KR850002478A - 2-(n-피롤리디노)-3-이소부톡시-n-치환된 페닐-n-벤질-프로필아민의 제조방법 - Google Patents

2-(n-피롤리디노)-3-이소부톡시-n-치환된 페닐-n-벤질-프로필아민의 제조방법 Download PDF

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KR850002478A
KR850002478A KR1019840005947A KR840005947A KR850002478A KR 850002478 A KR850002478 A KR 850002478A KR 1019840005947 A KR1019840005947 A KR 1019840005947A KR 840005947 A KR840005947 A KR 840005947A KR 850002478 A KR850002478 A KR 850002478A
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South Korea
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compound
preparing
general formula
formula
pyrrolidino
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KR1019840005947A
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KR910003711B1 (ko
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쟝 끌로드 몽떼이 앙드레 (외 2)
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쟝 미셀 바르느리아
리옴 라보라뜨와르 쎄. 으. 에르. 엠. 에르엘-세름 에스. 아
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

2-(N-피롤리디노)-3-이소부톡시-N-치환된 페닐-N-벤질-프로필아민의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식〔A〕 화합물 또는 그것의 산부가염을 일반식〔B〕화합물 또는 그것의 산부가염과 반응시키고 Q가 산소일때는 산출된 카르보닐함유 화합물을 환원시킨후, 선택적으로 약학적 유용산 부가염으로 전환시키는 것을 특징으로 하는 하기 일반식(I) 화합물의 제조방법.
    여기에서, X는 할로겐, 수산기, 알킬기, 트리플루오로메틸 또는 메틸렌옥시기중의 하나 또는 두개의 기이며, Q는 산소 또는 두개의 수소원자(2H)를 Hal은 할로겐, 바람직하게는 염소를 나타낸다.
  2. 제1항에 있어서, 일반식〔B〕화합물을 알카리금속 하이드라이드 또는 알카리금속 아미드로 금속화하여 일반식〔A〕와 〔B〕의 화합물 반응을 촉진시킴을 특징으로 하는 제조방법.
  3. 일반식〔I〕화합물을 활성성분으로 하며 그 활성성분의 양을 1내지 15mg/kg 체중의 일일 투여분으로 투여될 수 있도록 포함하는 약학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840005947A 1983-09-27 1984-09-27 2-(n-피롤리디노)-3-이소부톡시-n-치환된 페닐-n-벤질-프로필아민의 제조방법 KR910003711B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8315367 1983-09-27
FR8315367 1983-09-27

Publications (2)

Publication Number Publication Date
KR850002478A true KR850002478A (ko) 1985-05-13
KR910003711B1 KR910003711B1 (ko) 1991-06-08

Family

ID=9292587

Family Applications (1)

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KR1019840005947A KR910003711B1 (ko) 1983-09-27 1984-09-27 2-(n-피롤리디노)-3-이소부톡시-n-치환된 페닐-n-벤질-프로필아민의 제조방법

Country Status (15)

Country Link
US (1) US4645778A (ko)
EP (1) EP0138684B1 (ko)
JP (1) JPS6092279A (ko)
KR (1) KR910003711B1 (ko)
AT (1) ATE42100T1 (ko)
AU (1) AU569326B2 (ko)
CA (1) CA1235417A (ko)
DE (1) DE3477664D1 (ko)
DK (1) DK156396C (ko)
ES (1) ES8602723A1 (ko)
FI (1) FI78081C (ko)
GR (1) GR80481B (ko)
HU (1) HU192589B (ko)
PT (1) PT79273B (ko)
ZA (1) ZA847508B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727072A (en) * 1986-02-12 1988-02-23 Mcneilab, Inc. 3-alkoxy-2-aminopropylamines compositions and use as cardiovascular agents
US4758563A (en) * 1986-02-12 1988-07-19 Mcneilab, Inc. 3-alkoxy-2-aminopropyamines, cardiovascular compositions and use
DE3726633A1 (de) * 1987-08-11 1989-02-23 Boehringer Mannheim Gmbh Neue 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE3726632A1 (de) * 1987-08-11 1989-05-18 Boehringer Mannheim Gmbh 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US4888335A (en) * 1988-07-25 1989-12-19 Mcneilab, Inc. 3-alkoxy-2-aminopropyl heterocyclic amines and their use as cardiovascular agents
US5185362A (en) * 1988-09-14 1993-02-09 Mcneilab, Inc. Diphenylamine cardiovascular agents, compositions and use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30577A (en) * 1860-11-06 Truss-bridge
BE795735A (fr) * 1972-03-06 1973-06-18 Cerm Cent Europ Rech Mauvernay Nouvelles ethylenediamines substituees a activite cardiovasculaire
FR2378024A1 (fr) * 1977-01-25 1978-08-18 Cerm Cent Europ Rech Mauvernay Nouvelle propylamine substituee, obtention et application
GB2087233A (en) * 1980-09-30 1982-05-26 Akzo Nv Pharmaceutical compositions containing n-aryl ethanamines having anti-atherothrombosclerotic activity
FR2504925A1 (en) * 1981-05-04 1982-11-05 Cerm Cent Europ Rech Mauvernay N-2-amino 3-alkoxy or phenoxy-propyl urea and thiourea derivs. - are cardiovascular agents esp. used to treat arrhythmia
GB8330197D0 (en) * 1983-11-11 1983-12-21 Akzo Nv Ether of n-propanolamine derivative

Also Published As

Publication number Publication date
JPH0336836B2 (ko) 1991-06-03
US4645778A (en) 1987-02-24
AU3354084A (en) 1985-04-04
FI78081C (fi) 1989-06-12
ES536264A0 (es) 1985-12-01
CA1235417A (en) 1988-04-19
DK156396C (da) 1990-01-08
JPS6092279A (ja) 1985-05-23
KR910003711B1 (ko) 1991-06-08
FI843785A0 (fi) 1984-09-26
DK451884D0 (da) 1984-09-21
AU569326B2 (en) 1988-01-28
DK156396B (da) 1989-08-14
PT79273A (en) 1984-10-01
HU192589B (en) 1987-06-29
EP0138684A2 (fr) 1985-04-24
GR80481B (en) 1985-01-28
PT79273B (en) 1986-08-28
ATE42100T1 (de) 1989-04-15
EP0138684B1 (fr) 1989-04-12
DE3477664D1 (en) 1989-05-18
EP0138684A3 (en) 1985-06-19
FI78081B (fi) 1989-02-28
HUT36469A (en) 1985-09-30
DK451884A (da) 1985-03-28
FI843785L (fi) 1985-03-28
ES8602723A1 (es) 1985-12-01
ZA847508B (en) 1985-05-29

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