KR860002512A - 세팔로스포린 중간체의 제조방법 - Google Patents

세팔로스포린 중간체의 제조방법 Download PDF

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Publication number
KR860002512A
KR860002512A KR1019850006755A KR850006755A KR860002512A KR 860002512 A KR860002512 A KR 860002512A KR 1019850006755 A KR1019850006755 A KR 1019850006755A KR 850006755 A KR850006755 A KR 850006755A KR 860002512 A KR860002512 A KR 860002512A
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KR
South Korea
Prior art keywords
amino
cepem
pyridiniummethyl
volume
mentioned
Prior art date
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KR1019850006755A
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English (en)
Inventor
조우(외 3) 타-센
Original Assignee
메리 앤 턱커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 메리 앤 턱커, 일라이 릴리 앤드 캄파니 filed Critical 메리 앤 턱커
Publication of KR860002512A publication Critical patent/KR860002512A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음

Description

세팔로스포린 중간체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 7-치환된-아미노-3-(1-피리디늄메틸)-3-세펨-4-카르복실레이트 분해 생성물을 함유하는 분해 반응혼합물을, 아세토니트릴, 아세톤 또는 이소프로필알코올로부터 선택된 용매와 혼합시키고(여기서, 언급된 용매 및/또는 반응 혼합물은 언급된 용매부피에 대해 총 약 5 내지 10부피%의 물을 함유한다); 결정형 디히드로클로라이드 디히드레이트로서 생성된 7-아미노-3-(1-피리디늄메틸)-3-세펨-4-카르복실-레이트를 분리시킴을 특징으로 하여, 7-치환된-아미노 세펨의 분해로부터 7-아미노-3-(1-피리디늄메틸)-3-세펨-4-카르복실레이트 디히드로클로라이드를 제조하는 방법.
  2. 제1항에 있어서, 언급된 7-치환된-아미노 세펨이 7-아실아미노 세펨 화합물인 방법.
  3. 제2항에 있어서, 언급된 7-아실아미노기가 2-티에닐아세틸아미노, 페닐아세틸아미노, 페녹시아세틸-아미노, 또는 포름일아미노인 방법.
  4. 제3항에 있어서, 7-(2-티에닐아세틸아미노)-3-(1-피리디늄메틸)-3-세펨-4-카르복실레이트 또는 7-포름일아미노-3-(1-피리디늄메틸)-3-세펨-4-카르복실레이트를 N-탈아실화시키는 방법.
  5. 제1항에 있어서, 7-치환된-아미노 세펨 화합물이 트리알킬실릴아미노 세펨인 방법.
  6. 제5항에 있어서, 7-트리메틸실릴아미노-3-(1-피리디늄메틸)-3-세펨-4-카르복실산 트리메틸실릴에스테르를 가수분해에 의해 분해시키는 방법.
  7. 제1항에 있어서, 약 5 내지 약 10부피%의 물을 함유하는 아세토니트릴을 분해 반응 혼합물과 혼합시키는 방법.
  8. 제1항에 있어서, 분해 반응 혼합물을 언급된 반응 혼합물의 부피의 약 1/4 내지 약 1/2에 해당하는 부피의 용매와 혼합시키는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850006755A 1984-09-17 1985-09-16 세팔로스포린 중간체의 제조방법 KR860002512A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65101284A 1984-09-17 1984-09-17
US651.012 1984-09-17

Publications (1)

Publication Number Publication Date
KR860002512A true KR860002512A (ko) 1986-04-26

Family

ID=24611234

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850006755A KR860002512A (ko) 1984-09-17 1985-09-16 세팔로스포린 중간체의 제조방법

Country Status (6)

Country Link
EP (1) EP0175544A3 (ko)
JP (1) JPS6172790A (ko)
KR (1) KR860002512A (ko)
ES (1) ES8604975A1 (ko)
HU (1) HUT38355A (ko)
IL (1) IL76367A0 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90660A0 (en) * 1988-06-22 1990-01-18 Lilly Co Eli Intermiediate for 1-carba(dethia)cephalosporin
JPH02101081A (ja) * 1988-10-08 1990-04-12 Meiji Seika Kaisha Ltd セファロスポリン誘導体結晶性二塩酸塩及びその製造法
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
FR2457295A1 (fr) * 1979-05-25 1980-12-19 Glaxo Group Ltd Composes intermediaires pour la preparation de cephalosporines

Also Published As

Publication number Publication date
ES547016A0 (es) 1986-03-01
HUT38355A (en) 1986-05-28
EP0175544A3 (en) 1987-06-03
JPS6172790A (ja) 1986-04-14
IL76367A0 (en) 1986-01-31
ES8604975A1 (es) 1986-03-01
EP0175544A2 (en) 1986-03-26

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