KR880002507A - 페닐퀴놀린 카복실산의 동결건조 약제 조성물 - Google Patents

페닐퀴놀린 카복실산의 동결건조 약제 조성물 Download PDF

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KR880002507A
KR880002507A KR870009364A KR870009364A KR880002507A KR 880002507 A KR880002507 A KR 880002507A KR 870009364 A KR870009364 A KR 870009364A KR 870009364 A KR870009364 A KR 870009364A KR 880002507 A KR880002507 A KR 880002507A
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salt
sodium
acid
composition
fluoro
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KR870009364A
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KR950006218B1 (ko
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더블유유 치엔-칭
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도날드 에이.호스
이 . 아이. 듀퐁드 네모아 앤드 캄파니
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

페닐퀴놀린 카복실산의 동결건조 약제 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 필수적으로(a)실온에서 mg/ml범위의 수용해도를 갖는 유리산 형태의 약물의 염과(b) 필수적으로 (1) 담즙산 염 및 (2) 수용액으로 재구성시에 8.5 내지 11의 pH를 제공할 수 있는 약제학적으로 무독한 염기 또는 완충제로 이루어진 안정화계의 동결건조 혼합물[여기에서, (a) : (b)(1)의 중량비는 약1:0.1이상이다]로 조성된 비경구 투여용 용액으로 재구성하기에 적합한 분말 약제 조성물.
  2. 제 1 항에 있어서, (a) : (b)(1)의 중량비가 약1:0.1내지 1:0.8의 범위인 분말 조성물.
  3. 제 2 항에 있어서, 담즙산 염(b)(1)이 콜산 또는 데스옥시콜산인 분말 조성물.
  4. 제 3 항에 있어서, 염기 또는 완충제(b)(2)가 수용액으로 재구성시에 약9의 pH를 제공하기에 충분한 글리신 또는 수산화나트륨인 분말 조성물.
  5. 제 4 항에 있어서, 약물이 페닐퀴놀린카복실산의 나트륨 또는 칼륨 염인 분말 조성물.
  6. 제 5 항에 있어서, 페닐퀴놀린 카복실산 염이 6-플루오로-2-(2′-플루오로-1′-비페닐-4-일)-3-메틸-4-퀴놀린-카복실산, 나트륨염 또는 2-(1,15-페닐-4-일)-5-클로로-3-메틸-4-퀴놀린카복실산, 나트륨 염인 분말 조성물.
  7. 필수적으로 (a)1중량부의 6-플루오로-2-(2′-플루오로-1′-비페닐-4-일)-3-메틸-4-퀴놀린카복실산, 나트륨 염과 (b)필수적으로 (1)약 0.1내지 0.8중량부의 나트륨 콜레이트 및 (2) 수용액으로 재구성시에 약9의 pH를 제공하기에 충분한 글리신으로 이루어진 안정화계의 동결건조 혼합물로 구성된 비경구 투여용 용액으로 재구성하기에 적합한 분말 약제 조성물.
  8. 실온에서 mg/ml범위의 수용해도를 갖는 유리산 형태의 약물의 염1중량부의 수용액, 약물 1부당 약 0.1중량부 이상의 담즙산 염 및 약 8.5내지 11범위의 pH를 제공하기에 충분한 양의 약제학적으로 무독한 염기 또는 완충제로 이루어진 안정한 주사용 약제 조성물.
  9. 제 8 항에 있어서, 담즙산 염이 약물 1부당 약0.1내지 0.8중량부의 농도로 존재하는 나트륨 콜레이트 또는 나트륨 데스옥시콜레이트 주사용 조성물.
  10. 제 9 항에 있어서, 염기 또는 완충제가 pH 약9를 제공하기에 충분한 양의 글리신 또는 수산화 나트륨인 주사용 조성물.
  11. 제10항에 있어서, 약물이 페닐퀴놀린 카복실산의 나트륨 또는 칼륨 염인 주사용 조성물.
  12. 제11항에 있어서, 페닐퀴놀린 카복실산 염이 6-플루오로-2-(2′-플루오로-1′-비페닐-4-일)-3-메틸-4-퀴놀린카복실 산, 나트륨 염 또는 2-(1,1′-비페닐-4-일)-5-클로로-3-메틸-4-퀴놀린카복실산, 나트륨 염인 주사용 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870009364A 1986-08-28 1987-08-27 페닐퀴놀린 카복실산의 동결건조 약제 조성물 KR950006218B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US90125486A 1986-08-28 1986-08-28
US901,254 1986-08-28
US60203 1987-06-10
US07/060,203 US4889862A (en) 1986-08-28 1987-06-10 Freeze-dried pharmaceutical compositions of phenylquinoline carboxylic acids
US901254 1987-06-10
US060,203 1987-06-10

Publications (2)

Publication Number Publication Date
KR880002507A true KR880002507A (ko) 1988-05-09
KR950006218B1 KR950006218B1 (ko) 1995-06-12

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KR1019870009364A KR950006218B1 (ko) 1986-08-28 1987-08-27 페닐퀴놀린 카복실산의 동결건조 약제 조성물

Country Status (17)

Country Link
US (1) US4889862A (ko)
EP (1) EP0261426B1 (ko)
JP (1) JP2629005B2 (ko)
KR (1) KR950006218B1 (ko)
AU (1) AU602715B2 (ko)
CA (1) CA1312824C (ko)
DE (1) DE3782480T2 (ko)
DK (1) DK168655B1 (ko)
ES (1) ES2052530T3 (ko)
FI (1) FI90824C (ko)
GR (1) GR3006608T3 (ko)
HU (1) HU199289B (ko)
IE (1) IE60490B1 (ko)
IL (1) IL83662A (ko)
NO (1) NO873626L (ko)
NZ (1) NZ221574A (ko)
PT (1) PT85612B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861783A (en) * 1988-04-26 1989-08-29 E. I. Du Pont De Nemours And Company 4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases
HU206975B (en) * 1991-03-14 1993-03-01 Reanal Finomvegyszergyar Process for producing granulation and veterinary composition comprising water-soluble flumequine complex
DK1016409T3 (da) * 1997-02-05 2004-09-20 Kirin Brewery Lyofiliseret sammensætning omfattende glycosphingolipider
US6417167B1 (en) 1997-02-05 2002-07-09 Kirin Beer Kabushiki Kaisha Lyophilized compositions containing shingoglycolipid and process for preparing them
TWI232102B (en) 2001-07-17 2005-05-11 Shionogi & Co A pharmaceutical formulation for injection
US20060008529A1 (en) * 2004-07-12 2006-01-12 Meyerhoff Mark E Use of additive sites to control nitric oxide release from nitric oxide donors contained within polymers
US20080241208A1 (en) * 2005-06-30 2008-10-02 Charles Shanley Methods, Compositions and Devices For Promoting Anglogenesis
WO2007064895A2 (en) * 2005-12-02 2007-06-07 The Regents Of The University Of Michigan Polymer compositions, coatings and devices, and methods of making and using the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US468299A (en) * 1892-02-02 John atkinson
DE433646C (de) * 1923-09-15 1926-09-09 Chem Fab Vorm E Schering Verfahren zur Herstellung in Wasser leicht loeslicher Derivate von Carbonsaeuren derChinolin- und Pyridinreihe
US3681495A (en) * 1969-08-25 1972-08-01 American Home Prod Freeze dried echothiophate iodide compositions
US4036954A (en) * 1973-11-02 1977-07-19 Yamanouchi Pharmaceutical Co., Ltd. Stable prostaglandin E group-containing formulation
JPS5071816A (ko) * 1973-11-02 1975-06-14
AT356278B (de) * 1976-07-12 1980-04-25 Hoffmann La Roche Verfahren zur herstellung von injektions- loesungen
JPS5976017A (ja) * 1983-01-20 1984-04-28 Yamanouchi Pharmaceut Co Ltd 安定なプロスタグランジンｅ類製剤の製法
US4680299A (en) * 1984-04-30 1987-07-14 E.I. Du Pont De Nemours And Company 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof
EP0133244B1 (en) * 1983-07-22 1990-12-05 E.I. Du Pont De Nemours And Company Phenylquinolinecarboxylic acids and derivatives as antitumor agents
DE3329952A1 (de) * 1983-08-19 1985-02-28 Behringwerke Ag, 3550 Marburg Verfahren zur verringerung einer truebung in kontrollseren
EP0179583A1 (en) * 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs

Also Published As

Publication number Publication date
DE3782480T2 (de) 1993-04-08
NO873626D0 (no) 1987-08-27
EP0261426A1 (en) 1988-03-30
JPS63115816A (ja) 1988-05-20
AU7762287A (en) 1988-03-03
FI873701A (fi) 1988-02-29
AU602715B2 (en) 1990-10-25
GR3006608T3 (ko) 1993-06-30
IE872290L (en) 1988-02-28
PT85612B (pt) 1990-05-31
IE60490B1 (en) 1994-07-27
IL83662A0 (en) 1988-01-31
DE3782480D1 (de) 1992-12-10
CA1312824C (en) 1993-01-19
FI90824C (fi) 1994-04-11
ES2052530T3 (es) 1994-07-16
IL83662A (en) 1991-09-16
US4889862A (en) 1989-12-26
HUT45398A (en) 1988-07-28
HU199289B (en) 1990-02-28
FI873701A0 (fi) 1987-08-26
FI90824B (fi) 1993-12-31
PT85612A (en) 1987-09-01
KR950006218B1 (ko) 1995-06-12
DK447887D0 (da) 1987-08-27
NZ221574A (en) 1989-11-28
DK447887A (da) 1988-02-29
EP0261426B1 (en) 1992-11-04
NO873626L (no) 1988-02-29
JP2629005B2 (ja) 1997-07-09
DK168655B1 (da) 1994-05-16

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