DE3686677D1 - Isoxazol- und furanderivate, verfahren zu ihrer herstellung und ihre verwendung als antivirale mittel. - Google Patents

Isoxazol- und furanderivate, verfahren zu ihrer herstellung und ihre verwendung als antivirale mittel.

Info

Publication number
DE3686677D1
DE3686677D1 DE8686108745T DE3686677T DE3686677D1 DE 3686677 D1 DE3686677 D1 DE 3686677D1 DE 8686108745 T DE8686108745 T DE 8686108745T DE 3686677 T DE3686677 T DE 3686677T DE 3686677 D1 DE3686677 D1 DE 3686677D1
Authority
DE
Germany
Prior art keywords
isoxazole
production
antiviral agent
furan derivatives
furan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686108745T
Other languages
English (en)
Other versions
DE3686677T2 (de
Inventor
Guy Dominic Diana
Philip Michael Carabateas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Application granted granted Critical
Publication of DE3686677D1 publication Critical patent/DE3686677D1/de
Publication of DE3686677T2 publication Critical patent/DE3686677T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
DE8686108745T 1985-07-02 1986-06-26 Isoxazol- und furanderivate, verfahren zu ihrer herstellung und ihre verwendung als antivirale mittel. Expired - Fee Related DE3686677T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75134885A 1985-07-02 1985-07-02

Publications (2)

Publication Number Publication Date
DE3686677D1 true DE3686677D1 (de) 1992-10-15
DE3686677T2 DE3686677T2 (de) 1993-03-11

Family

ID=25021592

Family Applications (3)

Application Number Title Priority Date Filing Date
DE3689924A Expired - Fee Related DE3689924D1 (de) 1985-07-02 1986-06-26 Durch eine heterocyclische Gruppe substituierte Phenoxyalkylisoxazole und ihre Verwendung als antivirale Mittel.
DE3689924T Expired - Lifetime DE3689924T4 (de) 1985-07-02 1986-06-26 Durch eine heterocyclische Gruppe substituierte Phenoxyalkylisoxazole und ihre Verwendung als antivirale Mittel.
DE8686108745T Expired - Fee Related DE3686677T2 (de) 1985-07-02 1986-06-26 Isoxazol- und furanderivate, verfahren zu ihrer herstellung und ihre verwendung als antivirale mittel.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE3689924A Expired - Fee Related DE3689924D1 (de) 1985-07-02 1986-06-26 Durch eine heterocyclische Gruppe substituierte Phenoxyalkylisoxazole und ihre Verwendung als antivirale Mittel.
DE3689924T Expired - Lifetime DE3689924T4 (de) 1985-07-02 1986-06-26 Durch eine heterocyclische Gruppe substituierte Phenoxyalkylisoxazole und ihre Verwendung als antivirale Mittel.

Country Status (21)

Country Link
EP (2) EP0207454B1 (de)
JP (2) JPH0768242B2 (de)
KR (2) KR900001315B1 (de)
AR (4) AR241705A1 (de)
AT (2) ATE107645T1 (de)
AU (2) AU589190B2 (de)
CA (2) CA1280753C (de)
DE (3) DE3689924D1 (de)
DK (2) DK171275B1 (de)
ES (5) ES8802518A1 (de)
FI (2) FI85021C (de)
GR (2) GR861697B (de)
IE (2) IE59755B1 (de)
IL (2) IL79308A (de)
MX (4) MX2954A (de)
MY (1) MY102908A (de)
NO (2) NO164977C (de)
NZ (1) NZ216678A (de)
PH (2) PH23197A (de)
PT (2) PT82892B (de)
ZA (2) ZA864872B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1280753C (en) * 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
US5051437A (en) * 1986-06-24 1991-09-24 Sterling Drug Inc. Thiazolylphenoxyalkylisoxazoles, related compounds, and their use as antiviral agents
GB8807275D0 (en) * 1988-03-26 1988-04-27 Synphar Lab Inc Chemical compounds
US6051231A (en) * 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
EP0362531B1 (de) 1988-09-01 1999-11-10 Bayer Corporation Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
US5070090A (en) * 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
US5175178A (en) * 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5110821A (en) * 1989-08-18 1992-05-05 Sterling Drug Inc. 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
EP0468257B1 (de) * 1990-07-20 1999-09-01 Bayer Corporation Multimere Formen des menschlichen Rhinovirus-Rezeptorproteins
US5686582A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
IT1247509B (it) * 1991-04-19 1994-12-17 Univ Cagliari Composti di sintesi atti all'impiego nella terapia delle infezioni da rhinovirus
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5514781A (en) * 1994-04-11 1996-05-07 Bayer Corporation Use of azoles as virucidal agents in solutions of biologically active proteins
US5514679A (en) * 1994-05-13 1996-05-07 Sterling Winthrop Inc. Therapeutic phenoxyalklpyridazines and intermediates therefor
US5453433A (en) * 1994-05-13 1995-09-26 Sterling Winthrop Inc. Thiadiazoles and antipicornaviral compositions
WO2005005423A1 (en) 2003-07-02 2005-01-20 F. Hoffmann-La Roche Ag Indolyl derivatives substituted with a thiazole ring and their use as ppar modulators
US7790720B2 (en) * 2005-03-31 2010-09-07 Ucb Pharma, S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
AP2012006094A0 (en) * 2009-06-30 2012-02-29 Siga Technologies Inc Treatment and prevention of dengue virus infections.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451476A (en) * 1982-12-13 1984-05-29 Sterling Drug Inc. Isoxazoles as antiviral agents
NZ209209A (en) * 1983-08-29 1988-02-12 Sterling Drug Inc Substituted phenyl-aliphatic isoxazole derivatives and pharmaceutical compositions
CA1280753C (en) * 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans

