KR910009672A - 피리다진 유도체, 이의 제조방법 및 이것을 함유하는 약학 조성물 - Google Patents

피리다진 유도체, 이의 제조방법 및 이것을 함유하는 약학 조성물 Download PDF

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KR910009672A
KR910009672A KR1019900018663A KR900018663A KR910009672A KR 910009672 A KR910009672 A KR 910009672A KR 1019900018663 A KR1019900018663 A KR 1019900018663A KR 900018663 A KR900018663 A KR 900018663A KR 910009672 A KR910009672 A KR 910009672A
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substituted
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phenyl
methyl
straight
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브아쥬그렝 로베르
로제브로멩
뽈 깡 쟝
올리에로 도미니끄
죠르쥬 베르무트 까미유
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원본미기재
소시에떼 아노님 사노피
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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Abstract

내용 없음

Description

피리다진 유도체, 이의 제조방법 및 이것을 함유하는 약학 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기식(I)의 화합물 및 이의 무기 또는 유기산과의 염.
    [상기식에서, Ar은 R1및 R2로 치환된 페닐기, 또는 헤테로환식 라디칼로서, 예를들면 메틸 또는 메토기로 치환 또는 비치환된 피리딜기, 또는 염소, 메틸 또는 메톡시로 치환 또는 비치환된 티에닐기를 나타내고, R1및 R2각각은 독립적으로 수소, 할로겐, 트리플루오로메틸, 히드록실, C1∼C4알콕시 또는 C1∼C4알킬을 나타내고, R3은 직쇄 또는 측쇄 C1∼C4알킬, C3∼C7시클로알킬, 벤질, 펜에틸 또는 Ar′라디칼을 나타내며, Ar′는 R1및 R2로 치환된 페닐이고, R4는 하기식의 기를 나타낸다.
    (식중에서, X는 수소 또는 메틸을 나타내고, R5는 직쇄 C1∼C6알킬기를 나타내고, R6은 직쇄 C1∼C6알킬기를 나타내거나, 또는 R5및 R6은 이들이 부착된 질소 원자와 함께 모르폴린, 피롤리딘 또는 피페리딘에서 선택되는 헤테로환을 구성한다.)]
  2. 제1항에 있어서, Ar이 염소, 히드록실 또는 메톡시로2-위치에 치환 또는 비치환된 페닐을 나타내고, R3는 페닐 또는 n-프로필이고, R5및 R6각각은 에틸을 나타내고, n은 0이고, x1=H임을 특징으로 하는 식(I)의 화합물 및 무기 또는 유기산과의 염.
  3. 3-(2-디에틸아미노-2-메틸프로필)아미노-6-페닐-5-프로필 피리다진아미 및 이의 염.
  4. 3-(2-디에틸아미노-2-메틸프로필)아미노-5,6-디페닐 피리다진아민 및 이의 염.
  5. 아민R4NH2를 하기식(Ⅱ)의 6-클로로피리다진과 반응시키고, 경우에 따라서, 이렇게 수득된 화합물을 그의 무기 또는 유기산과의 염으로 전환시킴을 특징으로 하는 하기식(Ⅰ)의 화합물 또는 그의 무기 또는 유기산과의 염의 제조방법.
    [상기식에서, Ar은 R1및 R2로 치환된 페닐기, 또는 헤테로환식 라디칼로서, 예를들면 메틸 또는 메톡시로 치환 또는 비치환된 피리딜기, 또는 염소, 메틸 또는 메톡시로 치환 또는 비치환된 티에닐기를 나타내고, R1및 R2각각은 독립적으로 수소, 할로겐, 트리플루오로메틸, 히드록실, C1∼C4알콕시 또는 C1∼C4알킬을 나타내고, R3은 직쇄 또는 측쇄 C1∼C4알킬, C3∼C7시클로알킬, 벤질, 펜에틸 또는 Ar′라디칼을 나타내며, Ar′는 R1및 R2로 치환된 페닐이고, R4는 하기식의 기를 나타낸다.
    (식중에서, X는 수소 또는 메틸을 나타내고, R5는 직쇄 C1∼C6알킬기를 나타내고, R6은 직쇄 C1∼C6알킬기를 나타내거나, 또는 R5및 R6은 이들이 부착된 질소 원자와 함께 모르폴린, 피롤리딘 또는 피페리딘에서 선택되는 헤테로환을 구성한다.)]
  6. 활성성분으로서 제1 내지 4항중 어느 한 항에 따른 화합물을 함율함을 특징으로 하는 약학 조성물.
  7. 제6항에 있어서, 매 투여단위마다 0.5 내지 100㎎의 활성 성분을 함유함을 특징으로 하는 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900018663A 1989-11-17 1990-11-17 피리다진 유도체 이의 제조방법 및 이것을 함유하는 약학 조성물 KR0164599B1 (ko)

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Application Number Priority Date Filing Date Title
FR8915137A FR2654727B1 (fr) 1989-11-17 1989-11-17 Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR15137/89 1989-11-17
FR07533/90 1990-06-15
FR909007533A FR2663326B2 (fr) 1989-11-17 1990-06-15 Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR7533/90 1990-06-15

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KR910009672A true KR910009672A (ko) 1991-06-28
KR0164599B1 KR0164599B1 (ko) 1999-01-15

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FR2665442B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2676444B1 (fr) * 1991-05-16 1995-03-10 Sanofi Elf Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
WO1997026258A1 (en) * 1996-01-15 1997-07-24 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
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FR2904314A1 (fr) * 2006-07-26 2008-02-01 Centre Nat Rech Scient Composes pyridaziniques et pyrroliques lineaires, procedes d'obtention et applications
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) * 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
EP4129986A4 (en) * 2020-03-27 2024-05-22 Astellas Pharma Inc SUBSTITUTED PYRIDAZINE COMPOUND
WO2022166890A1 (zh) * 2021-02-08 2022-08-11 南京明德新药研发有限公司 取代的哒嗪苯酚类衍生物

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FR2510998B1 (fr) * 1981-08-07 1986-01-10 Sanofi Sa Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
DE3629929A1 (de) * 1986-09-03 1988-03-10 Thomae Gmbh Dr K Neue sulfonamido-aethylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
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FR2642648B1 (fr) * 1989-02-07 1991-06-21 Sanofi Sa Utilisation de derives d'alkyl-5 pyridazine comme medicaments actifs sur le systeme cholinergique

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GR3021933T3 (en) 1997-03-31
FR2663326A2 (fr) 1991-12-20
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ATE143010T1 (de) 1996-10-15
EP0429344A1 (fr) 1991-05-29
ES2094146T3 (es) 1997-01-16
EP0429344B1 (fr) 1996-09-18
HU207852B (en) 1993-06-28
NO178967B (no) 1996-04-01
FI905663A (fi) 1991-05-18
IL96384A (en) 1995-10-31
AU639043B2 (en) 1993-07-15
HUT56078A (en) 1991-07-29
DE69028602T2 (de) 1997-04-03
CA2030133C (ko) 1991-05-18
NZ236107A (en) 1992-10-28
LV11972A (lv) 1998-02-20
AR247557A1 (es) 1995-01-31
IE904145A1 (en) 1991-05-22
HU907178D0 (en) 1991-05-28
DK0429344T3 (ko) 1997-03-03
FI101881B1 (fi) 1998-09-15
AU6667290A (en) 1991-05-23
PT95902B (pt) 1998-01-30
NO904984D0 (no) 1990-11-16
FR2663326B2 (fr) 1992-10-16
NO178967C (no) 1996-07-10
KR0164599B1 (ko) 1999-01-15
PT95902A (pt) 1991-09-13
DE69028602D1 (de) 1996-10-24
HK1000597A1 (en) 1998-04-09
IE75697B1 (en) 1997-09-10
JPH03170465A (ja) 1991-07-24
FI905663A0 (fi) 1990-11-15
NO904984L (no) 1991-05-21
LV11972B (lv) 1998-04-20
FI101881B (fi) 1998-09-15
CA2030133A1 (en) 1991-05-18

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