KR950700257A - 콜레시스토키닌 길항제로서 유용한 3-페닐우레이도-아제핀-2-온 및 벤즈아제핀-2-온(3-phenylureido-azepin-2-ones and-benzazepin-2-ones useful as cholecystokinin antagonists) - Google Patents

콜레시스토키닌 길항제로서 유용한 3-페닐우레이도-아제핀-2-온 및 벤즈아제핀-2-온(3-phenylureido-azepin-2-ones and-benzazepin-2-ones useful as cholecystokinin antagonists)

Info

Publication number
KR950700257A
KR950700257A KR1019940702565A KR19940702565A KR950700257A KR 950700257 A KR950700257 A KR 950700257A KR 1019940702565 A KR1019940702565 A KR 1019940702565A KR 19940702565 A KR19940702565 A KR 19940702565A KR 950700257 A KR950700257 A KR 950700257A
Authority
KR
South Korea
Prior art keywords
phenyl
formula
ureido
alkyl
compound
Prior art date
Application number
KR1019940702565A
Other languages
English (en)
Korean (ko)
Inventor
에이.로위 존
Original Assignee
알렌 제이.스피겔
화이자 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 알렌 제이.스피겔, 화이자 인코포레이티드 filed Critical 알렌 제이.스피겔
Publication of KR950700257A publication Critical patent/KR950700257A/ko

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019940702565A 1992-01-27 1992-12-16 콜레시스토키닌 길항제로서 유용한 3-페닐우레이도-아제핀-2-온 및 벤즈아제핀-2-온(3-phenylureido-azepin-2-ones and-benzazepin-2-ones useful as cholecystokinin antagonists) KR950700257A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82567792A 1992-01-27 1992-01-27
US825,677 1992-01-27
PCT/US1992/010720 WO1993015059A1 (en) 1992-01-27 1992-12-16 3-phenylureido-azepin-2-ones and -benzazepin-2-ones useful as cholecystokinin antagonists

Publications (1)

Publication Number Publication Date
KR950700257A true KR950700257A (ko) 1995-01-16

Family

ID=25244657

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940702565A KR950700257A (ko) 1992-01-27 1992-12-16 콜레시스토키닌 길항제로서 유용한 3-페닐우레이도-아제핀-2-온 및 벤즈아제핀-2-온(3-phenylureido-azepin-2-ones and-benzazepin-2-ones useful as cholecystokinin antagonists)

Country Status (19)

Country Link
EP (1) EP0625145A1 (pt)
JP (1) JPH07503465A (pt)
KR (1) KR950700257A (pt)
CN (1) CN1074903A (pt)
AU (1) AU3276193A (pt)
BR (1) BR9207071A (pt)
CA (1) CA2117367A1 (pt)
CZ (1) CZ391092A3 (pt)
FI (1) FI943513A0 (pt)
HU (1) HUT70496A (pt)
IL (1) IL104472A0 (pt)
MX (1) MX9300409A (pt)
NO (1) NO942775L (pt)
NZ (1) NZ245759A (pt)
RU (1) RU94038063A (pt)
TW (1) TW213901B (pt)
WO (1) WO1993015059A1 (pt)
YU (1) YU4393A (pt)
ZA (1) ZA93582B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2097688A1 (es) * 1993-07-14 1997-04-01 Pfizer Hexahidroazepinonas y tetrahidrobenzazepinonas sustituidas.
DK0711283T3 (da) * 1993-07-26 1999-11-22 Pfizer Tetrahydro-1H-benzazepinoner og hexahydroazepinoner som selektive cholecystokinin-B-receptorantagonister
ATE206402T1 (de) * 1993-11-22 2001-10-15 Merck & Co Inc 3-acylaminobenzazepine
US5453424A (en) * 1993-11-22 1995-09-26 Merck & Co., Inc. Furanodiazepines
MX9702507A (es) * 1994-10-04 1997-07-31 Pfizer Nuevos intermedios y procedimientos para preparar antagonistas cck.
IL115589A0 (en) 1994-10-14 1996-01-19 Glaxo Spa Use of cck-b antagonists in pharmaceutical compositions
DE10153348A1 (de) * 2001-10-29 2003-05-08 Gruenenthal Gmbh Substituierte Benzo(b)azepin-2-on-Verbindungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
US4767756A (en) * 1987-07-17 1988-08-30 E. R. Squibb & Sons, Inc. 3-substituted benzazepines
EP0322779A3 (en) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Benzolactam compounds and pharmaceutical uses thereof
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck

Also Published As

Publication number Publication date
TW213901B (pt) 1993-10-01
HU9402195D0 (en) 1994-09-28
FI943513A (fi) 1994-07-26
YU4393A (sr) 1996-01-09
IL104472A0 (en) 1993-05-13
RU94038063A (ru) 1996-05-27
EP0625145A1 (en) 1994-11-23
CA2117367A1 (en) 1993-08-05
NO942775D0 (no) 1994-07-26
HUT70496A (en) 1995-10-30
WO1993015059A1 (en) 1993-08-05
JPH07503465A (ja) 1995-04-13
CZ391092A3 (en) 1994-01-19
BR9207071A (pt) 1995-12-05
CN1074903A (zh) 1993-08-04
FI943513A0 (fi) 1994-07-26
NO942775L (no) 1994-09-20
ZA93582B (en) 1994-07-27
MX9300409A (es) 1993-07-01
AU3276193A (en) 1993-09-01
NZ245759A (en) 1997-06-24

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KR950700257A (ko) 콜레시스토키닌 길항제로서 유용한 3-페닐우레이도-아제핀-2-온 및 벤즈아제핀-2-온(3-phenylureido-azepin-2-ones and-benzazepin-2-ones useful as cholecystokinin antagonists)
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E601 Decision to refuse application