KR840006766A - 항 진균제의 제조방법 - Google Patents
항 진균제의 제조방법 Download PDFInfo
- Publication number
- KR840006766A KR840006766A KR1019830005566A KR830005566A KR840006766A KR 840006766 A KR840006766 A KR 840006766A KR 1019830005566 A KR1019830005566 A KR 1019830005566A KR 830005566 A KR830005566 A KR 830005566A KR 840006766 A KR840006766 A KR 840006766A
- Authority
- KR
- South Korea
- Prior art keywords
- gel
- active compound
- compound contains
- mixture
- forming agent
- Prior art date
Links
- 229940121375 antifungal agent Drugs 0.000 title 1
- 239000003429 antifungal agent Substances 0.000 title 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 2
- DALSNPRWUFOYDT-UHFFFAOYSA-N 1-[(2-chlorophenyl)-(4-phenylphenyl)methyl]imidazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)C1=CC=C(C=2C=CC=CC=2)C=C1 DALSNPRWUFOYDT-UHFFFAOYSA-N 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 150000007980 azole derivatives Chemical class 0.000 claims 1
- 235000019445 benzyl alcohol Nutrition 0.000 claims 1
- 229920003086 cellulose ether Polymers 0.000 claims 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims 1
- 229960004022 clotrimazole Drugs 0.000 claims 1
- 239000000417 fungicide Substances 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 1
- 229950000194 lombazole Drugs 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 통상적인 계형화보조제를 함유하는 탈무기질수중의 벤질 알코올의 1% 용액에 60°C에서 격렬히 교반하면서 겔-형성제로서 2.5내지 17.5%의 셀룰로오즈 에테르, 및 0.1내지 1.5%의 바이오폴리 사카라이드를 가하고, 혼합물을 30℃ 로 냉각시킨후, 0.05내지 1%, 바람직하게는 0.1내지 1%의 아졸유도체를 가하여 혼합물을 실온으로 냉각시킴을 특징으로 하여, 구강내 진균 감염증을 치료하는 겔 형태의 항 진균제를 제조하는 방법.
- 제1항에 있어서, 활성화합물로서 다음 구조식의 클로트리마졸을 함유함을 특징으로 하는 방법.
- 제1항에 있어서, 활성 화합물로서 다음 구조식의 비포나졸을 함유함을 특징으로 하는 방법.
- 제1항에 있어서, 활성 화합물로서 다음 구조식의 롬바졸을 함유함을 특징으로 하는 방법.
- 제1항에 있어서, 겔-형성제로서 하이드록시 프로필 셀룰로오즈를 함유함을 특징으로 하는 방법.
- 제1항에 있어서 안정화제 및 겔-형성제로서 바이오폴리사카라이드를 함유함을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP3243546.0 | 1982-11-25 | ||
DE19823243546 DE3243546A1 (de) | 1982-11-25 | 1982-11-25 | Antimykotische mittel in gelform zur behandlung von pilzinfektionen der mundhoehle |
Publications (1)
Publication Number | Publication Date |
---|---|
KR840006766A true KR840006766A (ko) | 1984-12-03 |
Family
ID=6178958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019830005566A KR840006766A (ko) | 1982-11-25 | 1983-11-24 | 항 진균제의 제조방법 |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0112485B1 (ko) |
JP (1) | JPS59108712A (ko) |
KR (1) | KR840006766A (ko) |
AT (1) | ATE33759T1 (ko) |
CA (1) | CA1209920A (ko) |
DE (2) | DE3243546A1 (ko) |
DK (1) | DK538683A (ko) |
ES (1) | ES527514A0 (ko) |
GR (1) | GR79726B (ko) |
IL (1) | IL70290A (ko) |
NO (1) | NO834160L (ko) |
ZA (1) | ZA838774B (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4542020A (en) * | 1984-08-17 | 1985-09-17 | E. R. Squibb & Sons, Inc. | Long-lasting adhesive antifungal suppositories |
JPS61151117A (ja) * | 1984-12-25 | 1986-07-09 | Bayer Yakuhin Kk | 抗真菌ゲル製剤 |
DE3614095A1 (de) * | 1986-04-25 | 1987-10-29 | Goedecke Ag | Oxyalkylcellulose enthaltende gelzubereitung |
US5093133A (en) * | 1990-01-24 | 1992-03-03 | Mcneil-Ppc, Inc. | Method for percutaneous delivery of ibuprofen using hydroalcoholic gel |
US20050054583A1 (en) * | 2003-08-20 | 2005-03-10 | Matsumoto Dental University | Composition for an antifungal agent for suppressing fungal growth in an oral cavity |
JP2005097271A (ja) * | 2003-08-20 | 2005-04-14 | Matsumoto Shika Univ | 抗真菌剤用組成物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE626627A (ko) * | 1962-04-26 | |||
US4056611A (en) * | 1973-04-16 | 1977-11-01 | Stiefel Laboratories, Inc. | Therapeutic composition |
US4313765A (en) * | 1980-09-24 | 1982-02-02 | Merck & Co., Inc. | Synergistic blends of cellulase-free xanthan gum and cellulosics |
