KR930004476A - 인자(xiii)의 정제방법, 인자(xiiia)에 대한 모노클로날 항체, 이의 제조방법 및 용도 - Google Patents
인자(xiii)의 정제방법, 인자(xiiia)에 대한 모노클로날 항체, 이의 제조방법 및 용도 Download PDFInfo
- Publication number
- KR930004476A KR930004476A KR1019920014956A KR920014956A KR930004476A KR 930004476 A KR930004476 A KR 930004476A KR 1019920014956 A KR1019920014956 A KR 1019920014956A KR 920014956 A KR920014956 A KR 920014956A KR 930004476 A KR930004476 A KR 930004476A
- Authority
- KR
- South Korea
- Prior art keywords
- factor
- xiii
- monoclonal antibody
- methods
- monoclonal antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/104—Aminoacyltransferases (2.3.2)
- C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 인자(Ⅹ Ⅲ)또는 (Ⅹ Ⅲ A)를 함유하는 용액을 지지체 물질(친화성 물질)에 결합된 인자(Ⅹ Ⅲ A)에 대한 모노클로날 항체와 접촉시키고, 서로로부터 친화성 물질 및 액체를 분리하여, 친화성 물질로부터 인자(Ⅹ Ⅲ)또는 (Ⅹ Ⅲ A)를 생물학적으로 활성인 형태로 용출함을 특징으로 하여, 면역친화성 크로마토그래피에 의해 응고 인자(Ⅹ Ⅲ)또는 (Ⅹ Ⅲ A)를 정제하는 방법.
- 제1항에 있어서, 모노클로날 항체의 면역반응성 단편 또는 유도체를 지지체 물질에 결합시키는 방법.
- 제1항에 있어서, IgG 부류의 모노클로날 항체가 사용되는 방법.
- 제1항 내지 제3항중의 어느 한 항에 있어서, 0.5내지 3mol/ℓ의 알칼리 금속 또는 알칼리 토금속염을 함유하는 완충액을 용출용을 사용하는 방법.
- IgM 부류를 제외한, 인자(Ⅹ Ⅲ A)에 대한 모노클로날 항체.
- 제5항에 있어서, IgM 부류인 모노클로날 항체.
- 제5항에 있어서, 지지체 물질에 결합된 모노클로날 항체.
- 인자(Ⅹ Ⅲ) 또는 (Ⅹ Ⅲ A)를 정제하기 위한 인자(Ⅹ Ⅲ A)에 대한 모노클로날 항체 또는 이러한 유형의 항체의 단편 또는 유도체이 용도.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4127841A DE4127841A1 (de) | 1991-08-22 | 1991-08-22 | Verfahren zur reinigung von faktor xiii, monoklonale antikoerper gegen faktor xiiia, ihre herstellung und verwendung |
DEP4127841.0 | 1991-08-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR930004476A true KR930004476A (ko) | 1993-03-22 |
KR100245542B1 KR100245542B1 (ko) | 2000-02-15 |
Family
ID=6438873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920014956A KR100245542B1 (ko) | 1991-08-22 | 1992-08-20 | 응고 인자 xiii 또는 xiiia의 정제방법 및 인자 xiiia에 대한 모노클로날 항체 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5688919A (ko) |
EP (1) | EP0529348B1 (ko) |
JP (1) | JPH05268990A (ko) |
KR (1) | KR100245542B1 (ko) |
AT (1) | ATE226595T1 (ko) |
AU (1) | AU649868B2 (ko) |
CA (1) | CA2076557C (ko) |
DE (2) | DE4127841A1 (ko) |
ES (1) | ES2183803T3 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100389197B1 (ko) * | 2000-03-17 | 2003-06-27 | 유지현 | 실내의 매연 농도에 따라 다단식으로 자동 작동되는환풍방법 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6660486B2 (en) * | 2001-05-31 | 2003-12-09 | Bio-Rad Laboratories, Inc. | FXIII detection for verifying serum sample and sample size and for detecting dilution |
US20070208163A1 (en) * | 2003-07-10 | 2007-09-06 | Novo Nordisk A/S | Method for treatment of protein precipitates |
CN110382547B (zh) * | 2016-12-14 | 2023-06-06 | 盼展生物技术有限公司 | 抗凝血因子viii抗体及其用途 |
WO2018111010A1 (ko) * | 2016-12-14 | 2018-06-21 | (주) 팬젠 | 항-혈액응고 제viii인자 항체 및 그 용도 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0087898A1 (en) * | 1982-02-22 | 1983-09-07 | Cancer Research Campaign Technology Limited | Antibodies and antigens useful in the diagnosis and treatment of cancer |
JPH01258700A (ja) * | 1988-04-05 | 1989-10-16 | Green Cross Corp:The | 血液凝固第4因子の精製方法 |
-
1991
- 1991-08-22 DE DE4127841A patent/DE4127841A1/de not_active Withdrawn
-
1992
- 1992-08-03 ES ES92113176T patent/ES2183803T3/es not_active Expired - Lifetime
- 1992-08-03 DE DE59209970T patent/DE59209970D1/de not_active Expired - Lifetime
- 1992-08-03 AT AT92113176T patent/ATE226595T1/de active
- 1992-08-03 EP EP92113176A patent/EP0529348B1/de not_active Expired - Lifetime
