KR960703558A - 항진균성 조갑 용액(antifungal nail solution) - Google Patents
항진균성 조갑 용액(antifungal nail solution) Download PDFInfo
- Publication number
- KR960703558A KR960703558A KR1019960700429A KR19960700429A KR960703558A KR 960703558 A KR960703558 A KR 960703558A KR 1019960700429 A KR1019960700429 A KR 1019960700429A KR 19960700429 A KR19960700429 A KR 19960700429A KR 960703558 A KR960703558 A KR 960703558A
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- crude
- glycerin
- addition
- thioconazole
- Prior art date
Links
- 230000000843 anti-fungal effect Effects 0.000 title 1
- 229940121375 antifungal agent Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract 17
- 208000031888 Mycoses Diseases 0.000 claims abstract 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- 235000011187 glycerol Nutrition 0.000 claims 6
- 239000004014 plasticizer Substances 0.000 claims 4
- 241000282412 Homo Species 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- 239000012871 anti-fungal composition Substances 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 208000024386 fungal infectious disease Diseases 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Seeds, Soups, And Other Foods (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cosmetics (AREA)
Abstract
본 발명은 티오코나졸, 겔 형성제 및 하이드로-알콜성 비히클을 포함하는, 조갑 진균증의 치료에 유용한 조성물에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (18)
- (a) 효과량의 티오코나졸, (b) 물, (c) 알콜 및 (d) 겔-형성체를 포함하며, 조갑 진균증에 감염된 인간의 조갑에 적용하는 경우 티오코나졸이 연속적으로 조갑을 침투하는 병원소를 생성하는 항진균성 조성물.
- 제1항에 있어서, 상기 알콜이 에탄올인 조성물.
- 제1항에 있어서, 상기 겔 형성제가 하이드록시프로필 셀룰로지인 조성물.
- 제1항에 있어서, 가소화제의 첨가를 또한 포함하는 조성물.
- 제4항에 있어서, 상기 가소화제가 프로필렌 글리콜 디펠아르고네이트인 조성물.
- 제1항에 있어서, 글리세린의 첨가를 또한 포함하는 조성물.
- 제4항에 있어서, 글리세린의 첨가를 또한 포함하는 조성물.
- (a) 약 15 내지 약 30중량%의 티오코나졸; (b) 약 1내지 약 10중량%의 물; (c) 약 50 내지 약 90중량%의 알콜; 및 (d) 약 0.5 내지 약 5중량%의 겔 형성체를 포함하며, 조갑 진균중에 감염된 인간의 조갑에 적용하는 경우 티오코나졸이 연속적으로 조갑을 침투하는 병원소를 생성하는 항진균성 조성물.
- 제8항에 있어서, 가소화제를 또한 포함하는 조성물.
- 제9항에 있어서, 상기 가소화제가 프로필렌 글리콜 디펠아르고네이트인 조성물.
- 제8항에 있어서, 상기 알콜이 에탄올인 조성물.
- 제8항에 있어서, 상기 겔 형성제가 하이드로시프로필 셀룰로이즈인 조성물.
- 제8항에 있어서, 글리세린의 첨가를 또한 포함하는 조성물.
- 제9항에 있어서, 글리세린의 첨가를 또한 포함하는 조성물.
- 제13항에 있어서, 상기 글리세린이 약 0.5 내지 약 5.0중량%의 농도로 존재하는 조성물.
- 제14항에 있어서, 상기 글리세린이 약 0.5 내지 약 5.0중량%의 농도로 존재하는 조성물.
- 조갑 진균증의 치료를 필요로 하는 인간의 조갑에 제1항의 조성물을 적용시킴을 포함하는 상기 조갑 진균증의 치료 방법.
- 조갑 진균증의 치료를 필요로 하는 인간의 조갑에 제8항의 조성물을 적용시킴을 포함하는 상기 조갑 진균증의 치료 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/097,422 US5391367A (en) | 1993-07-28 | 1993-07-28 | Antifungal nail solution |
US08/097,422 | 1993-07-28 | ||
US8/097422 | 1993-07-28 | ||
PCT/IB1994/000198 WO1995003775A1 (en) | 1993-07-28 | 1994-07-04 | Antifungal nail solution |
Publications (2)
Publication Number | Publication Date |
---|---|
KR960703558A true KR960703558A (ko) | 1996-08-31 |
KR0179465B1 KR0179465B1 (ko) | 1999-03-20 |
Family
ID=22263261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019960700429A KR0179465B1 (ko) | 1993-07-28 | 1994-07-04 | 항진균성 조갑 용액 |
Country Status (14)
Country | Link |
---|---|
US (1) | US5391367A (ko) |
EP (1) | EP0711140B1 (ko) |
JP (1) | JP3064423B2 (ko) |
KR (1) | KR0179465B1 (ko) |
AT (1) | ATE185066T1 (ko) |
AU (1) | AU684826B2 (ko) |
CA (1) | CA2168248C (ko) |
DE (1) | DE69420967T2 (ko) |
DK (1) | DK0711140T3 (ko) |
ES (1) | ES2137372T3 (ko) |
GR (1) | GR3031897T3 (ko) |
NZ (1) | NZ267489A (ko) |
WO (1) | WO1995003775A1 (ko) |
ZA (1) | ZA945546B (ko) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5916545A (en) * | 1993-07-28 | 1999-06-29 | Pfizer Inc. | Antifungal nail solution |
US5696105A (en) * | 1996-03-14 | 1997-12-09 | Hackler; Walter A. | Antifungal nail composition |
GB9626513D0 (en) * | 1996-12-20 | 1997-02-05 | Bioglan Ireland R & D Ltd | A pharmaceutical composition |
US6264628B1 (en) | 1998-08-06 | 2001-07-24 | Profoot, Inc. | Set depth nail notcher and method for treating nail fungus |
US6572580B2 (en) | 1998-08-06 | 2003-06-03 | Profoot, Inc. | Set depth nail notcher with patch system and method for treating nail fungus |
US6287276B1 (en) | 1998-08-06 | 2001-09-11 | Profoot, Inc. | Set depth nail notcher and method for treating nail fungus |
US6403063B1 (en) | 1999-07-26 | 2002-06-11 | Kenneth I. Sawyer | Method of treating nail fungus |
US6495124B1 (en) | 2000-02-14 | 2002-12-17 | Macrochem Corporation | Antifungal nail lacquer and method using same |
US7074392B1 (en) * | 2000-03-27 | 2006-07-11 | Taro Pharmaceutical Industries Limited | Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections |
US8257688B2 (en) * | 2000-03-27 | 2012-09-04 | Taro Pharmaceuticals Industries | Controlled delivery system of antifungal and keratolytic agents for local treatment of fungal infections of the nail and surrounding tissues |
US6878365B2 (en) * | 2001-03-10 | 2005-04-12 | James Edward Brehove | Topical application for treating toenail fungus |
US6664292B2 (en) | 2001-06-04 | 2003-12-16 | Mark H. Bogart | Methods for the treatment of nail fungus and other microbial and mycotic conditions and compositions useful therefor |
US20030049307A1 (en) * | 2002-08-15 | 2003-03-13 | Gyurik Robert J. | Pharmaceutical composition |
US8404751B2 (en) * | 2002-09-27 | 2013-03-26 | Hallux, Inc. | Subunguicide, and method for treating onychomycosis |
DE10341944A1 (de) * | 2003-09-11 | 2005-04-28 | York Pharma Plc | Antimykotisch wirksame Nagellackformulierung mit substituierten 2-Aminothiazolen als Wirkstoff |
WO2006013963A1 (ja) * | 2004-08-05 | 2006-02-09 | Hisamitsu Pharmaceutical Co., Inc. | 爪用外用剤 |
JP2008523101A (ja) | 2004-12-10 | 2008-07-03 | タリマ セラピューティクス, インコーポレイテッド | 爪ユニットの状態を治療するための組成物および方法 |
US20060275230A1 (en) * | 2004-12-10 | 2006-12-07 | Frank Kochinke | Compositions and methods for treating conditions of the nail unit |
US20060251593A1 (en) * | 2005-04-07 | 2006-11-09 | Work By Docs, Inc. | Colored nail enamel treatment |
US9579297B2 (en) | 2005-12-28 | 2017-02-28 | Teikoku Seiyaku Co., Ltd. | Pharmaceutical composition for application to nail |
CN101121967B (zh) * | 2006-08-09 | 2010-11-24 | 中国科学院金属研究所 | 一种真空感应熔炼TiAl基合金的方法 |
US20090175810A1 (en) | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
JP2011051966A (ja) * | 2009-09-03 | 2011-03-17 | Daiya Seiyaku Kk | 爪白癬治療用貼付剤 |
ES2369101B2 (es) | 2010-05-07 | 2012-08-02 | Universidade De Santiago De Compostela | Sistema farmacéutico acuoso para la administración de fármacos en las uñas. |
US8039494B1 (en) | 2010-07-08 | 2011-10-18 | Dow Pharmaceutical Sciences, Inc. | Compositions and methods for treating diseases of the nail |
