KR880013948A - 경구용 피페라실린 피발로일옥시메틸 에스테르의 제조방법 - Google Patents
경구용 피페라실린 피발로일옥시메틸 에스테르의 제조방법 Download PDFInfo
- Publication number
- KR880013948A KR880013948A KR870005217A KR870005217A KR880013948A KR 880013948 A KR880013948 A KR 880013948A KR 870005217 A KR870005217 A KR 870005217A KR 870005217 A KR870005217 A KR 870005217A KR 880013948 A KR880013948 A KR 880013948A
- Authority
- KR
- South Korea
- Prior art keywords
- piperacillin
- pivaloyloxymethyl ester
- preparing oral
- general formula
- iii
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
- C07D499/32—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
- C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 피페라실린 피발로일옥시메틸에스테르의 HPLC 크로마토그램을 나타내며, 제2도는 25℃에서, 피페라실린과 피페라실린 피발로일옥시메틸에스테르의 용해도 -pH곡선을 나타내며, 제3도는 제1액(pH 1.2±0.1)에서 피페라실린과 피페라실린 피발로일옥시메틸에스테르의 용출곡선(37±0.5℃).
Claims (1)
- 일반식(Ⅱ)(식중, M은 수소 또는 알칼리금속을 나타낸다.)의 피페라실린 또는 그 알칼리금속염을 일반식(Ⅲ)X-CH2-O-COC(CH3)3(Ⅲ)(식중, X는 할로겐을 타나낸다.)의 할로 메틸 피발레이트와 반응시켜, 일반식(Ⅰ)의 피페라실린 피발로일옥시메틸에스테르를 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019870005217A KR890003624B1 (ko) | 1987-05-26 | 1987-05-26 | 경구용 피페라실린 피발로일옥시메틸 에스테르의 제조방법 |
JP62161442A JPS63297388A (ja) | 1987-05-26 | 1987-06-30 | 経口用ピペラシリンピバロイルオキシメチルエステル及びその製造方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019870005217A KR890003624B1 (ko) | 1987-05-26 | 1987-05-26 | 경구용 피페라실린 피발로일옥시메틸 에스테르의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880013948A true KR880013948A (ko) | 1988-12-22 |
KR890003624B1 KR890003624B1 (ko) | 1989-09-28 |
Family
ID=19261648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019870005217A KR890003624B1 (ko) | 1987-05-26 | 1987-05-26 | 경구용 피페라실린 피발로일옥시메틸 에스테르의 제조방법 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS63297388A (ko) |
KR (1) | KR890003624B1 (ko) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5123284A (en) * | 1974-08-13 | 1976-02-24 | Toyama Chemical Co Ltd | Shinkina penishirinruino seizoho |
-
1987
- 1987-05-26 KR KR1019870005217A patent/KR890003624B1/ko not_active IP Right Cessation
- 1987-06-30 JP JP62161442A patent/JPS63297388A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPS63297388A (ja) | 1988-12-05 |
KR890003624B1 (ko) | 1989-09-28 |
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