KR930001910A - 혈압강하 배합물 - Google Patents

혈압강하 배합물 Download PDF

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Publication number
KR930001910A
KR930001910A KR1019920012932A KR920012932A KR930001910A KR 930001910 A KR930001910 A KR 930001910A KR 1019920012932 A KR1019920012932 A KR 1019920012932A KR 920012932 A KR920012932 A KR 920012932A KR 930001910 A KR930001910 A KR 930001910A
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KR
South Korea
Prior art keywords
formula
pyridazodizepine
alkyl
tetrahydronaphthalene derivative
combination
Prior art date
Application number
KR1019920012932A
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English (en)
Other versions
KR100260479B1 (ko
Inventor
클로겔 장-폴
뮐러 리타
오스테르리더 볼프강
Original Assignee
프리돌린 클라우스너, 롤란드 보어러
에프. 호프만-라 로슈 에이지
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Application filed by 프리돌린 클라우스너, 롤란드 보어러, 에프. 호프만-라 로슈 에이지 filed Critical 프리돌린 클라우스너, 롤란드 보어러
Publication of KR930001910A publication Critical patent/KR930001910A/ko
Application granted granted Critical
Publication of KR100260479B1 publication Critical patent/KR100260479B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
  • External Artificial Organs (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음.

Description

혈압강하 배합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실라자프릴 및 화합물 A의 단독 투여 효과 및 이들 2가지 물질의 동시 투여 효과를 예시하며,
제2도는 배합물의 상승 효과를 보여주고,
제3도는 실라자프릴, 화합물 A및 이들 성분의 배합물이 중막 면적에 미치는 효과를 비교한 것이다,

Claims (5)

  1. 유리 염기, 수화물 또는 약제학적으로 유용한 염의 형태의 일반식(I)의 테트라하이드로나프탈렌 유도체 및 일반식(II)의 피리다조디아제핀을 함유하는 약제학적 배합물.
    상기식에서, R1은 할로겐이고, R2는 저급-알콕시-저급-알킬카보닐옥시이며, R4는 알킬 잔기중의 C1-6-아르알킬 또는 할로겐, C1-6-알콕시 또는 페닐에 의해 임의로 일치환된 아릴 잔기로서의페닐이고, R5및 R6는 각각 독립적으로 수소 또는 C1-6알킬이며, R7및 R8은 각각 독립적으로 수소이거나 함께 옥소 그룹을 형성하고, X는 C2-8알킬렌이며, A는 C1-2알킬에 의해 질소 원자에서 임의로 치환된 벤즈 이미다졸릴이다.
  2. 제1항에 있어서, 피리다조디아제핀에 대한 테트라하이드로나프탈렌 유도체의 중량비가 20 : 1 내지 2 : 1인 배합물.
  3. 제1항에 있어서, 일반식(I)의 테트라하이드로나프탈렌 유도체로서 [1S,2S]-2-[2-[2-[[3-(2-벤즈이미다졸릴)프로필]메틸아미노]에틸]-6-플루오로-1,2,3,4-테트라하이드로-1-이소프로필-2-나프틸메톡시아세테이트 디하이드로클로라이드를 함유하는 배합물.
  4. 제1항에 있어서, 일반식(II)의 피리다조디아제핀으로서 9(S)-[1(S)-에톡시카보닐-3-페닐프로필아미노]옥타하이드로-10-옥소-6H-피리다조[1,2-a][1,2)디아제핀-1(S)-카복실산을 함유하는 배합물.
  5. 제1항 내지 제4항 중의 어느 한 항에 있어서, 순환계 질환, 특히 고혈압 및 이에 기인하는 질환의 억제 또는 예방에 동시에, 따로 또는 계획된 단계에 따라 사용하기 위한 배합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920012932A 1991-07-23 1992-07-21 혈압강하용 복합제제 KR100260479B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH219191 1991-07-23
CH02-191/91-2 1991-07-23

Publications (2)

Publication Number Publication Date
KR930001910A true KR930001910A (ko) 1993-02-22
KR100260479B1 KR100260479B1 (ko) 2000-07-01

Family

ID=4228024

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920012932A KR100260479B1 (ko) 1991-07-23 1992-07-21 혈압강하용 복합제제

Country Status (31)

