LT3348140T - Histidinu pakeisti lengvosios grandinės antikūnai ir genetiškai modifikuoti graužikai, išvesti jų gamybai - Google Patents
Histidinu pakeisti lengvosios grandinės antikūnai ir genetiškai modifikuoti graužikai, išvesti jų gamybaiInfo
- Publication number
- LT3348140T LT3348140T LTEP18158960.7T LT18158960T LT3348140T LT 3348140 T LT3348140 T LT 3348140T LT 18158960 T LT18158960 T LT 18158960T LT 3348140 T LT3348140 T LT 3348140T
- Authority
- LT
- Lithuania
- Prior art keywords
- generating
- light chain
- same
- genetically modified
- chain antibodies
- Prior art date
Links
- 241000283984 Rodentia Species 0.000 title 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261611950P | 2012-03-16 | 2012-03-16 | |
US201261736930P | 2012-12-13 | 2012-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
LT3348140T true LT3348140T (lt) | 2021-01-25 |
Family
ID=48045078
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP15151655.6T LT2883449T (lt) | 2012-03-16 | 2013-03-15 | Histidinu modifikuoti lengvosios grandinės antikūnai ir juos gaminantys genetiškai modifikuoti graužikai |
LTEP18158960.7T LT3348140T (lt) | 2012-03-16 | 2013-03-15 | Histidinu pakeisti lengvosios grandinės antikūnai ir genetiškai modifikuoti graužikai, išvesti jų gamybai |
LTEP13713652.9T LT2825036T (lt) | 2012-03-16 | 2013-03-15 | Histidino pakeitimus lengvoje grandinėje turintys antikūnai ir genetiškai modifikuoti graužikai, išvesti ju gamybai |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP15151655.6T LT2883449T (lt) | 2012-03-16 | 2013-03-15 | Histidinu modifikuoti lengvosios grandinės antikūnai ir juos gaminantys genetiškai modifikuoti graužikai |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP13713652.9T LT2825036T (lt) | 2012-03-16 | 2013-03-15 | Histidino pakeitimus lengvoje grandinėje turintys antikūnai ir genetiškai modifikuoti graužikai, išvesti ju gamybai |
Country Status (26)
Country | Link |
---|---|
US (3) | US9334334B2 (lt) |
EP (4) | EP3348140B1 (lt) |
JP (5) | JP6185978B2 (lt) |
KR (1) | KR102228296B1 (lt) |
CN (3) | CN104302169B (lt) |
AU (3) | AU2013204579B2 (lt) |
BR (1) | BR112014022850A2 (lt) |
CA (1) | CA2865643A1 (lt) |
CY (2) | CY1120599T1 (lt) |
DK (2) | DK2825036T3 (lt) |
ES (3) | ES2665793T3 (lt) |
HK (2) | HK1200273A1 (lt) |
HR (2) | HRP20180682T1 (lt) |
HU (3) | HUE053310T2 (lt) |
IL (5) | IL234355B (lt) |
LT (3) | LT2883449T (lt) |
MX (1) | MX355732B (lt) |
MY (1) | MY172730A (lt) |
NZ (1) | NZ629639A (lt) |
PL (2) | PL2883449T3 (lt) |
PT (3) | PT2825036T (lt) |
RS (2) | RS57118B1 (lt) |
RU (2) | RU2017135754A (lt) |
SG (2) | SG10201607689PA (lt) |
SI (3) | SI2883449T1 (lt) |
WO (1) | WO2013138680A1 (lt) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2006381B1 (en) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Method for controlling blood pharmacokinetics of antibodies |
PL2202245T3 (pl) | 2007-09-26 | 2017-02-28 | Chugai Seiyaku Kabushiki Kaisha | Sposób modyfikowania punktu izoelektrycznego przeciwciała poprzez podstawienie aminokwasu w cdr |
ES2563483T3 (es) | 2008-04-11 | 2016-03-15 | Chugai Seiyaku Kabushiki Kaisha | Molécula de unión a antígeno capaz de unirse repetidamente a dos o más moléculas de antígeno |
US20140234340A1 (en) | 2010-11-30 | 2014-08-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
SG10201609665PA (en) | 2011-02-25 | 2017-01-27 | Chugai Pharmaceutical Co Ltd | FcɣRIIb-SPECIFIC Fc ANTIBODY |
JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
HUE057680T2 (hu) | 2011-10-17 | 2022-06-28 | Regeneron Pharma | Korlátozott immunglobulin-nehézlánccal rendelkezõ egerek |
CA3233142A1 (en) | 2011-11-30 | 2013-06-06 | Chugai Seiyaku Kabushiki Kaisha | Drug containing carrier into cell for forming immune complex |
KR102459666B1 (ko) | 2012-03-16 | 2022-10-27 | 리제너론 파마슈티칼스 인코포레이티드 | pH-민감성 면역글로불린 서열을 발현하는 비-사람 동물 |
US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
PL3597037T3 (pl) | 2012-06-12 | 2021-10-25 | Regeneron Pharmaceuticals, Inc. | Humanizowane zwierzęta inne niż ludzie z ograniczonymi loci łańcucha ciężkiego immunoglobuliny |
CA2882272C (en) | 2012-08-24 | 2023-08-29 | Chugai Seiyaku Kabushiki Kaisha | Fc.gamma.riib-specific fc region variant |
WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
US10766960B2 (en) | 2012-12-27 | 2020-09-08 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
MY178882A (en) | 2013-02-20 | 2020-10-21 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
EP2982689B1 (en) | 2013-04-02 | 2020-08-26 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
MY172430A (en) | 2013-04-29 | 2019-11-25 | Hoffmann La Roche | Human fcrn-binding modified antibodies and methods of use |
RU2698969C2 (ru) | 2014-01-15 | 2019-09-02 | Ф.Хоффманн-Ля Рош Аг | Варианты fc-области с улучшенной способностью связываться с белком а |
TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
EP3160996B1 (en) * | 2014-06-30 | 2022-06-08 | Merck Patent GmbH | Anti-tnfa antibodies with ph-dependent antigen binding |
KR20230044338A (ko) * | 2014-12-19 | 2023-04-03 | 추가이 세이야쿠 가부시키가이샤 | 항-c5 항체 및 그의 사용 방법 |
SG11201700841QA (en) | 2014-12-19 | 2017-03-30 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
US20180016327A1 (en) * | 2015-01-22 | 2018-01-18 | Chugai Seiyaku Kabushiki Kaisha | A Combination of Two or More Anti-C5 Antibodies and Methods of Use |
CN107108729A (zh) | 2015-02-05 | 2017-08-29 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il‑8‑结合抗体,及其应用 |
CN107438622A (zh) | 2015-03-19 | 2017-12-05 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
CN115925961A (zh) * | 2015-05-28 | 2023-04-07 | 生物辐射实验室股份有限公司 | 亲和配体及其相关方法 |
BR112018009067A8 (pt) * | 2015-12-18 | 2019-02-26 | Chugai Pharmaceutical Co Ltd | anticorpos anti-c5 e métodos de uso |
KR102501335B1 (ko) * | 2015-12-18 | 2023-02-17 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
KR102628909B1 (ko) | 2016-05-20 | 2024-01-25 | 리제너론 파마슈티칼스 인코포레이티드 | 다중 가이드 RNAs를 이용한 면역학적 내성 파괴 방법 |
PT3462853T (pt) | 2016-06-03 | 2023-04-21 | Regeneron Pharma | Animais não humanos que expressam desoxinucleotidiltransferase terminal exógena |
CA3026050A1 (en) | 2016-08-05 | 2018-02-08 | Chugai Seiyaku Kabushiki Kaisha | Composition for prophylaxis or treatment of il-8 related diseases |
GB201707484D0 (en) * | 2017-05-10 | 2017-06-21 | Argenx Bvba | Method of preparing ph-dependent antibodies |
WO2019175131A1 (en) * | 2018-03-14 | 2019-09-19 | F. Hoffmann-La Roche Ag | Method for affinity maturation of antibodies |
CN112040769B (zh) * | 2018-03-24 | 2023-05-16 | 瑞泽恩制药公司 | 用于产生针对肽-mhc复合物的治疗抗体的经过基因修饰的非人动物、制造方法和用途 |
SG11202008620VA (en) | 2018-03-26 | 2020-10-29 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
CN112312766A (zh) | 2018-06-14 | 2021-02-02 | 瑞泽恩制药公司 | 在免疫球蛋白重链编码序列中具有dh-dh重排能力的非人动物 |
JP6935383B2 (ja) * | 2018-09-27 | 2021-09-15 | 公益財団法人実験動物中央研究所 | 免疫不全マウス |
JP6780155B1 (ja) | 2019-04-04 | 2020-11-04 | 日精エー・エス・ビー機械株式会社 | 樹脂製容器の製造方法、射出コア型、射出成形用金型および樹脂製容器の製造装置 |
US20220330532A1 (en) | 2019-06-05 | 2022-10-20 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a limited lambda light chain repertoire expressed from the kappa locus and uses thereof |
EP4051707A1 (en) * | 2019-10-28 | 2022-09-07 | Regeneron Pharmaceuticals, Inc. | Anti-hemagglutinin antibodies and methods of use thereof |
CA3189225A1 (en) * | 2020-08-04 | 2022-02-10 | Seagen Inc. | Anti-cd228 antibodies and antibody-drug conjugates |
CN116194142A (zh) | 2020-09-03 | 2023-05-30 | 瑞泽恩制药公司 | 通过施用pd-1抑制剂治疗癌症疼痛的方法 |
JP2023540808A (ja) | 2020-09-11 | 2023-09-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗原特異的抗体の同定及び産生 |
JP2024500399A (ja) | 2020-12-16 | 2024-01-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化Fcアルファ受容体を発現するマウス |
TW202241934A (zh) | 2020-12-23 | 2022-11-01 | 美商再生元醫藥公司 | 編碼錨定修飾抗體之核酸及其用途 |
Family Cites Families (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
CA2075927A1 (en) | 1990-02-16 | 1991-08-17 | Victor A. Raso | Hybrid reagents capable of selectively releasing molecules into cells |
US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
DE69127627T2 (de) * | 1990-08-29 | 1998-02-19 | Genpharm Int | Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper |
US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
US7067284B1 (en) | 1992-01-27 | 2006-06-27 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
WO1994002602A1 (en) | 1992-07-24 | 1994-02-03 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
US5999908A (en) | 1992-08-06 | 1999-12-07 | Abelow; Daniel H. | Customer-based product design module |
AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
ATE352613T1 (de) | 1995-08-29 | 2007-02-15 | Kirin Brewery | Chimäres tier und methode zu dessen herstellung |
EP0970126B1 (en) | 1997-04-14 | 2001-04-18 | Micromet AG | Novel method for the production of antihuman antigen receptors and uses thereof |
AU751659B2 (en) | 1997-05-02 | 2002-08-22 | Genentech Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
WO1999018212A1 (fr) | 1997-10-03 | 1999-04-15 | Chugai Seiyaku Kabushiki Kaisha | Anticorps humain naturel |
GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
MXPA03002046A (es) | 2000-09-08 | 2003-07-24 | Massachusetts Inst Technology | Composiciones analogos de factor estimulador de colonias de granulocitos y metodos para su elaboracion. |
US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US20060199204A1 (en) | 2001-10-05 | 2006-09-07 | U.S. Epa | Genetic testing for male factor infertility |
US20030108925A1 (en) | 2001-10-05 | 2003-06-12 | U.S. Epa | Genetic testing for male factor infertility |
DK1461442T3 (en) | 2001-11-30 | 2017-12-04 | Amgen Fremont Inc | Transgenic animals with human Ig lambda light chain genes |
WO2003107009A2 (en) | 2002-06-12 | 2003-12-24 | Genencor International, Inc. | Methods for improving a binding characteristic of a molecule |
AU2003256266A1 (en) | 2002-06-12 | 2003-12-31 | Genencor International, Inc. | Methods and compositions for milieu-dependent binding of a targeted agent to a target |
ATE514717T1 (de) | 2002-07-18 | 2011-07-15 | Merus B V | Rekombinante produktion von antikörpermischungen |
EP1439234A1 (en) | 2003-01-08 | 2004-07-21 | ARTEMIS Pharmaceuticals GmbH | Targeted transgenesis using the rosa26 locus |
JP4477579B2 (ja) | 2003-01-21 | 2010-06-09 | 中外製薬株式会社 | 抗体の軽鎖スクリーニング方法 |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
AU2004257292A1 (en) | 2003-07-15 | 2005-01-27 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
CN1560081A (zh) | 2004-02-17 | 2005-01-05 | 大连帝恩生物工程有限公司 | 用能产生人IgGl重链-κ轻链小鼠作为制备人源化单克隆抗体和应用 |
EP2053062A1 (en) | 2004-03-24 | 2009-04-29 | Xencor, Inc. | Immunoglobin variants outside the Fc region |
US20050260711A1 (en) | 2004-03-30 | 2005-11-24 | Deepshikha Datta | Modulating pH-sensitive binding using non-natural amino acids |
AU2005295269B2 (en) | 2004-10-19 | 2010-05-13 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
WO2007001422A2 (en) | 2004-10-22 | 2007-01-04 | Medimmune, Inc. | High affinity antibodies against hmgb1 and methods of use thereof |
EP1874817A2 (en) | 2005-04-29 | 2008-01-09 | Innate Pharma | Transgenic animals and methods of making recombinant antibodies |
EP2314619A1 (en) | 2005-12-05 | 2011-04-27 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
JP5514539B2 (ja) | 2006-03-31 | 2014-06-04 | メダレックス・リミテッド・ライアビリティ・カンパニー | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
DK2374818T3 (da) | 2006-06-02 | 2013-01-21 | Regeneron Pharma | Højaffinitetsantistoffer mod human IL-6-receptor |
RS61650B1 (sr) | 2006-10-02 | 2021-04-29 | Regeneron Pharma | Visokoafinitetna humana antitela za humani il-4 receptor |
US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
US20100034194A1 (en) | 2006-10-11 | 2010-02-11 | Siemens Communications Inc. | Eliminating unreachable subscribers in voice-over-ip networks |
RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
CA2680613A1 (en) | 2007-03-13 | 2008-09-18 | National Jewish Medical And Research Center | Methods for generation of antibodies |
ITMI20071522A1 (it) | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
EP3753947A1 (en) | 2007-09-14 | 2020-12-23 | Adimab, LLC | Rationally designed, synthetic antibody libraries and uses therefor |
PL2202245T3 (pl) | 2007-09-26 | 2017-02-28 | Chugai Seiyaku Kabushiki Kaisha | Sposób modyfikowania punktu izoelektrycznego przeciwciała poprzez podstawienie aminokwasu w cdr |
KR101615935B1 (ko) | 2007-12-14 | 2016-04-28 | 노보 노르디스크 에이/에스 | 인간 nkg2d에 대한 항체 및 그것의 용도 |
ES2563483T3 (es) * | 2008-04-11 | 2016-03-15 | Chugai Seiyaku Kabushiki Kaisha | Molécula de unión a antígeno capaz de unirse repetidamente a dos o más moléculas de antígeno |
ES2487846T3 (es) * | 2008-05-01 | 2014-08-25 | Amgen, Inc. | Anticuerpos anti-hepcindina y métodos de uso |
HUE057994T2 (hu) | 2008-06-27 | 2022-06-28 | Merus Nv | Antitesttermelõ, transzgenikus, egérfélékhez tartozó állat |
TWI445716B (zh) | 2008-09-12 | 2014-07-21 | Rinat Neuroscience Corp | Pcsk9拮抗劑類 |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
WO2010039900A2 (en) | 2008-09-30 | 2010-04-08 | Aliva Biopharmaceuticals, Inc. | Non-human mammals for the production of chimeric antibodies |
JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
ES2613730T3 (es) | 2008-12-18 | 2017-05-25 | Erasmus University Medical Center Rotterdam | Animales transgénicos no humanos que expresan anticuerpos humanizados y su uso |
BRPI0925047A2 (pt) | 2009-05-07 | 2015-07-28 | Volvo Constr Equip Ab | Uma máquina de trabalho e um método para operação de uma máquina de trabalho |
SG175407A1 (en) | 2009-05-29 | 2011-11-28 | Morphosys Ag | A collection and methods for its use |
KR20120027055A (ko) | 2009-06-26 | 2012-03-20 | 리제네론 파라마큐티칼스 인코포레이티드 | 천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체 |
EP2792236B2 (en) | 2009-07-08 | 2023-03-22 | Kymab Limited | Animal models and therapeutic molecules |