DE3045915A1 (de) * | 1980-12-05 | 1982-07-08 | Bayer Ag, 5090 Leverkusen | Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern |
JPS57120576A (en) * | 1981-01-20 | 1982-07-27 | Sumitomo Chem Co Ltd | Novel imidazole ester |
DE3106635A1 (de) * | 1981-02-23 | 1982-09-09 | Bayer Ag | Antimykotisches mittel mit hoher wirkstoff-freisetzung in form von stiften |
-
1982
- 1982-11-25 DE DE19823243546 patent/DE3243546A1/de not_active Withdrawn
-
1983
- 1983-11-14 NO NO834160A patent/NO834160L/no unknown
- 1983-11-17 DE DE8383111479T patent/DE3376386D1/de not_active Expired
- 1983-11-17 AT AT83111479T patent/ATE33759T1/de not_active IP Right Cessation
- 1983-11-17 EP EP83111479A patent/EP0112485B1/de not_active Expired
- 1983-11-22 JP JP58218838A patent/JPS59108712A/ja active Pending
- 1983-11-22 IL IL70290A patent/IL70290A/xx unknown
- 1983-11-23 CA CA000441740A patent/CA1209920A/en not_active Expired
- 1983-11-23 GR GR73047A patent/GR79726B/el unknown
- 1983-11-24 DK DK538683A patent/DK538683A/da not_active Application Discontinuation
- 1983-11-24 KR KR1019830005566A patent/KR840006766A/ko not_active Application Discontinuation
- 1983-11-24 ZA ZA838774A patent/ZA838774B/xx unknown
- 1983-11-24 ES ES527514A patent/ES527514A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
ZA838774B (en) | 1984-07-25 |
DK538683D0 (da) | 1983-11-24 |
ES8502337A1 (es) | 1985-01-01 |
NO834160L (no) | 1984-05-28 |
ES527514A0 (es) | 1985-01-01 |
EP0112485A2 (de) | 1984-07-04 |
ATE33759T1 (de) | 1988-05-15 |
EP0112485A3 (en) | 1985-10-23 |
IL70290A (en) | 1988-01-31 |
GR79726B (ko) | 1984-10-31 |
CA1209920A (en) | 1986-08-19 |
DK538683A (da) | 1984-05-26 |
EP0112485B1 (de) | 1988-04-27 |
IL70290A0 (en) | 1984-02-29 |
JPS59108712A (ja) | 1984-06-23 |
DE3243546A1 (de) | 1984-05-30 |
DE3376386D1 (en) | 1988-06-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR840005083A (ko) | 항고혈압제로서 유용한 아미노산유도체의 제조방법 | |
GB1494868A (en) | Methyl cellulose ether compositions and method for preparing capsules therefrom | |
ES486280A1 (es) | Procedimiento para la obtencion de hidroxietil-azoles | |
KR840000236A (ko) | 포유류의 국부용 제형의 수분 손실량을 극소화시키는 방법 | |
DE2961083D1 (en) | Hydroxypropyl triazoles, process for their preparation and medicaments containing these compounds | |
KR840006766A (ko) | 항 진균제의 제조방법 | |
DK328684D0 (da) | Depot-antiphlogistika | |
KR850006425A (ko) | 세프타지딤 결정성염의 제조방법 | |
ES388883A1 (es) | Procedimiento para la preparacion de 1-(2-nitrilofenoxi)-2-hidroxi-3-etilaminopropano racemicos u opticamente activo. | |
ATE2649T1 (de) | Antimykotische mittel, die imidazolylenolether umfassen, ihre herstellung und ihre verwendung. | |
FR2208671A1 (en) | N-substd. 2-anilino-imidazolines - with hypotensive, sedative, secretion-inhibiting and analgesic activity | |
KR830001952A (ko) | 세펄옥심(Cefuroxim)의 제조방법 | |
SE8103106L (sv) | Forfarande for framstellning av 4a-aryl-oktahydro-1h-2-pyrindiner | |
GB1195180A (en) | Use of Alkyl 2-Benzimidazole-Carbamate Salts a Fungicides | |
KR840006767A (ko) | 항진균성 겔 조성물 | |
NL7506765A (nl) | Werkwijze voor de bereiding van een 3-methyl-pyra- zolon-5-derivaat als antitromboticum. | |
KR830001890A (ko) | 카바졸 유도체의 제조방법 | |
ES421327A1 (es) | Procedimiento para preparar 2-metil-5-nitro-1-(2-feniltioe-til) imidazoles. | |
ES386969A1 (es) | Un metodo para preparar una amidinourea. | |
JPS5662801A (en) | Production of cationic cellulose ether | |
ES390952A1 (es) | Procedimiento para la preparacion de 2-piperidilcarbinoles. | |
KR850000405A (ko) | 항진균제의 제조방법 | |
ES465346A1 (es) | Procedimiento para preparar imidazoles 4,5-disustituidos. | |
SU457686A1 (ru) | Способ стабилизации водных растворов формальдегида | |
SU1045049A2 (ru) | Способ приработки деталей |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |