DK1075461T3 - Perfluorerede estere af alkanoyl-L-carnitin til fremstillingen af kationiske lipider til den intracellulære levering af farmakologisk aktive forbindelser - Google Patents

Perfluorerede estere af alkanoyl-L-carnitin til fremstillingen af kationiske lipider til den intracellulære levering af farmakologisk aktive forbindelser

Info

Publication number
DK1075461T3
DK1075461T3 DK99921126T DK99921126T DK1075461T3 DK 1075461 T3 DK1075461 T3 DK 1075461T3 DK 99921126 T DK99921126 T DK 99921126T DK 99921126 T DK99921126 T DK 99921126T DK 1075461 T3 DK1075461 T3 DK 1075461T3
Authority
DK
Denmark
Prior art keywords
carnitine
alkanoyl
active compounds
pharmacologically active
cationic lipids
Prior art date
Application number
DK99921126T
Other languages
English (en)
Inventor
Maria Ornella Tinti
Claudio Pisano
Mose Santaniello
Lucia Critelli
Nazareno Scafetta
Maria Grazia Cima
Andrea Pucci
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK1075461T3 publication Critical patent/DK1075461T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK99921126T 1998-05-06 1999-05-04 Perfluorerede estere af alkanoyl-L-carnitin til fremstillingen af kationiske lipider til den intracellulære levering af farmakologisk aktive forbindelser DK1075461T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT98RM000293A IT1299172B1 (it) 1998-05-06 1998-05-06 Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti
EP99921126A EP1075461B1 (en) 1998-05-06 1999-05-04 Perfluorinated esters of alkanoyl l-carnitine for the preparation of cationic lipids for the intracellular delivery of pharmacologically active compounds

Publications (1)

Publication Number Publication Date
DK1075461T3 true DK1075461T3 (da) 2004-12-06

Family

ID=11405901

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99921126T DK1075461T3 (da) 1998-05-06 1999-05-04 Perfluorerede estere af alkanoyl-L-carnitin til fremstillingen af kationiske lipider til den intracellulære levering af farmakologisk aktive forbindelser

Country Status (13)

Country Link
US (1) US6476243B1 (da)
EP (1) EP1075461B1 (da)
JP (1) JP4366014B2 (da)
KR (1) KR100573008B1 (da)
AT (1) ATE272047T1 (da)
AU (1) AU3846599A (da)
CA (1) CA2329659C (da)
DE (1) DE69918974T2 (da)
DK (1) DK1075461T3 (da)
ES (1) ES2226384T3 (da)
IT (1) IT1299172B1 (da)
PT (1) PT1075461E (da)
WO (1) WO1999057094A2 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1306129B1 (it) 1999-04-13 2001-05-30 Sigma Tau Ind Farmaceuti Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
IT1316990B1 (it) * 2000-02-17 2003-05-26 Sigma Tau Ind Farmaceuti Metodo per aumentare l'espressione genica per geni trasfettati.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1116037B (it) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1258370B (it) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
US5846516A (en) * 1992-06-03 1998-12-08 Alliance Pharmaceutial Corp. Perfluoroalkylated amphiphilic phosphorus compounds: preparation and biomedical applications
FR2694195B1 (fr) * 1992-07-30 1994-09-23 Sederma Sa Nouvelles compositions cosmétiques amincissantes.

Also Published As

Publication number Publication date
IT1299172B1 (it) 2000-02-29
ITRM980293A1 (it) 1999-11-06
US6476243B1 (en) 2002-11-05
DE69918974T2 (de) 2005-08-11
EP1075461A2 (en) 2001-02-14
ITRM980293A0 (it) 1998-05-06
WO1999057094A2 (en) 1999-11-11
CA2329659A1 (en) 1999-11-11
JP2002513779A (ja) 2002-05-14
AU3846599A (en) 1999-11-23
JP4366014B2 (ja) 2009-11-18
PT1075461E (pt) 2004-11-30
ES2226384T3 (es) 2005-03-16
KR20010043234A (ko) 2001-05-25
CA2329659C (en) 2010-07-20
DE69918974D1 (de) 2004-09-02
ATE272047T1 (de) 2004-08-15
WO1999057094A3 (en) 2000-01-27
KR100573008B1 (ko) 2006-04-24
EP1075461B1 (en) 2004-07-28

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