KR870002043A - 4-비페닐일아세트산의 제조방법 - Google Patents
4-비페닐일아세트산의 제조방법 Download PDFInfo
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- KR870002043A KR870002043A KR1019860006978A KR860006978A KR870002043A KR 870002043 A KR870002043 A KR 870002043A KR 1019860006978 A KR1019860006978 A KR 1019860006978A KR 860006978 A KR860006978 A KR 860006978A KR 870002043 A KR870002043 A KR 870002043A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/12—Saturated polycyclic compounds
- C07C61/125—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
- C07C61/13—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system having two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
- C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/42—One oxygen atom attached in position 5
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- (a) 하기 일반식 (II)로 표시되는 4-비페닐일알데히데와 하기 일반식 (III)으로 표시되는 N-아실글리신을 염기의 존재하에 반응시켜 4-비페닐일알데히데를 하기 일반식 (V)로 표시되는 아즈락톤 화합물로 전환시키고, 생성된 일반식 (V)의 아즈락톤 화합물을 가열하고, 필요에 따라 중화시켜 하기 일반식 (VII)로 표시되는 알파-케토산으로 만든 후, 알파-케토산을 탈카르복실화 시킴을 특징으로 하는; 또는 (b) 하기 일반식 (II)로 표시되는 4-비페닐알데히데와 하기 일반식 (IV)로 표시되는 락탐 화합물을 염기의 존재하에 반응시켜 하기 일반식 (VI)으로 표시되는 응축물을 만들고, 생성된 일반식 (VI)의 응축물을 알칼리 염기의 존재하에 가열하고, 필요에 따라 중화시켜 하기 일반식 (VIII)로 표시되는 유도체를 만든 후, 일반식 (VIII)의 유도체를 수용성 염기의 존재하에 과산화물로 처리함을 특징으로 하는 하기 일반식 (I)로 표시되는 4-비페닐일아세트산 또는 그의 염의 제조방법.(식중, R은 치환 또는 비치환된 페닐 또는 저급알킬기를 나타내고, M은 알칼리 금속 또는 수소원자를 나타내며, R1은 수소원자, 저급알킬기 또는 카르복시-저급 알킬기를 나타내고, X는 산소 또는 황원자를 나타내며, Y는 황원자 또는 -NH-를 나타낸다).
- 제1항에 있어서, 방법(a)가 일반식 (V)의 아즈락톤 화합물 및 일반식 (VII)의 알파-케토화합물의 분리없이 단일 반응기 내에서 수행되는 방법.
- 제2항에 있어서, 단일 반응기내에서 일반식 (II)의 4-비페닐일아세트산 및 일반식 (III)의 N-아실글리신의 염기의 존재하에 열처리된 후, 탈카르복실화 되는 방법.
- 제1항에 있어서, 탈카르복실화가 염기 조건하에 과산물로 처리되어 수행되는 방법.
- 하기 일반식 (V)로 표시되는 아즈락톤 화합물.식중, R은 비치환된 또는 치환된 페닐 또는 저급 알킬기를 나타낸다.
- 제1항에 있어서, 방법(b)가 일반식 (VI)로 표시되는 응축물 및 일반식 (VIII)로 표시되는 유도체의 분리없이 단일 반응기 내에서 수행되는 방법.
- 제6항에 있어서, 단일 반응기 내에서 일반식 (III)의 4-비페닐알데히데 및 일반식 (IV)의 락탐화합물이 염기의 존재하에 열처리된 후, 수용성 용매내에서 처리되는 방법.
- 하기 일반식 (VI)으로 표시되는 화합물.식중, R1은 수소원자, 저급알킬기 또는 카르복시-저급알킬기를 나타내고, X는 산소 또는 황원자를 나타내며, Y는 황원자 또는 -NH-를 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP60184085A JPS6245553A (ja) | 1985-08-23 | 1985-08-23 | フエニル酢酸誘導体の製造法 |
JP184085 | 1985-08-23 | ||
JP60184084A JPS6245554A (ja) | 1985-08-23 | 1985-08-23 | 4−ビフエニリル酢酸の簡易製造法 |
JP184,084 | 1985-08-23 | ||
JP184084 | 1985-08-23 | ||
JP184,085 | 1985-08-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR870002043A true KR870002043A (ko) | 1987-03-28 |
KR910006325B1 KR910006325B1 (ko) | 1991-08-20 |
Family
ID=26502273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860006978A KR910006325B1 (ko) | 1985-08-23 | 1986-08-23 | 4-비페닐일아세트산의 제조방법 |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0212617B1 (ko) |
KR (1) | KR910006325B1 (ko) |
CA (1) | CA1325222C (ko) |
DE (1) | DE3661732D1 (ko) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5705585A (en) | 1993-06-30 | 1998-01-06 | Arqule, Inc. | Aminimide-containing molecules and materials as molecular recognition agents |
ZA936492B (en) * | 1992-09-10 | 1995-03-02 | Lilly Co Eli | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease. |
JPH09507852A (ja) | 1994-01-05 | 1997-08-12 | アーキュール,インコーポレーテッド | 特定の性質を有するポリマーの製造方法 |
US6251928B1 (en) | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
US5734082A (en) | 1994-10-20 | 1998-03-31 | Arqule Inc. | Hydroxyethyl aminimides |
US5712171A (en) | 1995-01-20 | 1998-01-27 | Arqule, Inc. | Method of generating a plurality of chemical compounds in a spatially arranged array |
WO1996031263A1 (en) | 1995-04-06 | 1996-10-10 | Arqule, Inc. | Method for rapid purification, analysis and characterization of collections of chemical compounds |
US5962412A (en) | 1996-06-10 | 1999-10-05 | Arqule, Inc. | Method of making polymers having specific properties |
JP2003531104A (ja) | 1999-08-31 | 2003-10-21 | マキシア・ファーマシューティカルズ・インコーポレイテッド | ベンジリデン−チアゾリジンジオン類およびアナログ類ならびに炎症の治療におけるその使用 |
BR0207846A (pt) | 2001-03-07 | 2005-09-13 | Incyte San Diego Inc | Derivados heterocìclicos para o tratamento de câncer e outras doenças proliferativas |
US7265139B2 (en) | 2001-03-08 | 2007-09-04 | Incyte San Diego Inc. | RXR activating molecules |
SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
SE0103710D0 (sv) | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
WO2003043998A1 (en) | 2001-11-15 | 2003-05-30 | Incyte San Diego Incorporated | N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases |
US7196108B2 (en) | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
US7102000B2 (en) | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
SE0202539D0 (sv) | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
SE0401762D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
SE0403086D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
SE0403085D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
TW200831488A (en) | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
CN101684077B (zh) | 2008-09-24 | 2013-01-02 | 浙江九洲药业股份有限公司 | N-酰基联苯丙氨酸的制备方法 |
RU2534619C2 (ru) * | 2009-09-23 | 2014-11-27 | Чжэцзян Цзючжоу Фармасьютикл Ко., Лтд. | Способ получения n-ацилбифенилаланина |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1167192A (en) * | 1967-12-19 | 1969-10-15 | Boots Pure Drug Co Ltd | Improvements in the Preparation of Propionic Acids |
JPS582934B2 (ja) * | 1974-07-29 | 1983-01-19 | ニツシンセイフン カブシキガイシヤ | 2−(置換アリ−ル)−プロピオン酸の製法 |
DE3013647C2 (de) * | 1980-04-09 | 1985-07-11 | Degussa Ag, 6000 Frankfurt | Verfahren zur Herstellung von 5-Arylidenhydantoinen (B) |
-
1986
- 1986-08-18 CA CA000516132A patent/CA1325222C/en not_active Expired - Fee Related
- 1986-08-19 DE DE8686111429T patent/DE3661732D1/de not_active Expired
- 1986-08-19 EP EP86111429A patent/EP0212617B1/en not_active Expired
- 1986-08-23 KR KR1019860006978A patent/KR910006325B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0212617B1 (en) | 1989-01-11 |
CA1325222C (en) | 1993-12-14 |
EP0212617A1 (en) | 1987-03-04 |
DE3661732D1 (en) | 1989-02-16 |
KR910006325B1 (ko) | 1991-08-20 |
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