KR880700800A - 이소플라본 유도체와 그염 및 항암 및 면역 억제제 - Google Patents

이소플라본 유도체와 그염 및 항암 및 면역 억제제

Info

Publication number
KR880700800A
KR880700800A KR870700615A KR870700615A KR880700800A KR 880700800 A KR880700800 A KR 880700800A KR 870700615 A KR870700615 A KR 870700615A KR 870700615 A KR870700615 A KR 870700615A KR 880700800 A KR880700800 A KR 880700800A
Authority
KR
South Korea
Prior art keywords
anticancer
salts
immunosuppressive agents
isoflavone derivatives
isoflavone
Prior art date
Application number
KR870700615A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of KR880700800A publication Critical patent/KR880700800A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
KR870700615A 1985-11-18 1987-07-16 이소플라본 유도체와 그염 및 항암 및 면역 억제제 KR880700800A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP25960385 1985-11-18
PCT/JP1986/000586 WO1987002982A1 (en) 1985-11-18 1986-11-17 Isoflavone derivatives, salts thereof, and oncostatic and immunosuppressive agents

Publications (1)

Publication Number Publication Date
KR880700800A true KR880700800A (ko) 1988-04-12

Family

ID=17336387

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870700615A KR880700800A (ko) 1985-11-18 1987-07-16 이소플라본 유도체와 그염 및 항암 및 면역 억제제

Country Status (5)

Country Link
US (2) US4841077A (ko)
EP (1) EP0245518A4 (ko)
JP (1) JPS62201882A (ko)
KR (1) KR880700800A (ko)
WO (1) WO1987002982A1 (ko)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
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USH1427H (en) * 1988-04-06 1995-04-04 Briet; Phillipe Substituted flavonoid compounds, their salts, their manufacture and their use in combination with interleukin-2
FR2693724B1 (fr) * 1992-07-17 1994-10-07 Lipha Utilisation de composés benzopyraniques ou benzothiopyraniques pour l'induction de l'expression des gènes de la nodulation des bactéries du genre Rhizobium associées aux légumineuses.
EP0674530B1 (en) * 1992-12-21 2004-09-01 Mallinckrodt Inc. Radiolabeled polyhydric phenol compounds
US6140469A (en) * 1993-10-12 2000-10-31 Protein Technologies International, Inc. Protein isolate having an increased level of isoflavone compounds and process for producing the same
US5320949A (en) * 1993-10-12 1994-06-14 Protein Technologies International, Inc. Process for producing aglucone isoflavone enriched vegetable protein fiber
US5506211A (en) * 1994-05-09 1996-04-09 The Uab Research Foundation Genistein for use in inhibiting osteroclasts
US5424331A (en) * 1994-06-10 1995-06-13 Bio-Virus Research Incorporated Pharmaceutical compositions and dietary soybean food products for the prevention of osteoporosis
US5587459A (en) * 1994-08-19 1996-12-24 Regents Of The University Of Minnesota Immunoconjugates comprising tyrosine kinase inhibitors
US5827682A (en) * 1995-06-07 1998-10-27 Protein Technologies International, Inc. Two-step conversion of vegetable protein isoflavone conjugates to aglucones
US5703130A (en) * 1995-06-07 1997-12-30 Institute Of Materia Medica, An Institute Of The Chinese Academy Of Medical Sciences Chalcone retinoids and methods of use of same
US5716982A (en) * 1995-06-07 1998-02-10 Institute Of Materia Medica, An Institute Of The Chinese Academy Of Medical Sciences Retinoids and methods of use of same
US5968940A (en) * 1995-06-08 1999-10-19 Institute Of Materia Medica Retinoids and methods of use of same
US5554519A (en) * 1995-08-07 1996-09-10 Fermalogic, Inc. Process of preparing genistein
US5670632A (en) * 1996-01-18 1997-09-23 Acds Technologies, Ltd. Process for obtaining an isoflavone concentrate from a soybean extract
US5851792A (en) * 1996-04-03 1998-12-22 Shen; Jerome Aglucone isoflavone enriched vegetable protein whey whey protein material aglucone isoflavone material high genistein content material and high daidzein content material and process for producing the same from a vegetable protein whey
US5824702A (en) * 1996-06-07 1998-10-20 Mount Sinai School Of Medicine Of The City University Of New York Genistein as a preventive against ultraviolet induced skin photodamage and cancer
US5821361A (en) 1996-06-11 1998-10-13 Protein Technologies International, Inc. Recovery of isoflavones from soy molasses
US5855892A (en) * 1997-09-19 1999-01-05 Potter; Susan M. Method for decreasing LDL-cholesterol concentration and increasing HDL-cholesterol concentration in the blood to reduce the risk of atherosclerosis and vascular disease
US5952374A (en) * 1997-09-29 1999-09-14 Protein Technologies International, Inc. Method for inhibiting the development of Alzheimer's disease and related dementias- and for preserving cognitive function
AU4435199A (en) * 1998-06-12 1999-12-30 Vyrex Corporation Isoflavone derivatives
US6028088A (en) * 1998-10-30 2000-02-22 The University Of Mississippi Flavonoid derivatives
NZ511812A (en) 1998-11-25 2003-11-28 Nutri Pharma As Method of lowering lipid, triglyceride, total cholesterol and LDL-cholesterol serum levels and increasing the HDL/LDL cholesterol ratio thereby treating cardiovascular disease
DE69908809D1 (de) 1998-11-25 2003-07-17 Nutri Pharma Asa Oslo Verwendung einer zusammensetzung enthaltend sojaprotein, diätfasern und phytoestrogen zur vorbeugung und/oder behandlung von lungenerkrankungen
WO2003074045A1 (fr) * 2002-03-05 2003-09-12 Eisai Co., Ltd. Agent antitumoral comprenant une combinaison d'un compose heterocyclique contenant un sulfamide et d'un inhibiteur d'angiogenese
US6818668B2 (en) 2002-04-12 2004-11-16 Biotest Laboratories, Llc 5-alkyl-7-alkylcarbonate-isoflavone ester and related method
KR101052816B1 (ko) 2002-04-17 2011-07-29 스미스 클라인 비참 코포레이션 화합물, 조성물 및 방법
CA2491089A1 (en) * 2002-06-27 2004-01-08 The Endowment For Research In Human Biology, Inc. Compounds useful for the inhibition of aldh
ATE423110T1 (de) * 2002-07-17 2009-03-15 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen
AU2003268056A1 (en) * 2002-08-02 2004-02-23 The Ohio State University Research Foundation 2-heterosubstituted 3-aryl-4-h-1-benzopyran-4-ones as novel therapeutics in breast cancer
EP1554265A4 (en) * 2002-09-13 2008-05-07 Cytokinetics Inc COMPOSITIONS, COMPOSITIONS AND M THODES
US20050165089A1 (en) * 2003-10-06 2005-07-28 Gustave Bergnes Compounds, compositions and methods
GB0412769D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
GB0412768D0 (en) * 2004-06-08 2004-07-07 Novartis Ag Organic compounds
US8772269B2 (en) * 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
US8158810B2 (en) * 2006-07-27 2012-04-17 Gilead Sciences, Inc. ALDH-2 inhibitors in the treatment of addiction
US20080207610A1 (en) * 2006-07-27 2008-08-28 Jeff Zablocki Aldh-2 inhibitors in the treatment of addiction
EP2046769A2 (en) * 2006-07-27 2009-04-15 Cv Therapeutics, Inc. Aldh-2 inhibitors in the treatment of addiction
US7863325B2 (en) * 2008-12-11 2011-01-04 Axcentua Pharmaceuticals Ab Crystalline genistein sodium salt dihydrate
EP2373326B1 (en) * 2008-12-11 2016-03-09 Axcentua Pharmaceutucals AB Crystalline forms of genistein
MY173795A (en) 2009-11-05 2020-02-24 Incozen Therapeutics Pvt Ltd Novel benzopyran kinase modulators
KR102263079B1 (ko) * 2009-11-05 2021-06-10 리젠 파마슈티컬스 소시에떼 아노님 신규한 벤조피란 키나제 조절제
MY168757A (en) * 2011-05-04 2018-12-04 Rhizen Pharmaceuticals S A Novel compounds as modulators of protein kinases
EA039266B1 (ru) * 2012-01-09 2021-12-24 Ризен Фармасьютикалз Са Производные 4н-хромен-4-она в качестве модуляторов протеинкиназ
EA032812B1 (ru) * 2012-05-04 2019-07-31 Ризен Фармасьютикалз Са Способ получения оптически чистых и необязательно замещенных производных 2-(1-гидроксиалкил)хромен-4-она и их применение при получении лекарственных препаратов
US10130635B2 (en) 2012-05-04 2018-11-20 Rhizen Pharmaceuticals Sa Process for preparation of optically pure and optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives and their use in preparing pharmaceuticals
SI3260455T1 (sl) 2012-07-04 2019-07-31 Rhizen Pharmaceuticals S.A. Selektivni inhibitorji PI3K-delta
CN106008479B (zh) * 2015-03-06 2020-01-10 南京圣和药业股份有限公司 作为磷脂酰肌醇3-激酶δ抑制剂的取代嘧啶类化合物及其应用
CN105936635B (zh) * 2015-03-06 2019-06-21 南京圣和药业股份有限公司 作为磷脂酰肌醇3-激酶δ抑制剂的化合物及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR846M (ko) * 1960-01-19 1961-10-02
BE586723A (fr) * 1960-01-19 1960-07-19 Sarec S A Nouveaux composes chimiques et thérapeutiques dérives des isoflavones, et leurs procédés de préparation.

Also Published As

Publication number Publication date
US4841077A (en) 1989-06-20
JPS62201882A (ja) 1987-09-05
EP0245518A4 (en) 1988-09-07
US4960908A (en) 1990-10-02
EP0245518A1 (en) 1987-11-19
WO1987002982A1 (en) 1987-05-21

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Legal Events

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WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid