) 2001-06-08 2003-02-27 Ivan Diers Method for making insulin precursors and insulin analog precursors
US7169894B2 (en) * 2001-11-14 2007-01-30 Mirari Biosciences, Inc. Methods and compositions for reverse translation
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US20100143479A1 (en) 2008-12-04 2010-06-10 Oakwood Laboratories, Llc Method of making sustained release microparticles
US8569231B2 (en) 2009-03-20 2013-10-29 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
EP2413969A4 (en) * 2009-03-30 2012-09-05 Boehringer Ingelheim Int FUSION PROTEINS WITH DOG FC ELEMENTS
CN101891823B (zh) 2010-06-11 2012-10-03 北京东方百泰生物科技有限公司 一种Exendin-4及其类似物融合蛋白
WO2012015692A2 (en) * 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
CA2805739A1 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
AR087433A1 (es) 2011-08-08 2014-03-26 Merck Sharp & Dohme Analogos de insulina n-glicosilados
EP2780463A4 (en) 2011-11-18 2015-07-01 Merck Sharp & Dohme FC-CONTAINING POLYPEPTIDES WITH INCREASED INFLAMMATORY FEATURES AND INCREASED FCRN BINDING
KR102041412B1 (ko) 2011-12-30 2019-11-11 한미사이언스 주식회사 면역글로불린 Ｆｃ 단편 유도체
CN103509118B (zh) * 2012-06-15 2016-03-23 郭怀祖 胰岛素-Fc融合蛋白
AU2013302569B2 (en) * 2012-08-17 2017-09-28 Dresser-Rand Company System and method for detecting stall or surge in radial compressors
WO2014093387A1 (en) * 2012-12-10 2014-06-19 Kindred Biosciences, Inc. Vegf receptor fusion proteins for veterinary use
ES2868351T3 (es) 2013-02-26 2021-10-21 Hanmi Pharm Ind Co Ltd Conjugados de análogos de insulina y usos de los mismos
US10287336B2 (en) 2014-09-18 2019-05-14 AskGene Pharma, Inc. Feline erythropoietin receptor agonists
JP6829928B2 (ja) 2014-10-06 2021-02-17 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎ Ｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 二相性単鎖インスリン類似体
JP2017537065A (ja) 2014-10-20 2017-12-14 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎ Ｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 生物学的作用強度の高いハロゲン化インスリン類似体
WO2016105545A2 (en) 2014-12-24 2016-06-30 Case Western Reserve University Insulin analogues with enhanced stabilized and reduced mitogenicity
WO2016118631A1 (en) 2015-01-20 2016-07-28 Case Western Reserve University Insulin analogues with selective signaling properties and reduced mitogenicity
EP3250589A4 (en) 2015-01-29 2018-06-20 Nexvet Australia Pty Ltd Therapeutic and diagnostic agents
EP3260139A4 (en) 2015-02-17 2018-09-05 Hanmi Pharm. Co., Ltd. Long-acting insulin or insulin analogue complex
AU2016257000B2 (en) * 2015-05-04 2020-05-14 Apogenix Ag Single-chain CD40-receptor agonist proteins
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
US11208452B2 (en) 2015-06-02 2021-12-28 Novo Nordisk A/S Insulins with polar recombinant extensions
CN114835795A (zh) 2015-11-16 2022-08-02 Ubi蛋白公司 用于延长蛋白质半衰期的方法
WO2018014091A1 (en) 2016-07-22 2018-01-25 University Of Utah Research Foundation Insulin analogs
CN109071623B (zh) * 2016-05-04 2022-05-27 美国安进公司 用于扩增t调节性细胞的白细胞介素-2突变蛋白
WO2018009921A1 (en) * 2016-07-08 2018-01-11 AskGene Pharma, Inc. Fusion protein comprising leptin and methods for producing and using the same
EP3517544A4 (en) 2016-09-23 2020-06-03 Hanmi Pharm. Co., Ltd. INSULIN ANALOG HAVING REDUCED INSULIN RECEPTOR BINDING FORCE AND USE THEREOF
WO2018073185A1 (en) * 2016-10-17 2018-04-26 Vetoquinol Sa Modified antibody constant region
SI3551209T1 (sl) 2016-12-09 2021-10-29 Akston Biosciences Corp Inzulin-FC fuzije in postopki uporabe
UY37629A (es) 2017-03-07 2018-10-31 Univ Case Western Reserve Análogos de insulina de cadena simple estabilizados por un cuarto puente disulfuro
US10572594B2 (en) 2017-08-01 2020-02-25 Intuit Inc. Extracting domain-specific actions and entities in natural language commands recognized based on edition and recognition scores
JP2020531002A (ja) 2017-08-15 2020-11-05 キンドレッド バイオサイエンシズ インコーポレイテッド 獣医学用ｉｇｇ ｆｃ変異体
EP3781147A4 (en) 2018-04-16 2022-04-20 University of Utah Research Foundation GLUCOSE-SENSITIVE INSULIN
US11267862B2 (en) 2018-06-29 2022-03-08 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
HRP20221418T1 (hr) 2018-06-29 2023-01-06 Akston Biosciences Corporation Inzulin-fc fuzijski proteini ultra-dugog djelovanja i postupci uporabe
CA3114395A1 (en) 2018-09-25 2020-04-02 Absci, Llc Protein purification methods
MA53809A (fr) 2018-10-05 2022-01-12 Novo Nordisk As Composés bifonctionnels comprenant des peptides d'insuline et des peptides d'egf(a)
WO2020106748A1 (en) 2018-11-19 2020-05-28 Case Western Reserve University Single-chain insulin analogues with poly-alanine c-domain sub-segments
US20220235111A1 (en) 2019-05-17 2022-07-28 Case Western Reserve University Variant Single-Chain Insulin Analogues
WO2021011827A1 (en) 2019-07-16 2021-01-21 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
EP4004028A1 (en) 2019-07-31 2022-06-01 Eli Lilly and Company Relaxin analogs and methods of using the same
HRP20231433T1 (hr) 2019-12-19 2024-03-29 Akston Biosciences Corporation Inzulin-fc fuzijski proteini ultradugog djelovanja i načini uporabe
US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
US11192930B2 (en) 2020-04-10 2021-12-07 Askton Bioscences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
US11198719B2 (en) 2020-04-29 2021-12-14 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use

