KR960703558A - 항진균성 조갑 용액(antifungal nail solution) - Google Patents

항진균성 조갑 용액(antifungal nail solution) Download PDF

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Publication number
KR960703558A
KR960703558A KR1019960700429A KR19960700429A KR960703558A KR 960703558 A KR960703558 A KR 960703558A KR 1019960700429 A KR1019960700429 A KR 1019960700429A KR 19960700429 A KR19960700429 A KR 19960700429A KR 960703558 A KR960703558 A KR 960703558A
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KR
South Korea
Prior art keywords
composition
crude
glycerin
addition
thioconazole
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KR1019960700429A
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English (en)
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KR0179465B1 (ko
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데비 엘. 버네트
다리우스 디. 두바쉬
아타나시오스 에스. 라다스
테러사 제이. 데빈센티스
Original Assignee
알렌 제이. 스피겔
화이자 인코포레이티드
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Publication of KR960703558A publication Critical patent/KR960703558A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Seeds, Soups, And Other Foods (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)

Abstract

본 발명은 티오코나졸, 겔 형성제 및 하이드로-알콜성 비히클을 포함하는, 조갑 진균증의 치료에 유용한 조성물에 관한 것이다.

Description

항진균성 조갑 용액(ANTIFUNGAL NAIL SOLUTION)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (18)

  1. (a) 효과량의 티오코나졸, (b) 물, (c) 알콜 및 (d) 겔-형성체를 포함하며, 조갑 진균증에 감염된 인간의 조갑에 적용하는 경우 티오코나졸이 연속적으로 조갑을 침투하는 병원소를 생성하는 항진균성 조성물.
  2. 제1항에 있어서, 상기 알콜이 에탄올인 조성물.
  3. 제1항에 있어서, 상기 겔 형성제가 하이드록시프로필 셀룰로지인 조성물.
  4. 제1항에 있어서, 가소화제의 첨가를 또한 포함하는 조성물.
  5. 제4항에 있어서, 상기 가소화제가 프로필렌 글리콜 디펠아르고네이트인 조성물.
  6. 제1항에 있어서, 글리세린의 첨가를 또한 포함하는 조성물.
  7. 제4항에 있어서, 글리세린의 첨가를 또한 포함하는 조성물.
  8. (a) 약 15 내지 약 30중량%의 티오코나졸; (b) 약 1내지 약 10중량%의 물; (c) 약 50 내지 약 90중량%의 알콜; 및 (d) 약 0.5 내지 약 5중량%의 겔 형성체를 포함하며, 조갑 진균중에 감염된 인간의 조갑에 적용하는 경우 티오코나졸이 연속적으로 조갑을 침투하는 병원소를 생성하는 항진균성 조성물.
  9. 제8항에 있어서, 가소화제를 또한 포함하는 조성물.
  10. 제9항에 있어서, 상기 가소화제가 프로필렌 글리콜 디펠아르고네이트인 조성물.
  11. 제8항에 있어서, 상기 알콜이 에탄올인 조성물.
  12. 제8항에 있어서, 상기 겔 형성제가 하이드로시프로필 셀룰로이즈인 조성물.
  13. 제8항에 있어서, 글리세린의 첨가를 또한 포함하는 조성물.
  14. 제9항에 있어서, 글리세린의 첨가를 또한 포함하는 조성물.
  15. 제13항에 있어서, 상기 글리세린이 약 0.5 내지 약 5.0중량%의 농도로 존재하는 조성물.
  16. 제14항에 있어서, 상기 글리세린이 약 0.5 내지 약 5.0중량%의 농도로 존재하는 조성물.
  17. 조갑 진균증의 치료를 필요로 하는 인간의 조갑에 제1항의 조성물을 적용시킴을 포함하는 상기 조갑 진균증의 치료 방법.
  18. 조갑 진균증의 치료를 필요로 하는 인간의 조갑에 제8항의 조성물을 적용시킴을 포함하는 상기 조갑 진균증의 치료 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960700429A 1993-07-28 1994-07-04 항진균성 조갑 용액 KR0179465B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/097,422 US5391367A (en) 1993-07-28 1993-07-28 Antifungal nail solution
US08/097,422 1993-07-28
US8/097422 1993-07-28
PCT/IB1994/000198 WO1995003775A1 (en) 1993-07-28 1994-07-04 Antifungal nail solution

