LT3658B - Method for preparing aromatase inhibiting 4(5)-imidazole derivatives - Google Patents

Method for preparing aromatase inhibiting 4(5)-imidazole derivatives Download PDF

Info

Publication number
LT3658B
LT3658B LTIP916A LTIP916A LT3658B LT 3658 B LT3658 B LT 3658B LT IP916 A LTIP916 A LT IP916A LT IP916 A LTIP916 A LT IP916A LT 3658 B LT3658 B LT 3658B
Authority
LT
Lithuania
Prior art keywords
formula
compound
imidazole
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
LTIP916A
Other languages
English (en)
Lithuanian (lt)
Inventor
Arto Johannes Karjalainen
Lauri Veikko Matti Kangas
Kauko Oiva Antero Kurkela
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Publication of LTIP916A publication Critical patent/LTIP916A/xx
Publication of LT3658B publication Critical patent/LT3658B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
LTIP916A 1987-10-09 1993-08-31 Method for preparing aromatase inhibiting 4(5)-imidazole derivatives LT3658B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8723715A GB2210875B (en) 1987-10-09 1987-10-09 Aromatase inhibiting 4(5)-imidazoles

Publications (2)

Publication Number Publication Date
LTIP916A LTIP916A (en) 1995-03-27
LT3658B true LT3658B (en) 1996-01-25

Family

ID=10625036

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP916A LT3658B (en) 1987-10-09 1993-08-31 Method for preparing aromatase inhibiting 4(5)-imidazole derivatives

Country Status (24)

Country Link
US (1) US5098923A (ko)
EP (1) EP0311447B1 (ko)
JP (1) JPH01132568A (ko)
KR (1) KR890006593A (ko)
CN (1) CN1036993C (ko)
AU (1) AU615482B2 (ko)
CA (1) CA1329616C (ko)
DD (1) DD282912A5 (ko)
DE (1) DE3874073T2 (ko)
DK (1) DK550988A (ko)
ES (1) ES2043839T3 (ko)
FI (1) FI93105C (ko)
GB (1) GB2210875B (ko)
GR (1) GR3006343T3 (ko)
HU (1) HU201024B (ko)
IE (1) IE61180B1 (ko)
IL (1) IL87969A (ko)
LT (1) LT3658B (ko)
NO (1) NO172048C (ko)
NZ (1) NZ226483A (ko)
PT (1) PT88717B (ko)
RU (2) RU1819263C (ko)
UA (1) UA13218A (ko)
ZA (1) ZA887545B (ko)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2210875B (en) 1987-10-09 1991-05-29 Farmos Oy Aromatase inhibiting 4(5)-imidazoles
GB8818561D0 (en) * 1988-08-04 1988-09-07 Ici Plc Diphenylethane derivatives
US5439928A (en) * 1989-03-30 1995-08-08 Orion-Yhtyma Oy Aromatase inhibiting 4(5)-imidazoles
GB2248058B (en) * 1990-09-21 1994-09-14 Orion Yhtymae Oy Aromatase inhibiting 4(5)-imidazoles
GB2229719B (en) * 1989-03-30 1992-04-29 Farmos Oy Novel aromatase inhibiting 4(5)-imidazoles
AU627559B2 (en) * 1989-03-30 1992-08-27 Farmos-Yhtyma Oy Novel aromatase inhibiting 4(5)-imidazoles
GB9125924D0 (en) * 1991-06-18 1992-02-05 Orion Yhtymae Oy Stereoisomers of an imidazole derivative
ZA962879B (en) * 1995-04-12 1997-03-17 Procter & Gamble A pharmaceutical composition for inhibiting the growth of viruses and cancers
US6262093B1 (en) 1995-04-12 2001-07-17 The Proctor & Gamble Company Methods of treating cancer with benzimidazoles
US6479526B1 (en) 1995-04-12 2002-11-12 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
US6265427B1 (en) 1995-06-07 2001-07-24 The Proctor & Gamble Company Pharmaceutical composition for the method of treating leukemia
WO1997026246A1 (en) * 1996-01-16 1997-07-24 Warner-Lambert Company Substituted histidine inhibitors of protein farnesyltransferase
US5900429A (en) * 1997-01-28 1999-05-04 The Procter & Gamble Company Method for inhibiting the growth of cancers
US6506783B1 (en) 1997-05-16 2003-01-14 The Procter & Gamble Company Cancer treatments and pharmaceutical compositions therefor
US6245789B1 (en) 1998-05-19 2001-06-12 The Procter & Gamble Company HIV and viral treatment
US6423734B1 (en) 1999-08-13 2002-07-23 The Procter & Gamble Company Method of preventing cancer
US6462062B1 (en) 2000-09-26 2002-10-08 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6407105B1 (en) 2000-09-26 2002-06-18 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6608096B1 (en) 2000-09-26 2003-08-19 University Of Arizona Foundation Compounds and methods for use thereof in the treatment of cancer or viral infections
US6380232B1 (en) 2000-09-26 2002-04-30 The Procter & Gamble Company Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof
US6515074B2 (en) * 2001-01-22 2003-02-04 Delphi Technologies, Inc. Thermoplastic polymer alloy compositions and process for manufacture thereof
WO2003082787A1 (en) * 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
ES2298508T3 (es) 2002-03-26 2008-05-16 Boehringer Ingelheim Pharmaceuticals Inc. Mimeticos de glucocorticoides, metodos para prepararlos, composiciones farmaceuticas y sus usos.
US7074806B2 (en) 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
WO2004063163A1 (en) 2003-01-03 2004-07-29 Boehringer Ingelheim Pharmaceuticals, Inc. 1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
US7741361B2 (en) 2004-12-27 2010-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
AU2007329548A1 (en) 2006-12-06 2008-06-12 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
EP2095819A1 (en) * 2008-02-28 2009-09-02 Maastricht University N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors
DK2300472T3 (da) 2008-06-06 2012-04-10 Boehringer Ingelheim Int Glucocorticoidmimetika, fremgangsmåder til disses fremstilling, farmaceutiske sammensætninger samt anvendelser deraf

