KR830001947A - 화합물의 제조방법 - Google Patents
화합물의 제조방법Info
- Publication number
- KR830001947A KR830001947A KR1019800000546A KR800000546A KR830001947A KR 830001947 A KR830001947 A KR 830001947A KR 1019800000546 A KR1019800000546 A KR 1019800000546A KR 800000546 A KR800000546 A KR 800000546A KR 830001947 A KR830001947 A KR 830001947A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- general formula
- compound
- carboxy group
- reacting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 본문에 상술한 바와 같이 다음 일반식(5)의 화합물을 A 및 B 위치에서 접촉 수소화시키거나 가수분해시키고, 또는 다음 일반식(11)의 6-아미노페니실린산 에스테르를 다음 일반식(12)의 산반응성 유도체와 반응시키거나, 또는 다음 일반식(13)의 아미노페니실린을 다음 일반식(8)의 화합물과 반응시키는 것으로 구성된 다음 일반식(1)의 화합물을 제조하는 방법.식 중,R1은 페닐, 4-하이드록시페닐, 1,4-사이클로헥사디에닐 또는 3-티에닐기이고,R2는 1급 아미노 또는 카복시기이며,R3는 수소원자, 또는 저급알킬, 아릴 또는 아랄킬기, 바람직하기는 메틸, 페닐 또는 벤질기이고,A는 β-락탐환 뿐만 아니라 카복시기를 함유하는 β-락타마제 억제제의 기이며, A는 카복시기를 통하여 결합되고,B는 아지도기, 보호된 아미노기, 또는 보호된 카복시기이며,M은 양이온이고,X는 할로겐원자 또는 유사한 유리기이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB05020/79 | 1979-02-13 | ||
GB5020/79 | 1979-02-13 | ||
GB7905020 | 1979-02-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830001947A true KR830001947A (ko) | 1983-05-21 |
KR830001903B1 KR830001903B1 (ko) | 1983-09-19 |
Family
ID=10503160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019800000546A KR830001903B1 (ko) | 1979-02-13 | 1980-02-12 | 페니실란산유도체의 제조방법 |
Country Status (4)
Country | Link |
---|---|
JP (2) | JPS55113790A (ko) |
KR (1) | KR830001903B1 (ko) |
BE (1) | BE881675A (ko) |
ZA (1) | ZA80796B (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20020028298A (ko) * | 2000-10-09 | 2002-04-17 | 황해용 | 초배지 및 그 제조장치 |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4420426A (en) | 1979-03-05 | 1983-12-13 | Pfizer Inc. | 6-Alpha-halopenicillanic acid 1,1-dioxides |
US4714761A (en) * | 1979-03-05 | 1987-12-22 | Pfizer Inc. | 6,6-dihalopenicillanic acid 1,1-dioxides and process |
US4244951A (en) * | 1979-05-16 | 1981-01-13 | Pfizer Inc. | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide |
US4309347A (en) | 1979-05-16 | 1982-01-05 | Pfizer Inc. | Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide |
US4364957A (en) * | 1979-09-26 | 1982-12-21 | Pfizer Inc. | Bis-esters of alkanediols as antibacterial agents |
US4432970A (en) * | 1979-11-23 | 1984-02-21 | Pfizer Inc. | 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors |
IE51516B1 (en) * | 1980-10-06 | 1987-01-07 | Leo Pharm Prod Ltd | 1,1-dioxapenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate napsylate |
IL64009A (en) * | 1980-10-31 | 1984-09-30 | Rech Applications Therap | Crystalline 1,1-dioxopenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate tosylate hydrates,their production and pharmaceutical compositions containing them |
US4478748A (en) * | 1981-02-20 | 1984-10-23 | Pfizer Inc. | Bis-esters of alkanediols |
IN159362B (ko) * | 1981-03-23 | 1987-05-09 | Pfizer | |
US4419284A (en) * | 1981-03-23 | 1983-12-06 | Pfizer Inc. | Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide |
ZA821903B (en) * | 1981-03-23 | 1983-01-26 | Pfizer | Process for the preparation of penicillanic acid esters |
US4540687A (en) * | 1981-09-09 | 1985-09-10 | Pfizer Inc. | Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds |
JPS5857384A (ja) * | 1981-09-09 | 1983-04-05 | フアイザ−・インコ−ポレ−テツド | 抗菌性のペニシラン酸6′‐(2‐アミノ‐2‐〔4‐アシルオキシフェニル〕アセタミド)ペニシラノイルオキシメチル1,1‐ジオキシド化合物 |
US4582829A (en) * | 1981-09-09 | 1986-04-15 | Pfizer Inc. | Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds |
US4351840A (en) * | 1981-09-18 | 1982-09-28 | Pfizer Inc. | Antibacterial esters of resorcinol with ampicillin and penicillanic acid 1,1-dioxide derivatives |
US4359472A (en) * | 1981-12-22 | 1982-11-16 | Pfizer Inc. | Bis-hydroxymethyl carbonate bridged antibacterial agents |
US4444686A (en) * | 1982-01-25 | 1984-04-24 | Pfizer Inc. | Crystalline penicillin ester intermediate |
US4432987A (en) * | 1982-04-23 | 1984-02-21 | Pfizer Inc. | Crystalline benzenesulfonate salts of sultamicillin |
PH20068A (en) * | 1982-12-06 | 1986-09-18 | Pfizer | Process and intermediates for sultamicillin and analogs |
US4835674A (en) * | 1986-07-28 | 1989-05-30 | Bull Hn Information Systems Inc. | Computer network system for multiple processing elements |
DE102004021281A1 (de) * | 2004-04-29 | 2005-11-24 | Boehringer Ingelheim Vetmedica Gmbh | Verwendung von Meloxicam-Formulierungen in der Veterinärmedizin |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1578128A (en) * | 1976-03-30 | 1980-11-05 | Leo Pharm Prod Ltd | Amidinopenicillanoyloxyalkyl amoxycillinates |
-
1980
- 1980-02-12 ZA ZA00800796A patent/ZA80796B/xx unknown
- 1980-02-12 BE BE0/199363A patent/BE881675A/fr not_active IP Right Cessation
- 1980-02-12 KR KR1019800000546A patent/KR830001903B1/ko active
- 1980-02-13 JP JP1719780A patent/JPS55113790A/ja active Granted
-
1987
- 1987-05-11 JP JP62114399A patent/JPS62281879A/ja active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20020028298A (ko) * | 2000-10-09 | 2002-04-17 | 황해용 | 초배지 및 그 제조장치 |
Also Published As
Publication number | Publication date |
---|---|
JPS6259709B2 (ko) | 1987-12-12 |
JPS62281879A (ja) | 1987-12-07 |
KR830001903B1 (ko) | 1983-09-19 |
JPH0470315B2 (ko) | 1992-11-10 |
ZA80796B (en) | 1981-02-25 |
JPS55113790A (en) | 1980-09-02 |
BE881675A (fr) | 1980-08-12 |
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