DE3475786D1 - Chromanol derivatives - Google Patents

Chromanol derivatives

Info

Publication number
DE3475786D1
DE3475786D1 DE8484110098T DE3475786T DE3475786D1 DE 3475786 D1 DE3475786 D1 DE 3475786D1 DE 8484110098 T DE8484110098 T DE 8484110098T DE 3475786 T DE3475786 T DE 3475786T DE 3475786 D1 DE3475786 D1 DE 3475786D1
Authority
DE
Germany
Prior art keywords
chromanol derivatives
chromanol
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484110098T
Other languages
English (en)
Inventor
John Morris Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838323417A external-priority patent/GB8323417D0/en
Priority claimed from GB838334497A external-priority patent/GB8334497D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE3475786D1 publication Critical patent/DE3475786D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8484110098T 1983-09-01 1984-08-24 Chromanol derivatives Expired DE3475786D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838323417A GB8323417D0 (en) 1983-09-01 1983-09-01 Compounds
GB838334497A GB8334497D0 (en) 1983-12-24 1983-12-24 Compounds

Publications (1)

Publication Number Publication Date
DE3475786D1 true DE3475786D1 (de) 1989-02-02

Family

ID=26286815

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484110098T Expired DE3475786D1 (de) 1983-09-01 1984-08-24 Chromanol derivatives

Country Status (3)

Country Link
US (1) US4687779A (de)
EP (1) EP0139992B1 (de)
DE (1) DE3475786D1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8521857D0 (en) * 1985-09-03 1985-10-09 Beecham Group Plc Active compounds
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
AU628331B2 (en) * 1988-05-06 1992-09-17 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US4988723A (en) * 1988-06-02 1991-01-29 Fujisawa Pharmaceutical Co., Ltd. Benzopyran derivatives and their use as anti-hypertensives
DE3823533A1 (de) * 1988-07-12 1990-02-08 Beiersdorf Ag Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate
US5364878A (en) * 1988-07-19 1994-11-15 Hoechst Aktiengesellschaft Use of substituted 3,4-dihydro-2H-benzopyrans as remedies for obstructive functional disorders of the lungs
US5030736A (en) * 1988-09-23 1991-07-09 Ortho Pharmaceutical Corporation Substituted thienopyrans
US4992435A (en) * 1988-09-23 1991-02-12 Ortho Pharmaceutical Corporation Substituted thienopyrans as antihypertensive agents
NZ230711A (en) * 1988-09-23 1990-10-26 Ortho Pharma Corp Substituted thienopyrans as antihypertensive agents
GB8902118D0 (en) * 1989-02-01 1989-03-22 Beecham Group Plc Chemical process
US5239090A (en) * 1989-02-01 1993-08-24 Beecham Group P.L.C. Certain optically active 3,4-dihydrobenzopyran-4-ols which are intermediates
GB8916683D0 (en) * 1989-07-21 1989-09-06 Beecham Group Plc Novel compounds
GB8924373D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
US5276168A (en) * 1990-06-18 1994-01-04 E. R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
DE69327965T2 (de) * 1992-12-11 2000-10-19 Smithkline Beecham Plc Pharmazeutische zusammenstellung enthaltende bizyklisch typ verbindungen
US20010021780A1 (en) * 1992-12-11 2001-09-13 Smithkline Beecham P.L.C. Pharmaceutical composition containing bicyclic type compounds
CN1048723C (zh) * 1992-12-12 2000-01-26 史密丝克莱恩比彻姆有限公司 制备苯并吡喃衍生物的方法
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
US5574049A (en) * 1994-07-22 1996-11-12 Sandoz Ltd. 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2H-1-benzopyrans
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
GB0028697D0 (en) * 2000-11-23 2001-01-10 S P A Novel process
CA2877578A1 (en) 2012-07-03 2014-01-09 Proximagen Limited Pro-drug compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ183551A (en) * 1976-04-02 1978-09-20 Beecham Group Ltd Aminochromanols and pharmaceutical compositions containingthem
DE2965739D1 (en) * 1978-10-04 1983-07-28 Beecham Group Plc Chromanol derivatives, a process for their preparation and pharmaceutical compositions comprising them
EP0028449B1 (de) * 1979-09-28 1983-07-20 Beecham Group Plc Chromanol-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzung
DE3064286D1 (en) * 1979-09-28 1983-08-25 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
GB2064514B (en) * 1979-10-29 1984-01-18 Maruko Pharmaceutical Co Flavan compounds and acid addition salts thereof and pharmaceutical compositions thereof
US4521607A (en) * 1981-02-27 1985-06-04 Takeda Chemical Industries, Ltd. Chromanyl glycines
DE3274350D1 (en) * 1981-09-25 1987-01-08 Beecham Group Plc Pharmaceutically active benzopyran compounds
EP0091748B1 (de) * 1982-04-08 1986-06-18 Beecham Group Plc Blutdrucksenkende Benzopyranole
DE3368629D1 (en) * 1982-04-28 1987-02-05 Beecham Group Plc Novel chromenes and chromans
EP0095316B1 (de) * 1982-05-21 1986-12-03 Beecham Group Plc Pharmazeutisch wirksame Aminobenzopyrane
DE3364734D1 (en) * 1982-10-19 1986-08-28 Beecham Group Plc Novel chromans and chromenes
GB8308063D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
DE3479726D1 (de) * 1983-05-18 1989-10-19 Beecham Group Plc Benzopyran derivatives.

Also Published As

Publication number Publication date
EP0139992A1 (de) 1985-05-08
EP0139992B1 (de) 1988-12-28
US4687779A (en) 1987-08-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition