KR840006999A - 치환된 트로필 및 슈도트로필 벤조에이트의 제조방법 - Google Patents
치환된 트로필 및 슈도트로필 벤조에이트의 제조방법 Download PDFInfo
- Publication number
- KR840006999A KR840006999A KR1019830005847A KR830005847A KR840006999A KR 840006999 A KR840006999 A KR 840006999A KR 1019830005847 A KR1019830005847 A KR 1019830005847A KR 830005847 A KR830005847 A KR 830005847A KR 840006999 A KR840006999 A KR 840006999A
- Authority
- KR
- South Korea
- Prior art keywords
- chlorine
- trophylls
- pseudotropes
- benzoate
- preparing substituted
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 5
- 229910052801 chlorine Inorganic materials 0.000 claims 5
- 239000000460 chlorine Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 3
- 150000004820 halides Chemical class 0.000 claims 3
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 claims 2
- QIZDQFOVGFDBKW-DHBOJHSNSA-N Pseudotropine Natural products OC1C[C@@H]2[N+](C)[C@H](C1)CC2 QIZDQFOVGFDBKW-DHBOJHSNSA-N 0.000 claims 2
- XMLNCADGRIEXPK-KUMOIWDRSA-M chembl2146143 Chemical compound [Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C)C(=O)C(CO)C1=CC=CC=C1 XMLNCADGRIEXPK-KUMOIWDRSA-M 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- CYHOMWAPJJPNMW-RNLVFQAGSA-N pseudotropine Chemical compound C1[C@H](O)C[C@H]2CC[C@@H]1N2C CYHOMWAPJJPNMW-RNLVFQAGSA-N 0.000 claims 2
- 239000000010 aprotic solvent Substances 0.000 claims 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 claims 1
- -1 halide hydrochloride Chemical class 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (15)
- 트로핀 또는 슈도트로핀을 일반식(Ⅳ)의 산할라이드와 반응시킴을 특징으로 하여 일반식(Ⅰ)의 트로필 또는 슈도트로필 벤조에이트 유도체 또는 그의 약학적으로 무독한 염을 제조하는 방법.
-
- 상기식에서
- n은 0 또는 1내지 4의 정수를 나타내며 ;
- R1은 C1-C4알콕시 또는 염소를 나타내고 (단, n이 0이면 R1은 염소가 아니다) ;
- R2은 C1-C4알킬, C1-C4알콕시 또는 할로겐을 나타내고 (단, R1이 염소이고 n이 1이면, R2는 4, 5 또는 6위치에서의 염소가 아니며,
- n이 2, 3 또는 4이면 R2는 R1과 같다) ;
- X는 할로겐을 나타낸다.
- 제1항에 있어서, R1및 R2가 모두 염소를 나타내는 방법.
- 제1항에 있어서, n이 0인 방법.
- 제1항에 있어서, n이 1 또는 2인 방법.
- n이 1이고, 페닐그룹이 2, 3 ; 2, 4 ; 또는 2, 5 위치에서 치환된 방법.
- 제1항에 있어서, 트로핀의 할로겐화 수소산염을 용매의 부재하에 산할라이드와 가열하는 방법.
- 제1항에 있어서, 슈도트로핀을 주워 온도에서 비양자성 용매중에 산할라이드와 교반하는 방법.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08235296A GB2132189B (en) | 1982-12-10 | 1982-12-10 | Tropyl and pseudotropyl benzoates and their use in migraine treatment |
| GB8235296 | 1982-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR840006999A true KR840006999A (ko) | 1984-12-04 |
Family
ID=10534881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830005847A KR840006999A (ko) | 1982-12-10 | 1983-12-09 | 치환된 트로필 및 슈도트로필 벤조에이트의 제조방법 |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0112266B1 (ko) |
| JP (1) | JPS59152383A (ko) |
| KR (1) | KR840006999A (ko) |
| AT (1) | ATE32896T1 (ko) |
| AU (1) | AU558082B2 (ko) |
| CA (1) | CA1202027A (ko) |
| DE (1) | DE3375918D1 (ko) |
| DK (1) | DK568483A (ko) |
| ES (1) | ES8505636A1 (ko) |
| GB (1) | GB2132189B (ko) |
| GR (1) | GR79159B (ko) |
| IE (1) | IE56327B1 (ko) |
| IL (1) | IL70384A0 (ko) |
| NO (1) | NO834540L (ko) |
| NZ (1) | NZ206496A (ko) |
| PH (1) | PH20063A (ko) |
| ZA (1) | ZA839044B (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204356A (en) * | 1985-07-24 | 1993-04-20 | Glaxo Group Limited | Treatment of anxiety |
| US4906755A (en) * | 1986-11-03 | 1990-03-06 | Merrell Dow Pharmaceuticals Inc. | Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds |
| AUPR701101A0 (en) * | 2001-08-14 | 2001-09-06 | Commonwealth Scientific And Industrial Research Organisation | Agonists and antagonists of 5ht3-like receptors of invertebrates as pesticides |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1161325A (fr) * | 1954-01-22 | 1958-08-26 | Sandoz Ag | Procédé de préparation d'esters de 6-alcoxy-tropines présentant un atome d'azotequaternaire |
-
1982
- 1982-12-10 GB GB08235296A patent/GB2132189B/en not_active Expired
-
1983
- 1983-12-05 CA CA000442556A patent/CA1202027A/en not_active Expired
- 1983-12-05 ZA ZA839044A patent/ZA839044B/xx unknown
- 1983-12-05 IL IL70384A patent/IL70384A0/xx unknown
- 1983-12-06 ES ES527842A patent/ES8505636A1/es not_active Expired
- 1983-12-06 AT AT83440062T patent/ATE32896T1/de active
- 1983-12-06 EP EP83440062A patent/EP0112266B1/en not_active Expired
- 1983-12-06 NZ NZ206496A patent/NZ206496A/en unknown
- 1983-12-06 DE DE8383440062T patent/DE3375918D1/de not_active Expired
- 1983-12-07 AU AU22152/83A patent/AU558082B2/en not_active Ceased
- 1983-12-08 IE IE2885/83A patent/IE56327B1/xx unknown
- 1983-12-09 JP JP58231590A patent/JPS59152383A/ja active Pending
- 1983-12-09 NO NO834540A patent/NO834540L/no unknown
- 1983-12-09 PH PH29951A patent/PH20063A/en unknown
- 1983-12-09 GR GR73205A patent/GR79159B/el unknown
- 1983-12-09 KR KR1019830005847A patent/KR840006999A/ko not_active Application Discontinuation
- 1983-12-09 DK DK568483A patent/DK568483A/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0112266A3 (en) | 1985-10-23 |
| AU558082B2 (en) | 1987-01-15 |
| GB2132189B (en) | 1986-02-05 |
| NZ206496A (en) | 1986-07-11 |
| IL70384A0 (en) | 1984-03-30 |
| ES527842A0 (es) | 1985-06-16 |
| DK568483D0 (da) | 1983-12-09 |
| IE56327B1 (en) | 1991-06-19 |
| PH20063A (en) | 1986-09-18 |
| IE832885L (en) | 1984-06-10 |
| GB2132189A (en) | 1984-07-04 |
| CA1202027A (en) | 1986-03-18 |
| JPS59152383A (ja) | 1984-08-31 |
| EP0112266A2 (en) | 1984-06-27 |
| DE3375918D1 (en) | 1988-04-14 |
| AU2215283A (en) | 1984-06-14 |
| EP0112266B1 (en) | 1988-03-09 |
| ATE32896T1 (de) | 1988-03-15 |
| NO834540L (no) | 1984-06-12 |
| DK568483A (da) | 1984-06-11 |
| GR79159B (ko) | 1984-10-02 |
| ES8505636A1 (es) | 1985-06-16 |
| ZA839044B (en) | 1984-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR880013888A (ko) | 신규 디티오아세탈 화합물, 그의 제조방법 및 이 화합물로 되는 제약 조성물 | |
| KR840004441A (ko) | 포스포리피드 유도체의 제조방법 | |
| KR850005829A (ko) | 2-시아노벤즈이미다졸 유도체의 제조방법 | |
| KR830007686A (ko) | 세팔로 스포린 유도체의 제조방법 | |
| KR850001184A (ko) | 1,5-벤조티아제핀 유도체의 제조방법 | |
| KR850005845A (ko) | 7-아미노-3-치환된-메틸-3-세펨-4-카복실산 및 그의 저급 알킬실릴 유도체의 제조방법 | |
| KR850002459A (ko) | 디히드록시벤즈아미드 유도체 및 그 제조방법 | |
| KR840006999A (ko) | 치환된 트로필 및 슈도트로필 벤조에이트의 제조방법 | |
| YU91483A (en) | Process for obtaining new thiomethylpyridine derivatives | |
| KR860003231A (ko) | 2-시아노벤즈 이미다졸 유도체의 제조방법 | |
| KR850001188A (ko) | 벤조푸란 유도체의 제조방법 및 조성물 | |
| KR860002474A (ko) | 치환된 페닐술포닐아졸의 제조방법 | |
| KR840002821A (ko) | N-(2,3-에폭시프로필렌)-n-아르알킬술폰아미드 유도체의 제조방법 | |
| KR860700352A (ko) | 2--(1-피페라지닐)-4-치환 페닐퀴놀린 유도체와 그 염의 제조방법 | |
| KR830003460A (ko) | 면역조절 활성을 갖는 치환된 피페라진 및 피페리딘 | |
| KR840004420A (ko) | N-(1,3-디티올린-2-알리덴)아닐린 유도체의 제조방법 | |
| KR840005107A (ko) | 피리미디온 및 그의 산부가염의 제조방법 | |
| KR840005092A (ko) | 벤조페논 유도체의 제조방법 | |
| KR840001172A (ko) | 편두통 치료제인 트로필 벤조에이트 유도체의 제조방법 | |
| KR840006967A (ko) | N-알킬-피페리디닐 벤조에이트 유도체의 제조방법 | |
| KR850004581A (ko) | α,α-디메틸페닐아세트아닐리드 유도체의 제조방법 | |
| KR830002718A (ko) | 피라졸 유도체의 제조법 | |
| KR850006397A (ko) | 치환된 이소크로만 및 옥세핀의 제조방법 | |
| KR840002848A (ko) | 유기인산염의 제조방법 | |
| KR840002835A (ko) | 트로필 및 슈도트로필 알킬- 벤조에이트의 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |