KR880001641A - 니트로푸란 유도체, 그의 제법 및 치료에의 응용 - Google Patents

니트로푸란 유도체, 그의 제법 및 치료에의 응용 Download PDF

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Publication number
KR880001641A
KR880001641A KR1019870007252A KR870007252A KR880001641A KR 880001641 A KR880001641 A KR 880001641A KR 1019870007252 A KR1019870007252 A KR 1019870007252A KR 870007252 A KR870007252 A KR 870007252A KR 880001641 A KR880001641 A KR 880001641A
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KR
South Korea
Prior art keywords
imidazo
pyrid
indolizinyl
pyrazin
preparation
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KR1019870007252A
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English (en)
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마누리 필리쁘
쟝비네
알레뜨뤼 미셸
Original Assignee
에 뚜레 레메뜨르
신떼라보 소시에떼 아노님
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Application filed by 에 뚜레 레메뜨르, 신떼라보 소시에떼 아노님 filed Critical 에 뚜레 레메뜨르
Publication of KR880001641A publication Critical patent/KR880001641A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

니트로푸란 유도체, 그의 제법 및 치료에의 응용
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 다음 일반식(I)에 해당하는 니트로푸란 유도체
    상기식에서 n은 0 또는 1이고, R은 이미다조[1,2-a]피리드-2-일, 이미다조[2,1-a]티아조-6-일, 이미다조[1,2-a]피라진-2-일, 5,6,7,8-테트라히드로이미다조[1,2-a]피라진-2-일, 7-아세틸-5,6,7,8-테트라히드로이미다조[1,2-a]피라진-2-일, 이미다조-[1,5-a]피리드-1-일, 이미다조[1,5-a]피리드-3-일, 피라졸로[1,5-a]피리드-3-일, 1-인돌리지닐, 3-인돌리지닐, 5,6,7,8-테트라히드로-1-인돌리지닐, 5,6,7,8-테트라히드로-2-인돌리지닐, 6H-티에노[2,3-b]피롤-5-일, 4H-티에노[3,2-b]피롤-5-일, 4-옥소-4H-피리도[1,2a]피리미딘-3-일, 2H-벤즈이미다졸-2-일 또는 이미다조[1,2-a]피리드-3-일기이다.
  2. 일반식(Ⅱ)
    의 히드라지드를 알코올 용매에서, 20℃ 내지 용매의 환류온도에 이르는 온도에서 5-니트로-2-푸란 카바알데이히드 또는 3-(5-니트로-2-푸릴)-2-플로페날과 축합시키는 것을 특징으로 하는 제 1항에 따르는 화합물의 제조방법.
  3. 제 1항에 명시된 화합물을 포함시키는 것을 특징으로 하는 의약 생성물.
  4. 어떤 적합한 부형제와 조합하여 제 1항에 명시된 화합물을 포함하는 것을 특징으로 하는 제약 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870007252A 1986-07-08 1987-07-07 니트로푸란 유도체, 그의 제법 및 치료에의 응용 KR880001641A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8609886 1986-07-08
FR8609886A FR2601368B1 (fr) 1986-07-08 1986-07-08 Derives de nitrofuranne, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
KR880001641A true KR880001641A (ko) 1988-04-25

Family

ID=9337175

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870007252A KR880001641A (ko) 1986-07-08 1987-07-07 니트로푸란 유도체, 그의 제법 및 치료에의 응용

Country Status (18)

Country Link
US (1) US4794120A (ko)
EP (1) EP0252809A3 (ko)
JP (1) JPS6323879A (ko)
KR (1) KR880001641A (ko)
CN (1) CN87104648A (ko)
AU (1) AU594170B2 (ko)
CA (1) CA1287049C (ko)
DK (1) DK349387A (ko)
FI (1) FI873010A (ko)
FR (1) FR2601368B1 (ko)
HU (1) HU196413B (ko)
IL (1) IL83093A (ko)
MA (1) MA21029A1 (ko)
NO (1) NO165398C (ko)
NZ (1) NZ220986A (ko)
PT (1) PT85279B (ko)
TN (1) TNSN87086A1 (ko)
ZA (1) ZA874939B (ko)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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GB8901423D0 (en) * 1989-01-23 1989-03-15 Fujisawa Pharmaceutical Co Pyrazolopyridine compound and processes for preparation thereof
ES2081747B1 (es) * 1993-09-07 1997-01-16 Esteve Labor Dr Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos.
US6711297B1 (en) * 1998-07-03 2004-03-23 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and apparatus for dynamic transfer of image data
GB0021831D0 (en) * 2000-09-06 2000-10-18 Astrazeneca Ab Chemical compounds
GB0205175D0 (en) * 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205165D0 (en) * 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205162D0 (en) * 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205166D0 (en) * 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205176D0 (en) * 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0318463D0 (en) * 2003-08-07 2003-09-10 Astrazeneca Ab Chemical compounds
GB0318464D0 (en) * 2003-08-07 2003-09-10 Astrazeneca Ab Chemical compounds
GB0319759D0 (en) * 2003-08-22 2003-09-24 Astrazeneca Ab Chemical compounds
GB0319690D0 (en) * 2003-08-22 2003-09-24 Astrazeneca Ab Chemical compounds
US7632928B2 (en) * 2004-04-19 2009-12-15 Charm Sciences, Inc Method and antibodies for detecting nitrofuran
GB0710121D0 (en) 2007-05-25 2007-07-04 F2G Ltd Antifungal agents
CA2721944C (en) 2008-04-24 2016-06-07 F2G Ltd Pyrrole antifungal agents
CN101624376B (zh) 2009-08-19 2011-09-14 沈阳中海药业有限公司 取代酰肼类化合物及其应用
WO2011069039A1 (en) * 2009-12-04 2011-06-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hydrazone and diacyl hydrazine compounds and methods of use
US20140200241A1 (en) * 2011-05-24 2014-07-17 Northeastern University Prodrugs for treating microbial infections
CA2982660C (en) 2014-11-21 2023-01-24 F2G Limited 2-(1,5-dimethyl-3-phenyl-1h-pyrrol-2-yl)-n-(4-(4-(5-fluoropyrimidin-2-yl)piperazine-1-yl)phenyl)-2-oxoacetamide and derivatives thereof for use as antifungal agents
GB201609222D0 (en) 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation
CN107417673B (zh) * 2017-04-25 2019-10-01 西华大学 N-(2-吡啶基)亚甲基-2-氰基-3-杂环基丙烯酰肼类衍生物及其应用
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection
CN110590771B (zh) * 2019-09-05 2021-11-12 南通大学 一种[1,5-a]-吡啶并咪唑-1-腈及其化学合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH479615A (de) * 1959-12-24 1969-10-15 Ciba Geigy Verfahren zur Herstellung neuer Methylidenverbindungen
US3424845A (en) * 1967-05-25 1969-01-28 Salsbury Lab 3,5-dinitrosalicylic acid, 5-nitrofurfurylidene hydrazide and compositions containing and methods employing the same for the control of histomoniasis
LU71111A1 (ko) * 1974-10-15 1976-08-19

Also Published As

Publication number Publication date
FI873010A0 (fi) 1987-07-07
TNSN87086A1 (fr) 1990-01-01
PT85279B (pt) 1990-03-30
NZ220986A (en) 1989-09-27
JPS6323879A (ja) 1988-02-01
AU594170B2 (en) 1990-03-01
NO872831D0 (no) 1987-07-07
US4794120A (en) 1988-12-27
NO165398C (no) 1991-02-06
EP0252809A2 (fr) 1988-01-13
FI873010A (fi) 1988-01-09
IL83093A (en) 1991-07-18
AU7529387A (en) 1988-01-14
NO872831L (no) 1988-01-11
DK349387D0 (da) 1987-07-07
CN87104648A (zh) 1988-04-13
EP0252809A3 (fr) 1989-07-19
HU196413B (en) 1988-11-28
IL83093A0 (en) 1987-12-31
DK349387A (da) 1988-01-09
MA21029A1 (fr) 1988-04-01
PT85279A (fr) 1987-08-01
ZA874939B (en) 1988-03-30
NO165398B (no) 1990-10-29
HUT44787A (en) 1988-04-28
FR2601368A1 (fr) 1988-01-15
CA1287049C (en) 1991-07-30
FR2601368B1 (fr) 1989-04-07

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