AU2010271586B2 (en) | 2009-07-16 | 2016-08-11 | Wageningen Universiteit | Regulation of zinc deficiency and tolerance in plants |
GB2472108B (en) | 2009-08-27 | 2011-07-13 | Budha Singh Dhinjan | Wall bead |
SG181477A1 (en) | 2009-12-10 | 2012-07-30 | Regeneron Pharma | Mice that make heavy chain antibodies |
HUE045591T2 (hu) * | 2010-02-08 | 2019-12-30 | Regeneron Pharma | Közönséges könnyûláncú egér |
US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
US20130185821A1 (en) | 2010-02-08 | 2013-07-18 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
SG183867A1 (en) | 2010-03-11 | 2012-10-30 | Rinat Neuroscience Corp | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
TWI667257B (zh) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
NZ605966A (en) | 2010-06-17 | 2015-04-24 | Kymab Ltd | Animal models and therapeutic molecules |
ES2576928T3 (es) | 2010-06-22 | 2016-07-12 | Regeneron Pharmaceuticals, Inc. | Ratones que expresan una cadena ligera con las regiones variable lambda humana y constante de ratón |
RS59661B2 (sr) | 2011-02-25 | 2023-06-30 | Regeneron Pharma | Adam6 miševi |
MY172718A (en) | 2011-08-05 | 2019-12-11 | Regeneron Pharma | Humanized universal light chain mice |
KR102528622B1 (ko) | 2011-09-30 | 2023-05-04 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존성 결합 분자 라이브러리 |
GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
SG11201405088QA (en) | 2012-03-06 | 2014-11-27 | Regeneron Pharma | Common light chain mouse |
KR102459666B1 (ko) | 2012-03-16 | 2022-10-27 | 리제너론 파마슈티칼스 인코포레이티드 | pH-민감성 면역글로불린 서열을 발현하는 비-사람 동물 |
US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
SG11201407644UA (en) | 2012-06-05 | 2014-12-30 | Regeneron Pharma | Methods for making fully human bispecific antibodies using a common light chain |
MY178882A (en) | 2013-02-20 | 2020-10-21 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
-
2013
- 2013-03-15 MY MYPI2014002400A patent/MY172730A/en unknown
- 2013-03-15 MX MX2014011051A patent/MX355732B/es active IP Right Grant
- 2013-03-15 AU AU2013204579A patent/AU2013204579B2/en active Active
- 2013-03-15 EP EP18158960.7A patent/EP3348140B1/en active Active
- 2013-03-15 CA CA2865643A patent/CA2865643A1/en active Pending
- 2013-03-15 PL PL15151655T patent/PL2883449T3/pl unknown
- 2013-03-15 HU HUE18158960A patent/HUE053310T2/hu unknown
- 2013-03-15 PT PT137136529T patent/PT2825036T/pt unknown
- 2013-03-15 PL PL13713652T patent/PL2825036T3/pl unknown
- 2013-03-15 HU HUE13713652A patent/HUE039573T2/hu unknown
- 2013-03-15 CN CN201380025684.4A patent/CN104302169B/zh active Active
- 2013-03-15 LT LTEP15151655.6T patent/LT2883449T/lt unknown
- 2013-03-15 NZ NZ629639A patent/NZ629639A/en not_active IP Right Cessation
- 2013-03-15 EP EP20208322.6A patent/EP3808175A1/en active Pending
- 2013-03-15 PT PT181589607T patent/PT3348140T/pt unknown
- 2013-03-15 CN CN201710968748.4A patent/CN107840890A/zh active Pending
- 2013-03-15 DK DK13713652.9T patent/DK2825036T3/en active
- 2013-03-15 US US13/832,247 patent/US9334334B2/en active Active
- 2013-03-15 ES ES15151655.6T patent/ES2665793T3/es active Active
- 2013-03-15 SI SI201330992T patent/SI2883449T1/en unknown
- 2013-03-15 PT PT151516556T patent/PT2883449T/pt unknown
- 2013-03-15 RS RS20180416A patent/RS57118B1/sr unknown
- 2013-03-15 RU RU2017135754A patent/RU2017135754A/ru not_active Application Discontinuation
- 2013-03-15 ES ES18158960T patent/ES2849349T3/es active Active
- 2013-03-15 DK DK15151655.6T patent/DK2883449T3/en active
- 2013-03-15 ES ES13713652.9T patent/ES2679369T3/es active Active
- 2013-03-15 SG SG10201607689PA patent/SG10201607689PA/en unknown
- 2013-03-15 HU HUE15151655A patent/HUE037659T2/hu unknown
- 2013-03-15 LT LTEP18158960.7T patent/LT3348140T/lt unknown
- 2013-03-15 BR BR112014022850A patent/BR112014022850A2/pt not_active Application Discontinuation
- 2013-03-15 RS RS20180718A patent/RS57414B1/sr unknown
- 2013-03-15 WO PCT/US2013/031823 patent/WO2013138680A1/en active Application Filing
- 2013-03-15 SG SG11201405165UA patent/SG11201405165UA/en unknown
- 2013-03-15 KR KR1020147025407A patent/KR102228296B1/ko active IP Right Grant
- 2013-03-15 EP EP13713652.9A patent/EP2825036B1/en active Active
- 2013-03-15 CN CN201710968763.9A patent/CN107827979A/zh active Pending
- 2013-03-15 SI SI201331088T patent/SI2825036T1/en unknown
- 2013-03-15 RU RU2014141537A patent/RU2644684C2/ru not_active IP Right Cessation
- 2013-03-15 EP EP15151655.6A patent/EP2883449B1/en active Active
- 2013-03-15 JP JP2015500639A patent/JP6185978B2/ja active Active
- 2013-03-15 LT LTEP13713652.9T patent/LT2825036T/lt unknown
- 2013-03-15 SI SI201331847T patent/SI3348140T1/sl unknown
-
2014
- 2014-07-23 US US14/339,376 patent/US9422370B2/en active Active
- 2014-08-28 IL IL234355A patent/IL234355B/en active IP Right Grant
-
2015
- 2015-01-29 HK HK15101012.5A patent/HK1200273A1/xx unknown
- 2015-07-03 HK HK15106364.8A patent/HK1205642A1/xx unknown
-
2016
- 2016-02-10 IL IL244097A patent/IL244097A/en active IP Right Grant
- 2016-04-13 AU AU2016202323A patent/AU2016202323B2/en active Active
- 2016-07-14 US US15/210,506 patent/US11192947B2/en active Active
-
2017
- 2017-03-17 JP JP2017052358A patent/JP6574802B2/ja active Active
- 2017-08-01 IL IL253775A patent/IL253775B/en active IP Right Grant
-
2018
- 2018-04-30 HR HRP20180682TT patent/HRP20180682T1/hr unknown
- 2018-05-07 CY CY181100476T patent/CY1120599T1/el unknown
- 2018-05-25 AU AU2018203713A patent/AU2018203713B2/en active Active
- 2018-07-31 HR HRP20181228TT patent/HRP20181228T1/hr unknown
- 2018-08-01 CY CY20181100797T patent/CY1120491T1/el unknown
-
2019
- 2019-02-21 JP JP2019029627A patent/JP7304169B2/ja active Active
-
2020
- 2020-01-30 IL IL272357A patent/IL272357B/en active IP Right Grant
- 2020-04-02 JP JP2020066673A patent/JP7199398B2/ja active Active
-
2021
- 2021-04-20 IL IL282452A patent/IL282452B/en unknown
- 2021-11-10 JP JP2021183079A patent/JP2022017547A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20181228T1 (hr) | Antitijela lakog lanca proizvedena histidinom i genetski modificirani glodavci za njihovu proizvodnju | |
IL264358A (en) | Histidine engineered light chain antibodies and non-human animals genetically engineered to produce them | |
HK1216899A1 (zh) | 工程化免疫球蛋白重鏈-輕鏈對及其用途 | |
EP2863736A4 (en) | GENETICALLY MODIFIED ANIMALS AND METHODS OF PRODUCTION THEREFOR | |
EP2678434A4 (en) | GENETICALLY MODIFIED ANIMALS AND METHODS FOR PRODUCING THE SAME | |
EP3001185A4 (en) | OPTICAL GRANULATOR | |
GB201305732D0 (en) | Photonic and/or optoelectronic packaging assembly | |
TWI560906B (en) | Semiconductor light emitting device and method for manufacturing the same | |
HUE037613T2 (hu) | Anti-TLR4 antitestek és azok felhasználása | |
HK1205145A1 (en) | Improved antibody light chains | |
TWI563066B (en) | Compound and organic light emitting device including the same | |
TWI562428B (en) | Organic light emitting device and method for preparing the same |