KR910014122A - 에토포시드-2-디메틸아미노 화합물의 동결건조 제제 - Google Patents

에토포시드-2-디메틸아미노 화합물의 동결건조 제제 Download PDF

Info

Publication number
KR910014122A
KR910014122A KR1019910000254A KR910000254A KR910014122A KR 910014122 A KR910014122 A KR 910014122A KR 1019910000254 A KR1019910000254 A KR 1019910000254A KR 910000254 A KR910000254 A KR 910000254A KR 910014122 A KR910014122 A KR 910014122A
Authority
KR
South Korea
Prior art keywords
acid
lyophilized formulation
alkali metal
salt
dimethylamino
Prior art date
Application number
KR1019910000254A
Other languages
English (en)
Inventor
가즈오 오오쓰기
다끼아끼 오오구미
Original Assignee
디께다 가즈히꼬
닛뽕 가야꾸 가부시기가이야
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 디께다 가즈히꼬, 닛뽕 가야꾸 가부시기가이야 filed Critical 디께다 가즈히꼬
Publication of KR910014122A publication Critical patent/KR910014122A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Abstract

내용 없음.

Description

에토포시드-2-디메틸아미노 화합물의 동결건조 제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. (1)비휘발성 산 및/또는 그 염 약 5~약 50W/W%, (2) 4-O-(2-데옥시-2-디메틸아미노-4,6-O-에틸리덴-β-D-클루코피라노실)-4′-데메틸-4-에피포도필로톡신 염산염 약 1~약 95W/W%을 함유하는 동결견조 제제.
  2. 제1항에 있어서, 증류수중에 재차 용해시켰을 경우 용액의 pH값이 약 3~ 약 5인 동결건조 제제.
  3. 제1항에 있어서, 비휘발성 산 및 그 염을 인산 및 그 염의 조합중에서 또는 탄소원자수가 6개인 옥시카르복실산, 탄소원자수가 4개인 디카르복실산 및 아미노아세트산 중에서 선택되는 산과 이들의 염의 조합중에서 선택하여서 되는 동결건조 제제.
  4. 제1항에 있어서, 비휘발성 산과 그 염이 인산과 그 알칼리 금속염 또는 시트르산과 그 알칼리 금속염인 동결건조 제제.
  5. 제1항에 있어서, 당이 탄소원자수가 5개 내지 6개인 당알코올 또는 이당류인 동결건조 제제.
  6. 제1항에 있어서, 당을 락토오스, 말토오스, 수크로오스 및 만니톨 중에서 선택하여서 되는 동결건조 제제.
  7. (1)인산 및 그 알칼리 금속염 약 15~약 35W/W%, (2) 4-D-(2-데옥시-2-디메틸아미노-4,6-O-에틸리덴-β-D-클루코피라노실)-4′-데메틸-4-에피포도필로톡신 염산염 약 15~약 80W/W% 및 (3)락토오스 0~약 70W/W%을 함유하는 동결견조 제제.
  8. (10인산 및 그 알칼리 금속염 약 2- ~약 30W/W%, (2) 4-O-(2-데옥시-2-디메틸아미노-4,6-O-에틸리덴-β-D-클루코피라노실)-4′-데메틸-4-에피포도필로톡신 염산염 약 30~약 50W/W% 및 (3)락토오스 약30~약 50W/W%을 함유하는 동결견조 제제.
  9. 제8항에 있어서, 증류수에 재차 용해시켰을 경우 용액의 pH값이 약 3~ 약 5인 동결건조 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910000254A 1990-01-19 1991-01-10 에토포시드-2-디메틸아미노 화합물의 동결건조 제제 KR910014122A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP02-8153 1990-01-19
JP815390 1990-01-19

Publications (1)

Publication Number Publication Date
KR910014122A true KR910014122A (ko) 1991-08-31

Family

ID=11685378

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910000254A KR910014122A (ko) 1990-01-19 1991-01-10 에토포시드-2-디메틸아미노 화합물의 동결건조 제제

Country Status (8)