Also Published As

Publication number Publication date
AU587622B2 (en) 1989-08-24
EP0207453A2 (de) 1987-01-07
DE3686677T2 (de) 1993-03-11
CA1280753C (en) 1991-02-26
NO862651D0 (no) 1986-07-01
ES557778A0 (es) 1988-04-01
KR870001202A (ko) 1987-03-12
IL79309A (en) 1990-11-29
EP0207454A2 (de) 1987-01-07
DK171275B1 (da) 1996-08-19
ZA864873B (en) 1987-02-25
ES8801649A1 (es) 1988-02-16
ES556811A0 (es) 1988-07-01
EP0207454B1 (de) 1992-09-09
NO862650L (no) 1987-01-05
FI862794A0 (fi) 1986-07-01
EP0207453B1 (de) 1994-06-22
KR900001314B1 (ko) 1990-03-08
ES8802153A1 (es) 1988-04-01
EP0207454A3 (en) 1988-08-10
NO165023C (no) 1990-12-12
KR900001315B1 (ko) 1990-03-08
GR861697B (en) 1986-11-04
AR244686A1 (es) 1993-11-30
IL79308A0 (en) 1986-10-31
DE3689924T4 (de) 1995-05-11
KR870001205A (ko) 1987-03-12
DE3689924T2 (de) 1995-01-19
ES557780A0 (es) 1988-02-16
NO165023B (no) 1990-09-03
FI862795A0 (fi) 1986-07-01
ES8801651A1 (es) 1988-02-16
FI862795A (fi) 1987-01-03
DK173467B1 (da) 2000-12-04
ES8802517A1 (es) 1988-07-01
CA1299176C (en) 1992-04-21
IL79308A (en) 1991-01-31
NO164977B (no) 1990-08-27
JPH0768242B2 (ja) 1995-07-26
IL79309A0 (en) 1986-10-31
MX2954A (es) 1993-11-01
ZA864872B (en) 1987-02-25
PT82892B (pt) 1994-09-30
ATE107645T1 (de) 1994-07-15
AR242572A1 (es) 1993-04-30
DK312986D0 (da) 1986-07-01
AU5945686A (en) 1987-01-08
FI85021C (fi) 1992-02-25
IE59755B1 (en) 1994-03-23
EP0207453A3 (en) 1988-11-23
ES8802518A1 (es) 1988-07-01
PT82891A (en) 1986-08-01
DK313086D0 (da) 1986-07-01
DE3689924D1 (de) 1994-07-28
JPS6216480A (ja) 1987-01-24
JPH0819128B2 (ja) 1996-02-28
PH23197A (en) 1989-05-29
IE861723L (en) 1987-01-02
AR241705A1 (es) 1992-11-30
IE66234B1 (en) 1995-12-13
ES556812A0 (es) 1988-07-01
ES557779A0 (es) 1988-02-16
NZ216678A (en) 1989-10-27
MX9100029A (es) 1993-01-01
AU589190B2 (en) 1989-10-05
AR242573A1 (es) 1993-04-30
FI85021B (fi) 1991-11-15
IE861724L (en) 1987-01-02
PT82891B (pt) 1988-05-27
PT82892A (pt) 1987-01-26
NO862650D0 (no) 1986-07-01
FI862794A (fi) 1987-01-03
DK313086A (da) 1987-01-03
MX9100033A (es) 1993-01-01
NO862651L (no) 1987-01-05
NO164977C (no) 1990-12-05
AU5945786A (en) 1987-01-08
PH22321A (en) 1988-07-29
MX9100032A (es) 1993-01-01
GR861695B (en) 1986-11-04
ATE80397T1 (de) 1992-09-15
DK312986A (da) 1987-01-03
MY102908A (en) 1993-03-31
JPS6216479A (ja) 1987-01-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI, PARIS, FR

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8328 Change in the person/name/address of the agent

Free format text: MUELLER, SCHUPFNER & GAUGER, 80539 MUENCHEN

8339 Ceased/non-payment of the annual fee