KR890005118A - 마크롤리드 화합물의 제조방법 - Google Patents
마크롤리드 화합물의 제조방법 Download PDFInfo
- Publication number
- KR890005118A KR890005118A KR1019880011660A KR880011660A KR890005118A KR 890005118 A KR890005118 A KR 890005118A KR 1019880011660 A KR1019880011660 A KR 1019880011660A KR 880011660 A KR880011660 A KR 880011660A KR 890005118 A KR890005118 A KR 890005118A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- general formula
- preparing
- group
- methyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 5
- 238000000034 method Methods 0.000 title claims 4
- 239000003120 macrolide antibiotic agent Substances 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- -1 triethyloxonium tetrafluoroborate Chemical group 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims 1
- 150000008041 alkali metal carbonates Chemical class 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000006196 deacetylation Effects 0.000 claims 1
- 238000003381 deacetylation reaction Methods 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- DWCSXQCXXITVKE-UHFFFAOYSA-N triethyloxidanium Chemical class CC[O+](CC)CC DWCSXQCXXITVKE-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 하기 일반식(II)의 화합물을 트리에틸 옥소늄염으로 처리하고, 이어서 OR2가 히드록시기인 일반식(I)의 화합물을 필요로 할 경우, OR2가 아세틸옥시기인 일반식(I)의 화합물을 탈아세틸화시키는 것으로 됨을 특징으로 하는 하기 일반식(I)의 화합물의 제조방법.상기식중, R1은 메틸, 에틸 또는 이소프로필기이고, R2는 수소원자 또는 메틸 또는 아세틸기이며, R3은 수소원자이거나, 또는 OR2및 R3은 이들이 결합된 탄소원자와 함께 기 〉 C=0이다.
- 제1항에 있어서, 상기 염이 트리에틸옥소늄 테트라플루오로보레이트인 것을 특징으로 하는 방법.
- 제1항에 있어서, 반응을 염기 존재하에서 행하는 것을 특징으로 하는 방법.
- 제1항에 있어서, 반응을 알칼리금속 탄산염 또는 알칼리토금속 탄산염 존재하에서 행하는 것을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8721375 | 1987-09-11 | ||
GB878721375A GB8721375D0 (en) | 1987-09-11 | 1987-09-11 | Chemical process |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890005118A true KR890005118A (ko) | 1989-05-11 |
Family
ID=10623612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880011660A KR890005118A (ko) | 1987-09-11 | 1988-09-09 | 마크롤리드 화합물의 제조방법 |
Country Status (14)
Country | Link |
---|---|
US (1) | US4933474A (ko) |
EP (1) | EP0307223A3 (ko) |
JP (1) | JPH01156993A (ko) |
KR (1) | KR890005118A (ko) |
AU (1) | AU621832B2 (ko) |
BR (1) | BR8804666A (ko) |
CA (1) | CA1302407C (ko) |
DD (1) | DD274224A5 (ko) |
DK (1) | DK504888A (ko) |
GB (1) | GB8721375D0 (ko) |
HU (1) | HU203760B (ko) |
NZ (1) | NZ226113A (ko) |
PT (1) | PT88466B (ko) |
ZA (1) | ZA886741B (ko) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4579864A (en) * | 1984-06-11 | 1986-04-01 | Merck & Co., Inc. | Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives |
CS268803B2 (en) * | 1984-09-14 | 1990-04-11 | Glaxo Group Ltd | Pesticide |
US4581345A (en) * | 1985-04-08 | 1986-04-08 | Merck & Co., Inc. | Avermectin 8,9-cyclopropyl compounds, pharmaceutical composition and therapeutic methods of use |
ES8802229A1 (es) * | 1985-04-30 | 1988-04-16 | Glaxo Group Ltd | Un procedimiento para preparar nuevos derivados lactonicos macrociclicos. |
JP2577734B2 (ja) * | 1986-03-12 | 1997-02-05 | アメリカン・サイアナミツド・カンパニー | マクロライド抗生物質 |
-
1987
- 1987-09-11 GB GB878721375A patent/GB8721375D0/en active Pending
-
1988
- 1988-09-09 DK DK504888A patent/DK504888A/da not_active Application Discontinuation
- 1988-09-09 AU AU22091/88A patent/AU621832B2/en not_active Ceased
- 1988-09-09 US US07/242,221 patent/US4933474A/en not_active Expired - Lifetime
- 1988-09-09 KR KR1019880011660A patent/KR890005118A/ko not_active Application Discontinuation
- 1988-09-09 NZ NZ226113A patent/NZ226113A/en unknown
- 1988-09-09 BR BR8804666A patent/BR8804666A/pt unknown
- 1988-09-09 PT PT88466A patent/PT88466B/pt not_active IP Right Cessation
- 1988-09-09 HU HU884656A patent/HU203760B/hu not_active IP Right Cessation
- 1988-09-09 DD DD88319663A patent/DD274224A5/de not_active IP Right Cessation
- 1988-09-09 EP EP88308347A patent/EP0307223A3/en not_active Ceased
- 1988-09-09 ZA ZA886741A patent/ZA886741B/xx unknown
- 1988-09-09 JP JP63224830A patent/JPH01156993A/ja active Pending
- 1988-09-09 CA CA000576927A patent/CA1302407C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH01156993A (ja) | 1989-06-20 |
PT88466A (pt) | 1988-10-01 |
US4933474A (en) | 1990-06-12 |
GB8721375D0 (en) | 1987-10-21 |
DD274224A5 (de) | 1989-12-13 |
AU2209188A (en) | 1989-03-16 |
AU621832B2 (en) | 1992-03-26 |
ZA886741B (en) | 1989-08-30 |
PT88466B (pt) | 1992-11-30 |
EP0307223A2 (en) | 1989-03-15 |
CA1302407C (en) | 1992-06-02 |
BR8804666A (pt) | 1989-04-18 |
HUT48255A (en) | 1989-05-29 |
DK504888D0 (da) | 1988-09-09 |
EP0307223A3 (en) | 1989-10-25 |
DK504888A (da) | 1989-03-12 |
HU203760B (en) | 1991-09-30 |
NZ226113A (en) | 1989-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |