KR830002722A - 이미다졸리딘 유도체의 제조방법 - Google Patents

이미다졸리딘 유도체의 제조방법

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Publication number
KR830002722A
KR830002722A KR1019800001691A KR800001691A KR830002722A KR 830002722 A KR830002722 A KR 830002722A KR 1019800001691 A KR1019800001691 A KR 1019800001691A KR 800001691 A KR800001691 A KR 800001691A KR 830002722 A KR830002722 A KR 830002722A
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KR
South Korea
Prior art keywords
compound
structural formula
general formula
signifies
see diagramm
Prior art date
Application number
KR1019800001691A
Other languages
English (en)
Other versions
KR850000719B1 (ko
Inventor
링크 헬므트
Original Assignee
쿠르트 네셀보쉬·한스 스튀클린
에프. 호프만-라롯슈 앤드 캄파니 아크티엔 게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 쿠르트 네셀보쉬·한스 스튀클린, 에프. 호프만-라롯슈 앤드 캄파니 아크티엔 게젤샤프트 filed Critical 쿠르트 네셀보쉬·한스 스튀클린
Publication of KR830002722A publication Critical patent/KR830002722A/ko
Application granted granted Critical
Publication of KR850000719B1 publication Critical patent/KR850000719B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Control Of Transmission Device (AREA)
  • Emergency Protection Circuit Devices (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Resins (AREA)
  • Pyrrole Compounds (AREA)

Abstract

내용 없음

Description

이미다졸리딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 다음 구조식(Ⅱ)의 화합물과 구조식(Ⅲ)의 화합물을 반응시켜 구조식(Ia)의 화합물을 만들고, 필요시에는 구조식(Ia) 화합물을 가수분해시켜 구조식(Ib)의 히단토인 화합물을 만드는 것을 특징으로 하는 다음 구조식(Ⅰ) 화합물의 제조방법.
  3. 상기식에서 X는 아미노 또는 산소원자이고,
  4. R은 다음 구조식(A)로 표시되는 치환된 페닐그룹을 나타낸다.
  6. R1은 할로겐 또는 트리풀루오로 메틸이고
  7. R2는 수소, 할로겐 또는 트리풀루오로 메틸이며
  8. R3은 수소 또는 할로겐을 나타낸다.
  9. R4는 하나가 수소이면 다른 하나는 COOR5그룹을 나타낸다.
  10. R5는 임의로 치환된 페닐그룹이다.
  11. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800001691A 1979-04-24 1980-04-24 이미다졸리딘 유도체의 제조방법 KR850000719B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH3837 1979-04-24
CH383779 1979-04-24

Publications (2)

Publication Number Publication Date
KR830002722A true KR830002722A (ko) 1983-05-30
KR850000719B1 KR850000719B1 (ko) 1985-05-23

Family

ID=4264536

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800001691A KR850000719B1 (ko) 1979-04-24 1980-04-24 이미다졸리딘 유도체의 제조방법

Country Status (13)

Country Link
EP (1) EP0017976B1 (ko)
JP (1) JPS55143974A (ko)
KR (1) KR850000719B1 (ko)
AT (1) ATE3860T1 (ko)
CA (1) CA1135706A (ko)
DE (1) DE3063837D1 (ko)
DK (1) DK174480A (ko)
ES (1) ES490799A0 (ko)
FI (1) FI801184A (ko)
GR (1) GR67605B (ko)
HU (1) HU184271B (ko)
NO (1) NO801182L (ko)
PT (1) PT71135B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE35956E (en) * 1991-01-09 1998-11-10 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2715402B1 (fr) * 1994-01-05 1996-10-04 Roussel Uclaf Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
TW521073B (en) * 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2724169B1 (fr) * 1994-09-06 1997-01-03 Roussel Uclaf Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
WO2005060661A2 (en) 2003-12-19 2005-07-07 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies
NZ550102A (en) 2004-02-24 2010-10-29 Univ California Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives)
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
DK2368550T3 (da) 2006-03-27 2013-09-30 Univ California Androgenreceptormodulator til behandlingen af prostatakræft og androgenreceptor-associerede sygdomme
SG170809A1 (en) 2006-03-29 2011-05-30 Univ California Diarylthiohydantoin compounds
JP5535925B2 (ja) 2007-10-26 2014-07-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア アンドロゲン受容体調節物質としてのジアリールヒダントイン化合物
EP3124481B1 (en) 2010-02-16 2018-03-28 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
CN104661658A (zh) 2012-09-26 2015-05-27 阿拉贡药品公司 用于治疗非转移性去势抵抗性***癌的抗雄激素
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CN111479560A (zh) 2017-10-16 2020-07-31 阿拉贡药品公司 用于治疗非转移性去势难治性***癌的抗雄激素

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB997037A (en) * 1962-03-19 1965-06-30 Ici Ltd New hydrantoin derivatives
US3340070A (en) * 1963-08-23 1967-09-05 Shell Oil Co Artificial sweetening agent
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
MC1220A1 (fr) * 1977-10-28 1979-07-20 Hoffmann La Roche Nouveaux derives d'imidazolidine
CA1138334A (en) * 1977-10-28 1982-12-28 Karl Bernauer Pharmaceutical preparations containing certain urea derivatives

Also Published As

Publication number Publication date
PT71135A (en) 1980-05-01
PT71135B (en) 1981-08-07
JPS55143974A (en) 1980-11-10
ES8104243A1 (es) 1981-04-16
NO801182L (no) 1980-10-27
CA1135706A (en) 1982-11-16
FI801184A (fi) 1980-10-25
ES490799A0 (es) 1981-04-16
ATE3860T1 (de) 1983-07-15
EP0017976B1 (de) 1983-06-22
DE3063837D1 (en) 1983-07-28
DK174480A (da) 1980-10-25
GR67605B (ko) 1981-08-31
EP0017976A2 (de) 1980-10-29
EP0017976A3 (en) 1981-04-01
KR850000719B1 (ko) 1985-05-23
HU184271B (en) 1984-07-30

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