KR870001205A - 이속사졸 및 푸란의 제조방법 - Google Patents

이속사졸 및 푸란의 제조방법 Download PDF

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KR870001205A
KR870001205A KR1019860005307A KR860005307A KR870001205A KR 870001205 A KR870001205 A KR 870001205A KR 1019860005307 A KR1019860005307 A KR 1019860005307A KR 860005307 A KR860005307 A KR 860005307A KR 870001205 A KR870001205 A KR 870001205A
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compound
formula
alkyl
hydrogen
halogen
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KR1019860005307A
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KR900001314B1 (ko
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도미니크 다이애너 가이
도미니코 다이애너 가이
마이클 캐라바티즈 필립
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스터어링 드럭그 인코포레이팃드
벤자민 웃드로우 와이넛트
스터어링 드럭그 인코포이팃드
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Publication of KR870001205A publication Critical patent/KR870001205A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

내용 없음.

Description

이속사졸 및 푸란의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. a) 하기 구조식III)의 화합물을 산-수용체 존재하에 불활성 용매 중에서 가열하여 고리화해줌으로써 Y가 올레핀 결합이 개재된 알킬렌 다리를 나타내는 화합물들을 제외한, 옥사졸 또는 옥사진 고리의 4,5-위치에 이중 결합을 갖고 있지 않으며 R이 수소 또는 C1-3저급 알킬의 화합물을 제조하거나,
    (상기 식에서 Hal′은 염소 또는 브롬임) b) 하기 구조식(IV)의 화합물을 하기 구조식(V)의 화합물의 알칼리 금속염과 반응시켜 R1과 R2가 저급 알콕시 카보닐인 화합물을 제외한 X=O인 화합물을 얻은 다음
    (상기 식들에서 Hal은 염소, 브롬 또는 요드임) 소망에 따라; R이 하이드록시 알킬인 구조식(I)의 화합물을 산 할로겐화물 또는 산수물과 반응시켜 에스테르화하여 R이 저급-아실옥시인 화합물을 얻고; 소망에 따라; R이 하이드록시 알킬인 구조식(I)의 화합물을 강염기 존재하에 저급-알킬할로겐화물 또는 저급 알콕시 알킬 할로겐화물과 반응시켜 에테르화하여 R이 각기 저급-알콕시 또는 저급알콕시알콕시인 화합물을 얻고; 소망에 따라; 구조식(I)의 화합물을 지방족 하이드록시기를 할로겐으로 치환해 줄 수 있는 시약과 반응시켜 R이 할로겐에 의해 치환된 저급 알킬인 화합물을 얻고; 소망에 따라, R이 할로겐에 의해 치환된 저급 알킬인 화합물을 암모니아 또는 아민 NH=Z′와 반응시켜 N=Z1인 화합물을 제조하고; 소망에 따라, R이 아미노에 의해 치환된 저급알킬인 화합물을 저급-알카노일 할로겐화물 또는 무수물로 아실화하여 R이 저급 알카노일-아미노에 의해 치환된 알킬인 화합물을 얻고; 소망에 따라, 얻어진 염기 화합물을 그의 산부가염으로 전환시키는 것으로 구성된 하기 구조식(I)의 화합물의 제조 방법.
    상기 식에서 X는 O 또는 CH2이며; Y는 올레핀 결합이 임의로 개재된 C3-9알킬렌 다리이며, Z은 N 또는 R5C이며 R5는 수소 또는 저급알카노일이며, 단 Z이 N인 경우 R은 저급-알킬이며; m은 0 또는 1이며; R은 수소 또는 하이드록시, 저급-알콕시, 저급-알콕시알콕시, 저급-아실옥시, 할로, 또는 N=Z′에 의해 임의로 치환된 C1-3알킬이며 여기서 N=Z′는 아미노, 저급-알카노일아미노, 저급-알킬아미노, 디-저급알킬아미노, 1-피롤리딜, 1-피페리디닐, 4-모르폴리닐이며, R1및 R2는 할로겐, 메틸, 니트로, 저급-알콕시카보닐 또는 트리플루오로메틸이며; R3및 R4는 수소 또는 C1-3저급알킬이다.
  2. 제1항에 있어서, m이 0 또는 1이며, R이 메틸 또는 하이드록시메틸이며, R1과 R2가 각기 할로겐, 메틸, 니트로, 저급알콕시 카보닐 또는 트리플루오로메틸이며 R3과 R4가 각기 수소, 또는 C1-3저급 알킬인 하기 구조식의 화합물 또는 그의 제약상 허용되는 산-부가염을 제조하는 방법.
  3. 제2항에 있어서, 5-{5-[2,6-디클로로-4-(4,5-디하이드로-2-옥사졸릴)펜옥시]펜틸}-3-메틸이속사졸 또는 그의 제약상 허용되는 산부가염을 제조하는 방법.
  4. 하기 구조식(XII)의 화합물을 구조식의 화합물과 반응시키는 것으로 구성된 하기 구조식(III)의 화합물의 제조 방법.
    상기 식에서, X은 0 또는 CH2이며; Y는 C3-9알킬렌 다리이며; Z은 N 또는 R5C이며 여기서 R5는 수소 또는 저급알카노일이며; m은 0 또는 1이며; R1과 R2는 할로겐, 메틸, 니트로, 저급알콕시카보닐 또는 트리플루오로메틸이며; R, R3및 R4는 수소 또는 C1-3저급알킬이며 단 Z이 N인 경우 R은 저급알킬이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860005307A 1985-07-02 1986-07-01 신규한 이속사졸 및 푸란 KR900001314B1 (ko)

