KR860008183A - 카바펜엠 공정 - Google Patents

카바펜엠 공정 Download PDF

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Publication number
KR860008183A
KR860008183A KR1019860003263A KR860003263A KR860008183A KR 860008183 A KR860008183 A KR 860008183A KR 1019860003263 A KR1019860003263 A KR 1019860003263A KR 860003263 A KR860003263 A KR 860003263A KR 860008183 A KR860008183 A KR 860008183A
Authority
KR
South Korea
Prior art keywords
general formula
defined above
group
hydrogen
pharmaceutically acceptable
Prior art date
Application number
KR1019860003263A
Other languages
English (en)
Inventor
덱스트라지 삐에르
Original Assignee
이삭 쟈코브스키
브리스톨 마이어즈 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이삭 쟈코브스키, 브리스톨 마이어즈 캄파니 filed Critical 이삭 쟈코브스키
Publication of KR860008183A publication Critical patent/KR860008183A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

카바펜엠 공정
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. L이 통상적인 이탈그룹이고, R15가 수소이거나 메틸이며 R2'가 통상적으로 쉽게 제거할 수 있는 카복실 보호그룹인 일반식
    이 중간체를, R5가 C1-C4알킬이고 R6와 R7각각은 수소이거나 C1-C4알킬을 표시하는 일반식
    의 티올화합물과 불활성용매 및 염기의 존재하에서 반응시켜서 R15,R2'가 상기 정의한 바와 같고가 R5,R6및 R7이 상기 정의한 바와 같은 일반식
    이거나 또는 이것의 제약상 허용염 또는 이것의 에스텔중의 기를 나타내는 일반식
    의 카바펜엠 생성물을 생성하고, 필요하면, 보호그룹 R2'을 제거하여 그에 상당하는 탈-보호 카바펜엠 생성물을 얻는 것으로 구성되는 R15및가 상기에서 정의한 바와 같은 일반식
    의 화합물이나 일것의 제약상 허용염을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860003263A 1985-04-29 1986-04-28 카바펜엠 공정 KR860008183A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72800985A 1985-04-29 1985-04-29
US728,009 1985-04-29

Publications (1)

Publication Number Publication Date
KR860008183A true KR860008183A (ko) 1986-11-12

Family

ID=24925057

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860003263A KR860008183A (ko) 1985-04-29 1986-04-28 카바펜엠 공정

Country Status (12)

Country Link
KR (1) KR860008183A (ko)
CA (1) CA1273014A (ko)
CS (1) CS261240B2 (ko)
DK (1) DK193886A (ko)
ES (1) ES8706671A1 (ko)
FI (1) FI861721A (ko)
GR (1) GR861150B (ko)
HU (1) HU197904B (ko)
LU (1) LU86410A1 (ko)
NO (1) NO861667L (ko)
OA (1) OA08240A (ko)
YU (1) YU150986A (ko)

Also Published As

Publication number Publication date
FI861721A0 (fi) 1986-04-24
LU86410A1 (fr) 1986-11-05
ES8706671A1 (es) 1987-07-01
NO861667L (no) 1986-10-30
HUT41792A (en) 1987-05-28
OA08240A (en) 1987-10-30
CS261240B2 (en) 1989-01-12
DK193886A (da) 1986-10-30
GR861150B (en) 1986-09-02
ES554468A0 (es) 1987-07-01
CA1273014A (en) 1990-08-21
HU197904B (en) 1989-06-28
CS311886A2 (en) 1988-04-15
FI861721A (fi) 1986-10-30
DK193886D0 (da) 1986-04-28
YU150986A (en) 1987-12-31

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E601 Decision to refuse application