KR940014384A - 항바이러스제로서의 페녹시- 및 페녹시알킬-피페리딘 - Google Patents

항바이러스제로서의 페녹시- 및 페녹시알킬-피페리딘 Download PDF

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Publication number
KR940014384A
KR940014384A KR1019930018259A KR930018259A KR940014384A KR 940014384 A KR940014384 A KR 940014384A KR 1019930018259 A KR1019930018259 A KR 1019930018259A KR 930018259 A KR930018259 A KR 930018259A KR 940014384 A KR940014384 A KR 940014384A
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KR
South Korea
Prior art keywords
alkyl
hydrogen
methyl
compound
halogen
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KR1019930018259A
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English (en)
Inventor
도미니크 다이아나 가이
Original Assignee
폴 이. 듀퐁
스터링 윈드롭 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 폴 이. 듀퐁, 스터링 윈드롭 인코포레이티드 filed Critical 폴 이. 듀퐁
Publication of KR940014384A publication Critical patent/KR940014384A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

본 발명은 신규의 치환된 페녹시-페페리디닐 및 페녹시 알킬피페리디닐 화합물, 그의 약학 조성물, 및 바이러스 감염의 치료 또는 예방법에 관한 것이다.

Description

항바이러스제로서의 페녹시- 및 페녹시알킬 -피페리딘
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식( I ) 의 화합물 또는 그의 약학적으로 허용가능한 산부가염 :
    상기식에서, R1은
    중에서 선택되고 ; Y는 결합 또는 저급 - 알킬렌이고 ; R2및 R3는 독립적으로 수소, 저급 - 알킬 또는 할로겐이고 ; R4는
    이고 ; R5는 수소, 할로겐 또는 저급-알킬이고 ; R6은 수소, 할로겐 또는 저급-알킬이고 ; R7은 수소 또는 저급 - 알킬이고 ; R8은 수소 저급-알킬 또는 트리플루오로메틸이고 ; R9는 저급-알킬이고 ; R10은 저급-알킬, 디플루오로메틸 또는 트리플루오로메틸이다.
  2. 제 1항에 있어서, R1이인 화합물.
  3. 제 2항에 있어서, Y가 결합, 메틸렌 또는 에틸렌인 화합물.
  4. 제 3항에 있어서, R4가 2-R7-5-테트라졸릴이고, R2, R3, R5및 R6가 수소 또는 저급-알킬인 화합물.
  5. 제 4항에 있어서, R2, R3, R5,R6및 R7이 수소 또는 메틸인 화합물.
  6. 제 5항에 있어서, R1이 5-메틸-2-피리딜이고, R2및 R3가 수소이고, R4가 2-메틸-5-테트라졸릴이고, Y가 결합이거나 ; 또는 R1이 2-메틸-4-피리딜이고, R2가 5-메틸이고, R3가 3-메틸이고, R4가 2-메틸-5-테트라졸릴이고, Y가 에틸렌이거나 ; 또는 R1이 5-메틸-2-피리딜이고, R2및 R3가 수소이고, R4가 2-메틸-5-테트라졸릴이고, Y가 에닐렌인 화합물.
  7. 제 3항에 있어서, R4가 COOR9인 화합물.
  8. 제 7항에 있어서 R1이 5-메틸-2-피리딜이고, R2및 R3가 수소이고, R9가 에틸이고, Y가 에틸렌인 화합물.
  9. 피코르나바이러스 감염의 치료약제를 제조하기 위한, 제 1 항 내지 제 8 항 중 어느 한 항에 따른 화합물의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930018259A 1992-12-30 1993-09-10 항바이러스제로서의 페녹시- 및 페녹시알킬-피페리딘 KR940014384A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/998,498 US5364865A (en) 1992-12-30 1992-12-30 Phenoxy- and phenoxyalkyl-piperidines as antiviral agents
US998,498 1992-12-30

Publications (1)

Publication Number Publication Date
KR940014384A true KR940014384A (ko) 1994-07-18

Family

ID=25545290

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930018259A KR940014384A (ko) 1992-12-30 1993-09-10 항바이러스제로서의 페녹시- 및 페녹시알킬-피페리딘

Country Status (19)