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US75134885A 1985-07-02 1985-07-02
US751.348 1985-07-02
US751348 1985-07-02

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KR900001314B1 KR900001314B1 (ko) 1990-03-08

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KR1019860005308A KR900001315B1 (ko) 1985-07-02 1986-07-01 치환된 페녹시알킬이속사졸 및 푸란
KR1019860005307A KR900001314B1 (ko) 1985-07-02 1986-07-01 신규한 이속사졸 및 푸란

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EP (2) EP0207453B1 (ko)
JP (2) JPH0819128B2 (ko)
KR (2) KR900001315B1 (ko)
AR (4) AR241705A1 (ko)
AT (2) ATE80397T1 (ko)
AU (2) AU587622B2 (ko)
CA (2) CA1280753C (ko)
DE (3) DE3689924T4 (ko)
DK (2) DK171275B1 (ko)
ES (5) ES8802518A1 (ko)
FI (2) FI862795A (ko)
GR (2) GR861695B (ko)
IE (2) IE66234B1 (ko)
IL (2) IL79308A (ko)
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MY (1) MY102908A (ko)
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NZ (1) NZ216678A (ko)
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DE3689924T2 (de) 1995-01-19
NO862651L (no) 1987-01-05
AU5945786A (en) 1987-01-08
ZA864872B (en) 1987-02-25
ZA864873B (en) 1987-02-25
IL79309A (en) 1990-11-29
DK312986D0 (da) 1986-07-01
AU5945686A (en) 1987-01-08
AR242573A1 (es) 1993-04-30
FI862794A0 (fi) 1986-07-01
EP0207453A3 (en) 1988-11-23
NO862650D0 (no) 1986-07-01
KR900001315B1 (ko) 1990-03-08
ES8802517A1 (es) 1988-07-01
ES8802153A1 (es) 1988-04-01
NO165023B (no) 1990-09-03
GR861695B (en) 1986-11-04
KR870001202A (ko) 1987-03-12
NO165023C (no) 1990-12-12
EP0207454A3 (en) 1988-08-10
FI862795A (fi) 1987-01-03
IL79308A0 (en) 1986-10-31
EP0207453B1 (en) 1994-06-22
ES557779A0 (es) 1988-02-16
ATE107645T1 (de) 1994-07-15
JPH0768242B2 (ja) 1995-07-26
ATE80397T1 (de) 1992-09-15
MY102908A (en) 1993-03-31
DK173467B1 (da) 2000-12-04
FI862795A0 (fi) 1986-07-01
DK312986A (da) 1987-01-03
FI862794A (fi) 1987-01-03
ES8801649A1 (es) 1988-02-16
NO862651D0 (no) 1986-07-01
IE59755B1 (en) 1994-03-23
EP0207454B1 (en) 1992-09-09
EP0207453A2 (en) 1987-01-07
IL79309A0 (en) 1986-10-31
ES557778A0 (es) 1988-04-01
JPS6216480A (ja) 1987-01-24
FI85021B (fi) 1991-11-15
CA1280753C (en) 1991-02-26
AU587622B2 (en) 1989-08-24
NO164977C (no) 1990-12-05
ES8802518A1 (es) 1988-07-01
KR900001314B1 (ko) 1990-03-08
GR861697B (en) 1986-11-04
DE3686677T2 (de) 1993-03-11
NZ216678A (en) 1989-10-27
DE3689924D1 (de) 1994-07-28
DK171275B1 (da) 1996-08-19
PT82891A (en) 1986-08-01
PH23197A (en) 1989-05-29
PH22321A (en) 1988-07-29
IE66234B1 (en) 1995-12-13
NO862650L (no) 1987-01-05
NO164977B (no) 1990-08-27
PT82892B (pt) 1994-09-30
CA1299176C (en) 1992-04-21
AU589190B2 (en) 1989-10-05
IE861724L (en) 1987-01-02
DE3686677D1 (de) 1992-10-15
AR242572A1 (es) 1993-04-30
MX2954A (es) 1993-11-01
FI85021C (fi) 1992-02-25
MX9100032A (es) 1993-01-01
DK313086A (da) 1987-01-03
PT82892A (pt) 1987-01-26
ES557780A0 (es) 1988-02-16
ES556811A0 (es) 1988-07-01
PT82891B (pt) 1988-05-27
EP0207454A2 (en) 1987-01-07
ES556812A0 (es) 1988-07-01
DK313086D0 (da) 1986-07-01
MX9100029A (es) 1993-01-01
AR244686A1 (es) 1993-11-30
JPS6216479A (ja) 1987-01-24
ES8801651A1 (es) 1988-02-16
IE861723L (en) 1987-01-02
AR241705A1 (es) 1992-11-30
MX9100033A (es) 1993-01-01
DE3689924T4 (de) 1995-05-11
JPH0819128B2 (ja) 1996-02-28
IL79308A (en) 1991-01-31

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