KR870002043A - 4-비페닐일아세트산의 제조방법 - Google Patents

4-비페닐일아세트산의 제조방법 Download PDF

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KR870002043A
KR870002043A KR1019860006978A KR860006978A KR870002043A KR 870002043 A KR870002043 A KR 870002043A KR 1019860006978 A KR1019860006978 A KR 1019860006978A KR 860006978 A KR860006978 A KR 860006978A KR 870002043 A KR870002043 A KR 870002043A
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South Korea
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formula
general formula
represented
following general
alkyl group
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KR1019860006978A
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KR910006325B1 (ko
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오사므 시마다
사까에 아오야기
유우노스께 나가세
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에이마스 시히리
니혼 레다리 가부시끼가이샤
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Priority claimed from JP60184085A external-priority patent/JPS6245553A/ja
Priority claimed from JP60184084A external-priority patent/JPS6245554A/ja
Application filed by 에이마스 시히리, 니혼 레다리 가부시끼가이샤 filed Critical 에이마스 시히리
Publication of KR870002043A publication Critical patent/KR870002043A/ko
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Publication of KR910006325B1 publication Critical patent/KR910006325B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/12—Saturated polycyclic compounds
    • C07C61/125—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
    • C07C61/13—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/42—One oxygen atom attached in position 5

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.

Description

4-비페닐일아세트산의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. (a) 하기 일반식 (II)로 표시되는 4-비페닐일알데히데와 하기 일반식 (III)으로 표시되는 N-아실글리신을 염기의 존재하에 반응시켜 4-비페닐일알데히데를 하기 일반식 (V)로 표시되는 아즈락톤 화합물로 전환시키고, 생성된 일반식 (V)의 아즈락톤 화합물을 가열하고, 필요에 따라 중화시켜 하기 일반식 (VII)로 표시되는 알파-케토산으로 만든 후, 알파-케토산을 탈카르복실화 시킴을 특징으로 하는; 또는 (b) 하기 일반식 (II)로 표시되는 4-비페닐알데히데와 하기 일반식 (IV)로 표시되는 락탐 화합물을 염기의 존재하에 반응시켜 하기 일반식 (VI)으로 표시되는 응축물을 만들고, 생성된 일반식 (VI)의 응축물을 알칼리 염기의 존재하에 가열하고, 필요에 따라 중화시켜 하기 일반식 (VIII)로 표시되는 유도체를 만든 후, 일반식 (VIII)의 유도체를 수용성 염기의 존재하에 과산화물로 처리함을 특징으로 하는 하기 일반식 (I)로 표시되는 4-비페닐일아세트산 또는 그의 염의 제조방법.
    (식중, R은 치환 또는 비치환된 페닐 또는 저급알킬기를 나타내고, M은 알칼리 금속 또는 수소원자를 나타내며, R1은 수소원자, 저급알킬기 또는 카르복시-저급 알킬기를 나타내고, X는 산소 또는 황원자를 나타내며, Y는 황원자 또는 -NH-를 나타낸다).
  2. 제1항에 있어서, 방법(a)가 일반식 (V)의 아즈락톤 화합물 및 일반식 (VII)의 알파-케토화합물의 분리없이 단일 반응기 내에서 수행되는 방법.
  3. 제2항에 있어서, 단일 반응기내에서 일반식 (II)의 4-비페닐일아세트산 및 일반식 (III)의 N-아실글리신의 염기의 존재하에 열처리된 후, 탈카르복실화 되는 방법.
  4. 제1항에 있어서, 탈카르복실화가 염기 조건하에 과산물로 처리되어 수행되는 방법.
  5. 하기 일반식 (V)로 표시되는 아즈락톤 화합물.
    식중, R은 비치환된 또는 치환된 페닐 또는 저급 알킬기를 나타낸다.
  6. 제1항에 있어서, 방법(b)가 일반식 (VI)로 표시되는 응축물 및 일반식 (VIII)로 표시되는 유도체의 분리없이 단일 반응기 내에서 수행되는 방법.
  7. 제6항에 있어서, 단일 반응기 내에서 일반식 (III)의 4-비페닐알데히데 및 일반식 (IV)의 락탐화합물이 염기의 존재하에 열처리된 후, 수용성 용매내에서 처리되는 방법.
  8. 하기 일반식 (VI)으로 표시되는 화합물.
    식중, R1은 수소원자, 저급알킬기 또는 카르복시-저급알킬기를 나타내고, X는 산소 또는 황원자를 나타내며, Y는 황원자 또는 -NH-를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860006978A 1985-08-23 1986-08-23 4-비페닐일아세트산의 제조방법 KR910006325B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP60184085A JPS6245553A (ja) 1985-08-23 1985-08-23 フエニル酢酸誘導体の製造法
JP184085 1985-08-23
JP60184084A JPS6245554A (ja) 1985-08-23 1985-08-23 ４−ビフエニリル酢酸の簡易製造法
JP184,084 1985-08-23
JP184084 1985-08-23
JP184,085 1985-08-23

Publications (2)

Publication Number Publication Date
KR870002043A true KR870002043A (ko) 1987-03-28
KR910006325B1 KR910006325B1 (ko) 1991-08-20

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KR1019860006978A KR910006325B1 (ko) 1985-08-23 1986-08-23 4-비페닐일아세트산의 제조방법

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EP (1) EP0212617B1 (ko)
KR (1) KR910006325B1 (ko)
CA (1) CA1325222C (ko)
DE (1) DE3661732D1 (ko)

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US5705585A (en) 1993-06-30 1998-01-06 Arqule, Inc. Aminimide-containing molecules and materials as molecular recognition agents
ZA936492B (en) * 1992-09-10 1995-03-02 Lilly Co Eli Compounds useful as hypoglycemic agents and for treating Alzheimer's disease.
JPH09507852A (ja) 1994-01-05 1997-08-12 アーキュール，インコーポレーテッド 特定の性質を有するポリマーの製造方法
US6251928B1 (en) 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
US5734082A (en) 1994-10-20 1998-03-31 Arqule Inc. Hydroxyethyl aminimides
US5712171A (en) 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
WO1996031263A1 (en) 1995-04-06 1996-10-10 Arqule, Inc. Method for rapid purification, analysis and characterization of collections of chemical compounds
US5962412A (en) 1996-06-10 1999-10-05 Arqule, Inc. Method of making polymers having specific properties
JP2003531104A (ja) 1999-08-31 2003-10-21 マキシア・ファーマシューティカルズ・インコーポレイテッド ベンジリデン−チアゾリジンジオン類およびアナログ類ならびに炎症の治療におけるその使用
BR0207846A (pt) 2001-03-07 2005-09-13 Incyte San Diego Inc Derivados heterocìclicos para o tratamento de câncer e outras doenças proliferativas
US7265139B2 (en) 2001-03-08 2007-09-04 Incyte San Diego Inc. RXR activating molecules
SE0100902D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0103710D0 (sv) 2001-11-07 2001-11-07 Astrazeneca Ab Compounds
WO2003043998A1 (en) 2001-11-15 2003-05-30 Incyte San Diego Incorporated N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases
US7196108B2 (en) 2002-03-08 2007-03-27 Incyte San Diego Inc. Bicyclic heterocycles for the treatment of diabetes and other diseases
US7102000B2 (en) 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
SE0401762D0 (sv) 2004-07-05 2004-07-05 Astrazeneca Ab Novel compounds
SE0403086D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
SE0403085D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
TW200831488A (en) 2006-11-29 2008-08-01 Astrazeneca Ab Novel compounds
CN101684077B (zh) 2008-09-24 2013-01-02 浙江九洲药业股份有限公司 N-酰基联苯丙氨酸的制备方法
RU2534619C2 (ru) * 2009-09-23 2014-11-27 Чжэцзян Цзючжоу Фармасьютикл Ко., Лтд. Способ получения n-ацилбифенилаланина

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JPS582934B2 (ja) * 1974-07-29 1983-01-19 ニツシンセイフン カブシキガイシヤ ２−（置換アリ−ル）−プロピオン酸の製法
DE3013647C2 (de) * 1980-04-09 1985-07-11 Degussa Ag, 6000 Frankfurt Verfahren zur Herstellung von 5-Arylidenhydantoinen (B)

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EP0212617B1 (en) 1989-01-11
CA1325222C (en) 1993-12-14
EP0212617A1 (en) 1987-03-04
DE3661732D1 (en) 1989-02-16
KR910006325B1 (ko) 1991-08-20

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