KR940005284A - 면역친화성 크로마토그래피에 의한 플라스미노겐 활성화제 억제제 2의 정제방법 - Google Patents
면역친화성 크로마토그래피에 의한 플라스미노겐 활성화제 억제제 2의 정제방법 Download PDFInfo
- Publication number
- KR940005284A KR940005284A KR1019930007716A KR930007716A KR940005284A KR 940005284 A KR940005284 A KR 940005284A KR 1019930007716 A KR1019930007716 A KR 1019930007716A KR 930007716 A KR930007716 A KR 930007716A KR 940005284 A KR940005284 A KR 940005284A
- Authority
- KR
- South Korea
- Prior art keywords
- plasminogen activator
- activator inhibitor
- immunoaffinity chromatography
- pai
- purification method
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L49/00—Packet switching elements
- H04L49/10—Packet switching elements characterised by the switching fabric construction
- H04L49/102—Packet switching elements characterised by the switching fabric construction using shared medium, e.g. bus or ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8132—Plasminogen activator inhibitors
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L49/00—Packet switching elements
- H04L49/10—Packet switching elements characterised by the switching fabric construction
- H04L49/103—Packet switching elements characterised by the switching fabric construction using a shared central buffer; using a shared memory
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L49/00—Packet switching elements
- H04L49/30—Peripheral units, e.g. input or output ports
- H04L49/3027—Output queuing
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- Computer Networks & Wireless Communication (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Data Exchanges In Wide-Area Networks (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
본 발명은 면역친화성 크로마토그래피에 의해 플라스미노겐 활성화제 억제제 2 (PAI-2)를 정제하는 방법 및 이러한 타입의 방법을 위해 적합한 모노클로날 항체에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- PA1-2를 함유하는 용액을 지지체 물질(친화성 물질)에 결합된, PAI-2에 대한 모노클로날 항체와 접촉시키고, 친화성 물질 및 액체를 서로로부터 분리시키고, 친화성 물질로부터 PAI-2를 생물학적 활성 형태로 용출시킴을 특징으로하여, 면역친화성 크로마토그래피에 의해 순수한 플라스미노겐 활성화제 억제제2(PAI-2)를 생물학적 활성 형태로 수득하는 방법.
- 제1항에 있어서, 모노클로날 항체의 면역반응성 단편 또는 유도체가 지지체 물질에 결합된 방법.
- 제1항에 있어서,pH 5.5 내지 8.5에서 전도성이 3mS미만인 완충액 또는 증류수를 사용하여 용출을 수행하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4214999.1 | 1992-05-06 | ||
| DE4214999A DE4214999C2 (de) | 1992-05-06 | 1992-05-06 | Reinigung von Plasminogen-Aktivator-Inhibitor 2 durch Immunaffinitätschromatographie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR940005284A true KR940005284A (ko) | 1994-03-21 |
Family
ID=6458317
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930007717A KR930024353A (ko) | 1992-05-06 | 1993-05-06 | 고속 패킷 교환기 |
| KR1019930007716A KR940005284A (ko) | 1992-05-06 | 1993-05-06 | 면역친화성 크로마토그래피에 의한 플라스미노겐 활성화제 억제제 2의 정제방법 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930007717A KR930024353A (ko) | 1992-05-06 | 1993-05-06 | 고속 패킷 교환기 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5362857A (ko) |
| EP (1) | EP0568836A1 (ko) |
| JP (1) | JPH069695A (ko) |
| KR (2) | KR930024353A (ko) |
| AU (1) | AU3837193A (ko) |
| CA (1) | CA2095577A1 (ko) |
| DE (1) | DE4214999C2 (ko) |
| IL (1) | IL105610A0 (ko) |
| MX (1) | MX9302629A (ko) |
| NO (1) | NO931629L (ko) |
| NZ (1) | NZ247533A (ko) |
| ZA (1) | ZA932443B (ko) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999049887A1 (en) | 1998-04-01 | 1999-10-07 | Biotech Australia Pty. Limited | Use of protease inhibitors for treating skin wounds |
| US7265248B1 (en) | 2005-04-29 | 2007-09-04 | Technology Innovations, Llc | Compositions and methods for the treatment of malaria |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5134065A (en) * | 1986-05-16 | 1992-07-28 | Monsanto Company | Tissue plasminogen activator inhibitor and method of purification |
| DE3713272A1 (de) * | 1987-04-18 | 1988-11-03 | Behringwerke Ag | Plasminogenaktivator-inhibitor, typ 2 (pai-2) |
| DE3929504A1 (de) * | 1989-09-06 | 1991-03-07 | Behringwerke Ag | Verfahren zur reinigung von plasminogen-aktivator-inhibitor 2 (pai-2) |
| US5204256A (en) * | 1989-09-06 | 1993-04-20 | Behringwerke Aktiengesellschaft | Process for the purification of plasminogen activator inhibitor 2 (pai-2) |
| EP0458937B1 (en) * | 1989-12-20 | 1997-08-13 | Biotech Australia Pty. Limited | Variants of pai-2 |
-
1992
- 1992-05-06 DE DE4214999A patent/DE4214999C2/de not_active Expired - Lifetime
-
1993
- 1993-04-05 ZA ZA932443A patent/ZA932443B/xx unknown
- 1993-04-08 EP EP93105854A patent/EP0568836A1/de not_active Withdrawn
- 1993-04-30 JP JP5103890A patent/JPH069695A/ja active Pending
- 1993-05-03 NZ NZ247533A patent/NZ247533A/en unknown
- 1993-05-04 US US08/056,393 patent/US5362857A/en not_active Expired - Fee Related
- 1993-05-04 MX MX9302629A patent/MX9302629A/es unknown
- 1993-05-05 NO NO93931629A patent/NO931629L/no unknown
- 1993-05-05 CA CA002095577A patent/CA2095577A1/en not_active Abandoned
- 1993-05-05 AU AU38371/93A patent/AU3837193A/en not_active Abandoned
- 1993-05-05 IL IL105610A patent/IL105610A0/xx unknown
- 1993-05-06 KR KR1019930007717A patent/KR930024353A/ko not_active Application Discontinuation
- 1993-05-06 KR KR1019930007716A patent/KR940005284A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0568836A1 (de) | 1993-11-10 |
| KR930024353A (ko) | 1993-12-22 |
| MX9302629A (es) | 1993-11-01 |
| DE4214999A1 (de) | 1993-11-11 |
| NO931629L (no) | 1993-11-08 |
| CA2095577A1 (en) | 1993-11-07 |
| IL105610A0 (en) | 1993-09-22 |
| NO931629D0 (no) | 1993-05-05 |
| AU3837193A (en) | 1993-11-11 |
| US5362857A (en) | 1994-11-08 |
| DE4214999C2 (de) | 1994-07-14 |
| NZ247533A (en) | 1994-12-22 |
| JPH069695A (ja) | 1994-01-18 |
| ZA932443B (en) | 1993-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |