ES482472A1 - Procedimiento para la preparacion de isoquinoleinas. - Google Patents

Procedimiento para la preparacion de isoquinoleinas.

Info

Publication number
ES482472A1
ES482472A1 ES482472A ES482472A ES482472A1 ES 482472 A1 ES482472 A1 ES 482472A1 ES 482472 A ES482472 A ES 482472A ES 482472 A ES482472 A ES 482472A ES 482472 A1 ES482472 A1 ES 482472A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
isoquinoline derivatives
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES482472A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES482472A1 publication Critical patent/ES482472A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Derivados 3-amino-4-fenil-isoquinoleínicos con efectos sobre el sistema nervioso central y 3- piperazinoisoquinoleínas con intenso efecto inhibidor sobre la aglomeración de trombocitos. Se han hallado ahora isoquinoleínas sustituidas con radicales básicos en posición 3, que poseen valiosas propiedades farmacológicas, especialmente propiedades psicótropas. Objeto de la invención es un procedimiento para la preparación de isoquinoleínas de la fórmula general **(Fórmula- 01)** donde: m significa uno ó dos R1 significa un grupo amino de la fórmula **(Fórmula-02)**, donde R4 y R5 son iguales o diferentes y significan hidrógeno o un radical alcohilo, saturado o insaturado, de cadena recta o ramificado, con 1 hasta 8 átomos de carbono, pudiendo los radicales alcohilo estar también sustituidos con un grupo hidroxi, alcoxi C1-C4 o con un grupo amino de la fórmula **(Fórmula-03), siendo R6 y R7 iguales o diferentes y representando hidrógeno o un radical alcohilo, de cadena recta o ramificado, con 1 hasta 6 átomos de carbono.
ES482472A 1978-04-27 1979-07-13 Procedimiento para la preparacion de isoquinoleinas. Expired ES482472A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782818403 DE2818403A1 (de) 1978-04-27 1978-04-27 Neue isochinolinderivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ES482472A1 true ES482472A1 (es) 1980-04-01

Family

ID=6038097

Family Applications (2)

Application Number Title Priority Date Filing Date
ES479820A Expired ES479820A1 (es) 1978-04-27 1979-04-21 Procedimiento para la preparacion de isoquinoleinas.
ES482472A Expired ES482472A1 (es) 1978-04-27 1979-07-13 Procedimiento para la preparacion de isoquinoleinas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES479820A Expired ES479820A1 (es) 1978-04-27 1979-04-21 Procedimiento para la preparacion de isoquinoleinas.

Country Status (16)

Country Link
US (1) US4282222A (es)
EP (1) EP0005232B1 (es)
JP (1) JPS54148792A (es)
AU (1) AU526681B2 (es)
CA (1) CA1149809A (es)
DE (2) DE2818403A1 (es)
DK (1) DK170679A (es)
EG (1) EG13857A (es)
ES (2) ES479820A1 (es)
FI (1) FI791343A (es)
GR (1) GR71694B (es)
HU (1) HU182028B (es)
IL (1) IL57138A0 (es)
NO (1) NO791391L (es)
PT (1) PT69553A (es)
ZA (1) ZA792018B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3034001A1 (de) * 1980-09-10 1982-04-22 Hoechst Ag, 6000 Frankfurt Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung
EP0135975B1 (en) * 1983-09-29 1988-09-14 Akzo N.V. Quinazoline and isoquinoline derivatives
GB8328052D0 (en) * 1983-10-20 1983-11-23 Beecham Group Plc Compounds
GB8426584D0 (en) * 1984-10-19 1984-11-28 Beecham Group Plc Compounds
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
WO1999011622A1 (en) * 1997-09-03 1999-03-11 Guilford Pharmaceuticals Inc. Amino-substituted compounds, methods, and compositions for inhibiting parp activity
US6346536B1 (en) 1997-09-03 2002-02-12 Guilford Pharmaceuticals Inc. Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same
US6197785B1 (en) 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6426415B1 (en) 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US6395749B1 (en) 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
US6387902B1 (en) 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
AU2001264595A1 (en) 2000-05-19 2001-12-03 Guilford Pharmaceuticals Inc. Sulfonamide and carbamide derivatives of 6(5h)phenanthridinones and their uses
WO2001091796A2 (en) 2000-06-01 2001-12-06 Guilford Pharmaceuticals Inc. Methods, compounds and compositions for treating gout
GB0229281D0 (en) * 2002-12-16 2003-01-22 Novartis Ag Organic compounds
US7683066B2 (en) * 2005-05-20 2010-03-23 Vertex Pharmaceuticals Incorporated Isoquinolines useful as modulators of ion channels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
DE2030675A1 (en) * 1969-06-23 1971-02-11 Arthur D Little, Inc , Cambridge, Mass (V St A) 3-amino-4-phenyl-isoquinoline derivs
AU465390B2 (en) * 1971-12-31 1975-09-10 Ici Australia Limited Isoquinolines
AT342057B (de) * 1974-04-25 1978-03-10 Thomae Gmbh Dr K Verfahren zur herstellung von neuen 3-piperazino-isochinolinen und deren salzen

Also Published As

Publication number Publication date
EP0005232B1 (de) 1982-08-25
DE2963573D1 (en) 1982-10-21
CA1149809A (en) 1983-07-12
DE2818403A1 (de) 1979-11-08
EG13857A (en) 1982-06-30
AU4648079A (en) 1979-11-22
GR71694B (es) 1983-06-21
AU526681B2 (en) 1983-01-27
FI791343A (fi) 1979-10-28
EP0005232A1 (de) 1979-11-14
ES479820A1 (es) 1979-11-16
PT69553A (de) 1979-05-01
NO791391L (no) 1979-10-30
ZA792018B (en) 1980-05-28
US4282222A (en) 1981-08-04
IL57138A0 (en) 1979-07-25
DK170679A (da) 1979-10-28
HU182028B (en) 1983-12-28
JPS54148792A (en) 1979-11-21

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