Publications (2)

Publication Number Publication Date
KR960703558A true KR960703558A (ko) 1996-08-31
KR0179465B1 KR0179465B1 (ko) 1999-03-20

Family

ID=22263261

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960700429A KR0179465B1 (ko) 1993-07-28 1994-07-04 항진균성 조갑 용액

Country Status (14)

Country Link
US (1) US5391367A (ko)
EP (1) EP0711140B1 (ko)
JP (1) JP3064423B2 (ko)
KR (1) KR0179465B1 (ko)
AT (1) ATE185066T1 (ko)
AU (1) AU684826B2 (ko)
CA (1) CA2168248C (ko)
DE (1) DE69420967T2 (ko)
DK (1) DK0711140T3 (ko)
ES (1) ES2137372T3 (ko)
GR (1) GR3031897T3 (ko)
NZ (1) NZ267489A (ko)
WO (1) WO1995003775A1 (ko)
ZA (1) ZA945546B (ko)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916545A (en) * 1993-07-28 1999-06-29 Pfizer Inc. Antifungal nail solution
US5696105A (en) * 1996-03-14 1997-12-09 Hackler; Walter A. Antifungal nail composition
GB9626513D0 (en) * 1996-12-20 1997-02-05 Bioglan Ireland R & D Ltd A pharmaceutical composition
US6264628B1 (en) 1998-08-06 2001-07-24 Profoot, Inc. Set depth nail notcher and method for treating nail fungus
US6572580B2 (en) 1998-08-06 2003-06-03 Profoot, Inc. Set depth nail notcher with patch system and method for treating nail fungus
US6287276B1 (en) 1998-08-06 2001-09-11 Profoot, Inc. Set depth nail notcher and method for treating nail fungus
US6403063B1 (en) 1999-07-26 2002-06-11 Kenneth I. Sawyer Method of treating nail fungus
US6495124B1 (en) 2000-02-14 2002-12-17 Macrochem Corporation Antifungal nail lacquer and method using same
US7074392B1 (en) * 2000-03-27 2006-07-11 Taro Pharmaceutical Industries Limited Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections
US8257688B2 (en) * 2000-03-27 2012-09-04 Taro Pharmaceuticals Industries Controlled delivery system of antifungal and keratolytic agents for local treatment of fungal infections of the nail and surrounding tissues
US6878365B2 (en) * 2001-03-10 2005-04-12 James Edward Brehove Topical application for treating toenail fungus
US6664292B2 (en) 2001-06-04 2003-12-16 Mark H. Bogart Methods for the treatment of nail fungus and other microbial and mycotic conditions and compositions useful therefor
US20030049307A1 (en) * 2002-08-15 2003-03-13 Gyurik Robert J. Pharmaceutical composition
US8404751B2 (en) * 2002-09-27 2013-03-26 Hallux, Inc. Subunguicide, and method for treating onychomycosis
DE10341944A1 (de) * 2003-09-11 2005-04-28 York Pharma Plc Antimykotisch wirksame Nagellackformulierung mit substituierten 2-Aminothiazolen als Wirkstoff
WO2006013963A1 (ja) * 2004-08-05 2006-02-09 Hisamitsu Pharmaceutical Co., Inc. 爪用外用剤
JP2008523101A (ja) 2004-12-10 2008-07-03 タリマ セラピューティクス， インコーポレイテッド 爪ユニットの状態を治療するための組成物および方法
US20060275230A1 (en) * 2004-12-10 2006-12-07 Frank Kochinke Compositions and methods for treating conditions of the nail unit
US20060251593A1 (en) * 2005-04-07 2006-11-09 Work By Docs, Inc. Colored nail enamel treatment
US9579297B2 (en) 2005-12-28 2017-02-28 Teikoku Seiyaku Co., Ltd. Pharmaceutical composition for application to nail
CN101121967B (zh) * 2006-08-09 2010-11-24 中国科学院金属研究所 一种真空感应熔炼TiAl基合金的方法
US20090175810A1 (en) 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