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0311447A1 (en) 1987-10-09 1989-04-12 Orion-Yhtymà„ Oy Aromatase inhibiting 4(5)-imidazoles
EP0390558A1 (en) 1989-03-30 1990-10-03 Orion-Yhtymà„ Oy Aromatase inhibiting 4(5)-imidazoles

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2069481B (en) * 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
GB2092569B (en) * 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB2096987B (en) * 1981-04-22 1984-04-04 Farmos Oy Substituted imidazole and imidazole derivatives and their preparation and use
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
LU85747A1 (fr) * 1985-01-28 1986-08-04 Continental Pharma Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0311447A1 (en) 1987-10-09 1989-04-12 Orion-Yhtymà„ Oy Aromatase inhibiting 4(5)-imidazoles
EP0390558A1 (en) 1989-03-30 1990-10-03 Orion-Yhtymà„ Oy Aromatase inhibiting 4(5)-imidazoles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A. LIPTON ET AL.: "Aromatase activity in primary and metastatic human breast cancer", CANCER, 1987, pages 779 - 782
M. PASANEN: "Human placental aromatase activity: use of a C18 reversed-phase cartridge for separation of tritiated water or steroid metabolites in placentas from both smoking and non-smoking mothers in vitro", BIOLOGICAL RESEARCH IN PREGNANCY AND PERINATOLOGY, 1985, pages 94 - 99

Also Published As

Publication number Publication date
EP0311447A1 (en) 1989-04-12
UA13218A (uk) 1997-02-28
CA1329616C (en) 1994-05-17
IE61180B1 (en) 1994-10-05
IL87969A0 (en) 1989-03-31
HUT49582A (en) 1989-10-30
ES2043839T3 (es) 1994-01-01
DD282912A5 (de) 1990-09-26
NO172048B (no) 1993-02-22
LTIP916A (en) 1995-03-27
AU615482B2 (en) 1991-10-03
CN1033995A (zh) 1989-07-19
NO884473D0 (no) 1988-10-07
DE3874073D1 (de) 1992-10-01
DK550988D0 (da) 1988-10-03
NZ226483A (en) 1991-02-26
FI93105B (fi) 1994-11-15
GB2210875B (en) 1991-05-29
EP0311447B1 (en) 1992-08-26
AU2349088A (en) 1989-04-13
HU201024B (en) 1990-09-28
PT88717B (pt) 1992-12-31
IL87969A (en) 1993-04-04
JPH01132568A (ja) 1989-05-25
DE3874073T2 (de) 1993-01-21
FI884497A (fi) 1989-04-10
NO172048C (no) 1993-06-02
GB2210875A (en) 1989-06-21
FI884497A0 (fi) 1988-09-30
GR3006343T3 (ko) 1993-06-21
US5098923A (en) 1992-03-24
ZA887545B (en) 1989-06-28
RU1819263C (ru) 1993-05-30
GB8723715D0 (en) 1987-11-11
DK550988A (da) 1989-04-10
CN1036993C (zh) 1998-01-14
IE883055L (en) 1989-04-09
RU2045519C1 (ru) 1995-10-10
FI93105C (fi) 1995-02-27
KR890006593A (ko) 1989-06-14
NO884473L (no) 1989-04-10

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Effective date: 19970831