Country Link
US (1) US5364865A (ko)
EP (1) EP0605031B1 (ko)
JP (1) JPH06211839A (ko)
KR (1) KR940014384A (ko)
AT (1) ATE155465T1 (ko)
AU (1) AU664640B2 (ko)
CA (1) CA2106728A1 (ko)
CZ (1) CZ283070B6 (ko)
DE (1) DE69312243D1 (ko)
FI (1) FI935517A (ko)
HU (1) HUT65837A (ko)
IL (1) IL107961A0 (ko)
MX (1) MX9306110A (ko)
MY (1) MY109337A (ko)
NO (1) NO934536L (ko)
NZ (1) NZ248536A (ko)
RU (1) RU2125565C1 (ko)
SK (1) SK279472B6 (ko)
TW (1) TW256835B (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
WO1997028128A1 (en) * 1996-02-02 1997-08-07 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
UA56197C2 (uk) * 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
EP0966462B1 (en) 1997-02-13 2003-06-11 AstraZeneca AB Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
US6440972B1 (en) 1997-02-13 2002-08-27 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
ATE245641T1 (de) * 1998-02-17 2003-08-15 Tularik Inc Antivirale pyrimidinderivate
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
KR100804452B1 (ko) * 2004-03-31 2008-02-20 닛뽕소다 가부시키가이샤 환형 아민 화합물 및 유해 생물 방제제
BRPI0509292B1 (pt) * 2004-03-31 2015-06-23 Nippon Soda Co Composto de amina cíclica e composição
CN1887875B (zh) * 2005-06-30 2011-04-06 深圳市东阳光实业发展有限公司 哒嗪胺衍生物及其用于制备小rna病毒抑制剂的用途
KR20080044296A (ko) * 2005-09-16 2008-05-20 아레나 파마슈티칼스, 인크. 대사 조절제 및 이와 관련된 장애의 치료
JP4871290B2 (ja) * 2005-10-06 2012-02-08 日本曹達株式会社 架橋環状アミン化合物および有害生物防除剤
KR20080087833A (ko) * 2005-12-21 2008-10-01 쉐링 코포레이션 히스타민 ｈ３ 길항제로서 유용한 페녹시피페리딘 및 이의유사체
TW200811147A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
TW200811140A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
CA2672059A1 (en) * 2006-12-14 2008-06-26 Merck & Co., Inc. Acyl bipiperidinyl compounds, compositions containing such compounds and methods of treatment
KR101726819B1 (ko) 2014-10-27 2017-04-13 동아에스티 주식회사 Gpr119 작용 활성을 갖는 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약제학적 조성물

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US4861791A (en) * 1983-08-29 1989-08-29 Sterling Drug Inc. Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents
MY104343A (en) * 1987-11-23 1994-03-31 Janssen Pharmaceutica Nv Novel pyridizinamine deravatives
US4992433A (en) * 1987-11-23 1991-02-12 Janssen Pharmaceutica N.V. Novel pyridazinamine derivatives
JO1645B1 (en) * 1989-12-26 1991-11-27 شركة جانسين فارماسوتيكا ان. في Pyridazine compounds are antibacterial viruses
US5100893A (en) * 1990-04-18 1992-03-31 Janssen Pharmaceutica N.V. Antipicornaviral pyridazinamines
US5242924A (en) * 1992-07-02 1993-09-07 Sterling Winthrop Inc. Tetrazolyl-(phenoxy and phenoxyalkyl)-piperidinylpyridazines as antiviral agents

Also Published As

Publication number Publication date
AU664640B2 (en) 1995-11-23
EP0605031A1 (en) 1994-07-06
TW256835B (ko) 1995-09-11
SK149893A3 (en) 1994-07-06
MY109337A (en) 1997-01-31
AU4497293A (en) 1994-07-14
US5364865A (en) 1994-11-15
ATE155465T1 (de) 1997-08-15
CZ283070B6 (cs) 1997-12-17
FI935517A0 (fi) 1993-12-09
SK279472B6 (sk) 1998-11-04
NO934536L (no) 1994-07-01
RU2125565C1 (ru) 1999-01-27
CZ283993A3 (en) 1994-07-13
NZ248536A (en) 1994-08-26
MX9306110A (es) 1994-06-30
EP0605031B1 (en) 1997-07-16
JPH06211839A (ja) 1994-08-02
NO934536D0 (no) 1993-12-10
DE69312243D1 (de) 1997-08-21
IL107961A0 (en) 1994-04-12
CA2106728A1 (en) 1994-07-01
HUT65837A (en) 1994-07-28
HU9303783D0 (en) 1994-04-28
FI935517A (fi) 1994-07-01

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