ES8102578A1 - Procedimiento de preparacion del acido 7-(d(-)-a-amino-p-hi-dro-xifenilacetamido)desacetoxicefalosporanico - Google Patents

Procedimiento de preparacion del acido 7-(d(-)-a-amino-p-hi-dro-xifenilacetamido)desacetoxicefalosporanico

Info

Publication number
ES8102578A1
ES8102578A1 ES488783A ES488783A ES8102578A1 ES 8102578 A1 ES8102578 A1 ES 8102578A1 ES 488783 A ES488783 A ES 488783A ES 488783 A ES488783 A ES 488783A ES 8102578 A1 ES8102578 A1 ES 8102578A1
Authority
ES
Spain
Prior art keywords
alpha
hydroxyphenylacetamido
amino
preparation
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES488783A
Other languages
English (en)
Other versions
ES488783A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz Industrial Products SA
Original Assignee
Gema SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gema SA filed Critical Gema SA
Priority to ES488783A priority Critical patent/ES488783A0/es
Priority to DE19813105397 priority patent/DE3105397A1/de
Publication of ES8102578A1 publication Critical patent/ES8102578A1/es
Publication of ES488783A0 publication Critical patent/ES488783A0/es
Priority to US06/234,896 priority patent/US4336376A/en
Priority to IT19831/81A priority patent/IT1136565B/it
Priority to FR8103326A priority patent/FR2476090A1/fr
Priority to JP2230581A priority patent/JPS56135490A/ja
Priority to GB8105382A priority patent/GB2070009A/en
Priority to NL8100862A priority patent/NL8100862A/nl
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARACION DE CD 7-((D(-)-ALFA-AMINO-P-HIDROXIFENIL-ACETAMIDO)DESACETOXICEFALOSPORANICO. SE HACE REACCIONAR UNA SAL DE ACIDO D(-)-P-HIDROXI-N-(1-ALCOXICARBONIL-2-PROPENIL)-ALFA-AMINOFENILACETICO CON UN EQUIVALENTE DE TRIMETIL-SILIL-2-OXAZOLIDINONA, PARA OBTENER UN COMPUESTO, EL CUAL SE HACE REACCIONAR CON UN COMPUESTO DE FORMULA: PARA OBTENER UN ANHIDRIDO MIXTO, EL CUAL REACCIONA NUEVAMENTE CON UNA SOLUCION DE ACIDO 7-AMINODESACETOXICEFALOSPORANICO, OBTENIDA POR SILILACION, EN UN DISOLVENTE ORGANICO ANHIDRO, CON TRIMETILSILIL-2-OXAZOLIDINONA PARA OBTENER LA P-HIDROXICEFALEXINA. ESTE COMPUESTO TIENE APLICACION EN MEDICINA Y VETERINARIA.
ES488783A 1980-02-20 1980-02-20 Procedimiento de preparacion del acido 7-(d(-)-a-amino-p-hi-dro-xifenilacetamido)desacetoxicefalosporanico Granted ES488783A0 (es)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES488783A ES488783A0 (es) 1980-02-20 1980-02-20 Procedimiento de preparacion del acido 7-(d(-)-a-amino-p-hi-dro-xifenilacetamido)desacetoxicefalosporanico
DE19813105397 DE3105397A1 (de) 1980-02-20 1981-02-14 Verfahren zur herstellung von 7-(d(-)-(alpha)-amino-p-hydroxyphenylacetamido)-desacetoxycephalosporansaeure
US06/234,896 US4336376A (en) 1980-02-20 1981-02-17 Process for the preparation of 7-(D(-)-alpha-amino-p-hydroxyphenylacetamido)desacetoxycephalosporanic acid
IT19831/81A IT1136565B (it) 1980-02-20 1981-02-18 Procedimento per la preparazione dell'acido 7-(d(-)-alfa-ammino-p.idrossifenilacetammido) desacetossicefalosporanico
FR8103326A FR2476090A1 (fr) 1980-02-20 1981-02-19 Procede de preparation de l'acide 7-(d(-)-a-amino-p-hydroxyphenyl-acetamido) desacetoxycephalosporanique
JP2230581A JPS56135490A (en) 1980-02-20 1981-02-19 Manufacture of 7-(d(-)-alpha-amino-p- hydroxyphenylacetamide)desacetoxycephalosporanic acid
GB8105382A GB2070009A (en) 1980-02-20 1981-02-20 Process for the preparation of 7-(d(-)-alpha-amino-p-hydroxyphenylacetamido)desacetoxycephalosporanic acid
NL8100862A NL8100862A (nl) 1980-02-20 1981-02-20 Werkwijze voor het bereiden van 7-(d(-)-alfa-amino-p-hydroxyfenylaceetamido)-desacetoxycefalosporanzuur.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES488783A ES488783A0 (es) 1980-02-20 1980-02-20 Procedimiento de preparacion del acido 7-(d(-)-a-amino-p-hi-dro-xifenilacetamido)desacetoxicefalosporanico

Publications (2)

Publication Number Publication Date
ES8102578A1 true ES8102578A1 (es) 1981-02-16
ES488783A0 ES488783A0 (es) 1981-02-16

Family

ID=8479856

Family Applications (1)

Application Number Title Priority Date Filing Date
ES488783A Granted ES488783A0 (es) 1980-02-20 1980-02-20 Procedimiento de preparacion del acido 7-(d(-)-a-amino-p-hi-dro-xifenilacetamido)desacetoxicefalosporanico

Country Status (8)

Country Link
US (1) US4336376A (es)
JP (1) JPS56135490A (es)
DE (1) DE3105397A1 (es)
ES (1) ES488783A0 (es)
FR (1) FR2476090A1 (es)
GB (1) GB2070009A (es)
IT (1) IT1136565B (es)
NL (1) NL8100862A (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109836438A (zh) * 2019-03-19 2019-06-04 河北科技大学 头孢氨苄杂质的合成方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9115203D0 (en) * 1991-07-15 1991-08-28 Biochemie Gmbh Improvements in or relating to beta lactam production
GB0118764D0 (en) * 2001-08-01 2001-09-26 Biochemie Gmbh Organic compounds
WO2005042543A1 (en) * 2003-10-30 2005-05-12 Cj Corporation Processes for the preparation of cephem derivatives
ATE420755T1 (de) * 2003-11-28 2009-01-15 Xenocs S A Verfahren zur herstellung einer abformungsmatrize,sowie abformungsmatrize
EP1725250A2 (en) * 2004-02-18 2006-11-29 Frutarom Ltd. Method for the preparation of peptide-oligonucleotide conjugates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148817A (en) * 1976-03-25 1979-04-10 Eli Lilly And Company Process and intermediates for preparing cephalosporin antibiotics

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109836438A (zh) * 2019-03-19 2019-06-04 河北科技大学 头孢氨苄杂质的合成方法

Also Published As

Publication number Publication date
ES488783A0 (es) 1981-02-16
GB2070009A (en) 1981-09-03
IT1136565B (it) 1986-09-03
NL8100862A (nl) 1981-09-16
JPS56135490A (en) 1981-10-22
US4336376A (en) 1982-06-22
IT8119831A0 (it) 1981-02-18
DE3105397A1 (de) 1981-12-24
FR2476090B1 (es) 1983-07-29
FR2476090A1 (fr) 1981-08-21

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