JP2011051966A (ja) * 2009-09-03 2011-03-17 Daiya Seiyaku Kk 爪白癬治療用貼付剤
ES2369101B2 (es) 2010-05-07 2012-08-02 Universidade De Santiago De Compostela Sistema farmacéutico acuoso para la administración de fármacos en las uñas.
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
US20140030209A1 (en) * 2012-07-30 2014-01-30 Meiji Seika Pharma Co., Ltd. Topical liquid agent for the treatment of dermatophytosis
EP2881114B1 (en) 2012-07-30 2018-09-05 Meiji Seika Pharma Co., Ltd. Anti-trichophytic adhesive patch
US8697753B1 (en) 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis
CA2904703A1 (en) 2013-03-14 2014-10-02 Hallux, Inc. Method of treating infections, diseases or disorders of nail unit
MY179756A (en) 2013-10-03 2020-11-12 Dow Pharmaceutical Sciences Stabilized efinaconazole formulations
CN112999223A (zh) 2013-11-22 2021-06-22 博世健康爱尔兰有限公司 抗感染的方法、组合物和装置
EP2952208A1 (en) 2014-06-04 2015-12-09 Universidade de Santiago de Compostela Hydroalcoholic system for nail treatment
CA2957880A1 (en) 2014-08-13 2016-02-18 Meiji Seika Pharma Co., Ltd. Crystalline anti-trichophyton agents and preparation process thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914131A (en) * 1971-08-23 1975-10-21 Emery Industries Inc Useful wax compositions
US4299826A (en) * 1979-10-12 1981-11-10 The Procter & Gamble Company Anti-acne composition
DE3520098A1 (de) * 1985-06-05 1986-12-11 Bayer Ag, 5090 Leverkusen Azolderivate enthaltende formulierungen sowie ihre verwendung zur atraumatischen nagelentfernung
CA1299098C (en) * 1985-10-28 1992-04-21 John H. White Alcohol-based antimicrobial compositions
ATE84208T1 (de) * 1985-11-04 1993-01-15 Owen Galderma Lab Inc Filmbildende arzneimitteltraeger zur verabreichung von arzneimitteln an naegeln; verfahren zur verwendung.
SE462139B (sv) * 1986-02-04 1990-05-14 Sven Moberg Farmaceutisk komposition, innehaallande propylenglykol och karbamid, foer behandling av bl.a. nagelsvamp och seborroiskt eksem
FR2613227B1 (fr) * 1987-04-01 1990-12-28 Oreal Compositions pharmaceutiques a base de nitrate de miconazole ou de nitrate d'econazole dans le traitement des infections fongiques des ongles
DE3720147A1 (de) * 1987-06-16 1988-12-29 Hoechst Ag Antimykotisch wirksamer nagellack sowie verfahren zu dessen herstellung
US5002938A (en) * 1988-03-21 1991-03-26 Bristol-Myers Squibb Company Antifungal gel formulations
IL97012A0 (en) * 1990-01-30 1992-03-29 Gist Brocades Nv Topical preparations for treating human nails

Also Published As

Publication number Publication date
ATE185066T1 (de) 1999-10-15
DK0711140T3 (da) 2000-01-03
EP0711140B1 (en) 1999-09-29
KR0179465B1 (ko) 1999-03-20
AU6979994A (en) 1995-02-28
CA2168248C (en) 1999-03-16
DE69420967D1 (de) 1999-11-04
CA2168248A1 (en) 1995-02-09
ES2137372T3 (es) 1999-12-16
EP0711140A1 (en) 1996-05-15
ZA945546B (en) 1996-01-29
AU684826B2 (en) 1998-01-08
DE69420967T2 (de) 2000-01-13
GR3031897T3 (en) 2000-02-29
JPH09504510A (ja) 1997-05-06
NZ267489A (en) 1999-09-29
JP3064423B2 (ja) 2000-07-12
US5391367A (en) 1995-02-21
WO1995003775A1 (en) 1995-02-09

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