Country Link
US (1) US5620975A (ko)
EP (1) EP0524512B1 (ko)
JP (1) JPH0680009B2 (ko)
KR (1) KR100260479B1 (ko)
CN (1) CN1040505C (ko)
AT (1) ATE260661T1 (ko)
AU (1) AU656207B2 (ko)
BG (1) BG60949B1 (ko)
BR (1) BR9202830A (ko)
CA (1) CA2074039C (ko)
CZ (1) CZ281691B6 (ko)
DE (1) DE59209993D1 (ko)
DK (1) DK0524512T3 (ko)
ES (1) ES2215160T3 (ko)
HR (1) HRP930953B1 (ko)
HU (1) HU214029B (ko)
IE (1) IE922378A1 (ko)
IL (1) IL102541A (ko)
IS (1) IS3887A (ko)
MX (1) MX9204212A (ko)
MY (1) MY118064A (ko)
NO (1) NO301047B1 (ko)
NZ (1) NZ243577A (ko)
PT (1) PT524512E (ko)
RO (1) RO110905B (ko)
RU (1) RU2084225C1 (ko)
SK (1) SK278918B6 (ko)
TW (1) TW216770B (ko)
UY (1) UY23449A1 (ko)
YU (2) YU72392A (ko)
ZA (1) ZA925322B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0634175B1 (de) * 1993-07-15 2001-01-10 F. Hoffmann-La Roche Ag Pharmazeutische Kombination, die einen Hemmer des Renin-Angiotensin-Systems und einen Endothelin-Antagonisten enthält
IL131816A (en) 1997-04-04 2003-06-24 Exxon Res & Engineering Compan Composite structures having high containment strength
US6608097B2 (en) 2001-10-10 2003-08-19 Aryx Therapeutics Materials and methods for the treatment of hypertension and angina
US7687086B1 (en) 2003-02-28 2010-03-30 University Of Portland Method for obtaining taxanes
EP2537534B1 (en) 2011-06-22 2014-12-17 Hexal AG Esters of (1S,9S)-9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid and their therapeutic use.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
DE3542794A1 (de) * 1985-12-04 1987-06-11 Bayer Ag Antihypertensives kombinationspraeparat
CA1319144C (en) * 1986-11-14 1993-06-15 Quirico Branca Tetrahydronaphthalene derivatives
FR2607004B1 (fr) * 1986-11-20 1990-06-01 Synthelabo Compositions pharmaceutiques contenant du diltiazem et un inhibiteur de l'enzyme de conversion de l'angiotensine
US5110813A (en) * 1987-09-15 1992-05-05 Alcoholism And Drug Addiction Research Foundation Reduction of voluntary alcohol consumption by treatment with angiotensin converting enzyme inhibitors
US4871731A (en) * 1987-10-07 1989-10-03 Marion Laboratories, Inc. Captopril and diltiazem composition and the like
KR940005408B1 (ko) * 1990-12-03 1994-06-18 만도기계 주식회사 파워 윈도우 모우터 회전자의 선단부 흔들림 측정장치

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YU72392A (sh) 1997-05-28
NO301047B1 (no) 1997-09-08
AU656207B2 (en) 1995-01-27
NO922903D0 (no) 1992-07-22
SK278918B6 (sk) 1998-04-08
DK0524512T3 (da) 2004-07-05
CZ281691B6 (cs) 1996-12-11
ZA925322B (en) 1993-03-31
BR9202830A (pt) 1993-03-23
HU214029B (en) 1997-12-29
JPH05194217A (ja) 1993-08-03
HUT62792A (en) 1993-06-28
JPH0680009B2 (ja) 1994-10-12
AU2041692A (en) 1993-01-28
MY118064A (en) 2004-08-30
US5620975A (en) 1997-04-15
MX9204212A (es) 1993-08-01
ATE260661T1 (de) 2004-03-15
RU2084225C1 (ru) 1997-07-20
SK227092A3 (en) 1996-02-07
HU9202367D0 (en) 1992-10-28
CA2074039C (en) 2004-11-02
EP0524512A3 (en) 1993-09-01
IS3887A (is) 1993-01-24
PT524512E (pt) 2004-07-30
CN1068737A (zh) 1993-02-10
UY23449A1 (es) 1993-01-21
IL102541A (en) 1995-12-08
IL102541A0 (en) 1993-01-14
CA2074039A1 (en) 1993-01-24
EP0524512A2 (de) 1993-01-27
CZ227092A3 (en) 1993-02-17
KR100260479B1 (ko) 2000-07-01
BG96664A (bg) 1993-12-24
BG60949B1 (bg) 1996-07-31
RO110905B (ro) 1996-05-30
HRP930953B1 (en) 2003-06-30
YU49198B (sh) 2004-09-03
TW216770B (ko) 1993-12-01
CN1040505C (zh) 1998-11-04
ES2215160T3 (es) 2004-10-01
DE59209993D1 (de) 2004-04-08
NO922903L (no) 1993-01-25
HRP930953A2 (en) 1995-10-31
IE922378A1 (en) 1993-01-27
NZ243577A (en) 1994-09-27
EP0524512B1 (de) 2004-03-03

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