Also Published As

Publication number Publication date
AU2019291945A1 (en) 2021-01-14
CA3104144A1 (en) 2020-01-02
US10961294B2 (en) 2021-03-30
HUE058005T2 (hu) 2022-06-28
US20220009990A1 (en) 2022-01-13
BR112020026777A2 (pt) 2021-03-30
US11773151B2 (en) 2023-10-03
US11673934B2 (en) 2023-06-13
HUE062719T2 (hu) 2023-11-28
DK4011908T3 (da) 2023-08-07
HRP20220091T1 (hr) 2022-04-15
SI3655006T1 (sl) 2022-04-29
LT3655006T (lt) 2022-03-10
EP3655006A4 (en) 2021-01-13
US20200231646A1 (en) 2020-07-23
EP4011908A1 (en) 2022-06-15
DK3892628T3 (da) 2022-11-14
US20200157169A1 (en) 2020-05-21
SI4186920T1 (sl) 2024-05-31
US20240101635A1 (en) 2024-03-28
KR20210029210A (ko) 2021-03-15
DK4186920T3 (da) 2024-03-25
EP4344738A2 (en) 2024-04-03
SI4011908T1 (sl) 2023-10-30
JP2021530210A (ja) 2021-11-11
JP7417277B2 (ja) 2024-01-18
HUE060471T2 (hu) 2023-03-28
US20200157170A1 (en) 2020-05-21
EP4011908B1 (en) 2023-06-07
LT4011908T (lt) 2023-09-11
US11261229B2 (en) 2022-03-01
SI3892628T1 (sl) 2023-01-31
HRP20240408T1 (hr) 2024-06-07
US10851147B2 (en) 2020-12-01
JP2024045117A (ja) 2024-04-02
EP4344738A3 (en) 2024-05-22
EP4186920A1 (en) 2023-05-31
HRP20230991T1 (hr) 2023-12-08
HRP20221418T1 (hr) 2023-01-06
FI4186920T3 (fi) 2024-03-20
EP3892628B1 (en) 2022-09-07
EP4186920B1 (en) 2024-01-03
EP3655006A1 (en) 2020-05-27
US20220017590A1 (en) 2022-01-20
EP3892628A1 (en) 2021-10-13
WO2020006529A1 (en) 2020-01-02
LT4186920T (lt) 2024-04-25
CN113038964A (zh) 2021-06-25
DK3655006T3 (da) 2022-02-21
US10947292B2 (en) 2021-03-16
US20200407413A1 (en) 2020-12-31
EP3655006B1 (en) 2021-11-17
FI4011908T3 (fi) 2023-08-04
US20200157171A1 (en) 2020-05-21
US10870686B2 (en) 2020-12-22

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