KR960037677A - 4-인돌릴피페라지닐 유도체 - Google Patents

4-인돌릴피페라지닐 유도체 Download PDF

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Publication number
KR960037677A
KR960037677A KR1019960010393A KR19960010393A KR960037677A KR 960037677 A KR960037677 A KR 960037677A KR 1019960010393 A KR1019960010393 A KR 1019960010393A KR 19960010393 A KR19960010393 A KR 19960010393A KR 960037677 A KR960037677 A KR 960037677A
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KR
South Korea
Prior art keywords
carbon atoms
alkyl
compound
piperazin
indolyl
Prior art date
Application number
KR1019960010393A
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English (en)
Inventor
패트릭 야들리 존
플레트처 3세 호리스
Original Assignee
이곤 이. 버그
아메리칸 홈 프러덕츠 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이곤 이. 버그, 아메리칸 홈 프러덕츠 코포레이션 filed Critical 이곤 이. 버그
Publication of KR960037677A publication Critical patent/KR960037677A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e

Abstract

본 발명은 다음 일반식의 불안 완화제/항우울제 또는 이의 약제학적으로 허용되는 염을 제공한다.
상기 식에서, R1은 알킬이고, R2및 R3은 알킬이거나 함께 폴리메틸렌을 형성하며, R4는 수소 또는 알킬이고, R5는 페닐, 벤질, 치환된 페닐 또는 치환된 페닐(여기서, 치환체는 하이드록시, 할로, 알콕시, 트리플루오로메틸, 니트로, 시아노, 알콕시카보닐, 아미노 또는 디알킬 아미노이다)이다.

Description

4-인돌릴피페라지닐 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 다음 일반식의 화합물 또는 이의 약제학적으로 허용되는 염.
    상기 식에서, R1은 탄소수 1 내지 6의 알킬이고, R2및 R3은 탄소수 1 내지 6의 알킬이거나 함께 탄소수 2 내지 12의 폴리메틸렌을 형성하며, R4는 수소 또는 탄소수 1 내지 6의 알킬이고, R5는 페닐, 벤질, 치환된 페닐 또는 치환된 페닐〔여기서, 치환체는 하이드록시, 할로 탄소수 1 내지 6의 알콕시, 트리플루오로메틸, 니트로, 시아노, 탄소수 2 내지 7의 알콕시카보닐, 아미노 또는 디알킬아미노(여기서, 각각 알킬 그룹은 탄소수 1 내지 6을 함유한다)이다〕이다.
  2. 제1항에 있어서, R1이 탄소수 1 내지 3의 알킬이고, R2및 R3이 탄소수 1 내지 3의 알킬이거나 함께 탄소수 3 내지 7의 폴리메틸렌을 형성하며, R4가 수소이고 R5가 페닐 또는 벤질인 (R)배열의 화합물 또는 이의 약제학적으로 허용되는 염.
  3. 제1항에 있어서, 1-메틸-사이클로헥산카복실산(2-〔4-인돌릴〕-피페라진-1-일〕-1-페닐-에틸〕-아미드 또는 이의 약제학적으로 허용되는 염.
  4. 제1항에 있어서, (R)-1-메틸-사이클로헥산카복실산(2-〔4-인돌릴〕-피페라진-1-일〕-1-페닐-에틸)-아미드 또는 이의 약제학적으로 허용되는 염.
  5. 제1항에 있어서, (S)-1-메틸-사이클로헥산카복실산(2-〔4-인돌릴〕-피페라진-1-일〕-1-페닐-에틸)-아미드 또는 이의 약제학적으로 허용되는 염.
  6. 제1항에 있어서, 1-메틸-사이클로헥산카복실산(2-〔4-인돌릴〕-피페라진-1-일〕-1-(페닐메틸)-에틸아미드 또는 이의 약제학적으로 허용되는 염.
  7. 제1항에 있어서, (R)-1-메틸-사이클로헥산카복실산(2-〔4-인돌릴〕-피페라진-1-일〕-1-페닐메틸)-에틸아미드 또는 이의 약제학적으로 허용되는 염.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960010393A 1995-04-10 1996-04-08 4-인돌릴피페라지닐 유도체 KR960037677A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/419,333 1995-04-10
US08/419,333 US5519025A (en) 1995-04-10 1995-04-10 4-indolylpiperazinyl derivatives

Publications (1)

Publication Number Publication Date
KR960037677A true KR960037677A (ko) 1996-11-19

Family

ID=23661806

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960010393A KR960037677A (ko) 1995-04-10 1996-04-08 4-인돌릴피페라지닐 유도체

Country Status (14)

Country Link
US (1) US5519025A (ko)
EP (1) EP0737677A1 (ko)
JP (1) JPH08283262A (ko)
KR (1) KR960037677A (ko)
AU (1) AU5052296A (ko)
BR (1) BR9601295A (ko)
CA (1) CA2173693A1 (ko)
CZ (1) CZ102896A3 (ko)
IL (1) IL117858A0 (ko)
MX (1) MX9601326A (ko)
NO (1) NO961404L (ko)
NZ (1) NZ286340A (ko)
SK (1) SK45196A3 (ko)
ZA (1) ZA962821B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2756283A1 (fr) * 1996-11-27 1998-05-29 Pf Medicament Amines aromatiques d'arylpiperazines, leur preparation et leurs applications comme medicaments
DE69819266T2 (de) 1997-09-02 2004-07-29 Duphar International Research B.V. Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
EP0900792B1 (en) * 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
US6831084B1 (en) 1999-11-12 2004-12-14 Wyeth Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1A activity
JP2003517468A (ja) 1999-11-12 2003-05-27 ワイス セロトニン５−ｈｔ１ａ活性を有する分枝アダマンチルおよびノルアダマチルアリール−およびアラルキルピペラジン
US6696450B2 (en) * 2001-04-04 2004-02-24 Wyeth Serotonergic agents with long-acting in vivo effects
US7067518B2 (en) * 2002-09-05 2006-06-27 Wyeth Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641029A (en) * 1970-02-02 1972-02-08 American Cyanamid Co Substituted benzoxazolecarboxamides and benzothiazolecarboxamides
US3646048A (en) * 1970-02-02 1972-02-29 American Cyanamid Co N-(tert-aminoalkyl)-2-indenecarboxamides
CA1340113C (en) * 1988-05-24 1998-11-03 Magid A. Abou-Gharbia Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity
CA2004670A1 (en) * 1988-12-08 1990-06-08 Jan Hartog Anxiolytically active piperazine derivatives
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
US5340812A (en) * 1989-04-22 1994-08-23 John Wyeth & Brother, Limited Piperazine derivatives
KR0173310B1 (ko) * 1989-04-22 1999-02-01 폴 에이 리쳐 피페라진 유도체
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives

Also Published As

Publication number Publication date
NO961404D0 (no) 1996-04-09
JPH08283262A (ja) 1996-10-29
MX9601326A (es) 1997-04-30
AU5052296A (en) 1996-10-24
CA2173693A1 (en) 1996-10-11
NO961404L (no) 1996-10-11
US5519025A (en) 1996-05-21
CZ102896A3 (en) 1996-10-16
BR9601295A (pt) 1998-01-13
EP0737677A1 (en) 1996-10-16
NZ286340A (en) 1997-06-24
IL117858A0 (en) 1996-08-04
ZA962821B (en) 1997-10-09
SK45196A3 (en) 1997-04-09

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