US20140030209A1 (en) * | 2012-07-30 | 2014-01-30 | Meiji Seika Pharma Co., Ltd. | Topical liquid agent for the treatment of dermatophytosis |
EP2881114B1 (en) | 2012-07-30 | 2018-09-05 | Meiji Seika Pharma Co., Ltd. | Anti-trichophytic adhesive patch |
US8697753B1 (en) | 2013-02-07 | 2014-04-15 | Polichem Sa | Method of treating onychomycosis |
CA2904703A1 (en) | 2013-03-14 | 2014-10-02 | Hallux, Inc. | Method of treating infections, diseases or disorders of nail unit |
MY179756A (en) | 2013-10-03 | 2020-11-12 | Dow Pharmaceutical Sciences | Stabilized efinaconazole formulations |
CN112999223A (zh) | 2013-11-22 | 2021-06-22 | 博世健康爱尔兰有限公司 | 抗感染的方法、组合物和装置 |
EP2952208A1 (en) | 2014-06-04 | 2015-12-09 | Universidade de Santiago de Compostela | Hydroalcoholic system for nail treatment |
CA2957880A1 (en) | 2014-08-13 | 2016-02-18 | Meiji Seika Pharma Co., Ltd. | Crystalline anti-trichophyton agents and preparation process thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3914131A (en) * | 1971-08-23 | 1975-10-21 | Emery Industries Inc | Useful wax compositions |
US4299826A (en) * | 1979-10-12 | 1981-11-10 | The Procter & Gamble Company | Anti-acne composition |
DE3520098A1 (de) * | 1985-06-05 | 1986-12-11 | Bayer Ag, 5090 Leverkusen | Azolderivate enthaltende formulierungen sowie ihre verwendung zur atraumatischen nagelentfernung |
CA1299098C (en) * | 1985-10-28 | 1992-04-21 | John H. White | Alcohol-based antimicrobial compositions |
ATE84208T1 (de) * | 1985-11-04 | 1993-01-15 | Owen Galderma Lab Inc | Filmbildende arzneimitteltraeger zur verabreichung von arzneimitteln an naegeln; verfahren zur verwendung. |
SE462139B (sv) * | 1986-02-04 | 1990-05-14 | Sven Moberg | Farmaceutisk komposition, innehaallande propylenglykol och karbamid, foer behandling av bl.a. nagelsvamp och seborroiskt eksem |
FR2613227B1 (fr) * | 1987-04-01 | 1990-12-28 | Oreal | Compositions pharmaceutiques a base de nitrate de miconazole ou de nitrate d'econazole dans le traitement des infections fongiques des ongles |
DE3720147A1 (de) * | 1987-06-16 | 1988-12-29 | Hoechst Ag | Antimykotisch wirksamer nagellack sowie verfahren zu dessen herstellung |
US5002938A (en) * | 1988-03-21 | 1991-03-26 | Bristol-Myers Squibb Company | Antifungal gel formulations |
IL97012A0 (en) * | 1990-01-30 | 1992-03-29 | Gist Brocades Nv | Topical preparations for treating human nails |
-
1993
- 1993-07-28 US US08/097,422 patent/US5391367A/en not_active Expired - Fee Related
-
1994
- 1994-07-04 JP JP7505715A patent/JP3064423B2/ja not_active Expired - Fee Related
- 1994-07-04 WO PCT/IB1994/000198 patent/WO1995003775A1/en active IP Right Grant
- 1994-07-04 EP EP94918497A patent/EP0711140B1/en not_active Expired - Lifetime
- 1994-07-04 ES ES94918497T patent/ES2137372T3/es not_active Expired - Lifetime
- 1994-07-04 DE DE69420967T patent/DE69420967T2/de not_active Expired - Fee Related
- 1994-07-04 NZ NZ267489A patent/NZ267489A/en active IP Right Revival
- 1994-07-04 DK DK94918497T patent/DK0711140T3/da active
- 1994-07-04 CA CA002168248A patent/CA2168248C/en not_active Expired - Fee Related
- 1994-07-04 AT AT94918497T patent/ATE185066T1/de not_active IP Right Cessation
- 1994-07-04 AU AU69799/94A patent/AU684826B2/en not_active Ceased
- 1994-07-04 KR KR1019960700429A patent/KR0179465B1/ko not_active IP Right Cessation
- 1994-07-27 ZA ZA945546A patent/ZA945546B/xx unknown
-
1999
- 1999-11-18 GR GR990402989T patent/GR3031897T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE185066T1 (de) | 1999-10-15 |
DK0711140T3 (da) | 2000-01-03 |
EP0711140B1 (en) | 1999-09-29 |
KR0179465B1 (ko) | 1999-03-20 |
AU6979994A (en) | 1995-02-28 |
CA2168248C (en) | 1999-03-16 |
DE69420967D1 (de) | 1999-11-04 |
CA2168248A1 (en) | 1995-02-09 |
ES2137372T3 (es) | 1999-12-16 |
EP0711140A1 (en) | 1996-05-15 |
ZA945546B (en) | 1996-01-29 |
AU684826B2 (en) | 1998-01-08 |
DE69420967T2 (de) | 2000-01-13 |
GR3031897T3 (en) | 2000-02-29 |
JPH09504510A (ja) | 1997-05-06 |
NZ267489A (en) | 1999-09-29 |
JP3064423B2 (ja) | 2000-07-12 |
US5391367A (en) | 1995-02-21 |
WO1995003775A1 (en) | 1995-02-09 |
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