Country Link
US (1) US5326753A (ko)
EP (1) EP0438091B1 (ko)
KR (1) KR910014122A (ko)
CN (1) CN1053550A (ko)
AU (1) AU632654B2 (ko)
DE (1) DE69100334T2 (ko)
ES (1) ES2060208T3 (ko)
HU (1) HU205857B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07309761A (ja) * 1994-05-20 1995-11-28 Kyowa Hakko Kogyo Co Ltd デュオカルマイシン誘導体の安定化法
AU1678900A (en) * 1998-08-11 2000-03-06 All India Institute Of Medical Sciences A novel liposomal formulation useful in treatment of cancer and other proliferation diseases
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
EG24184A (en) 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
EP3035697B1 (en) 2014-12-17 2019-02-06 GN Audio A/S Headset ear hook with wire holder
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH481094A (de) * 1966-12-13 1969-11-15 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
US4713246A (en) * 1984-03-19 1987-12-15 Bristol-Myers Company Etoposide oral dosage form
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
JPS61227590A (ja) * 1985-04-02 1986-10-09 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフイロトキシン誘導体
US4927638A (en) * 1986-10-08 1990-05-22 Bristol-Myers Company Etoposide solutions
US4772589A (en) * 1986-10-29 1988-09-20 Bristol-Myers Etoposide solution in NMP
US4853467A (en) * 1987-05-19 1989-08-01 Bristol-Myers Company Nitrogen containing derivatives of epipodophyllotoxin glucosides
US4935504A (en) * 1987-12-18 1990-06-19 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-acyl derivatives
ES2061891T3 (es) * 1988-11-16 1994-12-16 Nippon Kayaku Kk Cristales de dihidrato de dihidrocloruro de compuesto de etoposido-2-dimetilamina y un procedimiento para su produccion.

Also Published As

Publication number Publication date
EP0438091A2 (en) 1991-07-24
AU6945191A (en) 1991-07-25
DE69100334D1 (de) 1993-10-14
CN1053550A (zh) 1991-08-07
HU205857B (en) 1992-07-28
AU632654B2 (en) 1993-01-07
HU910166D0 (en) 1991-08-28
HUT56499A (en) 1991-09-30
ES2060208T3 (es) 1994-11-16
US5326753A (en) 1994-07-05
EP0438091B1 (en) 1993-09-08
DE69100334T2 (de) 1994-03-10
EP0438091A3 (en) 1991-10-16

Similar Documents

Publication Publication Date Title
PT814782E (pt) Composicao farmaceutica estabilizada com um agente basico
KR910014122A (ko) 에토포시드-2-디메틸아미노 화합물의 동결건조 제제
KR890004680A (ko) 좌 약
DE68924761T2 (de) Neue coenzym unabhängige l-sorbosone dehydrogenase.
EP0941999A3 (en) Preparation of azithromycin dihydrate
CA2210076A1 (en) Enrofloxacin injection or infusion solutions
KR910016767A (ko) 신규한 펩티드
AU6135898A (en) Enzymatic conversion of alpha-hydroxynitriles to the corresponding alpha-hydroxyamides, acids or acid salts
IT1274026B (it) Composizione antitosse
ATE162188T1 (de) Herstellung von derivaten von n-acetyl neuraminicsäure
DE69030044D1 (de) Tetrazolessigsäurederivate mit Aldosereduktase inhibierender Wirkung
KR900011470A (ko) 외용제
KR960014092A (ko) 이미노카르본산염 수용액 조성물 및 이미노카르본산염의 취급방법
ATE88902T1 (de) Polyprenylverbindung enthaltende zusammensetzung fuer weiche kapseln.
KR840002346A (ko) 펩타이드의 제조방법
ATE149354T1 (de) Pharmazeutische zusammensetzung von stabilisiertem (leu 13>-motilin-hse
KR890009405A (ko) 비경구용 세파만돌나페이트 제제의 제조방법
KR860003011A (ko) (-)시스-1,2-에폭시프로필포스폰산과 아미노산과의 염을 함유하는 수용성 제약 조성물
KR920002755A (ko) 안정화된 과탄산나트륨 조성물
FR2747923B1 (fr) Composition contenant une benzodiazepine et un agent antipyretique, stabilisee par l'acide benzoique, un de ses sels ou l'un de ses derives
ES2184115T3 (es) Estabilizacion de perfluoro-alquil-cetonas.tonas
SE9601483L (sv) Beredning av komposition
TH15901S1 (th) ยาดม
RU94019970A (ru) Водный раствор спарфлоксацина, способ его получения и соль спарфлоксацина и фармацевтическая композиция
KR960021045A (ko) 페루릭산을 포함하는 b형 간염 치료제

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid