KR840009310A - 디벤조디아제핀 유도체의 제조방법 - Google Patents

디벤조디아제핀 유도체의 제조방법 Download PDF

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Publication number
KR840009310A
KR840009310A KR1019840002660A KR840002660A KR840009310A KR 840009310 A KR840009310 A KR 840009310A KR 1019840002660 A KR1019840002660 A KR 1019840002660A KR 840002660 A KR840002660 A KR 840002660A KR 840009310 A KR840009310 A KR 840009310A
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South Korea
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compound
group
lower alkyl
defined above
hydrogen
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KR1019840002660A
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English (en)
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제이. 글람코스키(외 1) 에드워드
Original Assignee
마아크 이. 로가트
훽스트-러셀 파마슈티칼스 인코퍼레이티드
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Application filed by 마아크 이. 로가트, 훽스트-러셀 파마슈티칼스 인코퍼레이티드 filed Critical 마아크 이. 로가트
Publication of KR840009310A publication Critical patent/KR840009310A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

내용없음

Description

디벤조디아제핀 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 일반식(XXIII)의 화합물을 루이스산의 존재중에서 R5R6NH,CH2(CH2)nNR|7R8, (여기서, R5,R6,R7,R8,R9,R10및 n은 하기 정의한 바와 같다)로 구성된 그룹중에서 선택한 화합물과 반응시킴을 특징으로 하여 일반식(I)의 화합물 및 그의 약제학적으로 허용되는 산 부가염을 제조하는 방법.
    상기식에서 X 및 Y는 동일 또는 상이하며, 각각 수소, 할로겐, CF3, 저급 알콕시, 저급알킬티오 또는 저급 알킬설포닐이고 ;
    R1은 R2와 R3와 결합하여 -(CH2)m-CH2-|그룹(여기서 m은 1 또는 2이다)또는 -CH=CH-그룹을 형성하는 경우에는 수소이며;
    R3는 R1이 R2와 결합하여 -(CH2)m-CH2-|그룹(여기서 m은 1또는 2이다) 또는- CH=CH-그룹을 형성하는 경우에 수소이고;
    R4는 NR5R6, (CH2)nNR7R8, |또는이며, 여기서 R5는 수소 또는 저급 알킬이고, R6은 수소 또는 저급 알킬이며, R7및 R8은 저급 알킬이고, n은 2또는 3이며, R9는 저급 알킬이고, R10은 저급알킬, 페닐, 할로겐, CF3, 저급알킬, 저급알콕시 또는 저급 알킬티오로 치환된 페닐, 벤질, 페닐그룹이 할로겐, CF3, 저급알킬, 저급알콕시 또는 저급 알킬티오로 치환된 벤질, 또는 CO2R11(여기서, R11은 저급알킬이다)이다.
  2. 제1항에 있어서, 일반식('a)의 화합물 및 그의 약제학적으로 허용되는 산부가염을 제조하는 방법.
    상기식에서 R4,X 및 Y는 상기 정의한 바와 같다.
  3. 제1항에 있어서, 일반식(I b)의 화합물 및 그의 약제학적으로 허용되는 산부가염을 제조하는 방법.
    상기식에서 R4,X 및 Y는 상기 정의한 바와 같다.
  4. 제1항에 있어서, 일반식(I c)의 화합물 및 그의 약제학적으로 허용되는 산부 가염을 제조하는 방법.
    상기식에서 R44,X 및 Y는 상기 정의한 바와 같다.
  5. 제1항에 있어서, 일반식(I d)의 화합물 및 그의 약제학적으로 허용되는 산 부가염을 제조하는 방법.
    상기식에서 R4,X 및 Y는 상기 정의한 바와 같다.
  6. 제2항 내지 5항중 어느 하나에 있어서, R4가 NR5R6또는 (CH2)nNR|7R8그룹(여기서, R5,R6,R7,R8및 n은 상기 정의한 바와 같다)인 방법.
  7. 제2항 내지 5항중 어느 하나에 있어서, R4가또는(여기서, R9및 R10은 상기 정의한 바와 같다)인 방법.
  8. 제7항에 있어서, R4가(여기서, R10은 상기 정의한 바와 같다)인 방법.
  9. 제1항에 있어서, 루이스산을 사염화티탄, 염화알루미늄, 브롬화아연, 염와 제2천 및 염화 제2주석으로 이루어진 그룹중에서 선택하는 방법.
  10. 제9항에 있어서, 루이스산이 사염화티탄인 방법.
  11. 제1항에 있어서, 용매를 사용하는 방법.
  12. 제11항에 있어서, 벤젠, 톨루엔 및 크실렌으로 이루어진 그룹중에서 선택된 용매를 사용하는 방법.
  13. 제12항에 있어서, 벤젠을 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840002660A 1983-05-18 1984-05-16 디벤조디아제핀 유도체의 제조방법 KR840009310A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/495,569 US4761411A (en) 1983-05-18 1983-05-18 Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses
US495569 1983-05-18

Publications (1)

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KR840009310A true KR840009310A (ko) 1984-12-26

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Country Link
US (1) US4761411A (ko)
EP (1) EP0129692A3 (ko)
JP (1) JPS59219285A (ko)
KR (1) KR840009310A (ko)
AU (1) AU575830B2 (ko)
CA (1) CA1244414A (ko)
DK (1) DK246984A (ko)
ES (1) ES532509A0 (ko)
FI (1) FI77865C (ko)
GR (1) GR82273B (ko)
HU (1) HU193010B (ko)
IL (1) IL71856A0 (ko)
NZ (1) NZ208180A (ko)
PH (1) PH21087A (ko)
PT (1) PT78599B (ko)
ZA (1) ZA843722B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751223A (en) * 1986-10-14 1988-06-14 Hoechst-Roussel Pharmaceuticals, Inc. Antiinflammatory and analgesic aminoalkyl tetracyclic benzodiazepines
US4840947A (en) * 1986-10-14 1989-06-20 Hoechst-Roussel Pharmaceuticals, Inc. Antiinflammatory and analgesic piperidin-4-yl-tetracyclic benzodiazepines and use thereas
US5008262A (en) * 1988-04-19 1991-04-16 The United States Of America As Represented By The Department Of Health And Human Services Method of treating trichotillomania and onchyphagia
US4929615A (en) * 1989-06-12 1990-05-29 Hoechst-Roussel Pharmaceuticals Inc. 7H-benzo[b]pyrazino[1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines
US5312819A (en) * 1990-08-20 1994-05-17 Sandoz Ltd. Pharmaceutical compositions comprising clozapine and a radical scavenger
JP3188715B2 (ja) * 1995-11-01 2001-07-16 メルク エンド カンパニー インコーポレーテッド 一酸化窒素シンターゼの阻害物質としてのヘキサヒドロ−５−イミノ−１，４−ヘテロアゼピン誘導体
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
MX2007008434A (es) 2005-01-19 2007-07-25 Squibb Bristol Myers Co Derivados de 2-fenoxi-n-(1,3,4-tiadizol-2il)piridin-3-amina y compuestos relacionados como inhibidores del receptor p2y1 para el tratamiento de trastornos tromboembolicos.
EP1896466B1 (en) 2005-06-27 2011-04-13 Bristol-Myers Squibb Company N-linked heterocyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
EP1899299B1 (en) 2005-06-27 2010-10-20 Bristol-Myers Squibb Company C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
WO2007002634A1 (en) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
WO2007002584A1 (en) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Linear urea mimics antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
WO2012153796A1 (ja) * 2011-05-10 2012-11-15 協和発酵キリン株式会社 ピリミドジアゼピノン化合物

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* Cited by examiner, † Cited by third party
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AU2733371A (en) * 1970-04-14 1972-10-12 A. H. Robins Company, Incorporated 5, 7-DISUBSTITUTED-l, 9-ALKYLENE-l, 4-BENZODIAZEPIN-2 ONES
GB1451389A (en) * 1974-07-03 1976-09-29 Pierrel Spa Indolobenzazepines
US4192874A (en) * 1978-11-02 1980-03-11 American Hoechst Corporation Substituted 1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepines
US4186199A (en) * 1978-11-02 1980-01-29 American Hoechst Corporation Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines
IE57646B1 (en) * 1983-12-16 1993-02-10 Wyeth John & Brother Ltd Derivatives of imidazoquinolines and analogues thereof
GB8333581D0 (en) * 1983-12-16 1984-01-25 Wyeth John & Brother Ltd Heterocyclic compounds

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PT78599B (en) 1986-07-17
EP0129692A2 (en) 1985-01-02
ES8506652A1 (es) 1985-08-01
PT78599A (en) 1984-06-01
AU575830B2 (en) 1988-08-11
FI841965A0 (fi) 1984-05-16
HUT37432A (en) 1985-12-28
ZA843722B (en) 1985-01-30
FI77865B (fi) 1989-01-31
DK246984D0 (da) 1984-05-17
JPS59219285A (ja) 1984-12-10
EP0129692A3 (en) 1987-07-29
US4761411A (en) 1988-08-02
FI77865C (fi) 1989-05-10
NZ208180A (en) 1988-01-08
FI841965A (fi) 1984-11-19
IL71856A0 (en) 1984-09-30
AU2834784A (en) 1984-11-22
PH21087A (en) 1987-07-16
CA1244414A (en) 1988-11-08
HU193010B (en) 1987-08-28
DK246984A (da) 1984-11-19
GR82273B (ko) 1984-12-13
ES532509A0 (es) 1985-08-01

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