- 1992-08-20 KR KR1019920014956A patent/KR100245542B1/ko not_active IP Right Cessation
- 1992-08-21 CA CA002076557A patent/CA2076557C/en not_active Expired - Lifetime
- 1992-08-21 AU AU21246/92A patent/AU649868B2/en not_active Ceased
- 1992-08-21 JP JP4222336A patent/JPH05268990A/ja active Pending
-
1994
- 1994-07-15 US US08/275,656 patent/US5688919A/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100389197B1 (ko) * | 2000-03-17 | 2003-06-27 | 유지현 | 실내의 매연 농도에 따라 다단식으로 자동 작동되는환풍방법 |
Also Published As
Publication number | Publication date |
---|---|
KR100245542B1 (ko) | 2000-02-15 |
CA2076557C (en) | 2007-05-01 |
AU649868B2 (en) | 1994-06-02 |
ES2183803T3 (es) | 2003-04-01 |
EP0529348B1 (de) | 2002-10-23 |
AU2124692A (en) | 1993-02-25 |
EP0529348A1 (de) | 1993-03-03 |
ATE226595T1 (de) | 2002-11-15 |
DE59209970D1 (de) | 2002-11-28 |
US5688919A (en) | 1997-11-18 |
JPH05268990A (ja) | 1993-10-19 |
CA2076557A1 (en) | 1993-02-23 |
DE4127841A1 (de) | 1993-02-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8506902A1 (es) | Un procedimiento para la purificacion de un antigeno. | |
FI914298A0 (fi) | Monoklonala motkroppar foer metall- katjoner och smao molekyler. | |
ES2177632T3 (es) | Purificacion de anticuerpos. | |
EP0282317A3 (en) | Purified platelet-derived growth factor and methods for purification thereof | |
ES8802457A1 (es) | Un procedimiento para la preparacion de polipeptidos inmunogenicos | |
DE59208982D1 (de) | Verfahren zur Reinigung von IgG-monoklonalen Antikörpern | |
PT85490A (en) | Process for the preparation of specific monoclonal antibodies of apolipoprotein-b and essay processes for the determination o the above mentioned apolipoprotein | |
DE3581288D1 (de) | Antileishmania monoklonale antikoerper, diese antikoerper ausscheidende hybridomas, von diesen antikoerpern erkannte leishmaniaantigene, verfahren zur herstellung und verwendung von diesen monoklonalen antikoerpern und antigenen. | |
KR930004476A (ko) | 인자(xiii)의 정제방법, 인자(xiiia)에 대한 모노클로날 항체, 이의 제조방법 및 용도 | |
FR2560212B1 (fr) | Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps | |
MX9207459A (es) | Anticuerpos humanizados reactivos con gpiib/iiia. | |
Zeheb et al. | An analytical method for the selective retrieval of iminobiotin-derivatized plasma membrane proteins | |
KR910018041A (ko) | Pp4에 대한 모노클로날 항체, 이의 제조방법 및 용도 | |
DK0672685T3 (da) | Monoklonalt antistof specifik for tumor cytotoxisk faktor (TCF-11) | |
KR940005284A (ko) | 면역친화성 크로마토그래피에 의한 플라스미노겐 활성화제 억제제 2의 정제방법 | |
KR890016165A (ko) | 수도모나스 아에루기노사(Pseudomonas aeruginosa)에 대한 모노클로날 항체, 이의 제조방법 및 용도 | |
GR3030212T3 (en) | Platelet activating factor antagonists. | |
Naguib et al. | Purification of Chironex fleckeri venom components using Chironex immunoaffinity chromatography | |
DK134487D0 (da) | Monoklonalt antistof med affinitet for humant interleukin-2 | |
ES2080804T3 (es) | Separacion de anticuerpos anti-metal quelato. | |
EA199801011A1 (ru) | Моноклональное антитело против человеческого мр52 | |
Walker | Use of immobilized protein G to isolate IgG | |
AU3024289A (en) | The use of monoclonal antibodies (mabs) as procedure control for immunometric assays | |
KR950031110A (ko) | 인간 혈증 아포지단백질 비-100(b-100)에 대한 신규 단일클론 항체 및 이들의 생산을 위한 재조합 하이브리도마 세포주 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
N231 | Notification of change of applicant | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20101129 Year of fee payment: 12 |
|
LAPS | Lapse due to unpaid annual fee |