KR890017246A - 크로만 유도체 - Google Patents
크로만 유도체 Download PDFInfo
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- KR890017246A KR890017246A KR1019890006017A KR890006017A KR890017246A KR 890017246 A KR890017246 A KR 890017246A KR 1019890006017 A KR1019890006017 A KR 1019890006017A KR 890006017 A KR890006017 A KR 890006017A KR 890017246 A KR890017246 A KR 890017246A
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- oxy
- formula
- chroman
- cyano
- trimethyl
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 일반식(I)의 크로만 유도체 및 그의 염.상기식에서 R1과 R8는 각각 A이고, R2는 H 또는 A이고, R1과 R2는 모두 3-6 탄소원자를 지닌 알킬렌이고, R3는 OH 또는 OAc이고, R4는 수소이고, R3와 R4는 각각 결합이고, R5는 A, F, Cl, Br, J, OH, OA, OAc, NO2, NH2, AcNH, HOOC 및/또는 AOOC가 하나 또는 둘 치환되어 있거나 치환되지 않은 피리딜-옥시, 피리다진일-옥시, 피리미딘일-옥시, 피라진일-옥시, 옥시-디히드로-피리닐-옥시, 옥소-디히드로-피라다진일-옥시, 옥소-디히드로-피리미딘일-옥시, 옥소-디히드로-피라진일-옥시, 1H-2-피리돈-1-일, 1H-6-피리다진온-1-일, 1H-2-피리미딘온-1-일, 1H-6-피리미딘온-1-일, 1H-2-피라진온-1-일, 3H- 또는 5H-2-피롤린온-1-일 또는 1H-2-티오피리돈-1-일 등의 치환기를 말하면 이들은 전체적 또는 부분적으로 수소화 되어 있다. R6와 R7은 각각 H, A, HO, AO, CHO, ACO, ACS, HOOC, AOOC, AO-CS, ACOO, A-CS-O, 1-6탄소원자를 지닌 히드록시알킬, 1-6 탄소원자를 지닌 머르캅토알킬, NO2,NH2,NHA,NA2,CN,F,Cl,Br,I,CF3,ASO,ASO2AOSO,AOSO2,AcNH,AOCONH,H2NSO,HANSO,A2NSO,H2NSO2,HANSO2,A2NSO2,H2NCO,HANCO,A2NCO,H2NCS,HANCS,A2NCS,ASONH,ASO2NH,AOSONH,AOSO2NH,ACO-알킬, 니트로알킬, 시아노일킬, A-C(=NOH) 또는 A-C(=NNH2)이고, A는 1-6 탄소원자를 지닌 알킬이고, 알킬은 1-6 탄소원자를 지닌 알킬렌이고, Ac는 1-8 탄소원자를 지닌 알칸오일 또는 7-11 탄소원자를 지닌 아로일이다.
- a) 2,2,3-트리메틸-4-(1H-2-피리돈-1-일)-6-시아노-크로만-3-올. b) 2,2,3-트리메틸-4-(1H-2-피리돈-1-일)-6-시아노-2H-크로만. c) 2,2,3-트리메틸-4-(2-히드록시-피라딜-옥시)-6-시아노-크로만-3-올. d) 2,2,3-트리메틸-4-(6-히드록시-3-피리다진일-옥시)-6-시아노-크로만-3-올. e) 2,2,3-트리메틸-4-(1,5-디히드로-1메틸-6-옥소-3-피리다진일-옥시)-6-시아노-크로만-3-올. f) 2,2,3-트리메틸-4-(1,6-디히드로-1-에틸-6-옥소-3-피리다진일-옥시)-6-시아노-크로만-3-올. g) 2,2,3-트리메틸-4-(2-피롤리돈-1-일)-6-옥소-3-피리다진일-옥시)-6-시아노-크로만-3-올. h) 2,2,3-트리메틸-4-(2-피롤리돈-1일)-6-옥소-3-피리다진-일-옥시)-6-시아노-2H-크로만.
- 일반식(Ⅱ)의 3,4-에폭시크로만을 일반식(Ⅱ)의 화합물 또는 이의 반응성 유도체중 하나와 반응시키고/시키거나 R3가 OH이고 R4가 수소인 일반식(I)의 화합물을 탈수하고/하거나, 일반식(I)에 있어서 R3,R5,R6및/또는 R7의 치환기중 하나 이상을 다른 R3,R5,R6및/또는 R7의 치환기로 전환 시키고/시키거나, 일반식(I)의 염기성 화합물을 산으로 처리하여 그의 산부가염증 하나로 전환시킴을 특징으로 하는 일반식(I)의 크로만 유도체의 제조방법.상기식에서 R5,R6,R7및 R8은 제1항의 주어진 의미와 같다.
- 일반식(I)의 화합물 및/또는 그의 생리학적으로 허용될 수 있는 염을 투여에 적합하도록 적어도 하나 이상의 고형, 액체형 또는 반고형의 부형제 또는 보호제와 혼합하거나 하나 이상의 다른 활성 화합물과 혼합물을 특징으로 하는 약제학적 제제의 제조방법.
- 적어도 하나 이상의 일반식(I)의 화합물 및/또는 그의 생리학적으로 허용될 수 있는 염을 포함하는 약제학적 제제.
- 질병 치료용으로서의 일반식(I)의 화합물.
- 일반식(I)의 화합물의 의약제조용으로의 용도.
- 일반식(I)의 화합물의 질병치료 용도.
- 일반식(Ⅳ)의 화합물.상기식에서, -X,Y-은 (a) -CO-CH2-, (b) -CO-CR10, (c) -CHOH-CHR8-, (d) -CH=CR8- (e)이고, R9는 CHO,ACO,AOOC,NO2,CN,Br,H2NCO 또는 NSS이고 R10은 탄소수 1-6의 알킬디엔이고, R1과 R2는 제1항의 주어진 바와 같다.
- a) 2,2-디메틸-6-시아노-크로만-4-온. b) 2,2,3-트리메틸-3,4-에폭시-시아노-크로만.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3815504A DE3815504A1 (de) | 1988-05-06 | 1988-05-06 | 4-n-heterocyclyl-chromanderivate, verfahren sowie zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln |
DEP3815504.4 | 1988-05-06 | ||
DE3835011A DE3835011A1 (de) | 1988-10-14 | 1988-10-14 | Chromanderivate |
DEP3835011.4 | 1988-10-14 |
Publications (2)
Publication Number | Publication Date |
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KR890017246A true KR890017246A (ko) | 1989-12-15 |
KR0150781B1 KR0150781B1 (ko) | 1998-10-15 |
Family
ID=25867854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890006017A KR0150781B1 (ko) | 1988-05-06 | 1989-05-04 | 크로만 유도체 |
Country Status (17)
Country | Link |
---|---|
US (1) | US5013853A (ko) |
EP (1) | EP0340718B1 (ko) |
JP (1) | JPH01319481A (ko) |
KR (1) | KR0150781B1 (ko) |
AR (1) | AR246966A1 (ko) |
AT (1) | ATE108786T1 (ko) |
AU (1) | AU628331B2 (ko) |
DE (1) | DE58908062D1 (ko) |
DK (1) | DK223289A (ko) |
ES (1) | ES2057010T3 (ko) |
FI (1) | FI93358C (ko) |
HU (1) | HU207311B (ko) |
IE (1) | IE63794B1 (ko) |
IL (1) | IL90198A (ko) |
NO (1) | NO174467C (ko) |
NZ (1) | NZ228991A (ko) |
PT (1) | PT90471B (ko) |
Families Citing this family (26)
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US5387587A (en) * | 1986-12-23 | 1995-02-07 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chroman derivatives |
DE3835011A1 (de) * | 1988-10-14 | 1990-04-19 | Merck Patent Gmbh | Chromanderivate |
US5284838A (en) * | 1987-06-23 | 1994-02-08 | Elf Sanofi | Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma |
JPH03500542A (ja) * | 1988-05-09 | 1991-02-07 | ビーチャム グループ ピーエルシー | 新規な化合物及び治療法 |
EP0346724A1 (de) * | 1988-06-16 | 1989-12-20 | MERCK PATENT GmbH | Chromanderivate |
DE3918041A1 (de) * | 1989-06-02 | 1990-12-06 | Merck Patent Gmbh | Chromanderivate |
DE3923839A1 (de) * | 1989-07-19 | 1991-01-31 | Beiersdorf Ag | Benzopyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
US5223629A (en) * | 1989-07-21 | 1993-06-29 | Alkaloida Vegyeszeti Gyar | Process for the preparation of anti-hypertensive benzopyran |
DE3924417A1 (de) * | 1989-07-24 | 1991-01-31 | Merck Patent Gmbh | Chromanderivate |
DE3936616A1 (de) * | 1989-11-03 | 1991-05-08 | Merck Patent Gmbh | Verfahren zur enantiomerentrennung von benzopyranderivaten |
DE4038752A1 (de) * | 1990-12-05 | 1992-06-11 | Merck Patent Gmbh | Chromanderivate |
NZ240933A (en) * | 1990-12-21 | 1993-05-26 | Ortho Pharma Corp | Preparing enantiomerically pure thienopyran derivatives |
US5332168A (en) * | 1991-04-01 | 1994-07-26 | Fuji Photo Film Co., Ltd. | Photographic film cassette with improved separator claw |
JP3442815B2 (ja) * | 1992-05-13 | 2003-09-02 | 第一製薬株式会社 | ジアザビシクロアルケン誘導体 |
WO1994008536A1 (en) * | 1992-10-21 | 1994-04-28 | Gynetech Laboratories, Inc. | Vaginal sponge delivery system |
GB9316111D0 (en) * | 1993-08-04 | 1993-09-22 | Pfizer Ltd | Benzopyrans |
US5837702A (en) * | 1993-10-07 | 1998-11-17 | Bristol-Myers Squibb Co. | 4-arylamino-benzopyran and related compounds |
EP0677519A4 (en) * | 1993-11-10 | 1996-04-03 | Japan Tobacco Inc | CHROMAN DERIVATIVE AND THERAPEUTIC USE THEREOF. |
US5869478A (en) * | 1995-06-07 | 1999-02-09 | Bristol-Myers Squibb Company | Sulfonamido substituted benzopyran derivatives |
US5612323A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phosphinic ester substituted benzopyran derivatives |
US5612370A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phenylglycine and phenylalaninen amido benzopyran derivatives |
US5629429A (en) * | 1995-06-07 | 1997-05-13 | Bristol-Myers Squibb Company | Process for preparing 4-arylamino-benzopyran and related compounds |
EP1218367A1 (en) * | 1999-10-05 | 2002-07-03 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
FR2820974B1 (fr) * | 2001-02-21 | 2004-02-13 | Pharmascience Lab | Composition topique comprenant une solution vraie contenant un derive de chromane ou de chromene, son procede de preparation et son utilisation cosmetique et therapeutique |
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US10981951B2 (en) | 2014-01-31 | 2021-04-20 | Mayo Foundation For Medical Education And Research | Therapeutics for the treatment of glaucoma |
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-
1989
- 1989-05-01 AU AU33901/89A patent/AU628331B2/en not_active Ceased
- 1989-05-02 ES ES89107923T patent/ES2057010T3/es not_active Expired - Lifetime
- 1989-05-02 DE DE58908062T patent/DE58908062D1/de not_active Expired - Fee Related
- 1989-05-02 AT AT89107923T patent/ATE108786T1/de active
- 1989-05-02 EP EP89107923A patent/EP0340718B1/de not_active Expired - Lifetime
- 1989-05-02 JP JP1112370A patent/JPH01319481A/ja active Pending
- 1989-05-04 KR KR1019890006017A patent/KR0150781B1/ko not_active IP Right Cessation
- 1989-05-04 PT PT90471A patent/PT90471B/pt not_active IP Right Cessation
- 1989-05-04 IL IL9019889A patent/IL90198A/en not_active IP Right Cessation
- 1989-05-04 NZ NZ228991A patent/NZ228991A/en unknown
- 1989-05-05 FI FI892182A patent/FI93358C/fi not_active IP Right Cessation
- 1989-05-05 HU HU892189A patent/HU207311B/hu not_active IP Right Cessation
- 1989-05-05 DK DK223289A patent/DK223289A/da not_active Application Discontinuation
- 1989-05-05 US US07/347,710 patent/US5013853A/en not_active Expired - Fee Related
- 1989-05-05 NO NO891866A patent/NO174467C/no unknown
- 1989-05-05 IE IE147489A patent/IE63794B1/en unknown
- 1989-05-25 AR AR89313845A patent/AR246966A1/es active
Also Published As
Publication number | Publication date |
---|---|
NO891866D0 (no) | 1989-05-05 |
NO174467B (no) | 1994-01-31 |
AU628331B2 (en) | 1992-09-17 |
AU3390189A (en) | 1989-11-09 |
EP0340718B1 (de) | 1994-07-20 |
NZ228991A (en) | 1990-12-21 |
JPH01319481A (ja) | 1989-12-25 |
US5013853A (en) | 1991-05-07 |
KR0150781B1 (ko) | 1998-10-15 |
NO174467C (no) | 1994-05-11 |
EP0340718A1 (de) | 1989-11-08 |
FI892182A0 (fi) | 1989-05-05 |
AR246966A1 (es) | 1994-10-31 |
IL90198A0 (en) | 1989-12-15 |
ATE108786T1 (de) | 1994-08-15 |
DK223289A (da) | 1989-11-07 |
PT90471B (pt) | 1994-09-30 |
IE891474L (en) | 1989-11-06 |
FI93358B (fi) | 1994-12-15 |
FI892182A (fi) | 1989-11-07 |
IE63794B1 (en) | 1995-06-14 |
DK223289D0 (da) | 1989-05-05 |
ES2057010T3 (es) | 1994-10-16 |
NO891866L (no) | 1989-11-07 |
IL90198A (en) | 1994-01-25 |
PT90471A (pt) | 1989-11-30 |
HU207311B (en) | 1993-03-29 |
DE58908062D1 (de) | 1994-08-25 |
HUT56094A (en) | 1991-07-29 |
FI93358C (fi) | 1995-03-27 |
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